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Selected Publications

Neuropharmacology Group

(Total paper published: >480; Total number of citations > 38,800; H-factor: 97)

  1. Hou L, Zhang L, Hong JS, Zhang D, Zhao J, Wang Q. 2020. Nicotinamide Adenine Dinucleotide Phosphate Oxidase and Neurodegenerative Diseases: Mechanisms and Therapy. Antioxid Redox Signal; doi: 10.1089/ars.2019.8014 [Online 21 February 2020]. [Abstract Hou L, Zhang L, Hong JS, Zhang D, Zhao J, Wang Q. 2020. Nicotinamide Adenine Dinucleotide Phosphate Oxidase and Neurodegenerative Diseases: Mechanisms and Therapy. Antioxid Redox Signal; doi: 10.1089/ars.2019.8014 [Online 21 February 2020].]
  2. Lee SY, Wang TY, Chen SL, Chang YH, Chen PS, Huang SY, Tzeng NS, Wang LJ, Lee IH, Chen KC, Yang YK, Hong JS, Lu RB. 2020. Combination of dextromethorphan and memantine in treating bipolar spectrum disorder: a 12-week double-blind randomized clinical trial. Int J Bipolar Disord 8(1):11. [Abstract Lee SY, Wang TY, Chen SL, Chang YH, Chen PS, Huang SY, Tzeng NS, Wang LJ, Lee IH, Chen KC, Yang YK, Hong JS, Lu RB. 2020. Combination of dextromethorphan and memantine in treating bipolar spectrum disorder: a 12-week double-blind randomized clinical trial. Int J Bipolar Disord 8(1):11.]
  3. Lee PW, Wang TY, Chang YH, Lee SY, Chen SL, Wang ZC, Chen PS, Chu CH, Huang SY, Tzeng NS, Lee IH, Chen KC, Yang YK, Hong JS, Lu RB. 2020. ALDH2 Gene: Its Effects on the Neuropsychological Functions in Patients with Opioid Use Disorder Undergoing Methadone Maintenance Treatment. Clin Psychopharmacol Neurosci 18(1):136-144. [Abstract Lee PW, Wang TY, Chang YH, Lee SY, Chen SL, Wang ZC, Chen PS, Chu CH, Huang SY, Tzeng NS, Lee IH, Chen KC, Yang YK, Hong JS, Lu RB. 2020. ALDH2 Gene: Its Effects on the Neuropsychological Functions in Patients with Opioid Use Disorder Undergoing Methadone Maintenance Treatment. Clin Psychopharmacol Neurosci 18(1):136-144.] 
  4. Gao Y, Tu D, Yang R, Chu CH, Hong JS, Gao HM. 2020. Through Reducing ROS Production, IL-10 Suppresses Caspase-1-Dependent IL-1β Maturation, thereby Preventing Chronic Neuroinflammation and Neurodegeneration. Int J Mol Sci; doi: 10.3390/ijms21020465 [Online 20 January 2020]. [Abstract Gao Y, Tu D, Yang R, Chu CH, Hong JS, Gao HM. 2020. Through Reducing ROS Production, IL-10 Suppresses Caspase-1-Dependent IL-1β Maturation, thereby Preventing Chronic Neuroinflammation and Neurodegeneration. Int J Mol Sci; doi: 10.3390/ijms21020465 [Online 20 January 2020].]
  5. Zhao Z, Wang Y, Zhou R, Li Y, Gao Y, Tu D, Wilson B, Song S, Feng J, Hong JS, Yakel JL. 2020. A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration. J Neuroinflammation 17(1):64. [Abstract Zhao Z, Wang Y, Zhou R, Li Y, Gao Y, Tu D, Wilson B, Song S, Feng J, Hong JS, Yakel JL. 2020. A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration. J Neuroinflammation 17(1):64.]
