Trevor K. Archer, Ph.D.
Chief, Epigenetics & Stem Cell Biology Laboratory and NIH Distinguished Investigator
P.O. Box 12233Mail Drop D4-01Durham, N.C. 27709
Paul Wade, Ph.D.
Deputy Chief, Epigenetics & Stem Cell Biology Laboratory and Principal Investigator
P.O. Box 12233Mail Drop D4-04Durham, N.C. 27709
The Epigenetics and Stem Cell Biology Laboratory investigates fundamental mechanisms by which epigenetics — non-genetic modulation and alterations — influences chromatin architecture, transcription and gene expression in normal, cancer and embryonic stem cells and provides insights into biological processes that modulate the effects of environmental exposures. It also focuses on the molecular basis of self-renewal and pluripotency in embryonic stem (ES) cells and induced pluripotency stem (iPS) cells, as well as gene regulatory pathways using genomic, molecular, biochemical, computational and structural approaches.
Shared and Core Facilities
For more information about facilities that support research activities at the NIEHS campus, please see Shared and Core Facilities.
In addition to the cutting edge hypothesis driven research of its investigators the laboratory provides leadership and support to the NIEHS in areas of genomics, epigenomics, mass spectrometry, and bioinformatics analyses. These endeavors build and research strengths established in the prior Laboratory of Molecular Carcinogenesis and extend the scope of the research beyond cancer to examine a broad range of environmental impacts on human health and development.
Scientific Support Staff
Derrick L. Raynor