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Selected Publications

DNA Repair & Nucleic Acid Enzymology Group

  1. Wilson, S.H. and Kuff, E.L. A novel DNA polymerase activity found in association with intracisternal A-type particles. Proc. Natl. Acad. Sci. USA, 69:1531-1536, 1972.  [Abstract]
  2. Matsukage, A., Bohn, E.W., and Wilson, S.H. Multiple forms of DNA polymerase in mouse myeloma. Proc. Natl. Acad. Sci. USA, 71:578-582, 1974. [Abstract]
  3. Tanabe, K., Bohn, E.W., and Wilson, S.H. Steady-state kinetics of mouse DNA polymerase β. Biochemistry, 18:3401-3407, 1979. [Abstract]
  4. Zmudzka, B.Z., SenGupta, D., Matsukage, A., Cobianchi, F., Kumar, P., and Wilson, S.H. Structure of rat DNA polymerase β revealed by partial amino acid sequencing and cDNA cloning. Proc. Natl. Acad. Sci. USA, 83:5106-5110, 1986. [Abstract]
  5. Widen, S., Kedar, P., and Wilson, S.H. Human β-polymerase gene: Structure of the 5' flanking region and active promoter. J. Biol. Chem., 263:16992-16998, 1988.  [Abstract]
  6. Beard, W.A. and Wilson, S.H. Kinetic analysis of template primer interactions with recombinant forms of HIV-1 reverse transcriptase. Biochemistry, 32:9745-9753, 1993.  [Abstract]
  7. Narayan, S., Widen, S.G., Beard, W.A., and Wilson, S.H. RNA polymerse II transcription: Rate of promoter clearance is enhanced by a purified activating transcription factor/cAMP response element-binding protein. J. Biol. Chem., 269, 12755-12763, 1994. [Abstract]
  8. Sawaya, M.R., Pelletier, H., Kumar, A., Wilson, S.H., and Kraut, J. Crystal structure of rat DNA polymerase β: Evidence for a common polymerase mechanism. Science, 264:1930-1935, 1994. [Abstract]
  9. Pelletier, H., Sawaya, M.R., Kumar, A., Wilson, S.H., and Kraut, J. Structures of ternary complexes of rat DNA polymerase β, a DNA template-primer, and ddCTP. Science, 264:1891-1903, 1994. [Abstract]
  10. Singhal, R.K., Prasad, R., and Wilson, S.H. DNA polymerase β conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract. J. Biol. Chem., 270:949-957, 1995. [Abstract]
  11. Kunkel, T.A. and Wilson, S.H. DNA Repair. Push and pull of base flipping. Nature, 384:25-26, 1996. [Abstract]
  12. Sobol, R.W., Horton, J.K., Kühn, R., Gu, H., Singhal, R.K., Prasad, R., Rajewsky, K., and Wilson, S.H. Requirement of mammalian DNA polymerase-β in base-excision repair. Nature, 379:183-186, 1996. [Abstract]
  13. He, F., Narayan, S., and Wilson, S.H. Purification and characterization of a DNA polymerase β promoter initiator element-binding transcription factor from bovine testis. Biochemistry, 35:1775-1782, 1996. [Abstract]
  14. Srivastava, D.K., Evans, R.K., Kumar, A., Beard, W.A., and Wilson, S.H. dNTP binding site in rat DNA polymerase β revealed by controlled proteolysis and azido photoprobe cross-linking. Biochemistry, 35:3728-3734, 1996. [Abstract]
  15. Beard, W.A., Osheroff, W.P., Prasad, R., Jaju, M., Sawaya, M.R., Wood, T.G., Kraut, J., Kunkel, T.A., and Wilson, S.H. Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase β. J. Biol. Chem., 271:12141-12144, 1996. [Abstract]
  16. Beard, W.A., Minnick, D., Wade, C., Prasad, R., Won, R.L., Kumar, A., Kunkel, T.A., and Wilson, S.H. Role of the "Helix Clamp" in HIV-1 reverse transcriptase catalytic cycling as revealed by alanine-scanning mutagenesis. J. Biol. Chem., 271: 12213-12220, 1996. [Abstract]
  17. Liu, D., Prasad, R., Wilson, S.H., DeRose, E.F., and Mullen, G.P. Three-dimensional solution structure of the N-terminal domain of DNA polymerase β and mapping of the ssDNA interaction interface. Biochemistry, 35:6188-6200, 1996. [Abstract]
  18. Chyan, Y.-J., Strauss, P.R., Wood, T.G., and Wilson, S.H. Identification of novel mRNA isoforms for human DNA polymerase β. DNA and Cell Biology, 15:653-659, 1996.  [Abstract]
  19. Oda, N., Saxena, J.K., Jenkins, T.M., Prasad, R., Wilson, S.H., and Ackerman, E.J. DNA polymerases β and β are required for DNA repair in an efficient nuclear extract from Xenopus oocytes. J. Biol. Chem., 271:13816-13820, 1996. [Abstract]
