Translational Toxicology Division
The NIEHS Division of Translational Toxicology (DTT) Office of the Scientific Director provides scientific leadership and operational support for DTT. As a team-based scientific organization, DTT seeks to improve public health through the development of data and knowledge that are translatable, predictive, and timely. Offices supporting the Scientific Director:
- Coordinate acquisition and allocation of fiscal, contracted and administrative resource to operational units of the Division.
- Foster a productive environment for research, testing, and analysis activities.
- Promote interactions and coordination among DTT and NIEHS staff.
- Promote activities intended to increase interactions among DTT scientific staff including seminars, monthly science forum, and other programs.
- Serve as focal point for the DTT Training Fellowship Program.
- Serve as liaison with NIH, other federal agencies, and stakeholders regarding DTT activities.
Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration’s National Center for Toxicological Research, National Institute for Occupational Safety and Health, and National Institute of Environmental Health Sciences (NIEHS). DTT activities supporting NTP include toxicology testing, laboratory research, and literature-based assessments. It also includes oversight of NTP communications, databases, website, advisory groups, and the peer review of draft NTP products.
The Scientific Director provides policy, organizational, and scientific leadership for DTT as well as planning, managing, and coordinating its internal and external activities. The Scientific Director ensures that the resources provided to the Division in support of the NTP and NIEHS missions are used to bolster a strategic and impactful portfolio of scientific effort.
- Brian R. Berridge, D.V.M., Ph.D., D.A.C.V.P.
Scientific Director, Division of Translational Toxicology;
Associate Director, National Toxicology Program
- Tel 984-287-3111
- P.O. Box 12233Mail Drop K2-02Durham, N.C. 27709
Brian Berridge, D.V.M., Ph.D., D.A.C.V.P., joined the NIH in January of 2018 as the Scientific Director of the DTT at NIEHS, and the Associate Director of the NTP. Previous to NIEHS, Berridge spent 17 years in the pharmaceutical industry in varying roles as a toxicologic pathologist at Eli Lilly in Indianapolis, Indiana, and GlaxoSmithKline in Research Triangle Park, North Carolina.
Berridge is an Oklahoma State University-trained veterinarian with residency and Ph.D. training from Texas A&M University. He is a Diplomate of the American College of Veterinary Pathologists with post-doctoral training in comparative cardiovascular pathology from the Texas Heart Institute in Houston, Texas. His areas of interest and expertise include toxicologic and comparative pathology with particular interest in cardiovascular and renal pathology. He is a veteran of the U.S. Air Force where he was a non-commissioned officer trained as a histopathology and electron microscopy technologist. Berridge is currently active in various consortium efforts aimed at advancing innovative approaches to modeling human pathobiology that improve the translation of preclinical research to clinical outcomes and advance our ability to characterize human cardiovascular health hazards.
Since joining NIEHS, Berridge has worked to advance public health and toxicology in ways that are translatable, predictive, and timely. He has broadened DTT’s traditional focus on studying specific chemicals to include assessing how chemical exposures affect the development of human disease. Initiatives have been introduced to concentrate research and translation efforts in cardiovascular hazard assessment, developmental neurotoxicity, and carcinogenicity testing. These health effects innovations provide opportunity for working across a continuum of knowledge – using contemporary tools such as literature analysis, animal studies, in vitro systems, and in silico or computational analytics – to better understand how environmental exposures contribute to diseases in these systems. These efforts complement traditional strategic areas of study within DTT that are agent-focused and for which DTT scientists have led research, testing, and literature-analysis activities in support of the NTP since 1978.
Michelle J. Hooth, Ph.D., D.A.B.T.
Acting Deputy Director for Program Operations, Division of Translational Toxicology;
Director, Office of Program Operations
Mary S. Wolfe, M.S., Ph.D.
Acting Deputy Director for Policy and Communication, Division of Translational Toxicology;
Director, Office of Policy, Review, and Outreach;
Acting Director, Office of Workforce Development and Operations
Anna Lee S. Mosley
Contractor — Operations Coordinator