Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Selected Publications

Stem Cell Biology Group

  1. Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger K. Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell. 2018 Jan 11;172(1-2):106-120.e21. doi: 10.1016/j.cell.2017.11.023. Epub 2017 Dec 14. [Abstract] 
  2. Li P, Wang L, Bennett BD, Wang J, Li J, Qin Y, Takaku M, Wade PA, Wong J, Hu G. Rif1 promotes a repressive chromatin state to safeguard against endogenous retrovirus activation. Nucleic Acids Res. 2017 Dec 15;45(22):12723-12738. doi: 10.1093/nar/gkx884. [Abstract] 
  3. Chen Q, Hu G. Post-transcriptional regulation of the pluripotent state. Curr Opin Genet Dev. 2017 Oct;46:15-23. doi: 10.1016/j.gde.2017.06.010. Epub 2017 Jun 24. [Abstract] 
  4. Zhou B, Liu J, Ren Z, Yao F, Ma J, Song J, Bennett B, Zhen Y, Wang L, Hu G*, Hu S*. Cnot3 enhances human embryonic cardiomyocyte proliferation by promoting cell cycle inhibitor mRNA degradation. Sci Rep. 2017 May 4;7(1):1500. doi: 10.1038/s41598-017-01628-0. [Abstract] 
  5. Zheng X, Yang P, Lackford B, Bennett BD, Wang L, Li H, Wang Y, Miao Y, Foley JF, Fargo DC, Jin Y, Williams CJ, Jothi R, Hu G. CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State. Stem Cell Reports. 2016 Oct 8. pii: S2213-6711(16)30213-2. doi: 10.1016/j.stemcr.2016.09.007 [Abstract]
  6. Zhang S, Zhou B, Wang L, Li P, Bennett BD, Snyder R, Garantziotis S, Fargo DC, Cox AD, Chen L, Hu G. INO80 is required for oncogenic transcription and tumor growth in non-small cell lung cancer. Oncogene. 2016 Sep 19. doi: 10.1038/onc.2016.311. [Abstract]
  7. Zhou B, Wang L, Zhang S, Bennett BD, He F, Zhang Y, Xiong C, Han L, Diao L, Li P, Fargo DC, Cox AD, Hu G. INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma. Genes Dev. 2016 Jun 15;30(12):1440-53. doi: 10.1101/gad.277178.115. [Abstract]
  8. Wang L, Hu G. Remodeling super-enhancers and oncogenic transcription. Cell Cycle. 2016 Aug 11:1-2. [Abstract]
  9. Zhou B, Wang L, Zhang S, Bennett BD, He F, Zhang Y, Xiong C, Han L, Diao L, Li P, Fargo DC, Cox AD, Hu G. Genes Dev. 2016 Jun 15;30(12):1440-53. doi: 10.1101/gad.277178.115. [Abstract]
  10. Borkent M, Bennett B, Lackford B, Bar-Nur O, Brumbaugh J, Wang L, Du Y, Fargo DC, Apostolou E, Cheloufi S, Maherali N, Elledge SJ, Hu G, Hochedlinger K. A serial shRNA screen for roadblocks to reprogramming identifies the protein modifier Sumo2. Stem cell reports 2016 6(5):704-716. [Abstract]
  11. Williams LH, Fromm G, Gokey NG, Henriques T, Muse GW, Burkholder A, Fargo DC, Hu G, Adelman K. Pausing of RNA Polymerase II Regulates Mammalian Developmental Potential through Control of Signaling Networks. Molecular Cell 2015 58(2):311-322. [Abstract]
  12. Bunch H, Zheng X, Burkholder A, Dillon ST, Motola S, Birrane G, Ebmeier CC, Levine S, Fargo D, Hu G, Taatjes DJ, Calderwood SK. TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release. Nature structural & molecular biology 2014 21(10):876-883. [Abstract]
  13. Cinghu S*, Yellaboina S*, Freudenberg JM, Ghosh S, Zheng X, Oldfield AJ, Lackford BL, Zaykin DV, Hu G, Jothi R . (2014) Integrative framework for identification of key cell identity genes uncovers determinants of ES cell identity and homeostasis. Proc Natl Acad Sci 111(16):E1581-E1590. (*Co-first authors) [Abstract]
  14. Wang L, Du Y, Ward JM, Shimbo T, Lackford B, Zheng X, Miao YL, Zhou B, Han L, Fargo DC, Jothi R, Williams C, Wade P, Hu G. INO80-Dependent Promoter Access Facilitates Pluripotency Gene Activation by Master Transcription Factors. Cell Stem Cell. 2014 May 1;14(5):575-91. [Abstract]
  15. Lackford B, Yao C, Charles GM, Weng L, Zheng X, Choi E, Xie X, Wan J, Xing Y, Freudenberg JM, Jothi R, Hu G*, Shi Y*. Fip1 regulates mRNA alternative polyadenylation to promote embryonic stem cell self-renewal and somatic cell reprogramming. EMBO J. 2014 Apr 16;33(8):878-89. *: Co-corresponding authors. [Abstract]
  16. Wang L, Miao Y, Zheng X, Lackford B, Zhou B, Han L, Yao C, Ward J, Burkholder A, Lipchina I, Fargo DC,  Hochedlinger K, Shi Y, Williams CJ, Hu G. The THO Complex Regulates Pluripotency Gene mRNA Export and Controls Embryonic Stem Cell Self-renewal and Somatic Cell Reprogramming. Cell Stem Cell 13(6):676-690. [Abstract]