  20. Prasad, R., Singhal, R.K., Srivastava, D.K., Tomkinson, A.E., and Wilson, S.H. Specific interaction of DNA polymerase β and DNA ligase I in a multiprotein base excision repair complex from bovine testis. J. Biol. Chem., 271:16000-16007, 1996. [Abstract]
  21. Piersen, C.E., Prasad, R., Wilson, S.H., and Lloyd, R.S. Evidence for an imino intermediate in the DNA polymerase β deoxyribose phosphate excision reaction. J. Biol. Chem., 271:17811-17815, 1996. [Abstract]
  22. Narayan, S., He, F., and Wilson, S.H. Activation of the human DNA polymerase β promoter by a DNA-alkylating agent through induced phosphorylation of CREB-1. J. Biol. Chem., 271:18508-18513, 1996. [Abstract]
  23. Lavrik, O.I., Prasad, R., Beard, W.A., Safronov, I.V., Dobrikov, M.I., Srivastava, D.K., Shishkin, G.V., Wood, T.G., and Wilson, S.H. dNTP binding to HIV-1 reverse transcriptase and mammalian DNA polymerase β as revealed by affinity labeling with a photoreactive dNTP analog. J. Biol. Chem., 271:21891-21897, 1996. [Abstract]
  24. Pelletier, H., Sawaya, M.R., Wolfle, W., Wilson, S.H., and Kraut, J. Crystal structures of human DNA polymerase β complexed with DNA: Implications for catalytic mechanism, processivity, and fidelity. Biochemistry, 35:12742-12761, 1996. [Abstract]
  25. Pelletier, H., Sawaya, M.R., Wolfle, W., Wilson, S.H., and Kraut, J. A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase β. Biochemistry, 35:12762-12777, 1996. [Abstract]
  26. Reha-Krantz, L.J., Nonay, R.L., Day III, R.S., and Wilson, S.H. Replication of O6-Methylguanine-containing DNA by repair and replicative DNA polymerases. J. Biol. Chem., 271:20088-20095, 1996. [Abstract]
  27. Mullen, G.P. and Wilson, S.H. Repair activity in DNA polymerases: a structurally conserved helix-hairpin-helix motif in base excision repair enzymes and in DNA polymerase β. IN: Hickson, I.D. (ed), Base Excision Repair of DNA Damage. Landes Bioscience, 1997, pp. 121-135.
  28. Strauss, P.R., Beard, W.A., Patterson, T.A., and Wilson, S.H. Substrate binding by human apurinic/apyrimidinic endonuclease indicates a Briggs-Haldane Mechanism. J. Biol. Chem., 272:1302-1307, 1997. [Abstract]
  29. Efrati, E., Tocco, G., Eritja, R., Wilson, S.H., and Goodman, M.F. Abasic translesion synthesis by DNA polymerase β violates the "A-Rule": Novel types of nucleotide incorporation by human DNA polymerase β at an abasic lesion in different sequence contexts. J. Biol. Chem., 272:2559-2569, 1997. [Abstract]
  30. Forgacs, E., Latham, G., Beard, W.A., Prasad, R., Bebenek, K., Kunkel, T.A., Wilson, S.H., and Lloyd, R.S. Probing structure/function relationships of HIV-1 reverse transcriptase with styrene oxide N2-Guanine adducts. J. Biol. Chem., 272:8525-8530, 1997. [Abstract]
  31. Kim, S., Merrill, B.M., Rajpurohit, R., Kumar, A., Stone, K.L., Papov, V.V., Schneidersm J.M., Szer, W., Wilson, S.H., Paik, W.K., and Williams, K.R. Identification of NG-Methylarginine residues in human heterogeneous RNP protein A1: Phe/Gly-Gly-Gly-Arg-Gly-Gly-Gly/Phe is a preferred recognition motif. Biochemistry, 36:5185-5192, 1997. [Abstract]
  32. Mullen, G.P. and Wilson, S.H. DNA polymerase β in abasic site repair: a structurally conserved helix-hairpin-helix motif in lesion detection by base excision repair enzymes. Biochemistry, 36:4713-4717, 1997. [Abstract]
  33. Bebenek, K., Beard, W.A., Darden, T.A., Li, L., Prasad, R., Luxon, B.A., Gorenstein, D.G., Wilson, S.H., and Kunkel, T.A. A minor groove binding track in reverse transcriptase. Nat. Struct. Biol., 4:194-197, 1997. [Abstract]
  34. Butler, A.P., Johnson, D.G., Kumar, A.P., Narayan, S., Wilson, S.H., and MacLeod, M.C. Disruption of transcription in vitro and gene expression in vivo by DNA adducts derived from a benzo[a]pyrene diol epoxide located in heterologous sequences. Carcinogenesis, 18:239-244, 1997. [Abstract]
  35. Mullen, G.P., Antuch, W., Maciejewski, M.W., Prasad, R., and Wilson, S.H. Insights into the mechanism of the β-elimination catalyzed by the N-terminal domain of DNA polymerase β. Tetrahedron, 53:12057-12066, 1997.
