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Cystic Degeneration (Spongiosis hepatis)

The Digitized Atlas of Mouse Liver Lesions

Cystic degeneration is not as common in mice as in rats. It consists of multilocular cyst-like structures containing granular or flocculent eosinophilic material and, occasionally, erythrocytes. It is believed to represent a degenerative change in Ito cells (stellate cells) and may be seen in normal hepatic parenchyma as well as in proliferative hepatocellular lesions such as foci and neoplasms.