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Your Environment. Your Health.

Selected Publications

Structural Cell Biology Group

Publications (2009-Present)

  1. Kaminski AM, Tumbale PP, Schellenberg MJ, Williams RS, Williams JG, Kunkel TA, Pedersen LC, Bebenek K. Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis. Nat Commun. 2018 Jul 6;9(1):2642. doi: 10.1038/s41467-018-05024-8. [Abstract] [Full Text] 
  2. Tumbale P, Schellenberg MJ, Mueller GA, Fairweather E, Watson M, Little JN, Krahn J1, Waddell I, London RE, Williams RS. Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease. EMBO J. 2018 Jun 22. pii: e98875. doi: 10.15252/embj.201798875. [Epub ahead of print] [Abstract] [Full Text] 
  3. Schellenberg MJ, Petrovich RM, Malone CC, Williams RS. Selectable high-yield recombinant protein production in human cells using a GFP/YFP nanobody affinity support. Protein Sci. 2018 Jun;27(6):1083-1092. doi: 10.1002/pro.3409. Epub 2018 Apr 17. [Abstract] [Full Text] 
  4. Schellenberg MJ, Lieberman JA, Herrero-Ruiz A, Butler LR, Williams JG, Muñoz-Cabello AM, Mueller GA, London RE, Cortés-Ledesma F, Williams RS. ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links. Science 14 Sep 2017:eaam6468 doi: 10.1126/science.aam6468 [Abstract] [Full Text] [Reprint] 
  5. Andres SN, Williams RS. CtIP/Ctp1/Sae2, molecular form fit for function. DNA Repair 2017 Jun 9. pii: S1568-7864(17)30213-6. doi: 10.1016/j.dnarep.2017.06.013. PMID: 28623092 [Abstract] 
  6. Wallace BD, Berman Z, Mueller GA, Lin Y, Chang T, Andres SN, Wojtaszek JL, DeRose EF, Appel CD, London RE, Yan S, Williams RS. APE2 Zf-GRF facilitates 3'-5' resection of DNA damage following oxidative stress. Proc Natl Acad Sci USA 2017 Jan 10;114(2):304-309. doi: 10.1073/pnas.1610011114. Epub 2016 Dec 27. PMID: 28028224 [Abstract]
  7. Appel CD, Feld GK, Wallace BD, Williams RS.Structure of the sirtuin-linked macrodomain SAV0325 from Staphylococcus aureus. Protein Sci. 2016 Sep;25(9):1682-91. doi: 10.1002/pro.2974. Epub 2016 Jul 7. PMID: 27345688 [Abstract]
  8. Schellenberg MJ, Perera L, Strom CN, Waters CA, Monian B, Appel CD, Vilas CK, Williams JG, Ramsden DA, Williams RS. Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Nucleic Acids Res. 2016 May 5;44(8):3829-44. doi: 10.1093/nar/gkw228. Epub 2016 Apr 8. PMID: 27060144 [Abstract]
  9. Schellenberg MJ, Tumbale PP, Williams RS. Molecular underpinnings of Aprataxin RNA/DNA deadenylase function and dysfunction in neurological disease. Progress in biophysics and molecular biology 2015 117(2-3):157-165. [Abstract]
  10. Andres SN, Schellenberg MJ, Wallace BD, Tumbale P, Williams RS. Recognition and repair of chemically heterogeneous structures at DNA ends. Environmental and molecular mutagenesis 2015 56(1):1-21. [Abstract]
  11. Andres SN, Appel CD, Westmoreland JW, Williams JS, Nguyen Y, Robertson PD, Resnick MA, Williams RS. Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair. Nature structural & molecular biology 2015 22(2):158-166. [Abstract]
  12. Wallace BD, Williams RS. Ribonucleotide triggered DNA damage and RNA-DNA damage responses. RNA biology 2014 11(11):1340-1346. [Abstract]
  13. Gao R, Schellenberg MJ , Huang SY, Abdelmalak M, Marchand C, Nitiss KC, Nitiss JL, Williams RS, Pommier Y. Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2). The Journal of biological chemistry 2014 289(26):17960-17969. [Abstract]