  6. Lu RB, Chang YH, Lee SY, Wang TY, Cheng SL, Chen PS, Yang YK, Hong JS, Chen SL. 2020. Dextromethorphan Protect the Valproic Acid Induced Downregulation of Neutrophils in Patients with Bipolar Disorder. Clin Psychopharmacol Neurosci 18(1):145-152. [Abstract Lu RB, Chang YH, Lee SY, Wang TY, Cheng SL, Chen PS, Yang YK, Hong JS, Chen SL. 2020. Dextromethorphan Protect the Valproic Acid Induced Downregulation of Neutrophils in Patients with Bipolar Disorder. Clin Psychopharmacol Neurosci 18(1):145-152.]
  7. Wang QS, Oyarzabal EA, Song S , Wilson B, Santos JH, Hong JS. 2020. Locus coeruleus neurons are most sensitive to chronic neuroinflammation-induced neurodegeneration. Brain Behav Immun; doi: 10.1016/j.bbi.2020.01.003 [Online 7 January 2020]. [Abstract Wang QS, Oyarzabal EA, Song S , Wilson B, Santos JH, Hong JS. 2020. Locus coeruleus neurons are most sensitive to chronic neuroinflammation-induced neurodegeneration. Brain Behav Immun; doi: 10.1016/j.bbi.2020.01.003 [Online 7 January 2020].]
  8. Lu RB, Wang TY, Lee SY, Chen SL, Chang YH, Chen PS, Lin SH, Chu CH, Huang SY, Tzeng NS, Lee IH, Chen KC, Yang YK, Chen P, Chen SH, Hong JS. 2019. Correlation between interleukin-6 levels and methadone maintenance therapy outcomes. Drug Alcohol Depend; doi: 10.1016/j.drugalcdep.2019.06.018 [Online 1 November 2019]. [Abstract Lu RB, Wang TY, Lee SY, Chen SL, Chang YH, Chen PS, Lin SH, Chu CH, Huang SY, Tzeng NS, Lee IH, Chen KC, Yang YK, Chen P, Chen SH, Hong JS. 2019. Correlation between interleukin-6 levels and methadone maintenance therapy outcomes. Drug Alcohol Depend; doi: 10.1016/j.drugalcdep.2019.06.018 [Online 1 November 2019].]
  9. Tu D, Gao Y, Yang R , Guan T, Hong JS, Gao HM. The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration. J Neuroinflammation 2019 16(1):255. [Abstract Tu D, Gao Y, Yang R , Guan T, Hong JS, Gao HM. The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration. J Neuroinflammation 2019 16(1):255.]
  10. Wang QS, Oyarzabal EA, Song S, Wilson B, Santos JH, Hong JS. Locus coeruleus neurons are most sensitive to chronic neuroinflammation-induced neurodegeneration. Brain, Behavior, and Immunity 2019 (in press).
  11. Hou L, Zhang L , Cheng C, Zhang D, Hong JS, Wang QS. NADPH oxidase as a promising therapeutic target for neurodegenerative diseases. Antioxidants & Redox Signaling 2019 (in press).
  12. Song S, Wang Q, Jiang L, Oyarzabal E, Riddick NV, Wilson B, Moy SS, Shih YY, Hong JS. Noradrenergic Dysfunction Accelerates LPS-elicited Inflammation-related Ascending Sequential Neurodegeneration and Deficits in Non-motor/Motor Functions. Brain, Behavior, and Immunity 2019 81:374-387. [Abstract Song S, Wang Q, Jiang L, Oyarzabal E, Riddick NV, Wilson B, Moy SS, Shih YY, Hong JS. Noradrenergic Dysfunction Accelerates LPS-elicited Inflammation-related Ascending Sequential Neurodegeneration and Deficits in Non-motor/Motor Functions. Brain, Behavior, and Immunity 2019 81:374-387.]
