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Li W, Nakano H, Fan W, Li Y, Sil P, Nakano K, Zhao F, Karmaus PW, Grimm SA, Shi M, Xu X, Mizuta R, Kitamura D, Wan Y, Fessler MB, Cook DN, Shats I, Li X , Li L. (2023) DNASE1L3 enhances antitumor immunity and suppresses tumor progression in colon cancer. JCI Insight . 2023 Aug 15:e168161. doi: 10.1172/jci.insight.168161. [ Abstract Li W, Nakano H, Fan W, Li Y, Sil P, Nakano K, Zhao F, Karmaus PW, Grimm SA, Shi M, Xu X, Mizuta R, Kitamura D, Wan Y, Fessler MB, Cook DN, Shats I, Li X, Li L. (2023) DNASE1L3 enhances antitumor immunity and suppresses tumor progression in colon cancer. JCI Insight. 2023 Aug 15:e168161. doi: 10.1172/jci.insight.168161. ] Ji M, Xu X, Xu Q, Hsiao YC, Martin C, Ukraintseva S, Popov V, Arbeev KG, Randall TA, Wu X, Garcia-Peterson LM, Liu J, Xu X, Andrea Azcarate-Peril M, Wan Y, Yashin AI, Anantharaman K, Lu K, Li JL, Shats I, Li X . (2023) Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota. Nat Metab . doi: 10.1038/s42255-023-00854-3. [ Abstract Ji M, Xu X, Xu Q, Hsiao YC, Martin C, Ukraintseva S, Popov V, Arbeev KG, Randall TA, Wu X, Garcia-Peterson LM, Liu J, Xu X, Andrea Azcarate-Peril M, Wan Y, Yashin AI, Anantharaman K, Lu K, Li JL, Shats I, Li X. (2023) Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota. Nat Metab. doi: 10.1038/s42255-023-00854-3. ] Fan W, Li X . (2023) The SIRT1-c-Myc axis in regulation of stem cells. Front Cell Dev Biol . 11:1236968. doi: 10.3389/fcell.2023.1236968. [ Abstract Fan W, Li X. (2023) The SIRT1-c-Myc axis in regulation of stem cells. Front Cell Dev Biol. 11:1236968. doi: 10.3389/fcell.2023.1236968. ] Fang Y, Li X . (2023) Protein lysine four-carbon acylations in health and disease. J Cell Physiol . doi: 10.1002/jcp.30981. [ Abstract Fang Y, Li X. (2023) Protein lysine four-carbon acylations in health and disease. J Cell Physiol. doi: 10.1002/jcp.30981. ] Fang Y, Fan W, Xu X, Janoshazi AK, Fargo DC, Li X . (2022) SIRT1 regulates cardiomyocyte alignment during maturation. J Cell Sci . jcs.259076. doi: 10.1242/jcs.259076. [ Abstract Fang Y, Fan W, Xu X, Janoshazi AK, Fargo DC, Li X. (2022) SIRT1 regulates cardiomyocyte alignment during maturation. J Cell Sci. jcs.259076. doi: 10.1242/jcs.259076. ] Fang Y, Li X . (2022) Metabolic and epigenetic regulation of endoderm differentiation. Trends Cell Biol . 32(2):151-164. doi: 10.1016/j.tcb.2021.09.002. [ Abstract Fang Y, Li X. (2022) Metabolic and epigenetic regulation of endoderm differentiation. Trends Cell Biol. 32(2):151-164. doi: 10.1016/j.tcb.2021.09.002. ] Tang, S.*, Zhang, Z., Oakley, R. H., Li, W., Xu, X., Xu, Q., Ji, M., Chen, L., He, W., Li, Q., Li, X., Wellman, A. S., Li, L., Li, J.-L., Cidlowski, J. A.*, and Li, X. * (2021) Intestinal epithelial glucocorticoid receptor suppresses acute colitis but promotes chronic inflammation-associated colorectal cancer. JCI Insight . (* Co-correspondence). [ Abstract Tang, S.*, Zhang, Z., Oakley, R. H., Li, W., Xu, X., Xu, Q., Ji, M., Chen, L., He, W., Li, Q., Li, X., Wellman, A. S., Li, L., Li, J.-L., Cidlowski, J. A.*, and Li, X.