Epigenetics & Stem Cell Biology Laboratory
Awards and Recognitions
Members of the Epigenetics and Stem Cell Biology Laboratory have been recognized for their outstanding science and contributions to the NIEHS and the NIH with a number of awards. A sample of recent recognitions include the following:
Dr. Amanda Conway
Dr. Amanda Conway, a Postdoctoral IRTA Fellow in Dr. Raja Jothi’s group, has won a prestigious NIGMS PRAT Fellowship (2014 - 2017).
Awards For Scientific Presentations
Several members of ESCBL have been recognized within NIEHS for their scientific presentations within NIEHS.
A number of post-doctoral fellows in ESCBL have earned the very competitive NIH Fellows Awards for Research Excellence (FARE) in the last few years:
- 2014 – Senthilkumar Cinghu, mentored by Raja Jothi, and George Fromm, mentored by Karen Adelman.
- 2015 – Andrew Oldfield, Penyi Yang, and Senthilkumar Cinghu, all mentored by Raja Jothi.
NIEHS Director's Awards of Merit
Several ESCBL members were recognized with NIEHS Director’s Awards of Merit for their participation in groups that provided sustained support of key research efforts.
Papers of the Month
Researchers from within NIEHS (Division of Intramural Research) publish many peer-reviewed articles in a variety of journals each year. The NIEHS highlights some of these publications and their importance to the advancement of science by choosing a select few each month as one of the Papers of the Month. Members of ESCBL were recognized in this way multiple times over the last few years, and are listed below.
For 2017 (through March):
- Zhang J, Gonzalez LE, Hall TM. (2017) Structural analysis reveals the flexible C-terminus of Nop15 undergoes rearrangement to recognize a pre-ribosomal RNA folding intermediate. Nucleic Acids Res 45(5): 2829-2837.
- Zheng X, Yang P, Lackford B, Bennett BD, Wang L, Li H, Wang Y, Miao Y, Foley JF, Fargo DC, Jin Y, Williams CJ, Jothi R, Hu G. (2016) CNOT3-dependent mRNA deadenylation safeguards the pluripotent state. Stem Cell Reports 7(5):897−910.
- Zhang J, McCann KL, Qiu C, Gonzalez LE, Baserga SJ, Hall TM. (2016) Nop9 is a PUF-like protein that prevents premature cleavage to correctly process pre-18S rRNA. Nat Commun 7:13085.
- Zhang S, Zhou B, Wang L, Li P, Bennett BD, Snyder R, Garantziotis S, Fargo DC, Cox AD, Chen L, Hu G. (2016) INO80 is required for oncogenic transcription and tumor growth in non-small cell lung cancer. Oncogene 36(10):1430-1439.
- Harlid S, Adgent M, Jefferson WN, Panduri V, Umbach DM, Xu Z, Stallings VA, Williams CJ, Rogan WJ, Taylor JA. (2017) Soy formula and epigenetic modifications: analysis of vaginal epithelial cells from infant girls in the IFED Study. Environ Health Perspect 125(3):447-452.
- Lavender CA, Cannady KR, Hoffman JA, Trotter KW, Gilchrist DA, Bennett BD, Burkholder AB, Burd CJ, Fargo DC, Archer TK. (2016) Downstream antisense transcription predicts genomic features that define the specific chromatin environment at mammalian promoters. PLoS Genet 12(8):e1006224.
- Zhou B, Wang L, Zhang S, Bennett BD, He F, Zhang Y, Xiong C, Han L, Diao L, Li P, Fargo DC, Cox AD, Hu G. (2016) INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma. Genes Dev 30(12):1440-1453.
- Singh AP, Foley JF, Rubino M, Boyle MC, Tandon A, Shah R, Archer TK. (2016) Brg1 enables rapid growth of the early embryo by suppressing genes that regulate apoptosis and cell growth arrest. Mol Cell Biol 36(15):1990-2010.
- Takaku M, Grimm SA, Shimbo T, Perera L, Menafra R, Stunnenberg HG, Archer TK, Machida S, Kurumizaka H, Wade PA. (2016) GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler. Genome Biol 17(1):36.
- Wade SL, Langer LF, Ward JM, Archer TK. (2015) MiRNA-mediated regulation of the SWI/SNF chromatin remodeling complex controls pluripotency and endodermal differentiation in human ESCs. Stem Cells 33(10):2925-2935.
- Qiu C, McCann KL, Wine RN, Baserga SJ, Hall TM. (2014) A divergent Pumilio repeat protein family for pre-rRNA processing and mRNA localization. Proc Natl Acad Sci USA 111(52):18554-18559.
- Oldfield AJ*, Yang P*, Conway AE, Cinghu S, Freudenberg JM, Yellaboina S, Jothi R. (2014) Histone-Fold Domain Protein NF-Y Promotes Chromatin Accessibility for Cell Type-Specific Master Transcription Factors. Molecular Cell 55(5):708-22. (*Co-first authors) [Abstract]
- Zhang J, Tan D, DeRose EF, Perera L, Dominski Z, Marzluff WF, Tong L, Hall TM. (2014) Molecular mechanisms for the regulation of histone mRNA stem-loop-binding protein by phosphorylation. Proc Natl Acad Sci USA 111(29):E2937-E2946. [Abstract]
- Wang L, Du Y, Ward JM, Shimbo T, Lackford B, Zheng X, Miao YL, Zhou B, Han L, Fargo DC, Jothi R, Williams CJ, Wade PA, Hu G. (2014) INO80 Facilitates Pluripotency Gene Activation in Embryonic Stem Cell Self-Renewal, Reprogramming, and Blastocyst Development. Cell Stem Cell 14(5):575-91. [Abstract]
- Li R, Grimm SA, Chrysovergis K, Kosak J, Wang X, Du Y, Burkholder A, Janardhan K, May D, Shah R, Eling TE, Wade PA. Obesity, rather than diet, drives epigenomic alterations in colonic epithelium resembling cancer progression. (2014) Cell Metabolism 19(4):702-711. [Abstract]
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