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Your Environment. Your Health.

Signal Transduction Laboratory

Anant Parekh
Anant B. Parekh, D.Phil.
Chief, Signal Transduction Laboratory and Senior Investigator
Tel 984-287-4545
anant.parekh@nih.gov
P.O. Box 12233
Mail Drop F2-02
Durham, N.C. 27709
John A. Cidlowski, Ph.D.
John A. Cidlowski, Ph.D.
Deputy Chief, Signal Transduction Laboratory and Senior Investigator
Tel 984-287-3545
Fax 919-541-1367
cidlows1@niehs.nih.gov
NIH Intramural Profile John Cidlowski
P.O. Box 12233
Mail Drop F3-06
Durham, N.C. 27709

Research Summary

The overall goal of the Signal Transduction Laboratory is to define the mechanisms that cells, tissues and organisms use to respond to physiological and environmental stimuli. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer.

The delineation of the signal transduction pathways affected in these and other complex human diseases is likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms. The Signal Transduction Laboratory seeks to achieve this goal through cutting edge basic research and training of junior scientists in aspects of environmental health related science that are critical to the mission of NIEHS. It is anticipated that research in signal transduction will have a central role in environmental human health in the post-genomic era.

The depiction of several signal transduction pathways that are activated in a human cell following environmental stimuli
Several signal transduction pathways that occur in the human cell.
Anant Parakh, D.Phil. Xioling Li, Ph.D. Stephen Shears, Ph.D. Robin Stanley, Ph.D. Perry Blackshear, M.D., D.Phil. John Cidlowski, Ph.D.

Shared and Core Facilities

For more information about facilities that support research activities at the NIEHS campus, please see Shared and Core Facilities.

The Signal Transduction Laboratory investigates the following topics:

  • Glucocorticoid receptors and their actions in genetically modified animals
  • Mechanisms involved in the regulation of apoptosis in normal and neoplastic cells
  • Intracellular Ca2+ pools involved in cellular signaling, and the basis for intracellular [Ca2+]i oscillations
  • Inositol phosphate family of intracellular signals, and their responses to environmental insults
  • Gene-environment interactions in metabolism and metabolic diseases, with focus on sirtuins, post translational modifications, and epigenetics
  • The roles played by a small family of CCCH tandem zinc finger proteins in the physiological regulation of mRNA turnover and responses to environmental stimuli
  • Molecular mechanisms governing eukaryotic ribosome biogenesis

Scientific Support Staff

Pinkney Wilder
Pinkney Wilder III
Administrative Specialist

Tel 984-287-3499
Fax 919-541-2429
wilderp@niehs.nih.gov
Judy Bartz
Judy L. Bartz
Administrative Technician

Tel 984-287-3497
bartzjl@niehs.nih.gov
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