Office of Program Operations

Suramya Waidyanatha, Ph.D.
Suramya Waidyanatha, Ph.D.
Chemist, Chemistry and Absorption, Distribution, Metabolism and Excretion Resources Group Leader
Tel 984-287-3203
[email protected]
P.O. Box 12233
Mail Drop K2-07
Durham, NC 27709

Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.

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Suramya Waidyanatha, Ph.D. is the discipline leader for Chemistry and ADME (absorption, distribution, metabolism and excretion) and oversees the activities of the Chemistry and ADME (absorption, distribution, metabolism and excretion) Resources Group (CARG) in support of the National Toxicology Program’s mission. She designs the research needs in analytical chemistry, ADME and toxicokinetics for chemicals of interest to NTP and facilitates the use of ADME and toxicokinetic data in the design, interpretation, and reporting of NTP toxicity and carcinogenicity studies. She also manages contracts conducting ADME studies, toxicokinetics studies and analytical chemistry activities in support of the NTP toxicity and carcinogenicity studies. She serves as the NTP toxicokinetics faculty chair.

Waidyanatha’s research interests include: development, validation, and application of analytical methods to quantitate trace analytes in complex matrices; metabolism and disposition of xenobiotics and the kinetic parameters describing these processes in rodents in vivo and rodents and humans in vitro; mechanism(s) of interactions of xenobiotics and/or their metabolites with cellular macromolecules resulting in toxicity.

Waidyanatha received her B.S. (Honors) in Chemistry from University of Colombo, Sri Lanka in 1985, her M.S in Biochemistry from University of Illinois, Chicago in 1987 and her Ph.D. in Analytical Chemistry from University of Maine in 1990. She worked as an analytical chemistry resource support person for Glaxo Inc., RTP, North Carolina briefly prior to joining the School of Public Health at the University of North Carolina at Chapel Hill in 1991 as a Postdoctoral Fellow. She continued her career at the university as a Laboratory Director and then as a Senior Scientist. During her 17 years at the university, she investigated biomarkers of exposure to xenobiotics and their utility in elucidating xenobiotic metabolism and disposition which advanced her knowledge in toxicology, epidemiology and biostatistics. She joined NTP in 2008 as a staff scientist and currently holds an adjunct appointment at the University of North Carolina at Chapel Hill.

She is listed as an author in over 70 peer-reviewed research articles in scientific journals. She is a member of Society of Toxicology and American Chemical Society.

