Disaster Research Response (DR2) Program
Provides training, funding, and a resources portal of tools to empower human health research in response to disasters and public health emergencies.
First created in the 1930s, per- and poly-fluoroalkyl substances include about 5,000 man-made chemicals used to make various types of everyday products.
Articles and Journals
Multiple curated collections of journal articles and scientific resources.
- Climate Change and Human Health Literature Portal
NIEHS provides a curated database of global peer-reviewed scientific literature and high-quality gray literature on the impacts of climate change on human health.
- Environmental Health Economic Analysis
The Environmental Health Economic Analysis is a searchable database that summarizes key attributes from over 70 curated environmental health science articles that include economic analyses.
- Environmental Health Perspectives (EHP)
EHP is a monthly peer-reviewed journal of research and news published with support from the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, U.S. Department of Health and Human Services.
- Nanotechnology Notable Papers and Advances
NIEHS is working to understand the health effects of human exposure to nanomaterials.
- NIEHS-supported Bisphenol A Research
NIEHS and National Toxicology Program have developed an integrated research program to address data gaps and inform decision making about the health effects of BPA.
- NIEHS-supported Publications on Per- and Polyfluoroalkyl Substances (PFAS)
NIEHS is working to understand the health effects of human exposure to per- and polyfluoroalkyl substances (PFAS).
- Recently Published Research
NIEHS scientists help to advance public health and environmental science.
- Selected Extramural Publications
The Program Analysis Branch prepares Selected Extramural Publications from high impact papers published by Division of Extramural Research and Training (DERT) grantees.
Ethical and regulatory oversight of research that involves human subjects.
The Bioethics Program is a part of the NIEHS' Ethics Program that provides educational, scholarly, and administrative support for research integrity at the NIEHS.
- Rigor and Reproducibility at NIH
Two of the cornerstones of science advancement are rigor in designing and performing scientific research and the ability to reproduce biomedical research findings.
Clinical Research Unit Resources
- Participant Protections
The overall mission of the Office of Human Research Compliance (OHRC) is to manage a comprehensive Human Research Protection Program at the National Institute of Environmental Health Sciences (NIEHS).
- Policy for Data and Safety Monitoring of Human Subject Research Studies
The National Institutes of Health (NIH) requires the monitoring activities of all NIH-sponsored or -conducted clinical studies to be commensurate with their risks, nature, size, and complexity.
Interactive databases in the field of environmental sciences.
- Chemical Effects in Biological Systems (CEBS)
The CEBS database houses data of interest to environmental health scientists. CEBS is a public resource, and has received depositions of data from academic, industrial and governmental laboratories.
- Comparative Toxicogenomics Database
CTD is a robust, publicly available database that aims to advance understanding about how environmental exposures affect human health. It provides manually curated information about chemical–gene/protein interactions, chemical–disease and gene–disease relationships. These data are integrated with functional and pathway data to aid in development of hypotheses about the mechanisms underlying environmentally influenced diseases.
- Disaster Research Response (DR2) Resources Portal
A repository of data collection tools and related resources curated by the DR2 Program to empower human health research in response to disasters and public health emergencies.
The DrugMatrix database is one of the world's largest toxicogenomic reference resources.
- Environmental Genome Project
The NIEHS Environmental Genome Project is a multi-disciplinary, collaborative effort focused on examining the relationships between environmental exposures, inter-individual sequence variation in human genes and disease risk in U.S. populations.
- Human DNA Polymerase Gamma Mutation Database
Human DNA polymerase is composed of two subunits, a 140 kDa catalytic subunit encoded by the POLG on chromosome 15q25, and a 55kDa accessory subunit encoded by the POLG2 gene on chromosome 17q23-24.
- Integrated Chemical Environment (ICE)
The Integrated Chemical Environment (ICE) database provides curated data from NICEATM, its partners, and other resources, as well as tools to facilitate the safey assessment of chemicals.
- Mircoarray Center cDNA Clone Search
NIEHS Microarray Center Clone Set Search Form.
- Mouse Genome Resequencing Project
The Mouse Genome Resequencing Project allows users to download the imputed genotypes at all 8 million (8,285,037) SNPs discovered by NIEHS/Perlegen resequencing project.
- Nanomaterial Registry
The Nanomaterial Registry compiles data from multiple databases into a single resource. The goal of this resource is to establish a curated nanomaterial registry, whoe primary function is to provide consistent information on the biological and environmental interactions of well-characterized nanomaterials, as well as links to associated publications, modeling tools, computational results and manufacturing guidances.
- Online Resource for Integrative Omics (ORIOS)
A web-based platform for rapid integration of next generation sequencing data.