  36. Sawaya, M.R., Prasad, R., Wilson, S.H., Kraut, J., and Pelletier, H. Crystal structures of human DNA polymerase β complexed with gapped and nicked DNA: evidence for an induced fit mechanism. Biochemistry, 36:11205-11215, 1997. [Abstract]
  37. Yang, X-P., He, F., Rawson, T.Y., and Wilson, S.H. Human DNA polymerase β promoter: Phorbol ester activation is mediated through the cAMP response element and cAMP-response-element-binding protein. J. Biomed. Sci., 4:279-288, 1997. [Abstract]
  38. Wilson, S.H., Sobol, R.W., Beard, W.A., Horton, J.K., Prasad, R., and Vande Berg, B.J. DNA polymerase-β and mammalian base excision repair. IN: Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Laboratory Press, 2000, Vol. 65, pp. 143-155. [Abstract]
  39. Beard, W.A., Shock, D.D., Yang, X.-P., DeLauder, S.F., and Wilson, S.H. Loss of DNA polymerase β stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity. J. Biol. Chem., 277:8235-8242, 2002. [Abstract]
  40. Beard, W.A., Shock, D.D., Vande Berg, B.J., and Wilson, S.H. Efficiency of correct nucleotide insertion governs DNA polymerase fidelity. J. Biol. Chem., 277:47393-47398, 2002. [Abstract]
  41. Beard, W.A., and Wilson, S.H. Structural insights into the origins of DNA polymerase fidelity. Structure (Camb.), 11:489-496, 2003. [Abstract]
  42. Horton, J.K., Stefanick, D.F., Naron, J.M., Kedar, P.S., and Wilson, S.H. Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest following DNA methylating agent exposure. J. Biol. Chem., 280:15773-15785, 2005. [Abstract]
  43. Batra, V.K., Beard, W.A., Shock, D.D., Pedersen, L.C., and Wilson, S.H. Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. Structure (Camb.), 13:1225-1233, 2005.  [Abstract]
  44. Prasad, R., Batra, V.K., Yang, X.-P., Krahn, J.M., Pedersen, L.C., Beard, W.A., and Wilson, S.H. Structural insight into the DNA polymerase β deoxyribose phosphate lyase mechanism. DNA Repair (Amst.), 4:1347-1357, 2005. [Abstract]
  45. Kirby, T.W., DeRose, E.F., Beard, W.A., Wilson, S.H., and London, R.E. A thymine isostere in the templating position disrupts assembly of the closed DNA polymerase β ternary complex. Biochemistry, 44:15230-15237, 2005. [Abstract]
  46. Beard, W.A. and Wilson, S.H. Structure and mechanism of DNA polymerase β. Chemical Reviews, "DNA Damage and Repair," 106:361-382, 2006. [Abstract]
  47. Batra, V.K., Beard, W.A., Shock, D.D., Krahn, J.M., Pedersen, L.C., and Wilson, S.H. Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Structure (Camb.), 14:757-766, 2006. [Abstract]
  48. Yoshimura, M., Kohzaki, M., Nakamura, J., Asagoshi, K., Sonoda, E., Hou, E., Prasad, R., Wilson, S.H., Tano, K., Yasui, A., Lan, L., Seki, M., Wood, R.D., Arakawa, H. Buerstedde, J.-M., Hochegger, H., Okada, T., Hiraoka, M., and Takeda, S. Vertebrate PolQ and Polβ cooperate in base excision repair of oxidative DNA damage. Mol. Cell, 24:115-125, 2006. [Abstract]
  49. Lin, P., Pedersen, L.C., Batra, V.K., Beard, W.A., Wilson, S.H., and Pedersen, L.G. Energy analysis of chemistry for correct nucleotide insertion by DNA polymerase β. Proc. Natl. Acad. Sci. USA, 103:13294-13299, 2006. [Abstract]
  50. Batra, V.K., Shock, D.D., Prasad, R., Beard, W.A., Hou, E.W., Pedersen, L.C., Sayer, J.M., Yagi, H., Kumar, S., Jerina, D.M., and Wilson, S.H. Structure of DNA polymerase β with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. Proc. Natl. Acad. Sci. USA, 103:17231-17236, 2006. [Abstract]
  51. Radhakrishnan, R., Arora, K., Wang, Y., Beard, W.A., Wilson, S.H., and Schlick, T. Regulation of DNA repair fidelity by molecular checkpoints: "Gates" in DNA polymerase β’s substrate selection. Biochemistry, 45:15142-15156, 2006. [Abstract]
  52. Das A., Wiederhold L., Leppard J.B., Kedar P., Prasad R., Wang H., Boldogh I., Karimi-Busheri F., Weinfeld M., Tomkinson A.E., Wilson S.H., Mitra S., Hazra T. NEIL2-Initiated, APE-independent repair of oxidated bases in DNA: Evidence for a repair complex in human cell. DNA repair 5(12):1439-1448, 2006. [Abstract]