Selected Publications

  1. Harrington JM, Poitras EP, Weber FX, Fernando RA, Liyanapatirana C, Robinson VG, Levine KE, Waidyanatha S. 2022. Validation of analytical method for determination of thallium in rodent plasma and tissues by inductively coupled plasma-mass spectrometry (ICP-MS). Anal Lett 55(8):1269-1280. doi: 10.1080/00032719.2021.1993876. [Abstract Harrington JM, Poitras EP, Weber FX, Fernando RA, Liyanapatirana C, Robinson VG, Levine KE, Waidyanatha S. 2022. Validation of analytical method for determination of thallium in rodent plasma and tissues by inductively coupled plasma-mass spectrometry (ICP-MS). Anal Lett 55(8):1269-1280. doi: 10.1080/00032719.2021.1993876.]
  2. Waidyanatha S, Weber FX, Fallacara DM, Harrington JM, Levine K, Robinson VG, Sparrow BR, Stout MD, Fernando R, Hooth MJ, Xie G, Roberts GK. 2022. Systemic exposure and urinary excretion of vanadium following perinatal subchronic exposure to vanadyl sulfate and sodium metavanadate via drinking water. Toxicol Lett. 360:53-61. [Abstract Waidyanatha S, Weber FX, Fallacara DM, Harrington JM, Levine K, Robinson VG, Sparrow BR, Stout MD, Fernando R, Hooth MJ, Xie G, Roberts GK. 2022. Systemic exposure and urinary excretion of vanadium following perinatal subchronic exposure to vanadyl sulfate and sodium metavanadate via drinking water. Toxicol Lett. 360:53-61.]
  3. Waidyanatha S, Cristy T, Pierfelice J, Andre JC, Burback B, Mutlu E. 2022. Working with the natural complexity: Selection and characterization of black cohosh root extract for use in toxicology testing. Food Chem Toxicol. 160:112769. [Abstract Waidyanatha S, Cristy T, Pierfelice J, Andre JC, Burback B, Mutlu E. 2022. Working with the natural complexity: Selection and characterization of black cohosh root extract for use in toxicology testing. Food Chem Toxicol. 160:112769.]
  4. Harrington JM, Haines LG, Essader AS, Liyanapatirana C, Poitras EA, Weber FX, Levine KE, Fernando RA, Robinson VG, Waidyanatha S. 2021. Quantitation of total vanadium in rodent plasma and urine by inductively coupled plasma - mass spectrometry (ICP-MS). Anal Lett. 54(17):2777-2788. [Abstract Harrington JM, Haines LG, Essader AS, Liyanapatirana C, Poitras EA, Weber FX, Levine KE, Fernando RA, Robinson VG, Waidyanatha S. 2021. Quantitation of total vanadium in rodent plasma and urine by inductively coupled plasma - mass spectrometry (ICP-MS). Anal Lett. 54(17):2777-2788.]
  5. Waidyanatha S, Mutlu E, Gibbs S, Pierfelice J, Smith JP, Burback B, Blystone CT. 2021. Phenolic benzotriazoles: a class comparison of toxicokinetics of ultraviolet-light absorbers in male rats. Xenobiotica 51(7):831-841. [Abstract Waidyanatha S, Mutlu E, Gibbs S, Pierfelice J, Smith JP, Burback B, Blystone CT. 2021. Phenolic benzotriazoles: a class comparison of toxicokinetics of ultraviolet-light absorbers in male rats. Xenobiotica 51(7):831-841.]
  6. Waidyanatha S, Hackett M, Black SR, Stout MD, Fennell TR, Silinski MR, Watson SL, Licause J, Robinson VG, Sparrow B, Fernando RA, Cooper S, Rider CV. 2021. Toxicokinetic evaluation of the common indoor air pollutant, α-pinene, and its potential reactive metabolite, α-pinene oxide, following inhalation exposure in rodents. Toxicol Appl Pharmacol 418:115496. [Abstract Waidyanatha S, Hackett M, Black SR, Stout MD, Fennell TR, Silinski MR, Watson SL, Licause J, Robinson VG, Sparrow B, Fernando RA, Cooper S, Rider CV. 2021. Toxicokinetic evaluation of the common indoor air pollutant, α-pinene, and its potential reactive metabolite, α-pinene oxide, following inhalation exposure in rodents. Toxicol Appl Pharmacol 418:115496.]
  7. Watson ATD, Moeller BC, Doyle-Eisele M, Garner E, Blystone CR, McDonald JD, Waidyanatha S. 2021. Disposition and metabolism of ethylene glycol 2-ethylhexyl ether in Sprague Dawley rats, B6C3F1/N mice, and in vitro in rat hepatocytes. Xenobiotica 26:1-14. [Abstract Watson ATD, Moeller BC, Doyle-Eisele M, Garner E, Blystone CR, McDonald JD, Waidyanatha S. 2021. Disposition and metabolism of ethylene glycol 2-ethylhexyl ether in Sprague Dawley rats, B6C3F1/N mice, and in vitro in rat hepatocytes. Xenobiotica 26:1-14.]