* (2021) Intestinal epithelial glucocorticoid receptor suppresses acute colitis but promotes chronic inflammation-associated colorectal cancer. JCI Insight. (* Co-correspondence). ] Zhang, W., Sun, Y., Bai, L., Zhi, L., Yang, Y., Zhao, Q., Chen, C., Qi, Y., Gao, W., He, W., Wang, L., Chen, D., Fan, S., Chen, H., Piao, H.-L., Qiao, Q., Xu, Z., Zhang, J., Zhao, J., Zhang, S., Yin, Y., Peng, C., Li, X. , Liu, Q., Liu, H., and Wang, Y. (2021) Loss of RBMS1 promotes lung cancer ferroptosis through translational suppression of SLC7A11. Journal of Clinical Investigation . [ Abstract Zhang, W., Sun, Y., Bai, L., Zhi, L., Yang, Y., Zhao, Q., Chen, C., Qi, Y., Gao, W., He, W., Wang, L., Chen, D., Fan, S., Chen, H., Piao, H.-L., Qiao, Q., Xu, Z., Zhang, J., Zhao, J., Zhang, S., Yin, Y., Peng, C., Li, X., Liu, Q., Liu, H., and Wang, Y. (2021) Loss of RBMS1 promotes lung cancer ferroptosis through translational suppression of SLC7A11. Journal of Clinical Investigation. ] Ren, R., He, Y., Ding, D., Cui, A., Bao, H., Ma, J., Hou, X., Li, Y., Feng, D., Li, X. , Liangpunsakul, D., Bao, B., and Wang, H. (2021) Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C/EBPα-miRNA-223 axis. Hepatology . [ Abstract Ren, R., He, Y., Ding, D., Cui, A., Bao, H., Ma, J., Hou, X., Li, Y., Feng, D., Li, X., Liangpunsakul, D., Bao, B., and Wang, H. (2021) Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C/EBPα-miRNA-223 axis. Hepatology. ] Garcia-Peterson LM, Li X . 2021. Trending topics of SIRT1 in tumorigenicity. Biochim Biophys Acta Gen Subj 1865(9):129952. [ Abstract Garcia-Peterson LM, Li X. 2021. Trending topics of SIRT1 in tumorigenicity. Biochim Biophys Acta Gen Subj 1865(9):129952. ] Fan W, Tang S, Fan X, Fang Y, Xu X, Li L, Xu J, Li JL, Wang Z, Li X . 2021. SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B. Elife 10:e67452. [ Abstract Fan W, Tang S, Fan X, Fang Y, Xu X, Li L, Xu J, Li JL, Wang Z, Li X. 2021. SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B. Elife 10:e67452. ] Fang Y, Li X . 2021. A simple, efficient, and reliable endoderm differentiation protocol for human embryonic stem cells using crotonate. STAR Protocols 2(3):100659. [ Abstract Fang Y, Li X. 2021. A simple, efficient, and reliable endoderm differentiation protocol for human embryonic stem cells using crotonate. STAR Protocols 2(3):100659. ] Li Y, Umbach DM, Krahn JM, Shats I, Li X , and Li L. 2021. Predicting Tumor Response to Drugs based on Gene-Expression Biomarkers of Sensitivity Learned from Cancer Cell Lines. BMC Genomics . 22:272. [ Abstract Li Y, Umbach DM, Krahn JM, Shats I, Li X, and Li L. 2021. Predicting Tumor Response to Drugs based on Gene-Expression Biomarkers of Sensitivity Learned from Cancer Cell Lines. BMC Genomics. 22:272. ] Fang Y, Xu X, Ding J, Lu Y, Doan MT, Karmaus PWF, Snyder N, Zhao Y, Li JL, Li X *. 2021. Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells. Cell Stem Cell . 28:748-763. [ Abstract Fang Y, Xu X, Ding J, Lu Y, Doan MT, Karmaus PWF, Snyder N, Zhao Y, Li JL, Li X*. 2021. Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells. Cell Stem Cell. 28:748-763. ] Shats I, Li X . 