  53. Horton, J.K., Stefanick, D.F., Kedar, P.S., and Wilson, S.H. ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity. DNA Repair (Amst.), 6(6):742-50, 2007. [Abstract]
  54. Wang Y., Reddy S., Beard W.A., Wilson S.H., Schlick T. Differing conformational pathways before and after chemistry for insertion of dATP vs. dCTP opposite 8-oxoG in DNA polymerase beta. Biophysical journal, 9: 3063-3070, 2007. [Abstract]
  55. Das S., Chattopadhyay R., Bhakat K.K., Boldogh I., Kohno K., Prasad R., Wilson S.H., Hazra T.K. Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. The Journal of biological chemistry, 282(39):28474-28484, 2007. [Abstract]
  56. Moon, A.F., Garcia-Diaz, M., Batra, V.K., Beard, W.A., Bebenek, K., Kunkel, T.A., Wilson, S.H., Pedersen, L.C. The X family portrait: structural insights into biological functions of X family polymerases. DNA repair, 6(12):1709-1725, 2007. [Abstract]
  57. Kovtun, I.V., Liu, Y., Bjoras, M., Klungland, A., Wilson, S.H., McMurray, C.T. OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature, 447(7143):447-452, 2007. [Abstract]
  58. Liu, Y., Prasad, R., Beard, W.A., Kedar, P.S., Hou, E.W., Shock, D.D., Wilson, S.H. Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase β. The Journal of biological chemistry, 282(18):13532-13541, 2007. [Abstract]
  59. Nakanishi, S., Prasad R., Wilson S.H., Smerdon M. Different structural states in oligonucleosomes are required for early versus late steps of base excision repair. Nucleic Acids Research, 35(13):4313-4321, 2007. [Abstract]
  60. Palma, N., Cinelli S., Sapora O., Wilson S.H., Dogliotti E. Ochratoxin A-induced mutagenesis in mammalian cells is consistent with production of oxidative stress. Chemical research in toxicology, 20(7):1031-1037, 2007. [Abstract]
  61. Tano, K., Nakamura J., Asagoshi K., Arakawa H., Sonoda E., Braithwaite E.K., Prasad R., Buerstedde J.-M., Takeda S., Watanabe M., Wilson S.H. Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells. DNA repair, 6(6):869-875, 2007. [Abstract]
  62. Oelschlaeger, P., Klahn M., Beard W.A., Wilson S.H., Warshel A. Magnesium-cationic dummy atom molecules enhance representation of DNA polymerase beta in molecular dynamics simulations: Improved accuracy in studies of structural features and mutational effects. Journal of molecular biology, 366(2):687-701, 2007. [Abstract]
  63. Hou, E.W., Prasad R., Asagoshi K., Masaoka A., Wilson S.H. Comparative assessment of plasmid and oligonucleotide DNA substrates in measurement of in vitro base excision repair activity. Nucleic acids research, 35(17):e112, 2007. [Abstract]
  64. McKenna, C.E., Kashemirov B.A., Upton T.G., Batra V.K., Goodman M.F., Pedersen L.C., Beard W.A., Wilson S.H. (R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. Journal of the American Chemical Society, 129(50):15412-15413, 2007. [Abstract]
  65. Prasad, R., Liu Y., Deterding L.J., Poltoratsky V.P., Kedar P.S., Horton J.K., Kanno S.I., Asagoshi K., Hou E.W., Khodyreva S.N., Lavrik O.I., Tomer K.B., Yasui A., Wilson S.H. HMGB1 is a co-factor in mammalian base excision repair. Molecular cell, 27(5):829-841, 2007. [Abstract]
  66. Horton, J.K., Watson M., Stefanick D.F., Shaughnessy D.T., Taylor J.A., Wilson S.H. XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks. Cell research, 18(1):48-63, 2008. [Abstract]
  67. Xiang, Y., Goodman M.F., Beard W.A., Wilson S.H., Warshel A. Exploring the role of large conformational changes in the fidelity of DNA Polymerase beta. Proteins, 70(1):231-247, 2008. [Abstract]
  68. Batra, V.K., Beard W.A., Shock D.D., Pedersen L.C., Wilson S.H. Structures of DNA polymerase beta with active site mismatches suggest a transient abasic site intermediate during misincorporation. Molecular cell, 30(3):315-324, 2008. [Abstract]
