Small Business Innovation Research & Small Business Technology Transfer Grants (SBIR/STTR, R41, R42, R43, R44)

Program Lead

Daniel T. Shaughnessy, Ph.D.
Health Scientist Administrator

Tel 984-287-3321
Fax 919-541-0146
shaughn1@niehs.nih.gov

Program Description

NIEHS SBIR/STTR grants help small businesses develop innovative and commercially viable products or technologies to translate and communicate environmental health research to improve public health. The SBIR/STTR program uses a combination of research, technology transfer, and communication strategies to aid the mission of NIEHS. Research and training areas include:

• Exposure assessment tools such as sensors and computational tools and methods
• Tools for evaluating environmental health and safety of engineered nanomaterials
• Bio-monitoring technologies and biological response markers of exposure and response
• Assays and model systems for screening compounds for toxicity
• Intervention technologies to prevent or reduce exposures to environmental stressors
• Educational materials to support understanding of environmental health science
• Superfund Research Program - Detection and remediation technologies for contaminated sites
• NIEHS Worker Training Program - Advanced Training Technology (ATT) products for the health and safety training of hazardous materials (HAZMAT) workers, emergency responders, and skilled support personnel

For more details about NIEHS clinical trial not allowed and clinical trial allowed funding topics see pages 93 – 102 of the SBIR/STTR NIH, CDC, and FDA Program Descriptions and Research Topics document.

Who We Fund - is a database of Environmental Health Science Research Funded by NIEHS. Search GRANT NUMBER "R43" or "R44" for SBIR grants, and "R41" or "R42" for STTR grants.

Grant applications are accepted in response to the NIH Omnibus solicitation using the SF424 (R&R) SBIR/STTR application guide (Version F) and use the Annotated SF424 (R&R) SBIR/STTR Form Set (FORMS-F) for step-by-step instruction on how to complete the application. Be mindful that the electronic submission process for HHS SBIR and STTR grants is multi-step, and can take six to eight weeks to complete the five registrations required prior to submission.

NIEHS Participating HHS SBIR and STTR Omnibus Solicitations

• PA-22-176 - PHS 2022-2 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
• PA-22-177 - PHS 2022-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)
• PA-22-178 - PHS 2022-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
• PA-22-179 - PHS 2022-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required)

SBIR/STTR Application Types Accepted by NIEHS

• For PA-22-176 - Parent SBIR [R43/R44] Clinical Trial Not Allowed and PA-22-177 - Parent SBIR [R43/R44] Clinical Trial Required – Phase I, Phase II, Fast-Track, and Direct to Phase II.
• For PA-22-178 - Parent STTR [R41/R42] Clinical Trial Not Allowed and PA-22-179 - Parent STTR [R41/R42] Clinical Trial Required - Phase I, Phase II, and Fast-Track. Direct Phase II NOT Allowed.

Annual SBIR/STTR Application Receipt Dates

• September 5, 2022
• January 5, 2023
• April 5, 2023

Other NIEHS Specific/Participating Request for Applications and Program Announcements

• New – NIEHS SBIR Notice of Funding Opportunity (NOFO):
  • RFA-ES-23-008 - Novel Approaches for Developmental Neurotoxicity Testing (R43/R44 Clinical Trial Not Allowed)

    • Posted Date: March 21, 2023
      Open Date (Earliest Submission Date): June 07, 2023
      Letter of Intent Due Date: June 07, 2023
      Application Due Date: July 07, 2023, 5:00 p.m. local time of applicant organization.

• SBIR/STTR (SB1) - The “SMALL” CRP (Up to $300,000)
  • PAR-20-128 - SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance (SB1) - Clinical Trial Not Allowed
    • Standard receipt dates until April 6, 2023 (As per issuance of NOT-OD-22-085)
• NOTICE OF SPECIAL INTERESTS (NOSI):
  • NOT-ES-22-009 – Notice of Special Interest (NOSI): Innovative Technologies for Research on Climate Change and Human Health Small Business Technology Transfer (R41/R42 Clinical Trial Optional) for PA-22-178 and PA-22-179
  • NOT-ES-22-010 – Notice of Special Interest (NOSI): Innovative Technologies for Research on Climate Change and Human Health (R43/R44 Small Business Innovation Research (R43/R44 Clinical Trial Optional) for PA-22-176 and PA-22-177
    • These notices apply to receipt dates on or after September 5, 2022 and subsequent receipt dates through April 5, 2023
• Administrative Supplements to Promote Diversity in Research and Development Small Businesses - SBIR/STTR (Admin Supp Clinical Trial Not Allowed)
  • PA-21-345 - Administrative supplements to active NIEHS SBIR/STTR grants to enhance the diversity of the research workforce and increase the participation of women and socially and economically disadvantaged individuals in small businesses.
    • Potential Candidates and Small Business Eligibility: Refer PA-21-345 and Supplemental Funding to Diversify the Entrepreneurial Workforce | Seed (nih.gov)
      Due Dates: Not Applicable
      Expiration Date: September 10, 2024

General SBIR/STTR Information

• NIH SBIR/STTR FAQs
  Frequently asked questions applicable to all NIH SBIR/STTR applications and grants
• SBIR/STTR Application Process Infographic
  Step-by-step application process visual
• NIH SBIR/STTR Programs
  Description, eligibility, and associated NIH institutes
• NIH SBIR/STTR Omnibus Funding
  Description, and links to omnibus related topics
• NIEHS Small Business Programs
  General overview of NIEHS areas of interest
• Small Business Grants Homepage
  General information about SBIR and STTR grants
• Grant Tools and Strategies
  Resources from NIAID including sample applications and summary statements

Contacts

Additional contact for the NIEHS SBIR and STTR Program

Lingamanaidu V. Ravichandran, Ph.D.
Health Scientist Administrator

Tel 984-287-3309
lingamanaidu.ravichandran@nih.gov

P.O. Box 12233

Mail Drop K3-05

Durham, N.C. 27709

Delivery Instructions

The contact for the Superfund SBIR program is:

Heather Henry, Ph.D.
Health Scientist Administrator, Superfund Research Program

Tel 984-287-3268
henryh@niehs.nih.gov

The contact for the Worker Training SBIR program is:

Kathy A. Ahlmark
Program Analyst

Tel 984-287-3231
ahlmark@niehs.nih.gov