
Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
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Robert C. Sills, D.V.M., Ph.D.
Chief, Comparative and Molecular Pathogenesis Branch -
Tel 984-287-3839
[email protected] -
P.O. Box 12233Mail Drop B3-06Durham, NC 27709

The primary focus of the NIEHS Mouse Embryo Phenotyping Core is to provide expertise and support for the evaluation of pathology phenotypes of genetically altered mice. Efforts include evaluation of the causes of embryonic lethal phenotypes. Assistance is provided with the collection, histologic processing and pathological assessment of embryos.
Recent Publications
- Brooks A, Vornoli A, Kovi R, Ton T, Xu M, Mashal A, Tibaldi E, Gnudi F, Li J, Sills R, Bucher J, Mandrioli D, Belpoggi F, Pandiri A. Genetic profiling of rat gliomas and cardiac schwannomas from life-time radiofrequency radiation exposure study using a targeted next-generation sequencing gene panel. PloS one. 2024;19(1):e0296699. [ AbstractBrooks A, Vornoli A, Kovi R, Ton T, Xu M, Mashal A, Tibaldi E, Gnudi F, Li J, Sills R, Bucher J, Mandrioli D, Belpoggi F, Pandiri A. Genetic profiling of rat gliomas and cardiac schwannomas from life-time radiofrequency radiation exposure study using a targeted next-generation sequencing gene panel. PloS one. 2024 ]
- Panzacchi S, Belpoggi F, Bua L, Bucher J, Cora M, De Angelis L, Falcioni L, Gnudi F, Mandrioli D, Manservigi M, Manzoli I, Masten S, Menghetti I, Mutlu E, Roberts G, Shipkowski K, Sills R, Stout M, Strollo V, Tibaldi E, Tracy J, Vornoli A, Waidyanatha S. NIEHS Report on the Toxicity Studies of Nicotine Bitartrate Dihydrate (CASRN 6019-06-3) Administered in Drinking Water to Sprague Dawley Rats and Swiss Mice: NIEHS Report 11 NIEHS Report Series. 2024 Oct [Epub ahead of print]. [ AbstractPanzacchi S, Belpoggi F, Bua L, Bucher J, Cora M, De Angelis L, Falcioni L, Gnudi F, Mandrioli D, Manservigi M, Manzoli I, Masten S, Menghetti I, Mutlu E, Roberts G, Shipkowski K, Sills R, Stout M, Strollo V, Tibaldi E, Tracy J, Vornoli A, Waidyanatha S. NIEHS Report on the Toxicity Studies of Nicotine Bitartrate Dihydrate (CASRN 6019-06-3) Administered in Drinking Water to Sprague Dawley Rats and Swiss Mice: NIEHS Report 11 NIEHS Report Series. 2024 Oct ]
- Izawa T, Travlos G, Cortes R, Clayton N, Sills R, Pandiri A. Absence of Increased Susceptibility to Acetaminophen-Induced Liver Injury in a Diet-Induced NAFLD Mouse Model. Toxicologic pathology. 2023 Apr;51(3):112-125. [ AbstractIzawa T, Travlos G, Cortes R, Clayton N, Sills R, Pandiri A. Absence of Increased Susceptibility to Acetaminophen-Induced Liver Injury in a Diet-Induced NAFLD Mouse Model. Toxicologic pathology. 2023 Apr ]
- Letsinger A, Ward J, Fannin R, Mahapatra D, Bridge M, Sills R, Gerrish K, Yakel J. Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity. Scientific reports. 2023 Feb 04;13(1):2042. [ AbstractLetsinger A, Ward J, Fannin R, Mahapatra D, Bridge M, Sills R, Gerrish K, Yakel J. Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity. Scientific reports. 2023 Feb 04 ]
- Ton T, Hong H, Kovi R, Shockley K, Peddada S, Gerrish K, Janardhan K, Flake G, Stout M, Sills R, Pandiri A. Chronic Inhalation Exposure to Antimony Trioxide Exacerbates the MAPK Signaling in Alveolar Bronchiolar Carcinomas in B6C3F1/N Mice. Toxicologic pathology. 2023 Jan;51(1-2):39-55. [ AbstractTon T, Hong H, Kovi R, Shockley K, Peddada S, Gerrish K, Janardhan K, Flake G, Stout M, Sills R, Pandiri A. Chronic Inhalation Exposure to Antimony Trioxide Exacerbates the MAPK Signaling in Alveolar Bronchiolar Carcinomas in B6C3F1/N Mice. Toxicologic pathology. 2023 Jan ]
NTP Reports
- National Toxicology Program. Toxicology and carcinogenesis studies in Sprague Dawley (Hsd:Sprague Dawley SD) rats exposed to whole-body radio frequency radiation at a frequency (900 MHz) and modulations (GSM and CDMA) used by cell phones. National Toxicology Program technical report series. 2018 Nov [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicology and carcinogenesis studies in Sprague Dawley (Hsd:Sprague Dawley SD) rats exposed to whole-body radio frequency radiation at a frequency (900 MHz) and modulations (GSM and CDMA) used by cell phones. National Toxicology Program technical report series. 2018 Nov ]
- National Toxicology Program. Toxicology and carcinogenesis studies in B6C3F1/N mice exposed to whole-body radio frequency radiation at a frequency (1,900 MHz) and modulations (GSM and CDMA) used by cell phones. National Toxicology Program technical report series. 2018 Nov [Epub ahead of print]. [ AbstractNational Toxicology Program. Toxicology and carcinogenesis studies in B6C3F1/N mice exposed to whole-body radio frequency radiation at a frequency (1,900 MHz) and modulations (GSM and CDMA) used by cell phones. National Toxicology Program technical report series. 2018 Nov ]