2020. Bacteria boost host NAD metabolism. Aging (Albany NY) 12(23):23425-23426. [ Abstract Shats I, Li X. 2020. Bacteria boost host NAD metabolism. Aging (Albany NY) 12(23):23425-23426. ] Xu, Q., Li, Y., Gao, X., Kang, K., Williams, J. G., Tong, L., Liu, J., Ji, M., Deterding, L. J., Tong, X., Locasale, J. W., Li, L., Shats, I., and Li, X . (2020) HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer. Nature Communications , 11, 3978. [ Abstract Xu, Q., Li, Y., Gao, X., Kang, K., Williams, J. G., Tong, L., Liu, J., Ji, M., Deterding, L. J., Tong, X., Locasale, J. W., Li, L., Shats, I., and Li, X. (2020) HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer. Nature Communications, 11, 3978. ] Shats, I., Williams, J. G., Liu, J., Makarov, M. V., Wu, X., Lih, F. B., Deterding, L. J., Lim, C., Xu, X., Randall, T. A., Lee, E., Li, W., Fan, W., Li, J.-L., Sokolsky, M., Kabanov, A. V., Li, L., Migaud, M. E., Locasale, J. W., and Li, X . (2020) Bacteria boost mammalian host NAD metabolism by engaging the deamidated biosynthesis pathway. Cell Metabolism , 31:564-579. [ Abstract Shats, I., Williams, J. G., Liu, J., Makarov, M. V., Wu, X., Lih, F. B., Deterding, L. J., Lim, C., Xu, X., Randall, T. A., Lee, E., Li, W., Fan, W., Li, J.-L., Sokolsky, M., Kabanov, A. V., Li, L., Migaud, M. E., Locasale, J. W., and Li, X. (2020) Bacteria boost mammalian host NAD metabolism by engaging the deamidated biosynthesis pathway. Cell Metabolism, 31:564-579. ] Tang, S, Li, X , and Locasale, JW (2020) Dietary methionine in T cell biology and autoimmune disease. Cell Metabolism , 31:211-212. (* Co-correspondence). [ Abstract Tang, S, Li, X, and Locasale, JW (2020) Dietary methionine in T cell biology and autoimmune disease. Cell Metabolism, 31:211-212. (* Co-correspondence). ] Kang, K., Meng, Q., Shats, I., Umbach, D., Li, M., Li, Y., Li, X. , and Li, L. (2019) CDSeq: a novel complete deconvolution method for dissecting heterogeneous samples using RNA-seq data. PLOS Computational Biology , 15(12): e1007510. [ Abstract Kang, K., Meng, Q., Shats, I., Umbach, D., Li, M., Li, Y., Li, X., and Li, L. (2019) CDSeq: a novel complete deconvolution method for dissecting heterogeneous samples using RNA-seq data. PLOS Computational Biology, 15(12): e1007510. ] Hung, Y.-H., Kanke, M., Kurtz, C. L., Cubitt, R. L., Bunaciu, R. P., Zhou, L., White, P. J., Vickers, K. C., Hussain, M. M., Li, X. , and Sethupathy, P. (2019) MiR-29 regulates de novo lipogenesis in the liver and circulating triglyceride levels in a Sirt1-dependent manner. Frontiers In Physiology , 10:1367. [ Abstract Hung, Y.-H., Kanke, M., Kurtz, C. L., Cubitt, R. L., Bunaciu, R. P., Zhou, L., White, P. J., Vickers, K. C., Hussain, M. M., Li, X., and Sethupathy, P. (2019) MiR-29 regulates de novo lipogenesis in the liver and circulating triglyceride levels in a Sirt1-dependent manner. Frontiers In Physiology, 10:1367. ] Li, Y., Li, M., Shats, I., Krahn, J. M., Flake, G. P., Umbach, D. M., Li, X. , Li, L. (2019) Glypican 6 is a putative biomarker for metastatic progression of cutaneous melanoma. PLoS ONE , 14: e0218067. [ Abstract Li, Y., Li, M., Shats, I., Krahn, J. M., Flake, G. P., Umbach, D. M., Li, X., Li, L. (2019) Glypican 6 is a putative biomarker for metastatic progression of cutaneous melanoma. PLoS ONE, 14: e0218067. ] Fang Y, Tang S, Li X . (2019) Sirtuins in Metabolic and Epigenetic Regulation of Stem Cells. Trends in endocrinology and metabolism. 30(3):177-188 [ Abstract Fang Y, Tang S, Li X. (2019) Sirtuins in Metabolic and Epigenetic Regulation of Stem Cells. Trends in endocrinology and metabolism. 