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Your Environment. Your Health.

Selected Publications

Metabolism, Genes, and Environment Group

  1. Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW, Roeder RG, Zhao Y, and Li X. (2018) EP300-mediated lysine 2-hydroxyisobutyrylation regulates glycolysis. Molecular Cell, 70:663-678. [Abstract] [Full Text] 
  2. Tang S, Fang Y, Huang G, Xu X, Banks EP, Fan W, Xu Q, Sanderson SM, Foley JF, Dowdy S, McBurney MW, Fargo DC, Williams CJ, Locasale JW, Guan Z, Li X. (2017) Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development. EMBO Journal. 36:3175-3193. [Abstract] [Full Text]
  3. Kwon S, Seok S, Yau P, Li X, Kemper B, Kemper JK. (2017) Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3. J Biol Chem. 292:17312-17323. [Abstract] [Full Text] 
  4. Wellman AS, Metukuri MR, Kazgan N, Xu X, Xu Q, Ren, NSX, Czopik A, Shanahan MT, Kang A, Chen W, Azcarate-Peril MA, Gulati AS, Fargo DC, Guarente L, Li X. (2017). Intestinal epithelial Sirtuin 1 regulates intestinal inflammation during aging in mice by altering the intestinal microbiota. Gastroenterology. 153:772–786. [Abstract] [Full Text] 
  5. Choi S, Kwon S, Seok S, Xiao Z, Lee K-W, Kang Y, Li X, Shinoda K, Kajimura S, Kemper B, Kemper JK. (2017) Obesity-linked phosphorylation of SIRT1 by CK2 inhibits its nuclear localization and deacetylase activity and promotes fatty liver. Mol Cell Biol doi:10.1128/MCB.00006-17. [Abstract] [Full Text]
  6. Jiang Y, Cao Y, Wang Y, Li W, Liu X, Lv Y, Li X, Mi J. (2017) Cysteine transporter SLC3A1 promotes breast cancer tumorigenesis. Theranostics. 7:1036-1046. [Abstract] [Full Text]
  7. Wang Y, Gan G, Wang B, Wu J, Cao Y, Zhu D, Xu Y, Wang X, Han H, Li X, Ye M, Zhao J, Mi J. 2017. Cancer-associated fibroblasts promote irradiated cancer cell recovery through autophagy. EBioMedicine 17:45-56. [Abstract] 
  8. Lu J, Xu Q, Ji M, Guo X, Xu X, Fargo DC, Li X. 2017. The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice. EMBO Rep 18(5):841-857. [Abstract] 
  9. Ren N.S., Ji M., Tokar E.J., Busch E.L., Xu X., Lewis D., Li X., Jin A., Zhang Y., Wu W.K., Huang W., Li L., Fargo D.C., Keku T.O., Sandler R.S., Li X. 2017. Haploinsufficiency of SIRT1 enhances glutamine metabolism and promotes cancer development. Curr Biol; doi:10.1016/j.cub.2016.12.047 [Online 31 January 2017]. [Abstract]
  10. Tang, S., Huang, G., Fan, W., Chen, Y., Ward, J. M., Xu, X., Xu, Q., Kang, A., McBurney, M. W., Fargo, D. C., Hu, G., Baumgart-Vogt, E., Zhao, Y., and Li, X. (2014) SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation. Molecular Cell, 55:843-855. [Abstract]
  11. Ming, M., Soltani, K., Shea, C. R., Li, X., and He, Y.-Y. (2015) Dual role of SIRT1 in UVB-induced skin tumorigenesis. Oncogene, 34:357-363. [Abstract]
  12. Kazgan, N., Metukuri, M., Purushotham, A., Lu, J., Rao, A., Lee, S., Pratt-Hyatt, M., Lickteig, A., Csanaky, I., Zhao, Y., Dawson, P. A., and Li, X. (2014) Intestine-specific deletion of SIRT1 impairs DCoH2/HNF1∝/FXR signaling and alters systemic bile acid homeostasis in mice. Gastroenterology, 146:1006-1016.
  13. Yin, H., Hu, M., Liang, X., Ajmo, J. M., Li, X., Bataller, R., Odena, G., Stevens, S. M. Jr., and You, M. (2014) Deletion of SIRT1 from hepatocytes in mice disrupts Lipin-1 signaling and aggravates alcoholic fatty liver. Gastroenterology, 146:801-811.
