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Your Environment. Your Health.


Program Leads

Danielle Carlin, Ph.D.
Danielle J. Carlin, Ph.D.
Health Scientist Administrator
Tel 984-287-3244
P.O. Box 12233
Mail Drop K3-04
Durham, N.C. 27709
Bonnie R. Joubert, Ph.D.
Bonnie R. Joubert, Ph.D.
Health Scientist Administrator
Tel 984-287-3276
P.O. Box 12233
Mail Drop K3-12
Durham, N.C. 27709

Program Description

People are exposed to a multitude of environmental toxicants through the air we breathe, food and water we consume, or products we use in our home or on our bodies. Scientists are working to understand the implications of these complex chemical mixtures, which can sometimes produce health effects greater than each chemical would alone.

For example, exposure to ozone and aldehydes, which are components of smog, produces greater health effects than would be predicted based on each chemical. Also, smokers who are also exposed to radon or asbestos have a greater risk of developing lung cancer.  

What NIEHS is doing

Some exposure research has studied the health effects of single chemicals at specific times, but there is growing effort by environmental health scientists to develop methods to study environmental exposures in ways that more closely represent the mixture of exposures that we experience in modern life. They are examining how these mixtures interact using in vitro and in vivo systems and in humans to determine health effects. Efforts are being made to develop innovative statistical methods for assessing health effects of mixtures and to characterize real-life exposures.

The NIEHS Superfund Research Program also supports research of mixtures on human health and the environment.

For additional information on what NIEHS grantees are doing, visit our Who We Fund tool.


Powering Research through Innovative Methods for mixtures in Epidemiology (PRIME)