  13. Song S, Jiang L, Oyarzabal EA, Wilson B, Li Z, Shih YI, Wang Q, Hong JS. Loss of Brain Norepinephrine Elicits Neuroinflammation-Mediated Oxidative Injury and Selective Caudo-Rostral Neurodegeneration. Molecular Neurobiology 2019 56:2653-2669. [Abstract Song S, Jiang L, Oyarzabal EA, Wilson B, Li Z, Shih YI, Wang Q, Hong JS. Loss of Brain Norepinephrine Elicits Neuroinflammation-Mediated Oxidative Injury and Selective Caudo-Rostral Neurodegeneration. Molecular Neurobiology 2019 56:2653-2669.]
  14. Dang DK, Shin EJ, Kim DJ, Tran HQ, Jeong JH, Jang CG, Ottersen OP, Nah SY, Hong JS, Nabeshimah T, Kim HC. 2018. PKCδ-dependent p47phox activation mediates methamphetamine-induced dopaminergic neurotoxicity. Free Radic Biol Med 115:318-337. [Abstract Dang DK, Shin EJ, Kim DJ, Tran HQ, Jeong JH, Jang CG, Ottersen OP, Nah SY, Hong JS, Nabeshimah T, Kim HC. 2018. PKCδ-dependent p47phox activation mediates methamphetamine-induced dopaminergic neurotoxicity. Free Radic Biol Med 115:318-337.]
  15. Zhang W, Gao JH, Yan ZF, Huang XY, Guo P, Sun L, Liu Z, Hu Y, Zuo LJ, Yu SY, Cao CJ, Wang XM, Hong JS. Minimally Toxic Dose of Lipopolysaccharide and α-Synuclein Oligomer Elicit Synergistic Dopaminergic Neurodegeneration: Role and Mechanism of Microglial NOX2 Activation. Molecular Neurobiology 2018 55(1):619-632. [Abstract Zhang W, Gao JH, Yan ZF, Huang XY, Guo P, Sun L, Liu Z, Hu Y, Zuo LJ, Yu SY, Cao CJ, Wang XM, Hong JS. Minimally Toxic Dose of Lipopolysaccharide and α-Synuclein Oligomer Elicit Synergistic Dopaminergic Neurodegeneration: Role and Mechanism of Microglial NOX2 Activation. Molecular Neurobiology 2018 55(1):619-632.]
  16. Chen SH, Sung YF, Oyarzabal EA, Tan YM, Leonard J, Guo MG, Li S, Wang QS, ChuCH, ChenSL, Lu RB, Hong JS. Physiological concentration of prostaglandin E2 exerts anti-inflammatory effects by inhibiting microglial production of superoxide through a novel pathway. Molecular Neurobiology 2018 55:8001-8013. [Abstract Chen SH, Sung YF, Oyarzabal EA, Tan YM, Leonard J, Guo MG, Li S, Wang QS, ChuCH, ChenSL, Lu RB, Hong JS. Physiological concentration of prostaglandin E2 exerts anti-inflammatory effects by inhibiting microglial production of superoxide through a novel pathway. Molecular Neurobiology 2018 55:8001-8013.]
  17. Chang HH, Chen PS, Wang TY, Lee SY, Chen SL, Huang SY, Hong JS, Yang YK, Lu RB. 2017. Effect of memantine on C-reactive protein and lipid profiles in bipolar disorder. J Affect Disord 221:151-157. [Abstract Chang HH, Chen PS, Wang TY, Lee SY, Chen SL, Huang SY, Hong JS, Yang YK, Lu RB. 2017. Effect of memantine on C-reactive protein and lipid profiles in bipolar disorder. J Affect Disord 221:151-157.]
  18. Hou L, Zhou X, Zhang C, Wang K, Liu X, Che Y, Sun F, Li H, Wang Q, Zhang D, Hong JS. NADPH oxidase-derived H2O2 mediates the regulatory effects of microglia on astrogliosis in experimental models of Parkinson's disease. Redox Biology 2017, 12:162-170. doi: 10.1016/j.redox.2017.02.016.