- p53 Resources
p53 Resources incluing the human p53 Binding and Expression Resource (BAER) hub, the p53 ORIO webpage and the p53 cistrome R Shiny application.
- Personalized Environment and Genes Study (PEGS)
The Personalized Environment and Genes Study (PEGS), formerly the Environmental Polymorphisms Registry or EPR, is a long-term research project to collect health, exposure, medical and genetic data from a diverse group of people in North Carolina in the United States.
- SNPinfo Web Server
A set of web-based SNP selection tools where investigators can specify genes or linkage regions and select SNPs based on GWAS results, linkage disequilibrium (LD), and predicted functional characteristics of both coding and non-coding SNPs.
- Spin Trap Database
The Spin Trap Database is a database of more than 10,000 records of published Spin Trapping experiments. The database includes the experimental results (e.g. hyperfine coupling constants) and journal reference information.
The NIEHS Library manages information and knowledge to advance environmental health.
Outreach, Community and Leadership
NIEHS is the knowledge center for:
- Classroom Activities for Scientists
The Environmental Health Science Education website provides educators, students and scientists with easy access to reliable tools, resources and classroom materials.
- Shared and Core Facilities
NIEHS facilities provide state-of-the-art equipment and expertise, which support in-house (intramural) research activities at the institute. These shared and core services are available to NIH employees only.
- Electron Paramagnetic Resonance/Electron Spin Resonance (EPR/ESR)
Electron paramagnetic resonance (EPR), also known as electron spin resonance (ESR), is a sophisticated spectroscopic technique that detects free radicals in chemical and biological systems.
- International Myositis Assessment & Clinical Studies Group (IMACS)
The International Myositis Assessment and Clinical Studies Group (IMACS) is a coalition of health care providers and researchers with experience and interest in the myositis syndromes.
- Molecular Microscopy Consortium
The Molecular Microscopy Consortium allows scientists from NIEHS, the University of North Carolina at Chapel Hill, and Duke University to use single particle cryo-electron microscopy and other tools in molecular microscopy to solve macromolecular structures at the atomic level.
This video shows how the NIEHS Cryo-EM Facility generates 3D images of large proteins. (3:53)
- Speakers Bureau
NIEHS scientists, technicians, and administrators are also available to talk about their job responsibilities, as well as their educational and career experiences.
NIEHS researchers utilize many protocols to conduct repeatable scientific analysis. Protocols of interest to scientists are available below.
- Laser Capture Microdissection
Laser Microdissection provides information to NIEHS researchers interested in the process of microdissection.
The Immunohistochemistry staff has established optimized protocols for immunohistochemistry, immunocytochemistry, and immunofluorescence staining.
- Tissue Collection, RNA Extraction of High Quality RNA
Studies requiring gene expression analysis by microarray methods require the extraction of high quality RNA.
Software programs developed by NIEHS. These programs are open to the public and can be downloaded for free.
- Biostatistics & Computational Biology
NIEHS has several resources available to researchers, both inside and outside of the institute.
The Epidemiology Branch addresses the mission of the NIEHS by carrying out basic and applied research on the effects of the environment on human health.
- Free Radical Metabolism
The Free Radical Metabolism Group studied free radicals, which are atoms or molecules with unpaired electrons in an outer electron shell.
- Nuclear Magnetic Resonance
The Nuclear Magnetic Resonance (NMR) Group performs fundamental research on biological systems aimed at providing insight into the molecular mechanisms that underlie problems of environmental concern.
- Public Electron Paramagnetic Resonance Software Tools
NIEHS has produced software for Electron Paramagnetic Resonance analysis since 1983.
NIEHS provides visual guide to help researchers by providing best practices for creating highly repeatable results.
- Technology Transfer
The primary mission of this office is to enable NIEHS intramural researchers to more effectively interact with their counterparts — in academia, nonprofit organizations, and the private sector, such as biotechnology and pharmaceutical companies — to establish collaborative relationships that will benefit human health.
Training and Visual Guides
NIEHS provides visual guides to help researchers by providing best practices for creating highly repeatable results.
- The Digitized Atlas of Mouse Liver Lesions
The Atlas provides hundreds of color photographs and slides of various types of rodent liver lesions. Readers can search by both subject and by pathology.
- Mouse & Rat Embedding Suggestions
These images provide suggestions to scientists in the form of detailed illustrations, photos, interactive guides, and suggestions. These suggestions cover both rat and mouse tissues.
- NTP Nonneoplastic Lesion Atlas
A guide for standardizing terminology in toxicology pathology for rodents.
- Revised Guides for Organ Sampling and Trimming in Rats and Mice
This is the first part of a series of three articles on trimming instructions of rat and mouse protocol organs and tissues in regulatory type toxicity studies.