  69. Kronenberg, G., Harms C., Sobol R.W., Cardozo-Pelaez F., Linhart H., Winter B., Balkaya M., Gertz K., Gay S.B., Cox D., Eckart S., Ahmadi M., Juckel G., Kempermann G., Hellweg R., Sorh R., Hortnagl H., Wilson S.H., Jaenisch R., Endres M. Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase. The Journal of neuroscience: the official journal of the Society for Neuroscience. 28(28):7219-7230, 2008. [Abstract]
  70. Kedar, P.S., Stefanick D.F., Horton J.K., Wilson S.H. Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibition. DNA repair, 7(11):1787-1798, 2008. [Abstract]
  71. Allen, D., Herbert D.C., McMahan C.A., Rotrekl V., Sobol R.W., Wilson S.H., Walter C.A. Mutagenesis is elevated in male germs cells obtained from DNA polymerase-beta heterozygous mice. Biology of reproduction, 79(5):824-831, 2008. [Abstract]
  72. Poltoratsky, V.P., Horton, J.K., Prasad, R., Beard, W.A., Woodgate, R., Wilson, S.H. Negligible impact of pol iota expression on the alkylation sensitivity of pol beta-deficient mouse fibroblast cells. DNA repair, 7(6):830-833, 2008. [Abstract]
  73. Liang, F., Jain, N., Hutchens, T., Shock, D.D., Beard, W.A., Wilson, S.H., Chiarelli, N.P., Cho, B.P. Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT. Journal of medicinal chemistry, 51(20):6460-6470, 2008. [Abstract]
  74. Carrozza, M., Stefanick, D.F., Horton, J.K., Kedar, P.S., Wilson, S.H. PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM. DNA Repair, 8(11):1264-1272, 2009. [Abstract]
  75. Liu, Y., Prasad R., Beard W.A., Hou E.W., Horton J.K., McMurray C.T., Wilson S.H. Coordination between Pol ² and FEN1 can modulate CAG repeat expansion. The Journal of biological chemistry, 284(41):28352-28366, 2009. [Abstract]
  76. Dorjsuren, D., Wilson III D.M., Beard W.A., McDonald J.P., Austin C.P., Woodgate R., Wilson S.H., Simeonov A. A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Nucleic acids research, 37(19):e128, 2009. [Abstract]
  77. Yoshizawa, K., Jelezcova E., Brown A.R., Foley J.F., Nyska A., Cui X., Hofseth L., Maronpot R., Wilson S.H., Sepulveda A.R., Sobol R.W. Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. PloS one, 4(8):e6493, 2009. [Abstract]
  78. Simonelli, V., D'Errico M., Palli D., Prasad R., Wilson S.H., Dogliotti E. Characterization of DNA polymerase beta splicing variants in gastric cancer: the most frequent exon 2-deleted isoform is a non-coding RNA. Mutation research, 670(1-2):79-87, 2009. [Abstract]
  79. Prasad, R., Longley, M.J., Sharief, F.S., Hou, E.W., Copeland, W.C., and Wilson S.H. Human DNA polymerase theta¸ possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro. Nucleic acids research, 37(6):1868-1877, 2009. [Abstract]
  80. Masaoka, A., Horton, J.K., Beard, W.A., and Wilson, S.H. DNA polymerase beta and PARP activities in base excision repair in living cells. DNA repair, 8(11):1290-1299, 2009. [Abstract]
  81. Beard, W.A., Shock, D.D., Batra, V.K., Pedersen, L.C., and Wilson, S.H. DNA Polymerase Beta Substrate Specificity: Side chain modulation of the 'A-rule'. The Journal of biological chemistry, 284(46):31680-31689, 2009. [Abstract]
  82. Upton, T.G., Kashemirov, B.A., McKenna, C.E., Goodman, M.F., Prakash, G.K., Kultyshev, R., Batra, V.K., Shock, D.D., Pedersen, L.C., Beard, W.A., and Wilson, S.H. Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function. Organic Letters, 11(9):1883-1886, 2009. [Abstract]
  83. Tano, K., Chastain II, P.D., Asagoshi, K., Adachi, N., Sonoda, E., Kikuchi, K., Koyama, H., Nagata, K., Kaufman, D.G., Takeda, S., Wilson, S.H., Watanabe, M., Swenberg, J.A., and Nakamura, J. FEN1 Functions in Long Patch Base Excision Repair Under Conditions of Oxidative Stress in Vertebrate Cells. Molecular cancer research, 8(2):204-215, 2010. [Abstract]