  19. Shin EJ, Dang DK, Tran HQ, Nam Y, Jeong JH, Lee YH, Park KT, Lee YS, Jang CG, Hong JS, Nabeshima T, Kim HC. 2016. PKCδ knockout mice are protected from para-methoxymethamphetamine-induced mitochondrial stress and associated neurotoxicity in the striatum of mice. Neurochem Int 100:146-158. [Abstract Shin EJ, Dang DK, Tran HQ, Nam Y, Jeong JH, Lee YH, Park KT, Lee YS, Jang CG, Hong JS, Nabeshima T, Kim HC. 2016. PKCδ knockout mice are protected from para-methoxymethamphetamine-induced mitochondrial stress and associated neurotoxicity in the striatum of mice. Neurochem Int 100:146-158.]
  20. Chen SH, Oyarzabal EA, Hong JS. Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration. Current Opinion in Pharmacology 2016 26():54-60. [Abstract Chen SH, Oyarzabal EA, Hong JS. Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration. Current Opinion in Pharmacology 2016 26():54-60.]
  21. Wang Q, Qian L, Chen SH, Chu CH, Wilson B, Oyarzabal E, Ali S, Robinson B, Rao D, Hong JS. Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson's disease models. Brain. 2015 May;138(Pt 5):1247-62. doi: 10.1093/brain/awv034. Epub 2015 Feb 25. [Abstract Wang Q, Qian L, Chen SH, Chu CH, Wilson B, Oyarzabal E, Ali S, Robinson B, Rao D, Hong JS. Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson's disease models. Brain. 2015 May;138(Pt 5):1247-62. doi: 10.1093/brain/awv034. Epub 2015 Feb 25.]
  22. Wang S, Chu CH, Stewart T, Ginghina C, Wang Y, Nie H, Guo M, Wilson B, Hong JS, Zhang J. α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1926-35. doi: 10.1073/pnas.1417883112. Epub 2015 Mar 30. [Abstract Wang S, Chu CH, Stewart T, Ginghina C, Wang Y, Nie H, Guo M, Wilson B, Hong JS, Zhang J. α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1926-35. doi: 10.1073/pnas.1417883112. Epub 2015 Mar 30.]
  23. Chen SH, Oyarzabal EA, Sung YF, Chu CH, Wang Q, Chen SL, Lu RB, Hong JS. Microglial regulation of immunological and neuroprotective functions of astroglia. Glia. 2015 Jan;63(1):118-31. doi: 10.1002/glia.22738. Epub 2014 Aug 13. [Abstract Chen SH, Oyarzabal EA, Sung YF, Chu CH, Wang Q, Chen SL, Lu RB, Hong JS. Microglial regulation of immunological and neuroprotective functions of astroglia. Glia. 2015 Jan;63(1):118-31. doi: 10.1002/glia.22738. Epub 2014 Aug 13.]
  24. Wang Q, Chu CH, Qian L, Chen SH, Wilson B, Oyarzabal E, Jiang L, Ali S, Robinson B, Kim HC, Hong JS. Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase. J Neurosci. 2014 Sep 10;34(37):12490-503. doi: 10.1523/JNEUROSCI.2238-14.2014. [Abstract Wang Q, Chu CH, Qian L, Chen SH, Wilson B, Oyarzabal E, Jiang L, Ali S, Robinson B, Kim HC, Hong JS. Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase. J Neurosci. 2014 Sep 10;34(37):12490-503. doi: 10.1523/JNEUROSCI.2238-14.2014.]
  25. Kumar A, Chen SH, Kadiiska MB, Hong JS, Zielonka J, Kalyanaraman B, Mason RP. Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells. Free Radical Biology & Medicine 2014 73():51-59. [Abstract Kumar A, Chen SH, Kadiiska MB, Hong JS, Zielonka J, Kalyanaraman B, Mason RP. Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells. Free Radical Biology & Medicine 2014 73():51-59.]
  26. Qin LY, Liu Y, Hong JS, Crews FT. NADPH oxidase and aging drive microglial activation, oxidative stress and dopaminergic neurodegeneration following systemic LPS administration. Glia, 2013 (in press).