  14. Deshpande RA, Williams GJ, Limbo O, Williams RS, Kuhnlein J, Lee JH, Classen S, Guenther G, Williams RS, Russell P , Tainer JA, Paull TT. ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. The EMBO journal. 33(5):482-500 (2014). [Abstract]
  15. Tumbale P, Williams JS, Schellenberg MJ, Kunkel TA, Williams RS. Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity. Nature 506(7486):111-115 (2014). [Abstract]
  16. Crown NK, Savytskyy OP, Malik SB, Logsdon J , Williams RS, Tainer JA, Zolan ME. A Mutation in the FHA Domain of Coprinus cinereus Nbs1 Leads to Spo11-Independent Meiotic Recombination and Chromosome Segregation. G3 (Bethesda, Md.) 2013 3(11):1927-1943. [Abstract]
  17. Sharifi R, Morra R, Appel CD, Tallis , Chioza B , Jankevicius G , Simpson MA, Matic I , Ozkan E, Golia B , Schellenberg MJ, Weston R, Williams JG, Rossi MN, Galehdari H, Krahn J, Wan A , Trembath RC, Crosby AH, Ahel D, Hay R, Ladurner AG, Timinszky G, Williams RS, Ahel I. Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. The EMBO journal 32(9):1225-1237 (2013). [Abstract]
  18. Schellenberg MJ, Appel CD, Adhikari S, Robertson PD, Ramsden DA, Williams RS. Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2. Nature structural & molecular biology 19(12):1363-71 (2012).  [Abstract]
  19. Schellenberg, M.J. and Williams, R.S. DNA end processing by polynucleotide kinase/phosphatase. Proc Natl Acad Sci USA 108(52):20855-20856 (2011). [Abstract]
  20. Adhikari, S., Karmahapatra, S.K., Elias, H., Dhopeschwarkar, P., Williams, R.S., Byers, S., Uren, A., Roy, R. Development of a novel assay for human tyrosyl DNA phosphodiesterase 2. Anal Biochem 416(1):112-116 (2011). [Abstract]
  21. Tumbale, P., Appel, D.C., Kraehenbuehl, R., Robertson, P.D., Williams, J.S., Krahn, J., Ahel, I., and Williams, R.S. Structure of an Aprataxin-DNA complex with insights into AOA1 Neurodegenerative Disease. Nature Structural & Molecular Biology 18(11):1189-1195 (2011). [Abstract]
  22. Williams, R.S., and Kunkel, T.A. Fen Nucleases: Bind, Bend, Fray, Cut. Cell 145(2):171-172 (2011). [Abstract]
  23. Williams, G.J., Williams, R.S., Williams, J.S., Moncalian, G., Arvai, A.S., Limbo, O., Guenther, G., SilDas, S., Hammel, M., Russell, P., and Tainer, J.A. ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair. Nature Structural and Molecular Biology 18(4): 423-431 (2011). [Abstract]
  24. Rahal, E.A., Henricksen, L.A., Li, Y., Williams, R.S., Tainer, J.A. and Dixon, K. ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining. Cell Cycle 12(9): 14 (2010).   [Abstract]
  25. Lee, M.S., Green, R., Marsillac. S.M, Williams, R.S., Coquelle, N. Yeung, T., Foo, D., Hau,D.D, Hui, B., Monteiro, A.N.A., and Glover, J.N.M. Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays. Cancer Res. 70(12): 4880-4890 (2010). [Abstract]
  26. Williams, J.S., Williams, R.S., Dovey, C.L., Guenther, G., Tainer, J.A., and Russell, P. gammaH2A binds Brc1 to maintain genome integrity during S-phase. EMBO J. 29(6): 1136-48 (2010). [Abstract]
  27. Williams, R.S., Dodson, G.E., Limbo, O., Yamada, Y., Williams, J.S., Guenther, G., Classen, S., Glover, J.N., Iwasaki, H., Russell, P., and Tainer, J.A. Nbs1 is an extended flexible arm Binding to Ctp1 and Mre11-Rad50 to coordinate dsDNA break processing. Cell 139(1): 87-99 (2009). [Abstract]

