Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC. Get the latest research information from NIH.

Your Environment. Your Health.

Small Business Innovation Research & Small Business Technology Transfer Grants (SBIR/STTR, R41, R42, R43, R44)

Program Lead

Daniel Shaughnessy, Ph.D.
Daniel T. Shaughnessy, Ph.D.
Health Scientist Administrator

Tel 984-287-3321
Fax 919-541-0146

Sensor Technology for the 21st Century Website

Are you a sensor technology developer seeking SBIR/STTR funding? posted a new microsite, Sensor Technology for the 21st Century to help startups and small businesses interested in sensor technologies find relevant SBIR/STTR topics by providing a central web location for sensor-related funding topics across the federal government.

Connect With Us

Register for the SBIR-NIEHS LISTSERV to receive program updates and announcements.

Follow us on Twitter
Twitter Icon @NIEHS

Can't find what you are looking for? email-icon email us!

NIEHS Top 10 Resources for SBIR/STTR Applicants (241KB)

Webinar Recordings

NIEHS Superfund Research Program, EPA, USDA, and NSF Hosted Webinar
SBIR/STTR Funding Opportunties for Environmental Technologies
Webinar Slides and Resources

Program Description

NIEHS SBIR/STTR grants help small businesses develop innovative and commercially viable products or technologies to translate and communicate environmental health research to improve public health. The SBIR/STTR program uses a combination of research, technology transfer, and communication strategies to aid the mission of NIEHS. Research and training areas include:

  • Exposure assessment tools such as sensors and computational tools and methods
  • Tools for evaluating environmental health and safety of engineered nanomaterials
  • Bio-monitoring technologies and biological response markers of exposure and response
  • Assays and model systems for screening compounds for toxicity
  • Intervention technologies to prevent or reduce exposures to environmental stressors
  • Educational materials to support understanding of environmental health science
  • Superfund Research Program - Detection and remediation technologies for contaminated sites
  • NIEHS Worker Training Program - Advanced Training Technology (ATT) products for the health and safety training of hazardous materials (HAZMAT) workers, emergency responders, and skilled support personnel

For more details about NIEHS clinical trial not allowed and clinical trail allowed funding topics see pages 104-111 of the SBIR/STTR NIH, CDC, and FDA Program Descriptions and Research Topics document.

Who We Fund - is a database of Environmental Health Science Research Funded by NIEHS. Search GRANT NUMBER "R43" or "R44" for SBIR grants, and "R41" or "R42" for STTR grants.

Grant applications are accepted in response to the NIH Omnibus solicitation using the SF424 (R&R) SBIR/STTR application guide (Version E) and use the Annotated SF424 (R&R) SBIR/STTR Form Set (FORMS-E) for step-by-step instruction on how to complete the application. Be mindful that the electronic submission process for HHS SBIR and STTR grants is multi-step, and can take six to eight weeks to complete the five registrations required prior to submission.

NIEHS Participating HHS SBIR and STTR Omnibus Solicitations

  • PA-19-272 - PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed
  • PA-19-273 - PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required
  • PA-19-270 - PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed
  • PA-19-271 - PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required

SBIR/STTR Application Types Accepted by NIEHS

  • For PA-19-272 - Parent SBIR [R43/R44] Clinical Trial Not Allowed and PA-19-273 - Parent SBIR [R43/R44] Clinical Trial Required – Phase I, Phase II, Fast-Track, and Direct to Phase II
  • For PA-19-270 - Parent STTR [R41/R42] Clinical Trial Not Allowed and PA-19-271 - Parent STTR [R41/R42] Clinical Trial Required - Phase I, Phase II,  and Fast-Track. Direct Phase II NOT Allowed.

Annual SBIR/STTR Application Receipt Dates

  • September 5, 2019
  • January 6, 2020 (since January 5, 2020 is on a Sunday ) and
  • April 6, 2020 (since April 5, 2020 is on a Sunday )

Other NIEHS Specific/Participating Request for Applications and Program Announcements

SBIR/STTR (SB1, R44) - The “SMALL” CRP (Up to $300,000)
  • PAR-19-334 - SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance (SB1, R44) - Clinical Trial Not Allowed
    • Standard receipt dates until April 2022

    General SBIR/STTR Information


    Additional contact for the NIEHS SBIR and STTR Program
    Lingamanaidu (Ravi) Ravichandran
    Lingamanaidu V. Ravichandran, Ph.D.
    Health Scientist Administrator
    Tel 984-287-3309
    P.O. Box 12233
    Mail Drop K3-05
    Durham, N.C. 27709

    The contact for the Superfund SBIR program is:
    Heather F. Henry, Ph.D.
    Heather Henry, Ph.D.
    Health Scientist Administrator, Superfund Research Program

    Tel 984-287-3268
    The contact for the Worker Training SBIR program is:
    Kathy Ahlmark
    Kathy A. Ahlmark
    Program Analyst

    Tel 984-287-3231
    to Top