  27. Zhou H, Liao JY, Aloor J, Nie H, Wilson BC, Fessler MB, Gao HM, Hong JS.  CD11b/CD18 (Mac-1) is a novel surface receptor for extracellular double-stranded RNA to mediate cellular inflammatory responses. J Immunology 190(1):115-125, 2013. [Abstract Zhou H, Liao JY, Aloor J, Nie H, Wilson BC, Fessler MB, Gao HM, Hong JS.  CD11b/CD18 (Mac-1) is a novel surface receptor for extracellular double-stranded RNA to mediate cellular inflammatory responses. J Immunology 190(1):115-125, 2013.]
  28. Gao HM, Zhou H, Hong JS. NADPH oxidases: novel therapeutic targets for neurodegenerative diseases. Trends Parmacol Sci. 33(6):295-303, 2012. [Abstract Gao HM, Zhou H, Hong JS. NADPH oxidases: novel therapeutic targets for neurodegenerative diseases. Trends Parmacol Sci. 33(6):295-303, 2012.]
  29. Hu X, Zhou H, Zhang D, Yang SF, Qian L, Wu HM, Chen P, Wilson B, Gao HM, Lu RB, Hong JS. Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation.  J Neuroimmune Pharmacol. 7(1):187-201, 2012. [Abstract Hu X, Zhou H, Zhang D, Yang SF, Qian L, Wu HM, Chen P, Wilson B, Gao HM, Lu RB, Hong JS. Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation.  J Neuroimmune Pharmacol. 7(1):187-201, 2012.]
  30. Chen SH, Wu HM, Ossola B, Schendzielorz N, Wilson BC, Chu CH, Chen SL, Wang Q, Zhang D, Qian L, Li X, Hong JS, Lu RB. Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin-induced damage. Br J Pharmacol. 165(2):494-505, 2012. [Abstract Chen SH, Wu HM, Ossola B, Schendzielorz N, Wilson BC, Chu CH, Chen SL, Wang Q, Zhang D, Qian L, Li X, Hong JS, Lu RB. Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin-induced damage. Br J Pharmacol. 165(2):494-505, 2012.]
  31. Zhou H, Zhang F, Chen SH, Zhang D, Wilson B, Hong JS,Gao HM. Rotenone activates phagocyte NADPH oxidase through binding to its membrane subunit gp91phox. Free Radic Biol Med. 52(2):303-313, 2012. [Abstract Zhou H, Zhang F, Chen SH, Zhang D, Wilson B, Hong JS,Gao HM. Rotenone activates phagocyte NADPH oxidase through binding to its membrane subunit gp91phox. Free Radic Biol Med. 52(2):303-313, 2012.]
  32. Qian L, Wu HM, Chen SH, Zhang D, Ali SF, Peterson L, Wilson B, Lu RB, Hong JS, Flood PM. Beta2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway. J Immunol. 186(7):4443-4454, 2011. [Abstract Qian L, Wu HM, Chen SH, Zhang D, Ali SF, Peterson L, Wilson B, Lu RB, Hong JS, Flood PM. Beta2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway. J Immunol. 186(7):4443-4454, 2011.]
  33. Gao HM, Zhang F, Zhou H, Kam W, Wilson B, Hong JS. Neuroinflammation and α-synuclein dysfunction potentiate each other driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. Environ Health Perspect. 119(6):807-814, 2011. [Abstract Gao HM, Zhang F, Zhou H, Kam W, Wilson B, Hong JS. Neuroinflammation and α-synuclein dysfunction potentiate each other driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. Environ Health Perspect. 119(6):807-814, 2011.]
  34. Gao HM, Hong JS. Gene-environment interactions: key to unraveling the mystery of Parkinson's disease. Prog Neurobiol. 94(1):1-19, 2011. [Abstract Gao HM, Hong JS. Gene-environment interactions: key to unraveling the mystery of Parkinson's disease. Prog Neurobiol. 94(1):1-19, 2011.]
