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Your Environment. Your Health.

Selected Publications

Reproductive Developmental Biology Group

  • Plummer NW, Ungewitter EK, Smith KG, Yao HH, and Jensen P. A new mouse line for cell ablation by diphtheria toxin subunit A (DTA) controlled by a Cre-dependent FLEx switch. Genesis 2017 Oct;55(10). doi: 10.1002/dvg.23067. Epub 2017 Sep 19. [Abstract]
  • Wear HM, Eriksson A, Yao HHC, Watanabe KH. Cell-based computational model of early ovarian development in mice. Biology of Reproduction 2017: 97(3), 365–377. [Abstract] [Full Text]
  • Zhao F, Franco HL, Rodriguez K, Brown P, Tsai MJ, Tsai SY, and Yao HHC. Elimination of the male reproductive tract in the female mouse embryo is promoted by COUP-TFII. Science 2017 357(6352):717-720. doi: 10.1126/science.aai9136. PMID: 28818950 [Abstract] [Full Text] Highlighted in Perspectives and multiple news outlets; NIEHS Intramural paper of month in October 2017.
  • Ungewitter E, Rotgers E, Bantukul T, Brown P, Kawakami Y, Kissling G, and Yao HHC. Teratogenic Effects of in Utero Exposure to Di-(2-Ethylhexyl)-Phthalate (DEHP) in B6:129S4 Mice Toxicol Sci 2017 157 (1): 8-19. PubMed PMID: 28123099. [Abstract] (Selected as cover image of this issue)
  • McClelland KS, Yao HHC. Leveraging Online Resources to Prioritize Candidate Genes for Functional Analyses: Using the Fetal Testis as a Test Case. Sexual development: genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 2017 11(1):1-20. [Abstract] 
  • Liu C, Rodriguez K, Yao HHC. Mapping lineage progression of somatic progenitor cells in the mouse fetal testis. Development (Cambridge, England) 2016 ():-. [Abstract]
  • Rodriguez K, Ungewitter E, Crespo Y, Liu C, Nicol B, Yao HHC. Effects of in Utero Exposure to Arsenic during the Second Half of Gestation on Reproductive End Points and Metabolic Parameters in Female CD-1 Mice. Environmental health perspectives 2016 124(3):336-343. [Abstract]
  • Nicol B, Yao HHC. Gonadal Identity in the Absence of Pro-Testis Factor SOX9 and Pro-Ovary Factor Beta-Catenin in Mice. Biology of Reproduction 2015 93(2):35-. [Abstract]
  • Liu C, Peng J, Matzuk MM, Yao HH. Lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells. Nature communications 2015 6():6934-. [Abstract]
  • Archambeault DR, Yao HH. Loss of smad4 in sertoli and leydig cells leads to testicular dysgenesis and hemorrhagic tumor formation in mice. Biology of reproduction 2014 90(3):62-.  [Abstract]
  • Barsoum IB, Kaur J, Ge RS, Cooke PS, Yao HH. Dynamic changes in fetal Leydig cell populations influence adult Leydig cell populations in mice. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 2013 27(7):2657-2666. [Abstract]
  • Ungewitter EK, Yao HH. How to make a gonad: cellular mechanisms governing formation of the testes and ovaries. Sexual development 2013 7(1-3):7-20. [Abstract]
  • McDowell EN, Kisielewski AE, Pike JW, Franco HL, Yao HH-C, Johnson KJ. A transcriptome-wide screen for mRNAs enriched in fetal Leydig cells: CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesis. PloS one 2012 7(10):e47359. [Abstract]
  • Barsoum I, Yao HHC. Redundant and Differential Roles of Transcription Factors Gli1 and Gli2 in the Development of Mouse Fetal Leydig Cells. Biology of reproduction. 2011 May; 84(5):894-899. Epub 2011 Jan 5. [Abstract]
  • Liu CF, Liu C, Yao HH. Building pathways for ovary organogenesis in the mouse embryo. Curr Top Dev Biol. 2010;90C:263-290. [Abstract]
  • Huang CC, Yao HH. Inactivation of Dicer1 in Steroidogenic factor 1-positive cells reveals tissue-specific requirement for Dicer1 in adrenal, testis, and ovary. BMC Dev Biol. 2010 Jun 11;10:66. [Abstract]
  • Archambeault DR, Yao HH. Activin A, a product of fetal Leydig cells, is a unique paracrine regulator of Sertoli cell proliferation and fetal testis cord expansion. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10526-31. Epub 2010 May 24. [Abstract]
  • Liu CF, Parker K, Yao HH. WNT4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary. PLoS One. 2010 Apr 29;5(4):e10382. [Abstract]
