Vickie R. Walker

Health Assessment and Translation

Couse JF, Hewitt SC, Bunch DO, Sar M, Walker VR, Davis BJ, & Korach KS. 1999. Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta.  Science 286(5448):2328-2331. [Abstract Couse JF, Hewitt SC, Bunch DO, Sar M, Walker VR, Davis BJ, & Korach KS. 1999. Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta.  Science 286(5448):2328-2331.]

Vickie R. Walker serves as a health scientist in National Toxicology Program’s Office of Health Assessment and Translation at the NIEHS. Walker received her B.S. in biochemistry (1997) from North Carolina State University, Raleigh NC. Prior to joining the NTP, Vickie spent 20 years as a research scientist in the Division of Intramural Research program at NIEHS where she gained extensive training in environmental health, specifically reproductive and developmental toxicology. Research focused on investigating the mechanism and role of the estrogen receptor in development, reproduction, and carcinogenesis with an emphasis on the generation and study of transgenic and gene‐ disruption animal models.

Selected Publications

• Walker VR, Schmitt CP, Wolfe MS, Nowak AJ, Kulesza K, Williams AR, Shin R, Cohen J, Burch D, Stout MD, Shipkowski KA, Rooney AA. 2022. Evaluation of a semi-automated data extraction tool for public health literature-based reviews: Dextr. Environ Int. 159:107025. doi: 10.1016/j.envint.2021.107025. [Abstract Walker VR, Schmitt CP, Wolfe MS, Nowak AJ, Kulesza K, Williams AR, Shin R, Cohen J, Burch D, Stout MD, Shipkowski KA, Rooney AA. 2022. Evaluation of a semi-automated data extraction tool for public health literature-based reviews: Dextr. Environ Int. 159:107025. doi: 10.1016/j.envint.2021.107025.]
• Wolffe, Taylor, Whaley, Paul, Halsall, Crispin, Rooney, Andrew, Walker, Vickie. Systematic evidence maps as a novel tool to support evidence-based decision-making in chemicals policy and risk management. Environment International 2019 ():-. [Abstract Wolffe, Taylor, Whaley, Paul, Halsall, Crispin, Rooney, Andrew, Walker, Vickie. Systematic evidence maps as a novel tool to support evidence-based decision-making in chemicals policy and risk management. Environment International 2019 ():-.]
• Walker VR, Jefferson WN, Couse JF, & Korach KS. 2012. Estrogen Receptor Alpha (ERalpha) Mediates Diethylstilbestrol (DES)-induced Feminization of the Seminal Vesicle in Male Mice.  Environ Health Perspect 120(4):560-565. [Abstract Walker VR, Jefferson WN, Couse JF, & Korach KS. 2012. Estrogen Receptor Alpha (ERalpha) Mediates Diethylstilbestrol (DES)-induced Feminization of the Seminal Vesicle in Male Mice.  Environ Health Perspect 120(4):560-565.]
• Carey MA, Card JW, Bradbury JA, Moorman MP, Haykal-Coates N, Gavett SH, Graves JP, Walker VR, Flake GP, Voltz JW, Zhu D, Jacobs ER, Dakhama A, Larsen GL, Loader JE, Gelfand EW, Germolec DR, Korach KS, & Zeldin DC. 2007. Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice.  Am J Respir Crit Care Med 175(2):126-135. [Abstract Carey MA, Card JW, Bradbury JA, Moorman MP, Haykal-Coates N, Gavett SH, Graves JP, Walker VR, Flake GP, Voltz JW, Zhu D, Jacobs ER, Dakhama A, Larsen GL, Loader JE, Gelfand EW, Germolec DR, Korach KS, & Zeldin DC. 2007. Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice.  Am J Respir Crit Care Med 175(2):126-135.]
• Gabel SA, Walker VR, London RE, Steenbergen C, Korach KS, & Murphy E. 2005. Estrogen receptor beta mediates gender differences in ischemia reperfusion injury.  J Mol Cell Cardiol 38(2):289-297. [Abstract Gabel SA, Walker VR, London RE, Steenbergen C, Korach KS, & Murphy E. 2005. Estrogen receptor beta mediates gender differences in ischemia reperfusion injury.  J Mol Cell Cardiol 38(2):289-297.]
• Walker VR & Korach KS. 2004. Estrogen receptor knockout mice as a model for endocrine research.  Ilar J 45(4):455-461. [Abstract Walker VR & Korach KS. 2004. Estrogen receptor knockout mice as a model for endocrine research.  Ilar J 45(4):455-461.]
• Ma J, Graves J, Bradbury JA, Zhao Y, Swope DL, King L, Qu W, Clark J, Myers P, Walker VR, Lindzey J, Korach KS, & Zeldin DC. 2004. Regulation of mouse renal CYP2J5 expression by sex hormones.  Mol Pharmacol 65(3):730-743. [Abstract Ma J, Graves J, Bradbury JA, Zhao Y, Swope DL, King L, Qu W, Clark J, Myers P, Walker VR, Lindzey J, Korach KS, & Zeldin DC. 2004. Regulation of mouse renal CYP2J5 expression by sex hormones.  Mol Pharmacol 65(3):730-743.]
• Korach KS, Emmen JM, Walker VR, Hewitt SC, Yates M, Hall JM, Swope DL, Harrell JC, & Couse JF. 2003. Update on animal models developed for analyses of estrogen receptor biological activity.  J Steroid Biochem Mol Biol 86(3-5):387-391. [Abstract Korach KS, Emmen JM, Walker VR, Hewitt SC, Yates M, Hall JM, Swope DL, Harrell JC, & Couse JF. 2003. Update on animal models developed for analyses of estrogen receptor biological activity.  J Steroid Biochem Mol Biol 86(3-5):387-391.]
• He B, Rhodes-Brower S, Miller MR, Munson AE, Germolec DR, Walker VR, Korach KS, & Meade BJ. 2003.  Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha.  Toxicol Appl Pharmacol 192(3):254-261. [Abstract He B, Rhodes-Brower S, Miller MR, Munson AE, Germolec DR, Walker VR, Korach KS, & Meade BJ. 2003.  Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha.  Toxicol Appl Pharmacol 192(3):254-261.]
• Couse JF, Yates MM, Walker VR, & Korach KS. 2003. Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta.  Mol Endocrinol 17(6):1039-1053. [Abstract Couse JF, Yates MM, Walker VR, & Korach KS. 2003. Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta.  Mol Endocrinol 17(6):1039-1053.]
• Ogawa S, Chester AE, Hewitt SC, Walker VR, Gustafsson JA, Smithies O, Korach KS, & Pfaff DW. 2000. Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO).  Proc Natl Acad Sci U S A 97(26):14737-14741. [Abstract Ogawa S, Chester AE, Hewitt SC, Walker VR, Gustafsson JA, Smithies O, Korach KS, & Pfaff DW. 2000. Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO).  Proc Natl Acad Sci U S A 97(26):14737-14741.]
• Couse JF, Hewitt SC, Bunch DO, Sar M, Walker VR, Davis BJ, & Korach KS. 1999. Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta.  Science 286(5448):2328-2331. [Abstract Couse JF, Hewitt SC, Bunch DO, Sar M, Walker VR, Davis BJ, & Korach KS. 1999. Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta.  Science 286(5448):2328-2331.]