Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Selected Publications

Eukaryotic Transcriptional Regulation Group

2003 - present

  1. Takaku M, Grimm SA, Shimbo T, Perera L, Menafra R, Stunnenberg HG, Archer TK, Machida S, Kurumizaka H, Wade PS. GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler. Genome biology 2016 17(36):-. [Abstract]
  2. Shimbo, T, Takaku, M, Wade, PA. High-quality ChIP-seq analysis of MBD3 in human breast cancer cells. Genomics data 2016 7():173-174. [Abstract]
  3. Takaku M, Grimm SA, Wade PA. GATA3 in Breast Cancer: Tumor Suppressor or Oncogene? Gene expression 2015 16(4):163-168 [Abstract]
  4. Wade PA. Are genomic translocations predictable? BioEssays: news and reviews in molecular, cellular and developmental biology 2014 36(7):633-. [Abstract]
  5. Markunas CA, Xu Z, Harlid S, Wade PA, Lie RT, Taylor JA, Wilcox AJ. Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy. Environ Health Perspect 2014 122(10):1147-1153. [Abstract]
  6. Adomas AB, Grimm SA, Malone C, Takaku M, Sims JK, Wade PA. Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC cancer 2014 14():278-. [Abstract]
  7. Godfrey AC, Xu Z, Weinberg CR, Getts RC, Wade PA, DeRoo LA, Sandler DP, Taylor JA. Serum microRNA expression as an early marker for breast cancer risk in prospectively collected samples from the Sister Study cohort. Breast cancer research: BCR 2014 15(3):R42-.  [Abstract]
  8. Moran TP, Nakano H, Kondilis-Mangum HD, Wade PA, Cook DN. Epigenetic control of ccr7 expression in distinct lineages of lung dendritic cells. Journal of immunology (Baltimore, Md.: 1950) 2014 193(10):4904-4913. [Abstract]
  9. Wang L , Du Y, Ward JM, Shimbo T, Lackford B, Zheng X, Miao YL, Zhou B, Han L, Fargo DC, Jothi R, Williams CJ, Wade PA, Hu G. (2014) INO80 facilitates pluripotency gene activation in embryonic stem cell self-renewal, reprogramming, and blastocyst development. Cell Stem Cell 14(5):575-91. [Abstract]
  10. Li R, Mav D, Grimm SA, Jothi R, Shah R, Wade PA. Fine-tuning of epigenetic regulation with respect to promoter CpG content in a cell type-specific manner. Epigenetics 2014 9(5):747-59. [Abstract]
  11. Li R, Grimm SA, Chrysovergis K, Kosak J, Wang X, Du Y, Burkholder A, Janardhan K, May D, Shah R, Eling TE, Wade PA. Obesity, rather than diet, drives epigenomic alterations in colonic epithelium resembling cancer progression. Cell metabolism 2014 19(4):702-711. [Abstract]
  12. Shimbo T, Du Y, Grimm SA, Dhasarathy A, Mav D, Shah RR, Shi H, Wade PA. MBD3 localizes at promoters, gene bodies and enhancers of active genes. PLoS genetics 2013 9(12):e1004028. [Abstract]
  13. Lai AY, Mav D, Shah R, Grimm SA, Phadke D, Hatzi K, Melnick A, Geigerman C, Sobol SE, Jaye DL, Wade PA. DNA methylation profiling in human B cells reveals immune regulatory elements and epigenetic plasticity at Alu elements during B-cell activation. Genome research 2013 23(12):2030-2041. [Abstract]
  14. Hu G, Wade P. NuRD and Pluripotency: A Complex Balancing Act. Cell Stem Cell 2012 May 4;10(5):497-503. [Abstract]
  15. Vertino PM, Wade PA. (2012) R-loops: lassoing DNA methylation at CpGi. Molecular cell 45(6):708-9. [Abstract]
