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Your Environment. Your Health.

Small Business Innovation Research & Small Business Technology Transfer Grants (SBIR/STTR, R41, R42, R43, R44)

Program Lead

Daniel Shaughnessy, Ph.D.
Daniel T. Shaughnessy, Ph.D.
Health Scientist Administrator

Tel 984-287-3321
Fax 919-541-0146

Support for NIEHS Small Business Program Applicants - The NIH Applicant Assistance Program (AAP)

If your company has not received a NIH SBIR/STTR award and your research area of interest aligns with the mission of NIEHS, you may be eligible to apply for the AAP and get assistance in preparing and submitting the SBIR or STTR application.

The AAP Application Portal will be accepting applications November 14 – December 12, 2023, 5:00 p.m. EST.

NIH will be hosting AAP Information Webinar on November 14, 2:00 – 3:30 p.m. EST and Q&A Office Hour on December 5, 2:00 – 3:30 p.m. EST. Please check the AAP Application Portal for registration links.

SBIR/STTR Funding Opportunities for Water Nanotechnologies Webinar

Thursday, August 25, 2022 • 1:00 – 2:30 p.m. - Webinar Archive

The webinar was co-hosted by the U.S. Environmental Protection Agency (EPA) and the National Nanotechnology Initiative (NNI). Representatives from the EPA, NIEHS, the National Oceanic and Atmospheric Administration (NOAA), and the National Science Foundation (NSF) provided an overview of their current and upcoming SBIR/STTR funding opportunities for water nanotechnologies. The agencies' presentations were followed by a Q&A session.

Town Hall Recording

NIEHS hosted a SBIR/STTR Town Hall meeting on “Development of New Approach Methodologies to Reduce Animal Use in Toxicity Testing” on April 17, 2020 with presentations from NICEATM, EPA, FDA, DoD, 3M Corporation, Syngenta and Novartis.

The slides and presentations are available at SBIR/STTR Town Hall Meeting on NAMs.

Sensory Technology for the 21st Century Website

Are you a sensor technology developer seeking SBIR/STTR funding? posted a new microsite, Sensor Technology for the 21st Century to help startups and small businesses interested in sensor technologies find relevant SBIR/STTR topics by providing a central web location for sensor-related funding topics across the federal government.

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NIEHS Top 10 Resources for SBIR/STTR Applicants (199KB)

Program Description

NIEHS SBIR/STTR grants help small businesses develop innovative and commercially viable products or technologies to translate and communicate environmental health research to improve public health. The SBIR/STTR program uses a combination of research, technology transfer, and communication strategies to aid the mission of NIEHS. Research and training areas include:

  • Exposure assessment tools such as sensors and computational tools and methods
  • Tools for evaluating environmental health and safety of engineered nanomaterials
  • Bio-monitoring technologies and biological response markers of exposure and response
  • Assays and model systems for screening compounds for toxicity
  • Intervention technologies to prevent or reduce exposures to environmental stressors
  • Educational materials to support understanding of environmental health science
  • Superfund Research Program - Detection and remediation technologies for contaminated sites
  • NIEHS Worker Training Program - Advanced Training Technology (ATT) products for the health and safety training of hazardous materials (HAZMAT) workers, emergency responders, and skilled support personnel

For more details about NIEHS clinical trial not allowed and clinical trial allowed funding topics see pages 90 – 99 of the SBIR/STTR NIH, CDC, and FDA Program Descriptions and Research Topics document.

Who We Fund - is a database of Environmental Health Science Research Funded by NIEHS. Search GRANT NUMBER "R43" or "R44" for SBIR grants, and "R41" or "R42" for STTR grants.

Grant applications are accepted in response to the NIH Omnibus solicitation using the SF424 (R&R) SBIR/STTR application guide (Version H) and use the Annotated SF424 (R&R) SBIR/STTR Form Set (FORMS-H) for step-by-step instruction on how to complete the application. Be mindful that the electronic submission process for HHS SBIR and STTR grants is multi-step, and can take six to eight weeks to complete the five registrations required prior to submission.

NIEHS Participating HHS SBIR and STTR Omnibus Solicitations

  • PA-23-230 - PHS 2023-2 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
  • PA-23-231 - PHS 2023-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)
  • PA-23-232 - PHS 2023-2 Omnibus Solicitation of the NIH for Small Business 3Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
  • PA-23-233 - PHS 2023-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required)

SBIR/STTR Application Types Accepted by NIEHS

  • For PA-23-230 - Parent SBIR [R43/R44] Clinical Trial Not Allowed and PA-23-231 - Parent SBIR [R43/R44] Clinical Trial Required – Phase I, Phase II, Fast-Track, and Direct to Phase II.
  • For PA-23-232 - Parent STTR [R41/R42] Clinical Trial Not Allowed and PA-23-233 - Parent STTR [R41/R42] Clinical Trial Required - Phase I, Phase II, and Fast-Track. Direct Phase II NOT Allowed.

Annual SBIR/STTR Application Receipt Dates

    • September 5, 2023
    • January 5, 2024
    • April 5, 2024

Other NIEHS Specific/Participating Request for Applications and Program Announcements

  • SBIR/STTR Commercialization Readiness Program (SB1)
    • PAR-23-219 - SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1, Clinical Trial Not Allowed)
      • Standard receipt dates until April 5, 2025
  • Administrative Supplements to Promote Diversity in Research and Development Small Businesses - SBIR/STTR (Admin Supp Clinical Trial Not Allowed)

General SBIR/STTR Information


Additional contact for the NIEHS SBIR and STTR Program
Lingamanaidu (Ravi) Ravichandran
Lingamanaidu V. Ravichandran, Ph.D.
Health Scientist Administrator
Tel 984-287-3309
P.O. Box 12233
Mail Drop K3-05
Durham, N.C. 27709
The contact for the Superfund SBIR program is:
Heather F. Henry, Ph.D.
Heather Henry, Ph.D.
Health Scientist Administrator, Superfund Research Program

Tel 984-287-3268
The contact for the Worker Training SBIR program is:
Kathy Ahlmark
Kathy A. Ahlmark
Health Specialist

Tel 919-609-6428
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