30(3):177-188 ] Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW, Roeder RG, Zhao Y , and Li X . (2018) EP300-mediated lysine 2-hydroxyisobutyrylation regulates glycolysis. Molecular Cell , 70:663-678. [ Abstract Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW, Roeder RG, Zhao Y, and Li X. (2018) EP300-mediated lysine 2-hydroxyisobutyrylation regulates glycolysis. Molecular Cell, 70:663-678. ] [ Full Text Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW, Roeder RG, Zhao Y, and Li X. (2018) EP300-mediated lysine 2-hydroxyisobutyrylation regulates glycolysis. Molecular Cell, 70:663-678. ] Tang S, Fang Y, Huang G, Xu X, Banks EP, Fan W, Xu Q, Sanderson SM, Foley JF, Dowdy S, McBurney MW, Fargo DC, Williams CJ, Locasale JW, Guan Z, Li X . (2017) Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development. EMBO Journal . 36:3175-3193. [ Abstract Tang S, Fang Y, Huang G, Xu X, Banks EP, Fan W, Xu Q, Sanderson SM, Foley JF, Dowdy S, McBurney MW, Fargo DC, Williams CJ, Locasale JW, Guan Z, Li X. (2017) Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development. EMBO Journal. 36:3175-3193. ] [ Full Text Tang S, Fang Y, Huang G, Xu X, Banks EP, Fan W, Xu Q, Sanderson SM, Foley JF, Dowdy S, McBurney MW, Fargo DC, Williams CJ, Locasale JW, Guan Z, Li X. (2017) Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development. EMBO Journal. 36:3175-3193. ] Kwon S, Seok S, Yau P, Li X, Kemper B, Kemper JK. (2017) Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3. J Biol Chem . 292:17312-17323. [ Abstract Kwon S, Seok S, Yau P, Li X, Kemper B, Kemper JK. (2017) Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3. J Biol Chem. 292:17312-17323. ] [ Full Text Kwon S, Seok S, Yau P, Li X, Kemper B, Kemper JK. (2017) Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3. J Biol Chem. 292:17312-17323. ] Wellman AS, Metukuri MR, Kazgan N, Xu X, Xu Q, Ren, NSX, Czopik A, Shanahan MT, Kang A, Chen W, Azcarate-Peril MA, Gulati AS, Fargo DC, Guarente L, Li X. (2017). Intestinal epithelial Sirtuin 1 regulates intestinal inflammation during aging in mice by altering the intestinal microbiota. Gastroenterology . 153:772–786. [ Abstract Wellman AS, Metukuri MR, Kazgan N, Xu X, Xu Q, Ren, NSX, Czopik A, Shanahan MT, Kang A, Chen W, Azcarate-Peril MA, Gulati AS, Fargo DC, Guarente L, Li X. (2017). Intestinal epithelial Sirtuin 1 regulates intestinal inflammation during aging in mice by altering the intestinal microbiota. Gastroenterology. 153:772–786. ] [ Full Text Wellman AS, Metukuri MR, Kazgan N, Xu X, Xu Q, Ren, NSX, Czopik A, Shanahan MT, Kang A, Chen W, Azcarate-Peril MA, Gulati AS, Fargo DC, Guarente L, Li X. (2017). Intestinal epithelial Sirtuin 1 regulates intestinal inflammation during aging in mice by altering the intestinal microbiota. Gastroenterology. 