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Your Environment. Your Health.

Selected Publications

Environmental Epigenomics and Disease Group

  1. Su D, Wang X, Porter DK, Pittman GS, Crowl CL, Gimple RN, Adamski KN, Campbell MR, Huang Z, Murphy SK, Bell DA. Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes. PloS one 2016 11(12):-. [Abstract]
  2. Stracquadanio1 G, Wang X, Wallace MD, Grawenda AM, Zhang P, Hewitt J, Zeron-Medina J, Castro-Giner F, Tomlinson IP, Goding CR, Cygan KJ, Fairbrother WG, Thomas LF, Sætrom P, Gemignani F, Landi S, Schuster-Böckler B, Bell DA, Bond GL. The importance of p53 pathway genetics in inherited and somatic cancer genomes. Nature Reviews Cancer 2016 16(4):251-265. [Abstract]
  3. Reynolds LM, Wan M, Ding J, Taylor JR, Lohman K, Su D, Bennett BD, Porter DK, Gimple R, Pittman GS, Wang X, Howard TD, Siscovick D, Psaty BM, Shea S, Burke GL, Jacobs DR Jr, Rich SS, Hixson JE, Stein JH, Stunnenberg H, Barr RG, Kaufman JD, Post WS, Hoeschele I, Herrington DM, Bell DA*, Liu Y*. 2015. DNA methylation of the aryl hydrocarbon receptor repressor associations with cigarette smoking and subclinical atherosclerosis. Circ Cardiovasc Genet 8(5):707-716. [Abstract]
  4. Zhao N, Bell DA, Maity A, Staicu AM, Joubert BR, London SJ, Wu MC. 2015. Global analysis of methylation profiles from high resolution CpG Data. Genet Epidemiol 39(2)53-64. [Abstract]
  5. Lacher SE, Lee JS, Wang X, Campbell MR, Bell DA, Slattery M. 2015. Beyond antioxidant genes in the ancient Nrf2 regulatory network. Free Radic Biol Med 88(Pt B):452-465. [Abstract]
  6. Su D, Wang X, Campbell MR, Song L, Safi A, Crawford GE, Bell DA. (2015) Interactions of Chromatin Context, Binding Site Sequence Content, and Sequence Evolution in Stress-Induced p53 Occupancy and Transactivation. PLoS genetics 11(1):e1004885. [Abstract]
  7. Joubert BR, Haberg SE, Bell DA, Nilsen RM, Vollset SE, Midttun O, Ueland PM, Wu MC, Nystad W, Peddada SD, London SJ. 2014. Maternal smoking and DNA methylation in newborns: in utero effect or epigenetic inheritance? Cancer Epidemiol Biomarkers Prev 23(6):1007-1017. [Abstract]
  8. Wang X, Pittman GS, Bandele OJ, Bischof JJ, Liu G, Brothers JF 2nd, Spira A, Bell DA. (2014) Linking polymorphic p53 response elements with gene expression in airway epithelial cells of smokers and cancer risk. Human genetics 133(12):1467-1476. [Abstract]
  9. Azzam G, Wang X, Bell DA, Murphy ME.(2013) CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest. PloS one 8(9):e74297-. [Abstract]
  10. Campbell MR, Karaca M, Adamski KN, Chorley BN, Wang X, Bell DA. (2013) Novel hematopoietic target genes in the NRF2-mediated transcriptional pathway. Oxidative Medicine and Cellular Longevity 2012:120305. [Abstract]
  11. Zeron-Medina J , Wang X, Repapi E, Campbell MR, Su D, Castro-Giner FC, Davies B, Peterse EF, Sacilotto N, Walker GJ, Terzian T, Tomlinson IP, Box NF, Meinshausen N, De Val S, Bell DA, Bond GL. A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection. Cell 2013 155(2):410-422. [Abstract]
  12. Joubert BR, Håberg SE, Nilsen RM , Wang X, Vollset SE, Murphy SK, Huang Z, Hoyo C, Midttun O, Cupul-Uicab LA , Ueland PM, Wu MC, Nystad W , Bell DA , Peddada SD , London SJ. (2012) 450K Epigenome-Wide Scan Identifies Differential DNA Methylation in Newborns Related to Maternal Smoking during Pregnancy.. Environmental Health Perspectives 120(10):1425-31. [Abstract]
  13. Chorley BN, Campbell MR , Wang X , Karaca M, Sambandan D, Bangura F, Xue P, Pi J, Kleeberger SR , Bell DA. (2012) Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha. Nucleic Acids Research. 40(15):7416-29. [Abstract]
  14. Millau, J-F, Bandele, O..J, Perron, J., Bastien, N., Bouchard, E.F., Gaudreau, L., Bell, D.A., and Drouin, R. (2011) Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elements. Nucleic Acids Research  39(8):3053-3063, 2011. [Abstract]  
  15. Bandele, O.J., Wang, X., Campbell, M.R., Pittman, G.S., and Bell, D.A. (2010) Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements. Nucleic Acids Research 39(1):178-189. [Abstract]
  16. Wang, X., Chorley, B.N., Pittman, G.S., Kleeberger, S.R., Brothers, J., Liu, G., Spira, A., and Bell, D.A. (2010) Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. PloS one 5(8):e11934. [Abstract]
