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Your Environment. Your Health.

Nuclear Magnetic Resonance Group

NMR & Ligand-Macromolecule Interactions

Robert London, Ph.D.
Bob London, Ph.D.
Principal Investigator
Tel 919-541-4879
Fax 919-541-5707
london@niehs.nih.gov
P.O. Box 12233
Mail Drop MR-01
Durham, N.C. 27709
DNA Repair Complexes
DNA Polymerase Beta
DNA Repair Complexes
HIV Reverse Transcriptase
HIV-RT monomer
HIV Reverse Transcriptase
Allergic Diseases and Allergens
Cockroach allergen Bla g 1
Allergic Diseases and Allergens

Robert London, Ph.D., heads the Nuclear Magnetic Resonance Group and holds a secondary appointment in the NIEHS Immunity, Inflammation, and Disease Laboratory.

The Nuclear Magnetic Resonance (NMR) Group performs fundamental research on biological systems aimed at providing insight into the molecular mechanisms that underlie problems of environmental concern. As part of the Genome Integrity and Structural Biology Laboratory, our primary focus has been the evaluation of structural, conformational and dynamic responses of proteins to substrates, cofactors, allosteric effectors, other proteins, putative environmental toxins, nucleic acids, etc. In addition, we are interested in various aspects of allergic disease including the characterization of allergens and metabolomic analyses of pollens.

Major areas of research:

  • DNA repair complexes
  • HIV reverse transcriptase
  • Allergic Disease and Allergens

Current projects:

  • Structural and dynamic characterization of enzymes involved in DNA polymerization
  • Nuclear localization signals of DNA repair enzymes
  • Accessory proteins in DNA repair
  • Studies or HIV reverse transcriptase
  • Characterization of Allergens
  • Metabolomic analyses of pollens

London received his Ph.D. in biophysics from the University of Illinois in 1973. He has published over 200 peer-reviewed articles in leading biomedical journals, and contributed 20 book chapters. He served as principal investigator of the NIH-funded National Stable Isotope Resource at Los Alamos before joining NIEHS in 1983.