Alison A. Motsinger-Reif, Ph.D.
Tel 984-287-3705[email protected]
111 TW ALEXANDER DR
David P Rall Building
Research Triangle Park, NC 27709
Shyamal D. Peddada, Ph.D.
Tel 984-287-4586[email protected]
111 TW ALEXANDER DR
David P Rall Building
Research Triangle Park, NC 27709
Research Summary The Biostatistics and Computational Biology Branch carries out basic and applied research dealing with statistical issues of relevance to environmental health. The branch's members develop new methodologies and apply existing techniques in novel ways to address environmental health problems. Members of the branch also advise institute scientists on computational, study design, database and statistical issues via both long-term and short-term collaboration in research projects throughout NIEHS. The branch also offers training at regular intervals.
Research in the Biostatistics and Computational Biology Branch focuses on several areas:
Design and analysis of laboratory animal toxicology/carcinogenicity experiments and development of improved statistical methods Application and development of methodology for epidemiological and clinical human studies Application and development of new bioinformatics techniques for harvesting information from high-dimensional genomic, gene expression and proteomic data Development of new design and analysis approaches in statistical genetics Development of broadly applicable statistical approaches
Biostatistics & Computational Biology Branch Software
See
Software to access the data or computer instructions developed by members of the NIEHS Biostatistics & Computational Biology Branch.
Recent Publications
Bird G, Lin Y, Tucker C, Mueller G, Shi M, Padmanabhan S, Parekh A. L-type calcium channel blockers at therapeutic concentrations are not linked to CRAC channels and heart failure.
Clinical and experimental hypertension (New York, N.Y. : 1993) .
2025 Dec;47(1):2515924.
[
AbstractBird G, Lin Y, Tucker C, Mueller G, Shi M, Padmanabhan S, Parekh A. L-type calcium channel blockers at therapeutic concentrations are not linked to CRAC channels and heart failure. Clinical and experimental hypertension (New York, N.Y. : 1993). 2025 Dec
]
Jia G, Ping J, Tao R, Long J, Liu L, Xu S, Munro H, Ambs S, Barnard M, Chen Y, Choi J, Gao Y, Garcia-Closas M, Gu J, Hu J, Iwasaki M, John E, Kweon S, Matsuda K, Matsuo K, Nathanson K, Nemesure B, Olopade O, Pal T, Park S, Park B, Press M, Sanderson M, Sandler D, Yao S, Zheng Y, Adejumo P, Ahearn T, Brewster A, Hennis A, Ito H, Kubo M, Lee E, Low S, Makumbi T, Ndom P, Noh D, O'Brien K, Olshan A, Oluwasanu M, Park M, Reid S, Yamaji T, Zirpoli G, Butler E, Huang M, Ntekim A, Weinberg C, Li B, Huo D, Kang D, Ambrosone C, Troester M, Haiman C, Shu X, Palmer J, Guo X, Zheng W. Integrating multi-ancestry genomic and proteomic data to identify blood risk biomarkers and target proteins for breast cancer genetic risk loci.
International journal of cancer .
2025 Jul 14 [Epub ahead of print].
[
AbstractJia G, Ping J, Tao R, Long J, Liu L, Xu S, Munro H, Ambs S, Barnard M, Chen Y, Choi J, Gao Y, Garcia-Closas M, Gu J, Hu J, Iwasaki M, John E, Kweon S, Matsuda K, Matsuo K, Nathanson K, Nemesure B, Olopade O, Pal T, Park S, Park B, Press M, Sanderson M, Sandler D, Yao S, Zheng Y, Adejumo P, Ahearn T, Brewster A, Hennis A, Ito H, Kubo M, Lee E, Low S, Makumbi T, Ndom P, Noh D, O'Brien K, Olshan A, Oluwasanu M, Park M, Reid S, Yamaji T, Zirpoli G, Butler E, Huang M, Ntekim A, Weinberg C, Li B, Huo D, Kang D, Ambrosone C, Troester M, Haiman C, Shu X, Palmer J, Guo X, Zheng W. Integrating multi-ancestry genomic and proteomic data to identify blood risk biomarkers and target proteins for breast cancer genetic risk loci. International journal of cancer. 2025 Jul 14
]
Xu M, Li J, Hsiao Y, Kovi R, Li J, Klimczak L, Riva L, Adams D, Bushel P, Merrick B, Gordenin D, Bucher J, Sills R, Pandiri A. Environmental carcinogens often exacerbate endogenous mutagenic processes to enhance tumor promotion.
Cell reports .
2025 Jul 08;44(7):115978.
[
AbstractXu M, Li J, Hsiao Y, Kovi R, Li J, Klimczak L, Riva L, Adams D, Bushel P, Merrick B, Gordenin D, Bucher J, Sills R, Pandiri A. Environmental carcinogens often exacerbate endogenous mutagenic processes to enhance tumor promotion. Cell reports. 2025 Jul 08
]
Nair N, Mendicino L, Fiorica P, Omilian A, Khoury T, Bshara W, Bandera E, Hong C, Abdou Y, Freudenheim J, Hennis A, O'Brien K, Zirpoli G, Butler E, Obafunwa J, Weinberg C, Huo D, Li B, Guo X, Palmer J, Haiman C, Zheng W, Yao S, Ambrosone C. The African-specific variant in the Duffy Antigen Receptor for Chemokines (DARC) gene, CD8+ T-cell density and Aggressive Breast Cancer Subtypes in Black Women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology .
2025 Jul 08 [Epub ahead of print].
[
AbstractNair N, Mendicino L, Fiorica P, Omilian A, Khoury T, Bshara W, Bandera E, Hong C, Abdou Y, Freudenheim J, Hennis A, O'Brien K, Zirpoli G, Butler E, Obafunwa J, Weinberg C, Huo D, Li B, Guo X, Palmer J, Haiman C, Zheng W, Yao S, Ambrosone C. The African-specific variant in the Duffy Antigen Receptor for Chemokines (DARC) gene, CD8+ T-cell density and Aggressive Breast Cancer Subtypes in Black Women. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2025 Jul 08
]
O'Brien K, House M, Goldberg M, Jones M, Weinberg C, de Gonzalez A, Bertrand K, Blot W, DeHart J, Couch F, Garcia-Closas M, Giles G, Kirsh V, Kitahara C, Koh W, Park H, Milne R, Palmer J, Patel A, Rohan T, Schoemaker M, Swerdlow A, Teras L, Vachon C, Visvanathan K, Yuan J, Zheng W, Nichols H, Sandler D. Hormone therapy use and young-onset breast cancer: a pooled analysis of prospective cohorts included in the Premenopausal Breast Cancer Collaborative Group.
The Lancet. Oncology .
2025 Jul;26(7):911-923.
[
AbstractO'Brien K, House M, Goldberg M, Jones M, Weinberg C, de Gonzalez A, Bertrand K, Blot W, DeHart J, Couch F, Garcia-Closas M, Giles G, Kirsh V, Kitahara C, Koh W, Park H, Milne R, Palmer J, Patel A, Rohan T, Schoemaker M, Swerdlow A, Teras L, Vachon C, Visvanathan K, Yuan J, Zheng W, Nichols H, Sandler D. Hormone therapy use and young-onset breast cancer: a pooled analysis of prospective cohorts included in the Premenopausal Breast Cancer Collaborative Group. The Lancet. Oncology. 2025 Jul
]
More Recent Publications from PubMed