  17. Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA. VGLL4 Is a Novel Regulator of Survival in Human Embryonic Stem Cells. Stem Cells. 2013 Jun 14. [Abstract]
  18. Plank M, Hu G, Silva AS, Wood SH, Hesketh EE, Janssens G, Macedo A, de Magalhães JP, Church GM. An Analysis and Validation Pipeline for Large-Scale RNAi-Based Screens. Sci Rep. 2013;3:1076. [Abstract]
  19. Yang H, Qu F, Myers RE, Bao G, Hyslop T, Hu G, Fei F, Xing J. Genetic variations in stem cell-related genes and colorectal cancer prognosis. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2012 43(4):584-593. [Abstract]
  20. Zheng X, Hu G. Oct4GiP reporter assay to study genes that regulate mouse embryonic stem cell maintenance and self-renewal. Journal of visualized experiments: JoVE 2012 63:e3987-. [Abstract]
  21. Hu G, Wade P. NuRD and Pluripotency: A Complex Balancing Act. Cell Stem Cell 2012 May 4;10(5):497-503. [Abstract]
  22. Hu G, Luo J. A Primer on Using Pooled shRNA Libraries for Functional Genomic Screens. Acta Biochimica et Biophysica Sinica. 2012 Feb;44(2):103-12. [Abstract]
  23. Zheng X, Dumitru R, Lackford B, Freudenberg JM, Singh AP, Archer TK, Jothi R, Hu G. Cnot1, Cnot2, and Cnot3 Maintain Mouse and Human ES Cell Identity and Inhibit Extraembryonic Differentiation. Stem Cells. 2012 May;30(5):910-22. [Abstract]
  24. Aceto N, Sausgruber N, Brinkhaus H, Gaidatzis D, Martiny-Baron G, Mazzarol G, Confalonieri S, Quarto M, Hu G, Balwierz PJ, Pachkov M, Elledge SJ, van Nimwegen E, Stadler MB, Bentires-Alj M. Tyrosine Phosphatase SHP2 Promotes Breast Cancer Progression and Maintains Tumor-Initiating Cells via Activation of Key Transcription Factors and a Positive Feedback Signaling Loop. Nat Med. 2012 Mar 4;18(4):529-37. [Abstract]
  25. Freudenberg JM, Ghosh S, Lackford B, Yellaboina S, Zheng X, Li R, Cuddapah S, Wade P, Hu G*, Jothi R*. Acute Depletion of Tet1-dependent 5-hydroxymethylcytosine Levels Impairs LIF/Stat3 Signaling and Results in Loss of Embryonic Stem Cell Identity. Nucleic Acids Res. 2012 Apr;40(8):3364-77. *: Co-corresponding authors. [Abstract]
  26. Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TF. Activation of Multiple Proto-Oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase. Cell. 2011 Mar 4;144(5):703-18. [Abstract]
  27. Meerbrey KL#, Hu G#*, Kessler JD, Roarty K, Li M, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Bland CS, Cooper TA, Rosen JM, Westbrook TF*, Elledge SJ*. The pInducer Toolkit for Inducible RNA Interference in Vitro and in Vivo. Proc Natl Acad Sci. 2011 Mar 1;108(9):3665-70. #: Equal contribution. *: Co-corresponding authors. [Abstract]
  28. Hu G, Kim J, Xu Q, Leng Y, Orkin SH, Elledge SJ. A Genome-Wide RNAi Screen Identifies a New Transcriptional Module Required for Self-Renewal. Genes Dev. 2009 Apr 1;23(7):837-48 [Abstract]
  29. Ali N, Karlsson C, Aspling N, Hu G, Hacohen N, Scadden DT, Larsson J. Forward RNAi Screens in Primary Human Hematopoietic Stem/Progenitor Cells. Blood. 2009 Apr 16;113(16):3690-5. [Abstract]
  30. Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ. SCFbeta-TRCP Controls Oncogenic Transformation and Neural Differentiation through REST Degradation. Nature. 2008 Mar 20;452(7185):370-4. [Abstract]
  31. Schlabach MR#, Luo J#, Solimini NL#, Hu G#, Xu Q, Li M, Zhao Zh, Smogorzewska A,  Sowa ME, Ang XL, Westbrook TF, Liang A, Chang K, Hackett JA, Harper JW, Hannon GJ, Elledge SJ. Cancer Proliferation Gene Discovery Through Functional Genomics. Science. 2008 Feb 1;319(5863):620-4. #: Equal contribution. [Abstract]
  32. Silva JM, Li MZ, Chang K, Ge W, Golding MC, Rickles RJ, Siolas D, Hu G, Paddison PJ, Schlabach MR, Sheth N, Bradshaw J, Burchard J, Kulkarni A, Cavet G, Sachidanandam R, McCombie WR, Cleary MA, Elledge SJ, Hannon GJ. Second-Generation shRNA Libraries Covering the Mouse and Human Genomes. Nat Genet. 2005 Nov;37(11):1281-8. [Abstract]
  33. Stegmeier F, Hu G, Rickles RJ, Hannon GJ, Elledge SJ. A Lentiviral MicroRNA-Based System for Single-Copy Polymerase II-Regulated RNA Interference in Mammalian Cells. Proc Natl Acad Sci. 2005 Sep 13;102(37):13212-7. [Abstract]
to Top