153:772–786. ] Choi S, Kwon S, Seok S, Xiao Z, Lee K-W, Kang Y, Li X, Shinoda K, Kajimura S, Kemper B, Kemper JK. (2017) Obesity-linked phosphorylation of SIRT1 by CK2 inhibits its nuclear localization and deacetylase activity and promotes fatty liver. Mol Cell Biol doi:10.1128/MCB.00006-17. [ Abstract Choi S, Kwon S, Seok S, Xiao Z, Lee K-W, Kang Y, Li X, Shinoda K, Kajimura S, Kemper B, Kemper JK. (2017) Obesity-linked phosphorylation of SIRT1 by CK2 inhibits its nuclear localization and deacetylase activity and promotes fatty liver. Mol Cell Biol doi:10.1128/MCB.00006-17. ] [ Full Text Choi S, Kwon S, Seok S, Xiao Z, Lee K-W, Kang Y, Li X, Shinoda K, Kajimura S, Kemper B, Kemper JK. (2017) Obesity-linked phosphorylation of SIRT1 by CK2 inhibits its nuclear localization and deacetylase activity and promotes fatty liver. Mol Cell Biol doi:10.1128/MCB.00006-17. ] Jiang Y, Cao Y, Wang Y, Li W, Liu X, Lv Y, Li X , Mi J. (2017) Cysteine transporter SLC3A1 promotes breast cancer tumorigenesis. Theranostics . 7:1036-1046. [ Abstract Jiang Y, Cao Y, Wang Y, Li W, Liu X, Lv Y, Li X, Mi J. (2017) Cysteine transporter SLC3A1 promotes breast cancer tumorigenesis. Theranostics. 7:1036-1046. ] [ Full Text Jiang Y, Cao Y, Wang Y, Li W, Liu X, Lv Y, Li X, Mi J. (2017) Cysteine transporter SLC3A1 promotes breast cancer tumorigenesis. Theranostics. 7:1036-1046. ] Wang Y, Gan G, Wang B, Wu J, Cao Y, Zhu D, Xu Y, Wang X, Han H, Li X , Ye M, Zhao J, Mi J. 2017. Cancer-associated fibroblasts promote irradiated cancer cell recovery through autophagy. EBioMedicine 17:45-56. [ Abstract Wang Y, Gan G, Wang B, Wu J, Cao Y, Zhu D, Xu Y, Wang X, Han H, Li X, Ye M, Zhao J, Mi J. 2017. Cancer-associated fibroblasts promote irradiated cancer cell recovery through autophagy. EBioMedicine 17:45-56. ] Lu J, Xu Q, Ji M, Guo X, Xu X, Fargo DC, Li X. 2017. The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice. EMBO Rep 18(5):841-857. [ Abstract Lu J, Xu Q, Ji M, Guo X, Xu X, Fargo DC, Li X. 2017. The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice. EMBO Rep 18(5):841-857. ] Ren N.S., Ji M., Tokar E.J., Busch E.L., Xu X., Lewis D., Li X. , Jin A., Zhang Y., Wu W.K., Huang W., Li L., Fargo D.C., Keku T.O., Sandler R.S., Li X . 2017. Haploinsufficiency of SIRT1 enhances glutamine metabolism and promotes cancer development. Curr Biol; doi:10.1016/j.cub.2016.12.047 [Online 31 January 2017]. [ Abstract Ren N.S., Ji M., Tokar E.J., Busch E.L., Xu X., Lewis D., Li X., Jin A., Zhang Y., Wu W.K., Huang W., Li L., Fargo D.C., Keku T.O., Sandler R.S., Li X. 2017. Haploinsufficiency of SIRT1 enhances glutamine metabolism and promotes cancer development. Curr Biol; doi:10.1016/j.cub.2016.12.047 [Online 31 January 2017]. ] Tang, S., Huang, G., Fan, W., Chen, Y., Ward, J. M., Xu, X., Xu, Q., Kang, A., McBurney, M. W., Fargo, D. C., Hu, G., Baumgart-Vogt, E., Zhao, Y., and Li, X . (2014) SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation. Molecular Cell , 55:843-855. [ Abstract Tang, S., Huang, G., Fan, W., Chen, Y., Ward, J. M., Xu, X., Xu, Q., Kang, A., McBurney, M. W., Fargo, D. C., Hu, G., Baumgart-Vogt, E., Zhao, Y., and Li, X. (2014) SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation. Molecular Cell, 55:843-855. ] Ming, M., Soltani, K., Shea, C. R., Li, X. , and He, Y.-Y. (2015) Dual role of SIRT1 in UVB-induced skin tumorigenesis. Oncogene , 34:357-363. [ Abstract Ming, M., Soltani, K., Shea, C. R., Li, X., and He, Y.