  84. Asagoshi, K., Liu, Y., Masaoka, A., Lan, L., Prasad, R., Horton, J.K., Brown, A.R., Wang, X.H., Sobol, R.W., Bdour, H.M., Taylor, J.S., Yasui, A., and Wilson, S.H. DNA polymerase beta-dependent long patch base excision repair in living cells. DNA repair, 9(2):109-119, 2010. [Abstract]
  85. Lui, Y., Prasad, R., and Wilson, S.H. HMGB1: Roles in base excision repair and related function. Biochimica et biophysica acta, 1799(1-2):119-130, 2010. [Abstract]
  86. Heacock, M., Stefanick, D., Horton, J.K. and Wilson, S.H. Alkylation damage combined with PARP inhibition in cells results in S-phase dependent double-strand breaks. DNA repair, 9(8):929-936, 2010. [Abstract]
  87. Batra, V.K., Beard, W.A., Hou, E.W., Pedersen, L.C., Prasad, R., and Wilson, S.H. Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site. Nature structural & molecular biology, 17(7):889-890, 2010. [Abstract]
  88. Poltoratsky, V., Heacock, M., Kissling, G.E., Prasad, R., Wilson, S.H. Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break. Molecular immunology 48(1-3):164-170, 2010. [Abstract]
  89. Khodyreva, S.N., Prasad, R., Ilina, E.S., Sukhanova, M.M., Kutuzov, Y., Liu, Y., Hou, E.W., Wilson, S.H., Lavrik, O.I. Apurinic/apyrimidinic (AP) site recognition by the 5'-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1). Proceedings of the National Academy of Sciences of the United States of America 107(51):22090-22095, 2010. [Abstract]
  90. Braithwaite, E.K., Kedar, P.S., Stumpo, D.J., Bertocci, B., Freedman, J.H., Samson, L.D., Wilson, S.H. DNA Polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts. PloS one 5(8):e12229-, 2010. [Abstract]
  91. Cavanaugh, N.A., Beard, W.A., and Wilson, S.H. DNA Polymerase beta ribonucleotide discrimination: Insertion, misinsertion, extension, and coding. The Journal of biological chemistry, 285(32):24457-24465, 2010. [Abstract]
  92. Prasad R, Shock DD, Beard WA, Wilson SH. Passing the baton: Substrate channeling in mammalian base excision repair pathways. The Journal of biological chemistry 285(52):40479-40488, 2010. [Abstract]
  93. Beard, WA, Batra, VK, Wilson, SH. DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine. Mutation research 703(1):18-23, 2010. [Abstract]
  94. Surya-Prakash, G.K., Zibinsky, M., Upton, T.G., Kashemirov, B.A., McKenna, C.E., Oertel, K., Goodman, M.F., Batra, V.K., Pedersen, L.C., Beard, W.A., Shock, D.D., Wilson, S.H., Olah, G.A. Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. Proceedings of the National Academy of Sciences of the United States of America 107(36):15693-15698, 2010. [Abstract]
  95. Wilson SH, Beard WA, Shock DD, Batra VK, Cavanaugh NA , Prasad R, Hou EW, Liu Y, Asagoshi, K, Horton JK, Stefanick DF, Kedar PS , Carrozza, MJ, Masaoka A, Heacock ML. Base excision repair and design of small molecule inhibitors of human DNA polymerase β. Cellular and molecular life sciences  67(21):3633-47, 2010. [Abstract]
  96. Horton, J.K., Stefanick, D.F., Zeng, J.Y., Carrozza, M.J., Wilson, S.H. Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition. DNA repair 10(2):225-234, 2011. [Abstract]
  97. Cavanaugh, N.A., Beard, W.A., Batra, V.K., Perera, L., Pedersen, L.C., Wilson, S.H. Molecular insights into DNA polymerase deterrents for ribonucleotide insertion. The Journal of biological chemistry 286(36):31650-31660, 2011. [Abstract]
  98. Prasad, R., Beard, W.A., Batra, V.K., Liu, Y., Shock, D.D., Wilson, S.H. A review of recent experiments on step-to-step "hand-off" of the DNA intermediates in mammalian base excision repair pathways. Mol. Biol. 45(4):586-600, 2011. [Abstract]
  99. Kedar, P.S., Stefanick, D.F., Horton, J.K. and Wilson, S.H. Increased PARP-1 association with DNA in alkylation damaged, PARP-inhibited mouse fibroblasts. Molecular Cancer Research 10:360-368, 2012. [Abstract]
  100. Liu, Y. and Wilson, S.H. Linkage between trinucleotide repeat expansion, oxidative stress and base excision repair. Trends in Biochemical Sciences 37:162-172, 2012.