  16. Freudenberg JM, Ghosh S, Lackford B, Yellaboina S, Zheng X, Li R, Cuddapah S, Wade P, Hu G*, Jothi R*. Acute Depletion of Tet1-dependent 5-hydroxymethylcytosine Levels Impairs LIF/Stat3 Signaling and Results in Loss of Embryonic Stem Cell Identity. Nucleic Acids Res. 2012 Apr;40(8):3364-77. *: Co-corresponding authors. [Abstract]
  17. Kwintkiewicz J, Padilla-Banks E, Jefferson WN, Jacobs IM, Wade PA, Williams CJ. (2012) Metastasis-Associated Protein 3 (MTA3) Regulates G2/M Progression in Proliferating Mouse Granulosa Cells. Biology of reproduction 86(3):1-8. [Abstract]
  18. Dhasarathy A, Phadke D, Mav D, Shah R.R, Wade P.A. (2011) The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer. PLoS One 6(10):e26514. [Abstract]
  19. Sims, J.K., Wade, P.A. (2011) Mi-2/NuRD complex function is required for normal S phase progression and assembly of pericentric heterochromatin. Molecular biology of the cell 22(17):3094-3102. [Abstract]
  20. Lai, A.Y., Wade, P.A. (2011) Cancer biology and NuRD: a multifaceted chromatin remodelling complex. Nature reviews. Cancer 11(8):588-596. [Abstract]
  21. Lai, A.Y., Fatemi, M., Dhasarathy, A., Malone, C., Sobol, S.E., Geigerman, C., Jaye, D.L., Mav, D., Shah, R., Li, L., and Wade, P.A. (2010) DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. Journal of Experimental Medicine 207(9):1939-1950 [Abstract]
  22. Chadwick, L.H., Chadwick, B.P., Jaye, D.L., and Wade, P.A. (2009) The Mi-2/NuRD complex associates with pericentromeric heterochromatin during S phase in rapidly proliferating lymphoid cells. Chromosoma 118(4):445-457. [Abstract]
  23. Palmer, M.B., Majumder, P., Cooper, J.C., Yoon, H., Wade, P.A., and Boss, J.M. (2009) YY1 regulates the expression of snail through a distal enhancer. Molecular cancer research : MCR 7(2):221-229.  [Abstract]
  24. Dhasarathy, A., and Wade, P.A. (2008) The MBD protein family-Reading an epigenetic mark? Mutation research 647(1-2):39-43. [Abstract]
  25. Dhasarathy, A., Kajita, M., and Wade, P.A. (2007) The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor alpha. Molecular endocrinology (Baltimore, Md.) 21(12):2907-2918. [Abstract]
  26. Chadwick, L.H. and Wade, P.A. (2007) MeCP2: transcriptional repressor or chromatin architectural protein? Current Opin Genet Dev (in press).
  27. Palmer, M.B., Majumder, P., Green, M.R., Wade, P.A., and Boss, J.M. (2007) A 3’ enhancer controls Snail expression in melanoma cells. Cancer Research, in press.
  28. Horton, J.R., Elgar, S.J., Khan, S.I., Zhang, X., Wade, P.A., and Cheng, X. Structure of the SANT domain from the Xenopus chromatin remodeling factor ISWI. Proteins (in press).
  29. Wang, Z., Wade, P., Mandell, K.J., Akyildiz, A., Parkos, C.A., Mrsny, R.J., and Nusrat, A. (2007) Raf1 represses expression of the tight junction protein occludin via activation of the zinc finger transcription factor Slug. Oncogene 26, 1222-1230.
  30. Wade, P.A. and Archer, T.K. (2006) Epigenetics: Environmental instructions for the genome. Environ Health Perspect 114, A140-A141.
  31. Fatemi, M. and Wade, P.A. (2006) MBD family proteins: Reading the epigenetic code. J Cell Sci 119, 3033-3037.  [Abstract]
  32. Ahn, J.-Y., Liu, X., Liu, Z., Pereira, L., Chen, D., Peng, J., Wade, P.A., Hamburger, A.W., and Ye, K. (2006) Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase. EMBO J 25, 2083-2095.
