Ongoing Large Cohort Studies
For more information, please visit the study website links provided.
Agricultural Health Study (AHS; https://aghealth.nih.gov/) explores a wide range of health outcomes among licensed pesticide applicators, their spouses and children potentially exposed to pesticides and other agricultural hazards.
GuLF Long-term Follow-up Study (GuLF STUDY; https://gulfstudy.nih.gov/) is the largest study ever conducted on the potential health effects associated with an oil spill, with nearly 33,000 participants and is focused on both physical and mental health effects related to the oil spill. The GuLF STUDY is collecting information that can be used by individuals, communities and governments to better understand the consequences of oil spills and plan for future disasters.
Norwegian Mother & Child Cohort Study (MoBa; https://www.fhi.no/en/studies/moba/) is an ongoing long-term prospective cohort study of pregnant women and their babies. In collaboration with the Norwegian National Public Health Institute (NIPH), NIEHS is supporting the collection of additional biologic specimens to facilitate research into environmental causes of disease.
Study of Environment, Lifestyle & Fibroids (SELF; https://detroitself.org/) is designed to prospectively identify new cases of uterine fibroids and follow fibroid growth. The goal is to identify risk factors for fibroid development in order to discover new strategies for prevention.
The Sister Study ( https://sisterstudy.niehs.nih.gov) is a prospective cohort study of 50,000 sisters of women who had breast cancer, to explore environmental and genetic risk factors for breast cancer and other diseases and to identify potentially preventable risk factors.
Ongoing and Archived Study Resources
For more information contact the PI listed, or
Gitanjali S. Taneja, Ph.D.
Health Science Administrator
Tel (919) 541-2767
Farming and Movement Evaluation (FAME) Study (F Kamel, C Tanner) examined the relationship between Parkinson's disease and exposure to pesticides, other neurotoxicants and soil pathogens.
Lung Health Study (J Hoppin, S London) was a case-cohort study of current asthma in the AHS conducted from 2009 to 2013. More than 3,000 AHS participants completed home visits that included lung function tests, height and weight measurement, and collection of blood, urine, and dust samples. Participants also completed a telephone interview about their history of respiratory diseases and lifetime farm exposures.
Early Pregnancy Study (D Baird, A Wilcox, C Weinberg) was a detailed look at ovulation, conception and early pregnancy for a group of 221 women who provided a daily diary and urine specimens before and during early pregnancy.
Infant Feeding and Early Development (W Rogan, D Umbach) was a study looking for evidence of infants’ response to estrogen exposure from soy formula as well as other putative endocrine disrupting chemicals.
LIFE & VALID Lung Studies (J Taylor) — LIFE Study's evaluated the effectiveness of Lung Imaging Fluorescence Endoscopy (LIFE) in detecting and following early lung lesions in patients at high risk for developing lung cancer. VALID Study, a companion to the LIFE study, evaluated the effect of initial arterial ligation versus venous ligation during surgery on the risk of distant metastases in lung cancer patients.
OBOZ Study (S London), a collaborative effort between Genetics, Environment & Respiratory Group and investigators from the Center for Environmental Medicine and Lung Biology (CEMALB) at the University of North Carolina at Chapel Hill, investigated whether obesity affects respiratory response to ozone.
Singapore Chinese Health Study (S London) examined the environmental, dietary and genetic risk factors for respiratory disease. The study also examined gene-environment and gene-diet interactions with respect to respiratory symptoms and illness.