  35. Gao, H.M., Zhou, H., Zhang, F., Wilson, B.C., Kam, W. and Hong, J.S. HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration. The Journal of neuroscience. 31(3):1081-1092, 2011. [Abstract Gao, H.M., Zhou, H., Zhang, F., Wilson, B.C., Kam, W. and Hong, J.S. HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration. The Journal of neuroscience. 31(3):1081-1092, 2011.]
  36. Levesque S, Wilson B, Gregoria V, Thorpe LB, Dallas S, Polikov VS, Hong JS, Block ML.  Reactive microgliosis: extracellular micro-calpain and microglia-mediated dopaminergic neurotoxicity. Brain 133(Pt 3):808-821, 2010. [Abstract Levesque S, Wilson B, Gregoria V, Thorpe LB, Dallas S, Polikov VS, Hong JS, Block ML.  Reactive microgliosis: extracellular micro-calpain and microglia-mediated dopaminergic neurotoxicity. Brain 133(Pt 3):808-821, 2010.]
  37. Zhang F, Qian L, Flood PM, Jin Shi JS, Hong JS, Gao HM. Inhibition of IkappaB kinase-beta protects dopamine neurons against lipopolysaccharide-induced neurotoxicity. J Pharmcol Exp Ther. 333(3):822-833, 2010.   [Abstract Zhang F, Qian L, Flood PM, Jin Shi JS, Hong JS, Gao HM. Inhibition of IkappaB kinase-beta protects dopamine neurons against lipopolysaccharide-induced neurotoxicity. J Pharmcol Exp Ther. 333(3):822-833, 2010.  ]
  38. Zhang F, Shi JS, Zhou H, Hong JS, Gao HM. Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions. Mol Pharmacol. 78(3):466-477, 2010. [Abstract Zhang F, Shi JS, Zhou H, Hong JS, Gao HM. Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions. Mol Pharmacol. 78(3):466-477, 2010.]
  39. Luo L, Rodriguez E, Jerbi K, Lachaux JP, Martinerie J, Corbetta M, Shulman GL, Piomelli D, Turrigiano GG, Nelson SB, Joels M, de Kloet ER, Holsboer F, Amodio DM, Frith CD, Block ML, Zecca L, Hong JS, Dantzer R, Kelley KW, Craig AD. Ten years of Nature Reviews Neuroscience: insights from the highly cited. Nat Rev Neurosci. 11(10):718-726, 2010.   [Abstract Luo L, Rodriguez E, Jerbi K, Lachaux JP, Martinerie J, Corbetta M, Shulman GL, Piomelli D, Turrigiano GG, Nelson SB, Joels M, de Kloet ER, Holsboer F, Amodio DM, Frith CD, Block ML, Zecca L, Hong JS, Dantzer R, Kelley KW, Craig AD. Ten years of Nature Reviews Neuroscience: insights from the highly cited. Nat Rev Neurosci. 11(10):718-726, 2010.  ]
  40. Qian L, Flood PM, Hong JS.  Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy. J Neural Transm. 117(8):971-979, 2010. [Abstract Qian L, Flood PM, Hong JS.  Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy. J Neural Transm. 117(8):971-979, 2010.]
  41. Wu HM, Tzeng NS, Qian L, Wei SJ, Hu X, Chen SH, Rawls SM, Flood P, Hong JS, Lu RB. Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation.  Neuropsychopharmacology 34(10): 2344-2357, 2009. [Abstract Wu HM, Tzeng NS, Qian L, Wei SJ, Hu X, Chen SH, Rawls SM, Flood P, Hong JS, Lu RB. Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation.  Neuropsychopharmacology 34(10): 2344-2357, 2009.]
  42. Zhang D, Hu X, Qian L, Wilson B, Lee C, Flood P, Langenbach R, Hong JS. Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro. Toxicol Appl Pharmacol. 238(1):64-70, 2009. [Abstract Zhang D, Hu X, Qian L, Wilson B, Lee C, Flood P, Langenbach R, Hong JS. Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro. Toxicol Appl Pharmacol. 238(1):64-70, 2009.]
