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Your Environment. Your Health.

Molecular & Genetic Epidemiology Group

Genes, Environment & Human Carcinogenesis

Jack A. Taylor, M.D., Ph.D.
Jack Taylor, M.D., Ph.D.
Principal Investigator
Tel 984-287-3684
Fax 301-480-3290
P.O. Box 12233
Mail Drop A3-05
Durham, N.C. 27709

Research Summary

With dual appointments in the Epigenetics and Stem Cell Biology Laboratory and the Epidemiology Branch, Jack A. Taylor, M.D., Ph.D., leads the Molecular & Genetic Epidemiology Group. The group is focused on understanding the interaction between genes and environmental exposures in human carcinogenesis. The group studies human genetic variation in susceptibility to DNA damage and the frequency and pattern of DNA mutation from environmental exposure (Figure 1). In addition the group integrates field epidemiology in its work by applying what it learns to population-based studies of cancer risk.

These measures are being applied in samples from epidemiologic case-control and case-case studies of a variety of cancers including carcinoma of the bladder, lung, prostate and pancreas; and a variety of environmental exposures including radiation, arylamines, asbestos, nickel, chromate and smoking. One current clinical-translational study follows patients at high risk of developing lung cancer with sequential bronchoscopies and biopsies of preneoplastic lesions. Tissues from these lesions are microdissected using laser capture microdissection and analyzed for LOH and other molecular abnormalities.

The group utilizes an interdisciplinary approach with postdoctoral fellows in both epidemiology and molecular biology working together. It offers opportunities for cross-disciplinary training, providing epidemiologists with bench training and molecular biologists with field study and data analysis experience, and opportunities in the expanding field of molecular epidemiology.

H2AX foci following gamma irradiation for measurement of DNA double strand break repair
Figure 1. H2AX foci following gamma irradiation for measurement of DNA double strand break repair

Major areas of research:

  • Human genetic variation in susceptibility to DNA damage
  • Frequency and pattern of DNA mutation from environmental exposure

Current projects:

  • Development of in vitro functional assays for DNA repair rate following different types of DNA damage from different environmental exposures
  • Assessment of critical target gene mutation, mutation in preneoplastic lesions and development of sensitive measures of mutation in normal tissue in response to environmental exposure

Taylor earned his M.D. in 1984 from the University of Wisconsin, Madison. He completed his internship at Michigan State and residency in Preventive Medicine at the University of North Carolina. He obtained his Ph.D. in 1993 at the University of North Carolina. He has published more than 75 peer-reviewed articles in leading biomedical journals as well as several book chapters. He joined NIEHS in 1985 and holds adjunct appointments at both the University of North Carolina and Duke University.

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