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Constrained Linear Mixed Effects (CLME)

Developed by:

Shyamal D. Peddada
National Institute of Environmental Health Sciences
Biostatistics Branch

Programmed by Dr. Casey M. Jelsema, Research Fellow, Biostatistics Branch, NIEHS


In many applications, such as in dose-response studies or time-course experiments, researchers are interested in testing for specific inequality constraints or patterns among the means of experimental groups. This R package is designed to test for such inequality patterns using a robust residual bootstrap based methodology which does not require the data to be normally distributed. Furthermore, this software can also handle the situation when covariates and/or random effects are present. Thus, for example, this package can be used in the context of repeated measurement designs with covariates. This package comes with a user friendly graphical interface so no programming is necessary to run this package. All the user needs to do is to provide input source of the data and select options from the interface. 

Software info:

For windows users, the .zip file may be downloaded for local installation and mac/linux/unix users may download the .tar.gz file. 




Shyamal Peddada, Ph.D.
Former Chief, Biostatistics & Computational Biology Branch
7128 Parran Hall
130 DeSoto Street
Pittsburgh, PA 15261
Tel 412-383-4802