Cystic Degeneration (Spongiosis hepatis)
The Digitized Atlas of Mouse Liver Lesions
Cystic degeneration is not as common in mice as in rats. It consists of multilocular cyst-like structures containing granular or flocculent eosinophilic material and, occasionally, erythrocytes. It is believed to represent a degenerative change in Ito cells (stellate cells) and may be seen in normal hepatic parenchyma as well as in proliferative hepatocellular lesions such as foci and neoplasms.