  101. Kirby, T., DeRose, E., Cavanaugh, N., Beard, W.A., Shock, D.D., Mueller, G., Wilson, S.H. and London, R. Metal-induced DNA translocation leads to DNA polymerase conformational activation. Nucleic Acids Research 40: 2974-2983, 2012.
  102. Batra, V.K., Shock, D.D., Beard,W.A., McKenna, Charles E. and Wilson, S.H. Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion. Proceedings of the National Academy of Sciences, USA 109:113-118, 2012. [Abstract]
  103. Asagoshi, K., Lehmann, W., Braithwaite, E.K., Santana-Santos, L., Prasad, R., Freedman, J.K., Van Houten, B., and Wilson, S.H. Single nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β. Nucleic Acids Research 40:670-681, 2012 [Abstract]
  104. Chamberlain, B.T., Batra, V.K., Beard, W.A., Kadina, A.P., Shock, D.D., Kashemirov, B.A., McKenna, C.E., Goodman, M.F. and Wilson, S.H. Stereospecific formation of a ternary complex of (S)-α,β-fluoromethylene-dATP with DNA pol β. ChemBioChem 13:528-530, 2012. [Abstract]
  105. Nakano H, Free ME, Whitehead GS, Maruoka S, Wison RH, Nakano K, Cook DN. Pulmonary CD103(+) dendritic cells prime Th2 responses to inhaled allergens. Mucosal immunology 5(1):53-65, 2012. [Abstract]
  106. Liu Y, Wilson SH. DNA base excision repair: a mechanism of trinucleotide repeat expansion. Trends in biochemical sciences,  37(4):162-72, 2012. [Abstract]
  107. Gassman NR, Stefanick DF, Kedar PS, Horton JK, Wilson SH. Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts. PLOS ONE 7(11):e49301, 2012. [Abstract]
  108. Freudenthal BD, Beard WA, Wilson SH. Structures of dNTP intermediate states during DNA polymerase active site assembly. Structure (London, England: 1993) 20(11):1829-1837, 2012. [Abstract]
  109. Wu Y, Zakharova VM, Kashemirov BA, Goodman MF, Batra VK, Wilson SH, McKenna CE. β [beta],γ[gamma]-CHF- and β [beta],γ[gamma]-CHCl-dGTP diastereomers: synthesis, discrete 31P NMR signatures, and absolute configurations of new stereochemical probes for DNA polymerases. Journal of the American Chemical Society 134(21):8734-8737, 2012.  [Abstract]
  110. Masaoka A, Gassman NR, Kedar PS, Prasad R, Hou E, Horton JK, Bustin M, Wilson SH. HMGN1 protein regulates poly(ADP-ribose) polymerase-1 (PARP-1) self-PARylation in mouse fibroblasts. The Journal of biological chemistry, 287(22):27648-27658, 2012. [Abstract]
  111. Sassa A, Beard W.A., Prasad R., Wilson S.H. DNA sequence context effects on the glycosylase activity of human 8-oxoguanine DNA glycosylase. The Journal of biological chemistry 287(44):36702-36710, 2012. [Abstract]
  112. Freudenthal B.D., Beard W.A., and Wilson S.H. DNA Polymerase Minor Groove Interactions Modulate Mutagenic Bypass of a Templating 8-Oxoguanine Lesion. Nucleic acids research 41(3):1848-1858, 2013. [Abstract]
  113. Horton JK, Wilson SH. Predicting Enhanced Cell Killing through PARP Inhibition. Molecular cancer research: MCR 11(1):13-18, 2013. [Abstract]
  114. Sassa A, Beard WA, Shock DD, Wilson SH. Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity. Journal of visualized experiments: JoVE 78:e50695, 2013.  [Abstract]
  115. Horton JK, Stefanick DF, Gassman NR, Williams JG, Gabel SA, Cuneo MJ, Prasad R, Kedar PS, Derose EF, Hou EW, London RE, Wilson SH. Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. DNA repair 2013 12(9):774-785. [Abstract]
  116. An, C., Beard, W.A., Chen, D., Wilson, S.H., and Makridakis, N.M. Understanding the loss-of-function in a triple missense mutant of DNA polymerase β found in prostate cancer. International journal of oncology 43(4):1131-1140, 2013.