    Publications (2001-2008)

  28. Williams, R.S., Williams, G.J., and Tainer, J.A. A charged performance by gp17 in viral packaging. Cell 135 (7):1169-1171 (2008). [Abstract]
  29. Acharya, S., Many, A.M., Schroeder, A., Kennedy, F., Savytskyy, O.P., Grubb, J., Vincent, J., Friedle, E., Celerin, M., Maillet, D., Palmerini, H.J., Greischar, M.A., Moncalian, G., Williams, R.S., Tainer, J.A., and Zolan, M.E. Coprinus cinereus Rad50 mutants reveal an essential structural role for Rad50 in axial element and synaptonemal complex formation, homolog pairing, and meiotic recombination. Genetics 180(4):1889-1907 (2008). [Abstract]
  30. Edwards, R.A., Lee, M.S., Tsutakawa, S.E., Williams, R.S., Nazeer, I., Keliman, F.E., Tainer, J.A., and Glover, J.N. The Bard1 C-terminal domain structure and interactions with polyadenylation factor, CstF-50. Biochemistry 47(44):11446-11456 (2008). [Abstract]
  31. Williams, R.S., Moncalian, G., Williams, J.S., Yamada, Y, Limbo, O., Shin, D.S., Groocock, L.M., Cahill., D., Hitomi, C., Guenther, G., Moiani, D., Carney, J.P., Russell, P., and Tainer, J.A. Mre11 dimers coordinate DNA end bridging and nuclease processing in DNA double strand break repair. Cell 135 (1):97-109 (2008).   [Abstract]
  32. Williams, R.S., Williams, J.S., and Tainer, J.A. Mre11/Rad50/Nbs1 is a keystone complex connecting DNA repair machinery, double strand break signaling, and the chromatin template. Biochemistry and Cell Biology 85 (4):509-520 (2007). [Abstract]
  33. Williams, R.S., and Tainer, J.A. Learning our ABCs: Rad50 directs MRN repair functions via Adenylate Kinase activity from the conserved ATP Binding Cassette. Molecular Cell 25 (6):789-791 (2007). [Abstract]
  34. Simons, A.M., Horwitz, A.A., Starita, L.M., Griffin, K., Williams, R.S., Glover, J.N., and Parvin, J.D. BRCA1 DNA-binding activity is stimulated by BARD1. Cancer Research 66(4):2012-2018 (2006). [Abstract]
  35. Williams, R.S, Bernstein, N., Lee, M.S., Rakovszky, M.L., Cui, D., Green, R., Weinfeld, M., and Glover, J.N. Structural basis for phosphorylation-dependent signaling in the DNA damage response. Biochemistry and Cell Biology 83(6):721-727 (2005). [Abstract]
  36. Williams, R.S., and Tainer, J.A. A Nanomachine for Making Ends Meet: MRN is a flexing scaffold for the repair of DNA double strand breaks. Molecular Cell 19(6):724-726 (2005). [Abstract]
  37. Bernstein, N.K., Williams, R.S., Rakovszky, M.L, Cui, D., Green, R., Karimi-Busheri, F., Mani, R.S, Galicia, S., Koch C.A., Cass, C.E, Durocher, D., Weinfeld, M., and Glover, J.N. The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase. Molecular Cell 17(5):657-670 (2005). [Abstract]
  38. Glover, J.N.M, Williams, R.S., and Lee, MS. BRCT repeat-phosphoprotein interactions: tangled up in two. Trends in Biochemical Sciences 29(11):579-585 (2004). [Abstract]
  39. Williams, R.S., Lee, M.S., Hau., D.D., and Glover, J.N.M. Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1. Nature Structural and Molecular Biology 11(6):519-525 (2004). [Abstract]
  40. Dubin M.J., Stokes, P., Sum, E.Y.M, Williams, R.S., Valova, V., Robinson, P.,Lindeman, G.J., Glover, J.N., Visvader, J.E., and Matthews, J.M. Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif. Journal of Biological Chemistry 279(26):26932-26938 (2004). [Abstract]
  41. Williams, R.S., Hau, D, Chasman, D., Hui, B., and Glover, J.N.M. Detection of protein folding defects caused by BRCA1-BRCT truncation and missense mutations. Journal of Biological Chemistry 278(52):53007-53016 (2003). [Abstract]
  42. Williams, R.S., and Glover, J.N.M. Structural consequences of a cancer-causing BRCA1-BRCT missense mutation. Journal cover feature. Journal of Biological Chemistry 278(4):2630-2635 (2003). [Abstract]
  43. Hamilton, K.S., Ellison, M.J., Barber, K.R., Williams, R.S., Huzil, J.T., McKenna, S., Ptak, C., Glover, M., and Shaw, G.S. Structure of a conjugating enzyme-ubiquitin thiolester intermediate reveals a novel role for the ubiquitin tail. Structure 9:897-904 (2001). [Abstract]
  44. Williams, R.S., Green, R., and Glover, J.N.M. Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1. Nature Structural Biology 8(10):838-842 (2001). [Abstract]
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