  33. Wade, P.A. (2005) Switching off Methylated DNA. Nature Genetics 37, 4-5.  [Abstract]
  34. Ahn, J.-Y., Liu, X., Chen, D., Peng, J., Chan, P.-K., Wade, P.A., and Ye, K. (2005) Nucleophosmin/B23, a nuclear PI(3,4,5) receptor, mediates the anti-apoptotic actions of NGF by inhibiting CAD. Mol Cell 18, 435-445.
  35. Fujita, N., Jaye, D.L., Gigerman, C., Akyildiz, A., Mooney, M.R., Boss, J.M., and Wade, P.A. (2004) MTA3 and the Mi-2/NuRD complex regulate cell fate during B-lymphocyte differentiation. Cell 119, 75-86. [Abstract]
  36. Kajita, M., McClinic K.N., and Wade, P.A. (2004) Aberrant expression of the transcription factors Snail and Slug alter the response to genotoxic stress. Mol Cell Biol. 24, 7559-7566.  [Abstract]
  37. Fujita, N., Kajita, M., Taysavang, P., and Wade, P.A. (2004) Hormonal regulation of MTA3 transcription in breast cancer cells. Mol Endocrinol 18, 2937-2949. [Abstract]
  38. Bowen, N.J., Fujita, N., Kajita, M., and Wade, P.A. (2004) Mi-2/NuRD: Multiple complexes for many purposes. Biochim. Biophys. Acta 1677, 52-57. [Abstract]
  39. Fujita, N. and Wade, P.A. (2004) Use of bifunctional cross-linking reagents in mapping genomic distribution of chromatin remodeling complexes. Methods 33, 81-85.  [Abstract]
  40. Wade, P.A. (2004) Dynamic Regulation of DNA methylation coupled transcriptional repression: BDNF regulation by MeCP2. BioEssays 26, 217-220. [Abstract]
  41. Bowen, N.J., Palmer, M.B., and Wade, P.A. (2004) Chromosomal regulation by MeCP2: Structural and enzymatic considerations. Cellular and Molecular Life Sciences 61, 2163-2167. [Abstract]
  42. Fujita, N. and Wade, P.A. (2004) Nuclear Transfer: Epigenetics pays a visit. Nature Cell Biology 6, 920-922. [Abstract]
  43. Fujita, N., Jaye, D.L., Kajita, M., Geigerman, C., Moreno, C., and Wade, P.A. (2003) MTA3, an Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Cell 113, 207-219. [Abstract]
  44. Shimono, Y., Murakami, H., Kawai, K., Wade, P.A., Shimokata, K., and Takahashi, M. (2003) Mi-2β associates with BRG1 and RET finger proteins at the distinct regions with transcriptional activating and repressing abilities. J Biol Chem 278, 51638-51645.
  45. Aoyagi, S., Wade, P.A., and Hayes, J.J. (2003) Nucleosome sliding induced by the xMi-2 complex does not occur exclusively via a simple twist-diffusion mechanism. J Biol Chem 278, 30562-30568.
  46. Georgel, P.T., Horowitz-Scherer, R.A., Adkins,N., Woodcock, C.L., Wade, P.A., and Hansen, J.C. (2003) Chromatin compaction by human MeCP2: assembly of novel secondary chromatin structures in the absence of DNA methylation. J Biol Chem 278, 32181-32188.
  47. Fraga, M.F., Ballestar, E., Montoya, G., Taysavang, P., Wade, P.A., and Esteller, M. (2003) The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties. Nucleic Acids Res 31, 1765-1774.
  48. Etchegaray, J.P., Lee, C., Wade, P.A,, and Reppert S.M. (2003) Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature 421, 177-182.
to Top