    [Abstract ( ]
  117. Freudenthal BD, Beard WA, Shock DD, Wilson SH. Observing a DNA polymerase choose right from wrong. Cell 2013 154(1):157-168. [Abstract]
  118. Chary P, Beard WA, Wilson SH, Lloyd RS. Inhibition of HIV-1 reverse transcriptase-catalyzed synthesis by intercalated DNA Benzo[a]Pyrene 7,8-Dihydrodiol-9,10-Epoxide adducts. PloS one 2013 8(9):e72131-. [Abstract]
  119. Horton JK, Stefanick DF, Prasad R, Gassman NR, Kedar PS, Wilson SH. Base Excision Repair Defects Invoke Hypersensitivity to PARP Inhibition. Molecular cancer research: MCR 2014 12(8):11281139-1139. [Abstract]
  120. Cağlayan M, Batra VK, Sassa A, Prasad R, Wilson SH. Role of polymerase β in complementing aprataxin deficiency during abasic-site base excision repair. Nat Struct Mol Biol. 2014 May;21(5):497-9. doi: 10.1038/nsmb.2818. [Abstract]
  121. Sassa A, Çağlayan M, Dyrkheeva NS, Beard WA, Wilson SH. Base excision repair of tandem modifications in a methylated CpG dinucleotide. J Biol Chem. 2014 May 16;289(20):13996-4008. [Abstract]
  122. Gassman NR, Coskun E, Stefanick DF, Horton JK, Jaruga P, Dizdaroglu M, Wilson SH. Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts. PloS one 2015 10(2):e0118819-. [Abstract]
  123. Çağlayan M, Horton JK, Prasad R, Wilson SH. Complementation of aprataxin deficiency by base excision repair enzymes. Nucleic Acids Res. 2015 Feb 27;43(4):2271-81. doi: 10.1093/nar/gkv079. [Abstract]
  124. Freudenthal BD, Beard WA, Perera L, Shock DD, Kim T, Schlick T, Wilson SH. Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide. Nature 2015 517(7536):635-639. [Abstract]
  125. Gassman NR, Wilson SH. Micro-irradiation tools to visualize base excision repair and single-strand break repair. DNA repair 2015 31():52-63. [Abstract]
  126. Caglayan M., Wilson S.H. Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair. DNA Repair (Amst). 2015 Nov;35:85-9. doi: 10.1016/j.dnarep.2015.09.010. Epub 2015 Sep 16. [Abstract]
  127. Horton JK, Stefanick DF, Caglayan M, Zhao ML, Gassman NR, Wilson SH. Cellular aprataxin deadenylation activity is stimulated by phosphorylated XRCC1. DNA Repair (2018) – 64: 26 – 33. [Abstract] 
  128. Prasad R, Caglayan M, Da-Peng D, Nadalutti CA, Gassman NR, Zhao M, Stefanick DF, Horton JK, Krasich R, Longley MJ, Copeland WC, Griffith JD, Wilson SH. DNA polymerase β: The missing link of the base excision repair machinery in mammalian mitochondria. DNA Repair (2017) 60: 77 – 88. [Abstract] 
  129. Caglayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC, Wilson SH. Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts. Nucleic Acids Research (2017) 17: 10079 – 10088. [Abstract]
  130. Caglayan M, Wilson SH. Role of DNA polymerase β oxidized nucleotide insertion in DNA ligation failure. Journal of Radiation Research - Review article (2017) 1093: 1 – 5. [Abstract]
  131. Caglayan M, Horton JK, Da-Peng D, Stefanick DF, Wilson SH. Oxidized nucleotide insertion by pol β confounds ligation during base excision repair. Nature Communications (2017) 8: 14045. [Abstract] 
  132. Sassa A, Caglayan M, Rodriguez Y, Beard WA, Wilson SH, Nohmi T, Honma M, Yasui M. Impact of ribonucleotide backbone on translesion synthesis and repair of 7,8-Dihydro-8-oxoguanine. Journal of Biological Chemistry (2016) 291: 24314 – 24323. [Abstract] 
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