Chronic Disease Epidemiology Group
- Paula S. Juras, Ph.D.
Technical Information Specialist
- Tel 984-287-3728
- P.O. Box 12233Mail Drop A3-05Durham, N.C. 27709
Paula S. Juras, Ph.D., is the project officer for the Sister Study, a national effort to learn how the environment and genes affect breast cancer risk. It is a long-term study of 50,000 American women, from diverse backgrounds, whose sisters had breast cancer. Because of shared environment, genes and experiences, sisters of women with breast cancer have, on average, twice the risk of developing breast cancer themselves. By studying these sisters, researchers have a greater chance of identifying risk factors and discovering ways to prevent breast cancer.
Juras' dissertation research centered on an indicator of breast cancer prognosis, and her graduate research, as a whole, contributed directly to the development of protease inhibitor therapeutics for persons living with HIV. As a fellow at NIEHS, she studied lung disorders associated with some breast cancer treatments. She also serves as the project officer for the Division's DNA Isolation and Molecular Analysis contract.
- The Sister Study
("/Rhythmyx/assembler/render?sys_contentid=36268&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="36268" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="36268" sys_siteid="" sys_folderid="")The Sister Study will prospectively examine environmental and familial risk factors for breast cancer and other diseases in a cohort of 50,000 sisters of women who have had breast cancer. The study should enhance researchers’ ability to understand the interplay of genes and environment in breast cancer risk and to identify potentially preventable risk factors.
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- Zeldin DC, Wohlford-Lenane C, Chulada P, Bradbury JA, Scarborough PE, Roggli V, Langenbach R and Schwartz DA. (2001) Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. Am J Respir Cell Mol Biol, 25, 457-65. [Abstract]