  14. Laurent, G., de Boer, V. C. J., Finley, L. W. S., Sweeney, M., Schug, T. T., Cen, Y., Jeong, S. M., Li, X., Sauve, A. A., and Haigis, M. C. (2013) SIRT4 represses PPAR∝ activity and suppresses hepatic lipid catabolism gene expression. Mol. Cell. Biol., 33:4552-4561.
  15. Choi, S. E., Fu, T., Seok, S., Kim, D. H., Yu, E., Lee, K. W., Kang, Y., Li, X., Kemper, B., and Kemper, J. K. (2013) Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. Aging Cell, 12:1062-1072.
  16. Kulkarni, S. R., Donepudi, A. C., Xu, J., Wei, W., Cheng, Q. C., Driscoll, M., Johnson, D. A., Johnson, J. A., Li, X., and Slitt, A. L. (2013) Fasting induces nuclear factor E2-related factor 2 and ATP-Binding Cassette Transporters via Protein Kinase A and Sirtuin-1 in mouse and human. Antioxidants & Redox Signaling, 20:15-30.
  17. Revollo JR, Li X. 2013. The ways and means that fine-tune Sirt1 activity. Trends Biochem Sci; doi:10.1016/j.tibs.2012.12.004. [Abstract]
  18. Li X. 2013. SIRT1 and energy metabolism. Acta Biochim Biophys Sin 45(1):51-60. [Abstract]
  19. Guo X, Kesimer M, Tolun G, Zheng X, Xu Q, Lu J, Sheehan JK, Griffith JD, Li X. 2012. The NAD+-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status. Sci Rep 2:640; doi:10.1038/srep00640. [Abstract]
  20. Purushotham A, Xu Q, Lu J, Foley JF, Yan X, Kim DH, Kemper JK, Li X. 2012. Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1alpha/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice. Mol Cell Biol 32(7):1226-1236. [Abstract]
  21. Purushotham A, Xu Q, and Li X. 2012. Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high-fat diet feeding. FASEB J 26(2):656-667. [Abstract]
  22. Chen S, Wu H, Ossola B, Schendzielorz N, Wilson B, Chu C, Wang Q, Zhang D, Qian L, Li X, Hong J, and Lu R. 2012. Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin-induced damage. Br. J. Pharmacol., 165:494-505. [Abstract]
  23. Li X, Kazgan N. 2011. Mammalian sirtuins and energy metabolism. Int J Biol Sci 7(5):575-587. [Abstract]
  24. Schug TT, Li X. 2011. Sirtuin 1 in lipid metabolism and obesity. Ann Med 43(3):198-211. [Abstract]
  25. Ming M, Shea C R, Guo X, Li X, Soltani K, Han W, and He YY. 2010. Regulation of global genome nucleotide excision repair by SIRT1 through XPC. Proc. Natl. Acad. Sci. USA, 107(52):22623-22628. [Abstract]
  26. Schug TT, Xu Q, Gao H, Peres-da-Silva, A, Draper DW, Fessler MB, Purushotham A, and Li X. 2010. Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress. Mol Cell Biol 30(19):4712-4721. [Abstract]
  27. Schug TT, and Li X. 2010. Surprising sirtuin crosstalk in the heart. Aging 2(3):129-132. [Abstract]
  28. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Isrealian K, Westphal CH, Rodgers JT, Shioda T, Mulligan P, Najafi-Shoushtari H, Thakur JK, Kadyk LC, Mostoslavsky R, Puigserver P, Li X, Dyson, N, J Hart, AC, Naar AM. 2010. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev, 24(13):1403-1417. [Abstract]
  29. Guo X, Williams JG, Schug TT, Li X. 2010. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J. Biol. Chem. 285(17):13223-13232. [Abstract]
  30. Purushotham A, Schug TT, Li X. 2009. SIRT1 performs a balancing act on the tight-rope toward longevity. Aging 1(7):669-673. [Abstract]
  31. Purushotham A, Schug TT, Xu Q, Surapureddi S, Guo X, Li X. 2009. Hepatocytes-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab, 9(4):327-338. [Abstract]
  32. Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L. 2007. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell. 28(1):91-106. [Abstract]
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