  8. Rehder Silinski MA, Fletcher BL, Fernando RA, Robinson VG, Waidyanatha S. 2021. Development and validation of an analytical method for quantitation of bisphenol S in rodent plasma, amniotic fluid and fetuses by UPLC-MS-MS. J Anal Toxicol; doi: 10.1093/jat/bkab008 [Online 9 January 2021]. [Abstract Rehder Silinski MA, Fletcher BL, Fernando RA, Robinson VG, Waidyanatha S. 2021. Development and validation of an analytical method for quantitation of bisphenol S in rodent plasma, amniotic fluid and fetuses by UPLC-MS-MS. J Anal Toxicol; doi: 10.1093/jat/bkab008 [Online 9 January 2021].]
  9. Waidyanatha S, Black SR, Croutch CR, Collins BJ, Silinski MAR, Kerns S, Sutherland V, Robinson VG, Aillon K, Fernando RA, Mutlu E, Fennell TR. 2021. Comparative toxicokinetics of bisphenol S and bisphenol AF in male rats and mice following repeated exposure via feed. Xenobiotica 51(2):210-221. [Abstract Waidyanatha S, Black SR, Croutch CR, Collins BJ, Silinski MAR, Kerns S, Sutherland V, Robinson VG, Aillon K, Fernando RA, Mutlu E, Fennell TR. 2021. Comparative toxicokinetics of bisphenol S and bisphenol AF in male rats and mice following repeated exposure via feed. Xenobiotica 51(2):210-221.] 
  10. Fernando RA, Fennell TR, Watson SL, Silinski MAR, Blake JC, Robinson VG, Waidyanatha S. 2021. Development and Validation of an Analytical Method for Quantitation of Alpha-Pinene Oxide in Rodent Blood and Mammary Gland by GC-MS. J Anal Toxicol; doi: 10.1093/jat/bkab007 [Online13 January 2021]. [Abstract Fernando RA, Fennell TR, Watson SL, Silinski MAR, Blake JC, Robinson VG, Waidyanatha S. 2021. Development and Validation of an Analytical Method for Quantitation of Alpha-Pinene Oxide in Rodent Blood and Mammary Gland by GC-MS. J Anal Toxicol; doi: 10.1093/jat/bkab007 [Online13 January 2021].] 
  11. Waidyanatha S, Collins BJ, Cunny H, Aillon K, Riordan F, Turner K, McBride S, Betz L, Sutherland V. 2021. An investigation of systemic exposure to bisphenol AF during critical periods of development in the rat. Toxicol Appl Pharmacol; doi: 10.1016/j.taap.2020.115369 [Online 15 January 2021]. [Abstract Waidyanatha S, Collins BJ, Cunny H, Aillon K, Riordan F, Turner K, McBride S, Betz L, Sutherland V. 2021. An investigation of systemic exposure to bisphenol AF during critical periods of development in the rat. Toxicol Appl Pharmacol; doi: 10.1016/j.taap.2020.115369 [Online 15 January 2021].] 
  12. Harrington JM, Haines LG, Levine KE, Liyanapatirana C, Essader AS, Fernando RA, Robinson VG, Roberts GK, Stout MD, Hooth MJ, Waidyanatha S. 2021. Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water. Toxicol Appl Pharmacol; doi: 10.1016/j.taap.2021.115395 [Online 6 January 2021]. [Abstract Harrington JM, Haines LG, Levine KE, Liyanapatirana C, Essader AS, Fernando RA, Robinson VG, Roberts GK, Stout MD, Hooth MJ, Waidyanatha S. 2021. Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water. Toxicol Appl Pharmacol; doi: 10.1016/j.taap.2021.115395 [Online 6 January 2021].] 
  13. Silinski MAR, Licause J, Uenoyama T, Blake JC, Fernando RA, Robinson VG, Waidyanatha S. 2020. Development and validation of an analytical method for quantitation of alpha-pinene in rodent blood and mammary gland by headspace GC-MS. J Anal Toxicol; doi: 10.1093/jat/bkaa195 [Online 18 December 2020]. [Abstract Silinski MAR, Licause J, Uenoyama T, Blake JC, Fernando RA, Robinson VG, Waidyanatha S. 2020. Development and validation of an analytical method for quantitation of alpha-pinene in rodent blood and mammary gland by headspace GC-MS. J Anal Toxicol; doi: 10.1093/jat/bkaa195 [Online 18 December 2020].]
  14. Rehder Silinski MA, Uenoyama T, Fernando RA, Robinson VG, Roberts G, Cunny H, Hubbard T, Waidyanatha S. 2020. Development of an Analytical Method for Quantitation of 2,2'-Dimorpholinodiethyl Ether (DMDEE) in Rat Plasma, Amniotic Fluid, and Fetal Homogenate by UPLC-MS-MS for Determination of Gestational and Lactational Transfer in Rats. J Anal Toxicol; doi: 10.1093/jat/bkaa158 [Online 8 October 2020]. [Abstract Rehder Silinski MA, Uenoyama T, Fernando RA, Robinson VG, Roberts G, Cunny H, Hubbard T, Waidyanatha S. 2020. Development of an Analytical Method for Quantitation of 2,2'-Dimorpholinodiethyl Ether (DMDEE) in Rat Plasma, Amniotic Fluid, and Fetal Homogenate by UPLC-MS-MS for Determination of Gestational and Lactational Transfer in Rats. J Anal Toxicol; doi: 10.1093/jat/bkaa158 [Online 8 October 2020].]