  43. Qian, L., Wei, S-J, Zhang, D., Hu, X., Xu, Z., Wilson, B., El-Benna, J., Hong, J.S. and Flood, P.M. Potent anti-inflammatory and neuroprotective effects of TGFb1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia. J Immunol. 181(1):660-668, 2008. [Abstract Qian, L., Wei, S-J, Zhang, D., Hu, X., Xu, Z., Wilson, B., El-Benna, J., Hong, J.S. and Flood, P.M. Potent anti-inflammatory and neuroprotective effects of TGFb1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia. J Immunol. 181(1):660-668, 2008.]
  44. Block, M. Zecca, L. O’Callahan, J. and Hong, J.S. Microglia-mediated neurotoxicity: uncovering the molecular mechanism. Nature Rev Neurosci. 8(1):57-69, 2007.  [Abstract Block, M. Zecca, L. O’Callahan, J. and Hong, J.S. Microglia-mediated neurotoxicity: uncovering the molecular mechanism. Nature Rev Neurosci. 8(1):57-69, 2007. ]
  45. Zhang W, Wang T, Liu J, Wilson B, Meng Y, Ali S, Kim H, Zhang W, Hong JS. 3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited dopaminergic neurodegeneration both in vivo and in vitro. FASEB J. 20(14):2496-2511, 2006. [Abstract Zhang W, Wang T, Liu J, Wilson B, Meng Y, Ali S, Kim H, Zhang W, Hong JS. 3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited dopaminergic neurodegeneration both in vivo and in vitro. FASEB J. 20(14):2496-2511, 2006.]
  46. Chen, P., Peng, G, Li, G., Yang, S., Wu, X., Wang, C., Wilson, B., Lu, R., Gean, P., Chuang, D. and Hong, J.S. Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes. Mol Psychiatry 11(12): 1116-1125, 2006.  [Abstract Chen, P., Peng, G, Li, G., Yang, S., Wu, X., Wang, C., Wilson, B., Lu, R., Gean, P., Chuang, D. and Hong, J.S. Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes. Mol Psychiatry 11(12): 1116-1125, 2006. ]
  47. Zhang, W, Wang, T, Pei, Z, Meng, Y., Wu, X, Wilson, B, Zhang, W, Hong, JS and Zhang, J. Aggregated a-synuclein activates microglia: a process leading to disease progression in Parkinson’s disease. FASEB J. 19(6): 533-542, 2005.  [Abstract Zhang, W, Wang, T, Pei, Z, Meng, Y., Wu, X, Wilson, B, Zhang, W, Hong, JS and Zhang, J. Aggregated a-synuclein activates microglia: a process leading to disease progression in Parkinson’s disease. FASEB J. 19(6): 533-542, 2005. ]
  48. Qin, L., Block, M., Liu, Y., Bienstock, R., Pei, Z., Zhang, W., Wu, X., Wilson, B., Burka, T. and Hong, JS Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress. FASEB J. 19: 550-557, 2005.  [Abstract Qin, L., Block, M., Liu, Y., Bienstock, R., Pei, Z., Zhang, W., Wu, X., Wilson, B., Burka, T. and Hong, JS Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress. FASEB J. 19: 550-557, 2005. ]
  49. Zhang, W, Qin, L, Wang T, Wei S. Gao H. Liu J, Wilson B, Liu B, Zhang W, Kim H, and Hong JS. 3-Hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity. FASEB J. 19(3): 395-397, 2005.  [Abstract Zhang, W, Qin, L, Wang T, Wei S. Gao H. Liu J, Wilson B, Liu B, Zhang W, Kim H, and Hong JS. 3-Hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity. FASEB J. 19(3): 395-397, 2005. ]
  50. Qin L, Liu Y, Wang T, Wei S, Block M, Wilson B, Liu B. and Hong JS. NADPH oxidase mediates LPS-induced neurotoxicity and pro-inflammatory gene expression in activated microglia. J Biol Chem. 279(2):1415-1421, 2004.  [Abstract Qin L, Liu Y, Wang T, Wei S, Block M, Wilson B, Liu B. and Hong JS. NADPH oxidase mediates LPS-induced neurotoxicity and pro-inflammatory gene expression in activated microglia. J Biol Chem. 279(2):1415-1421, 2004. ]
  51. Liu B. and Hong JS. Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation. Environ Health Perspect. 111(8): 1065-1073, 2003.  [Abstract Liu B. and Hong JS. Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation. Environ Health Perspect. 111(8): 1065-1073, 2003. ]
  52. Gao H, Liu B, Zhang W, and Hong JS. Novel anti-inflammatory therapy for Parkinson’s disease. Trends Pharmacol Sci. 24(8):395-401, 2003. [Abstract Gao H, Liu B, Zhang W, and Hong JS. Novel anti-inflammatory therapy for Parkinson’s disease. Trends Pharmacol Sci. 24(8):395-401, 2003.]
