NMR & Ligand-Macromolecule Interactions
- Bob London, Ph.D.
Principal Investigator, Nuclear Magnetic Resonance
- Tel 984-287-3573
- P.O. Box 12233Mail Drop MR-01Durham, N.C. 27709
Robert London, Ph.D., heads the Nuclear Magnetic Resonance Group and holds a secondary appointment in the NIEHS Immunity, Inflammation, and Disease Laboratory.
The Nuclear Magnetic Resonance (NMR) Group performs fundamental research on biological systems aimed at providing insight into the molecular mechanisms that underlie problems of environmental concern. As part of the Genome Integrity and Structural Biology Laboratory, our primary focus has been the evaluation of structural, conformational and dynamic responses of proteins to substrates, cofactors, allosteric effectors, other proteins, putative environmental toxins, nucleic acids, etc. In addition, we are interested in various aspects of allergic disease including the characterization of allergens and metabolomic analyses of pollens.
Major areas of research:
- DNA repair complexes
- HIV reverse transcriptase
- Allergic Disease and Allergens
- Structural and dynamic characterization of enzymes involved in DNA polymerization
- Nuclear localization signals of DNA repair enzymes
- Accessory proteins in DNA repair
- Studies or HIV reverse transcriptase
- Characterization of Allergens
- Metabolomic analyses of pollens
London received his Ph.D. in biophysics from the University of Illinois in 1973. He has published over 200 peer-reviewed articles in leading biomedical journals, and contributed 20 book chapters. He served as principal investigator of the NIH-funded National Stable Isotope Resource at Los Alamos before joining NIEHS in 1983.