  17. Noureddine, M.A., Menendez, D., Campbell, M.R., Bandele, O.J., Horvath, M.M., Wang, X., Pittman, G.S., Chorley, B.N., Resnick, M.A., and Bell, D.A. (2009) Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extracts. PLoS Genet 5:e1000462. [Abstract]
  18. Jordan, J.J., Menendez, D., Inga, A., Nourredine, M., Bell, D., and Resnick, M.A. (2008) Noncanonical DNA motifs as transactivation targets by wild type and mutant p53. PLoS Genet 4:e1000104 [Abstract]
  19. Chorley, B.N., Wang, X., Campbell, M.R., Pittman, G.S., Noureddine, M.A., and Bell, D.A. (2008) Discovery and verification of functional single nucleotide polymorphisms in regulatory genomic regions: current and developing technologies. Mutat Res 659:147-157. [Abstract]
  20. Horvath, M.M., Wang, X, Resnick, M.A., and Bell, D.A. (2007) Divergent evolution of human p53 binding sites: cell cycle vs apoptosis. PloS Genet 3:e127. [Abstract]
  21. Wang, X., Tomso, D.J., Chorley, B.N., Cho, H.Y., Cheung, V.G., Kleeberger, S.R., and Bell, D.A. (2007) Identification of polymorphic antioxidant response elements in the human genome. Hum Mol Genet 16:1188-1200. [Abstract]
  22. Perera, F.P., Tang, D., Brandt-Rauf, P., Santella, R.M., Mooney, L.V., Tu, Y.H., Bendkowska, I., and Bell, D.A. (2006) Lack of associations among cancer and albumin adducts, ras p21 oncoprotein levels, and CYP1A1, CYP2D6, NAT1, and NAT2 in a nested case-control study of lung cancer within the physicians' health study. Cancer Epidemiol Biomarkers Prev 15, 1417-1419.
  23. Novak J.P., Miller, M.C. III, and Bell, D.A. (2006) Variation in fiberoptic bead-based oligonucleotide microarrays: dispersion characteristics among hybridization and biological replicate samples. Biol Direct 1, 18. [Abstract]
  24. Tomso, D.J., Inga, A., Menendez, D., Pittman, G.S., Campbell, M.R., Storici, R., and Bell, D.A.,  Resnick, M. A. (2005) Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation. Proc Natl Acad Sci USA 102:6431-6436. [Abstract]
  25. Liu, X., Campbell, M.R., Pittman, G.S., Faulkner, E.C., Watson, M.A., and Bell, D.A. (2005) Expression-based discovery of variation in the human glutathione S-transferase M3 promoter and functional analysis in a glioma cell line using allele-specific chromatin immunoprecipitation. Cancer Res 65, 99-104. [Abstract]
  26. Tomso, D.J. and Bell, D.A. (2003) Sequence context at human single nucleotide polymorphisms: overrepresentation of CpG dinucleotide at polymorphic sites and suppression of variation in CpG islands. J Mol Biol 327, 303-308. [Abstract]
  27. Perera, F.P., Mooney, L.A., Stampfer, M., Phillips, D.H., and Bell, D.A. (2002) Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study. Carcinogenesis 23, 1641-1646. [Abstract]
  28. Fritsche E, Baek SJ, King LM, Zeldin DC, Eling TE and Bell DA. (2001) Functional characterization of cyclooxygenase-2 polymorphisms. J Pharmacol Exp Ther, 299, 468-76. [Abstract]
  29. Whyatt, R.M., Perera, F.P., Jedrychowski, W., Santella, R.M., Garte, S., and Bell, D.A. (2000) Association between polycyclic aromatic hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and glutathione S-transferase P1 and CYP1A1 polymorphisms. Cancer Epidemiol Biomarkers Prev 9, 207-212. [Abstract]
  30. Fennell, T.R., MacNeela, J.P., Morris, R.W., Watson, M., Thompson, C.L., and Bell, D.A. (2000) Hemoglobin adducts from acrylonitrile and ethylene oxide in cigarette smokers: effects of glutathione S-transferase T1-null and M1-null genotypes. Cancer Epidemiol Biomarkers Prev 9, 705-712. [Abstract]
  31. Lunn, R.M., Langlois, R.G., Hsieh, L.L., Thompson, C.L., and Bell, D.A. (1999) XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency. Cancer Res 59, 2557-2561. [Abstract]
  32. Taylor, J.A., Umbach, D. M., Stephens, E., Castranio, T., Paulson, D., and Bell, D.A. (1998) The role of N-acetylation polymorphisms in smoking-associated bladder cancer: evidence of a gene-gene-exposure three-way interaction. Cancer Res 58, 3603-3610. [Abstract]
  33. Bell, D.A., Taylor, J.A., Paulson, D.F., Robertson, C.N., Mohler, J.L. and Lucier, G.W. (1993) Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J Natl Cancer Inst 85, 1159-1164. [Abstract]

^contributed equally as first authors; *contributed equally as senior authors