  53. Gao H, Liu B, and Hong JS. Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. J Neurosci. 23(15): 6181-6187, 2003.  [Abstract Gao H, Liu B, and Hong JS. Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. J Neurosci. 23(15): 6181-6187, 2003. ]
  54. Gao H, Hong JS, Zhang W, Liu B. Synergistic dopaminergic neurotoxicity of pesticide rotenone and inflammagen LPS: relevance to the etiology of Parkinson’s disease. J Neurosci. 23:1228-1236, 2003. [Abstract Gao H, Hong JS, Zhang W, Liu B. Synergistic dopaminergic neurotoxicity of pesticide rotenone and inflammagen LPS: relevance to the etiology of Parkinson’s disease. J Neurosci. 23:1228-1236, 2003.]
  55. Liu B. and Hong JS. Role of microglial activation in inflammation-mediated neurodegenerative diseases: study of mechanism and strategies for therapeutic intervention. J Pharma Exp Ther. 304(1): 1-7, 2003.  [Abstract Liu B. and Hong JS. Role of microglial activation in inflammation-mediated neurodegenerative diseases: study of mechanism and strategies for therapeutic intervention. J Pharma Exp Ther. 304(1): 1-7, 2003. ]
  56. Gao H, Jiang J, Wilson B, Zhang W, Hong JS, Liu B. Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J Neurochem. 81(6): 1285-1297, 2002.  [Abstract Gao H, Jiang J, Wilson B, Zhang W, Hong JS, Liu B. Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J Neurochem. 81(6): 1285-1297, 2002. ]
  57. Gao H, Hong JS, Zhang W, Liu B. Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J Neurosci. 22(3): 782-790, 2002.  [Abstract Gao H, Hong JS, Zhang W, Liu B. Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J Neurosci. 22(3): 782-790, 2002. ]
  58. Liu B, Qin L, Yang S, Wilson B, Liu Y, Hong, JS. Femtomolar concentrations of dynorphins protect rat mesencephalic dopaminergic neurons against inflammatory damage. J Pharm Exp Ther. 298(3): 1133-1141, 2001.  [Abstract Liu B, Qin L, Yang S, Wilson B, Liu Y, Hong, JS. Femtomolar concentrations of dynorphins protect rat mesencephalic dopaminergic neurons against inflammatory damage. J Pharm Exp Ther. 298(3): 1133-1141, 2001. ]
  59. Kim WG, Wilson BC, Jeohn GH, Hong JS. Differential susceptibility of neurons in different brain regions in lipopolysaccharide (LPS)-induced neurotoxicity. J Neurosci. 20(16): 6309-6316, 2000.  [Abstract Kim WG, Wilson BC, Jeohn GH, Hong JS. Differential susceptibility of neurons in different brain regions in lipopolysaccharide (LPS)-induced neurotoxicity. J Neurosci. 20(16): 6309-6316, 2000. ]
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