  • Huang CC, Yao HH. Diverse functions of Hedgehog signaling in formation and physiology of steroidogenic organs. Mol Reprod Dev. 2010 Jun;77(6):489-96. Review. [Abstract]
  • Huang CC, Miyagawa S, Matsumaru D, Parker KL, Yao HH. Progenitor cell expansion and organ size of mouse adrenal is regulated by sonic hedgehog. Endocrinology. 2010 Mar; 151(3):1119-28. Epub 2010 Jan 29. [Abstract]
  • Barsoum IB, Yao HH. Fetal Leydig cells: progenitor cell maintenance and differentiation. J Androl. 2010 Jan-Feb;31(1):11-5. Epub 2009 Oct 29. Review. [Abstract]
  • Gupta RK, Singh JM, Leslie TC, Meachum S, Flaws JA, Yao HH. Di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate inhibit growth and reduce estradiol levels of antral follicles in vitro. Toxicol Appl Pharmacol. 2010 Jan 15;242(2):224-30. Epub 2009 Oct 27. [Abstract]
  • Gupta RK, Meachum S, Hernández-Ochoa I, Peretz J, Yao HH, Flaws JA. Methoxychlor inhibits growth of antral follicles by altering cell cycle regulators. Toxicol Appl Pharmacol. 2009 Oct 1;240(1):1-7. Epub 2009 Jul 14. [Abstract]
  • Liu CF, Barsoum I, Gupta R, Hofmann MC, Yao HH. Stem cell potential of the mammalian gonad. Front Biosci (Elite Ed). 2009 Jun 1;1:510-8. Review. [Abstract]
  • Barsoum IB, Bingham NC, Parker KL, Jorgensen JS, Yao HH. Activation of the Hedgehog pathway in the mouse fetal ovary leads to ectopic appearance of fetal Leydig cells and female pseudohermaphroditism. Dev Biol. 2009 May 1;329(1):96-103. Epub 2009 Mar 3. [Abstract]
  • Liu CF, Bingham N, Parker K, Yao HH. Sex-specific roles of beta-catenin in mouse gonadal development. Hum Mol Genet. 2009 Feb 1;18(3):405-17. Epub 2008 Nov 3. [Abstract]
  • Archambeault DR, Tomaszewski J, Joseph A, Hinton BT, Yao HH. Epithelial-mesenchymal crosstalk in Wolffian duct and fetal testis cord development. Genesis. 2009 Jan;47(1):40-8. Review. [Abstract]
  • Tomaszewski J, Joseph A, Archambeault D, Yao HH. Essential roles of inhibin beta A in mouse epididymal coiling. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11322-7. Epub 2007 Jun 25. [Abstract]
  • Deutscher E, Hung-Chang Yao H. Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis. Dev Biol. 2007 Jul 15;307(2):227-36. Epub 2007 May 3.
  • Barsoum I, Yao HH. The road to maleness: from testis to Wolffian duct. Trends Endocrinol Metab. 2006 Aug;17(6):223-8. Epub 2006 Jul 5. Review. [Abstract]
  • Yao HH, Aardema J, Holthusen K. Sexually dimorphic regulation of inhibin beta B in establishing gonadal vasculature in mice. Biol Reprod. 2006 May;74(5):978-83. Epub 2006 Feb 1. [Abstract]
  • Yao HH, Capel B. Temperature, genes, and sex: a comparative view of sex determination in Trachemys scripta and Mus musculus. J Biochem. 2005 Jul;138(1):5-12. Review. [Abstract]
  • Ditewig AC, Yao HH. Organogenesis of the ovary: a comparative review on vertebrate ovary formation. Organogenesis. 2005 Apr;2(2):36-41. [Abstract]
  • Yao HH. The pathway to femaleness: current knowledge on embryonic development of the ovary. Mol Cell Endocrinol. 2005 Jan 31;230(1-2):87-93. Review. [Abstract]
  • Yao HH, DiNapoli L, Capel B. Cellular mechanisms of sex determination in the red-eared slider turtle, Trachemys scripta. Mech Dev. 2004 Nov;121(11):1393-401. [Abstract]
  • Yao HH, Matzuk MM, Jorgez CJ, Menke DB, Page DC, Swain A, Capel B. Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. Dev Dyn. 2004 Jun;230(2):210-5. [Abstract]
  • Yao HH, DiNapoli L, Capel B. Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonads. Development. 2003 Dec;130(24):5895-902. Epub 2003 Oct 15 [Abstract]
  • Schmahl J, Yao HH, Pierucci-Alves F, Capel B. Colocalization of WT1 and cell proliferation reveals conserved mechanisms in temperature-dependent sex determination. Genesis. 2003 Apr;35(4):193-201. [Abstract]
  • Yao HH, Capel B. Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis. Dev Biol. 2002 Jun 15;246(2):356-65. [Abstract]
  • Yao HH, Whoriskey W, Capel B. Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. Genes Dev. 2002 Jun 1;16(11):1433-40 [Abstract]
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