3-Dimensional Structural Characterization
- Lars C. Pedersen, Ph.D.
Director, X-ray Crystallography Facility and Principal Investigator
- Tel 984-287-3538
- P.O. Box 12233Mail Drop F3-09Durham, N.C. 27709
Lars Pedersen is head of the Structure Function Group which is focused on the study of enzymes involved in heparan sulfate (HS) biosynthesis and other HS binding partners to better understand determinants of protein specificity for HS, to improve and expand upon the use of HS based therapeutics.
Dr. Pedersen is also head of the X-ray Crystallography Facility within the Structural Biology Core in the Genomic Integrity and Structural Biology Laboratory (GISBL) which provides a resource to the NIEHS community that allows for 3-dimensional structural characterization of macromolecules using molecular biology, biochemistry and X-ray crystallographic techniques. Over the last few years, this facility has supported a number of researchers in determining crystal structures of allergens, nuclear receptors and proteins involved in DNA repair.
Examples of several studies performed by, or in collaboration with, this group. For more information, please click the following links to individual project webpages.
- Heparan Sulfate/Heparin Biosynthesis describes the structural studies being carried out on sulfotransferases involved in HS biosynthesis
- Virulence factors details the study of non-specific bacterial nucleases involved in infection
- DNA repair enzymes details the collaboration with the Kunkel Lab to study the X-family Polymerase pol µ