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Your Environment. Your Health.

Structure Function Group

3-Dimensional Structural Characterization

Lars C. Pedersen, Ph.D.
Lars C. Pedersen, Ph.D.
Director, X-ray Crystallography Facility
Tel 984-287-3538
pederse2@niehs.nih.gov
P.O. Box 12233
Mail Drop F3-09
Durham, N.C. 27709

Research Summary

Lars Pedersen is head of the Structure Function Group which is focused on the study of enzymes involved in heparan sulfate (HS) biosynthesis and other HS binding partners to better understand determinants of protein specificity for HS, to improve and expand upon the use of HS based therapeutics.

Dr. Pedersen is also head of the X-ray Crystallography Facility within the Structural Biology Core in the Genomic Integrity and Structural Biology Laboratory (GISBL) which provides a resource to the NIEHS community that allows for 3-dimensional structural characterization of macromolecules using molecular biology, biochemistry and X-ray crystallographic techniques. Over the last few years, this facility has supported a number of researchers in determining crystal structures of allergens, nuclear receptors and proteins involved in DNA repair.

Studies

Examples of several studies performed by, or in collaboration with, this group. For more information, please click the following links to individual project pages.

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