-Y. (2015) Dual role of SIRT1 in UVB-induced skin tumorigenesis. Oncogene, 34:357-363. ] Kazgan, N., Metukuri, M., Purushotham, A., Lu, J., Rao, A., Lee, S., Pratt-Hyatt, M., Lickteig, A., Csanaky, I., Zhao, Y., Dawson, P. A., and Li, X. (2014) Intestine-specific deletion of SIRT1 impairs DCoH2/HNF1∝/FXR signaling and alters systemic bile acid homeostasis in mice. Gastroenterology , 146:1006-1016. Yin, H., Hu, M., Liang, X., Ajmo, J. M., Li, X ., Bataller, R., Odena, G., Stevens, S. M. Jr., and You, M. (2014) Deletion of SIRT1 from hepatocytes in mice disrupts Lipin-1 signaling and aggravates alcoholic fatty liver. Gastroenterology , 146:801-811. Laurent, G., de Boer, V. C. J., Finley, L. W. S., Sweeney, M., Schug, T. T., Cen, Y., Jeong, S. M., Li, X. , Sauve, A. A., and Haigis, M. C. (2013) SIRT4 represses PPAR∝ activity and suppresses hepatic lipid catabolism gene expression. Mol. Cell. Biol. , 33:4552-4561. Choi, S. E., Fu, T., Seok, S., Kim, D. H., Yu, E., Lee, K. W., Kang, Y., Li, X ., Kemper, B., and Kemper, J. K. (2013) Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. Aging Cell , 12:1062-1072. Kulkarni, S. R., Donepudi, A. C., Xu, J., Wei, W., Cheng, Q. C., Driscoll, M., Johnson, D. A., Johnson, J. A., Li, X. , and Slitt, A. L. (2013) Fasting induces nuclear factor E2-related factor 2 and ATP-Binding Cassette Transporters via Protein Kinase A and Sirtuin-1 in mouse and human. Antioxidants & Redox Signaling , 20:15-30. Revollo JR, Li X. 2013. The ways and means that fine-tune Sirt1 activity. Trends Biochem Sci; doi:10.1016/j.tibs.2012.12.004. [ Abstract Revollo JR, Li X. 2013. The ways and means that fine-tune Sirt1 activity. Trends Biochem Sci; doi:10.1016/j.tibs.2012.12.004. ] Li X. 2013. SIRT1 and energy metabolism. Acta Biochim Biophys Sin 45(1):51-60. [ Abstract Li X. 2013. SIRT1 and energy metabolism. Acta Biochim Biophys Sin 45(1):51-60. ] Guo X, Kesimer M, Tolun G, Zheng X, Xu Q, Lu J, Sheehan JK, Griffith JD, Li X. 2012. The NAD+ -dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status. Sci Rep 2:640; doi:10.1038/srep00640. [ Abstract Guo X, Kesimer M, Tolun G, Zheng X, Xu Q, Lu J, Sheehan JK, Griffith JD, Li X. 2012. The NAD+ -dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status. Sci Rep 2:640; doi:10.1038/srep00640. ] Purushotham A, Xu Q, Lu J, Foley JF, Yan X, Kim DH, Kemper JK, Li X . 2012. Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1alpha/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice. Mol Cell Biol 32(7):1226-1236. [ Abstract Purushotham A, Xu Q, Lu J, Foley JF, Yan X, Kim DH, Kemper JK, Li X. 2012. Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1alpha/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice. Mol Cell Biol 32(7):1226-1236. ] Purushotham A, Xu Q, and Li X . 2012. Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high-fat diet feeding. FASEB J 26(2):656-667. [ Abstract Purushotham A, Xu Q, and Li X. 2012. Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high-fat diet feeding. FASEB J 26(2):656-667. ] Chen S, Wu H, Ossola B, Schendzielorz N, Wilson B, Chu C, Wang Q, Zhang D, Qian L, Li X , Hong J, and Lu R. 2012. Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin-induced damage. Br. J. Pharmacol. , 165:494-505. [ Abstract Chen S, Wu H, Ossola B, Schendzielorz N, Wilson B, Chu C, Wang Q, Zhang D, Qian L, Li X, Hong J, and Lu R. 2012. Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin-induced damage. Br. J. Pharmacol., 165:494-505. ] Li X, Kazgan N. 2011. Mammalian sirtuins and energy metabolism. Int J Biol Sci 7(5):575-587. [ Abstract Li X, Kazgan N. 2011. Mammalian sirtuins and energy metabolism. Int J Biol Sci 7(5):575-587. ] Schug TT, Li X. 2011. Sirtuin 1 in lipid metabolism and obesity. Ann Med 43(3):198-211. [ Abstract Schug TT, Li X. 2011. Sirtuin 1 in lipid metabolism and obesity. Ann Med 43(3):198-211. ] Ming M, Shea C R, Guo X, Li X , Soltani K, Han W, and He YY. 2010. Regulation of global genome nucleotide excision repair by SIRT1 through XPC. Proc. Natl. Acad. Sci. USA, 107(52):22623-22628. [ Abstract Ming M, Shea C R, Guo X, Li X, Soltani K, Han W, and He YY. 2010. Regulation of global genome nucleotide excision repair by SIRT1 through XPC. Proc. Natl. Acad. Sci. USA, 107(52):22623-22628. ] Schug TT, Xu Q, Gao H, Peres-da-Silva, A, Draper DW, Fessler MB, Purushotham A, and Li X . 2010. Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress. Mol Cell Biol 30(19):4712-4721. [ Abstract Schug TT, Xu Q, Gao H, Peres-da-Silva, A, Draper DW, Fessler MB, Purushotham A, and Li X. 2010. Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress. Mol Cell Biol 30(19):4712-4721. ] Schug TT, and Li X . 2010. Surprising sirtuin crosstalk in the heart. Aging 2(3):129-132. [ Abstract Schug TT, and Li X. 2010. Surprising sirtuin crosstalk in the heart. Aging 2(3):129-132. ] Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Isrealian K, Westphal CH, Rodgers JT, Shioda T, Mulligan P, Najafi-Shoushtari H, Thakur JK, Kadyk LC, Mostoslavsky R, Puigserver P, Li X , Dyson, N, J Hart, AC, Naar AM. 2010. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev, 24(13):1403-1417. [ Abstract Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Isrealian K, Westphal CH, Rodgers JT, Shioda T, Mulligan P, Najafi-Shoushtari H, Thakur JK, Kadyk LC, Mostoslavsky R, Puigserver P, Li X, Dyson, N, J Hart, AC, Naar AM. 2010. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev, 24(13):1403-1417. ] Guo X, Williams JG, Schug TT, Li X . 2010. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J. Biol. Chem. 285(17):13223-13232. [ Abstract Guo X, Williams JG, Schug TT, Li X. 2010. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J. Biol. Chem. 285(17):13223-13232. ] Purushotham A, Schug TT, Li X . 2009. SIRT1 performs a balancing act on the tight-rope toward longevity. Aging 1(7):669-673. [ Abstract Purushotham A, Schug TT, Li X. 2009. SIRT1 performs a balancing act on the tight-rope toward longevity. Aging 1(7):669-673. ] Purushotham A, Schug TT, Xu Q, Surapureddi S, Guo X, Li X . 2009. Hepatocytes-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab , 9(4):327-338. [ Abstract Purushotham A, Schug TT, Xu Q, Surapureddi S, Guo X, Li X. 2009. Hepatocytes-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab, 9(4):327-338. ] Li X , Zhang S, Blander G, Tse JG, Krieger M, Guarente L. 2007. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell . 28(1):91-106. [ Abstract Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L. 2007. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell. 28(1):91-106. ]
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Last Reviewed: September 30, 2024