  15. Collins BJ, Kerns SP, Aillon K, Mueller G, Rider CV, DeRose EF, London RE, Harnly JM, Waidyanatha S. 2020. Comparison of phytochemical composition of Ginkgo biloba extracts using a combination of non-targeted and targeted analytical approaches. Anal Bioanal Chem 412(25):6789-6809. [Abstract Collins BJ, Kerns SP, Aillon K, Mueller G, Rider CV, DeRose EF, London RE, Harnly JM, Waidyanatha S. 2020. Comparison of phytochemical composition of Ginkgo biloba extracts using a combination of non-targeted and targeted analytical approaches. Anal Bioanal Chem 412(25):6789-6809.]
  16. Waidyanatha S, Black SR, Silinski M, Sutherland V, Fletcher BL, Fernando RA, Fennell TR. 2020. Comparative toxicokinetics of bisphenol S in rats and mice following gavage administration. Toxicol Appl Pharmacol; doi: 10.1016/j.taap.2020.115207 [Online 24 August 2020]. [Abstract Waidyanatha S, Black SR, Silinski M, Sutherland V, Fletcher BL, Fernando RA, Fennell TR. 2020. Comparative toxicokinetics of bisphenol S in rats and mice following gavage administration. Toxicol Appl Pharmacol; doi: 10.1016/j.taap.2020.115207 [Online 24 August 2020].]
  17. Waidyanatha S, Black SR, Patel PR, Watson SL, Snyder RW, Sutherland V, Stanko J, Fennell TR. 2020. Disposition and metabolism of antibacterial agent, triclocarban, in rodents; a species and route comparison. Xenobiotica; doi: 10.1080/00498254.2020.1779391 [Online 24 June 2020]. [Abstract Waidyanatha S, Black SR, Patel PR, Watson SL, Snyder RW, Sutherland V, Stanko J, Fennell TR. 2020. Disposition and metabolism of antibacterial agent, triclocarban, in rodents; a species and route comparison. Xenobiotica; doi: 10.1080/00498254.2020.1779391 [Online 24 June 2020].]
  18. Garner CE, Wegerski CJ, Doyle-Eisele M, McDonald JD, Sanders JM, Moeller BC, Waidyanatha S. 2020. Disposition and metabolism of 2',2'"-Dithiobisbenzanilide in rodents following intravenous and oral administration and dermal application. Toxicol Rep 7:883-892. [Abstract Garner CE, Wegerski CJ, Doyle-Eisele M, McDonald JD, Sanders JM, Moeller BC, Waidyanatha S. 2020. Disposition and metabolism of 2',2'"-Dithiobisbenzanilide in rodents following intravenous and oral administration and dermal application. Toxicol Rep 7:883-892.]
  19. Mutlu E, Gibbs ST, South N, Pierfelice J, Burback B, Germolec D, Waidyanatha S. 2020. Comparative toxicokinetics of Trans-resveratrol and its major metabolites in Harlan Sprague Dawley rats and B6C3F1/N mice following oral and intravenous administration. Toxicol Appl Pharmacol; doi: 10.1016/j.taap.2020.114962 [Online 20 March 2020]. [Abstract Mutlu E, Gibbs ST, South N, Pierfelice J, Burback B, Germolec D, Waidyanatha S. 2020. Comparative toxicokinetics of Trans-resveratrol and its major metabolites in Harlan Sprague Dawley rats and B6C3F1/N mice following oral and intravenous administration. Toxicol Appl Pharmacol; doi: 10.1016/j.taap.2020.114962 [Online 20 March 2020].]
  20. Waidyanatha, S, Pierfelice, J, Cristy T, Mutlu E, Burback B, Rider CV, Ryan K. 2020. A strategy for test article selection and phytochemical characterization of Echinacea purpurea extract for safety testing. Food Chem Toxicol 137:111125. [Abstract Waidyanatha, S, Pierfelice, J, Cristy T, Mutlu E, Burback B, Rider CV, Ryan K. 2020. A strategy for test article selection and phytochemical characterization of Echinacea purpurea extract for safety testing. Food Chem Toxicol 137:111125.] 
  21. Waidyanatha S, Black SR, Patel PR, Rider CV, Watson SL, Snyder RW, Fennell TR. 2020. Disposition and Metabolism of N-butylbenzenesulfonamide in Sprague Dawley Rats and B6C3F1/N Mice and in Vitro in Hepatocytes From Rats, Mice, and Humans. Toxicol Lett 319:225-236. [Abstract Waidyanatha S, Black SR, Patel PR, Rider CV, Watson SL, Snyder RW, Fennell TR. 2020. Disposition and Metabolism of N-butylbenzenesulfonamide in Sprague Dawley Rats and B6C3F1/N Mice and in Vitro in Hepatocytes From Rats, Mice, and Humans. Toxicol Lett 319:225-236.]
  22. Waidyanatha S, Black SR, Blystone CR, Patel PR, Watson SL, Snyder RW, Fennell TR. 2019. Disposition and Metabolism of Sulfolane in Harlan Sprague Dawley Rats and B6C3F1/N Mice and in Vitro in Hepatocytes From Rats, Mice, and Humans. Xenobiotica; doi: 10.1080/00498254.2019.1630786 [Online 5 July 2019]. [Abstract Waidyanatha S, Black SR, Blystone CR, Patel PR, Watson SL, Snyder RW, Fennell TR. 2019. Disposition and Metabolism of Sulfolane in Harlan Sprague Dawley Rats and B6C3F1/N Mice and in Vitro in Hepatocytes From Rats, Mice, and Humans. Xenobiotica; doi: 10.1080/00498254.2019.1630786 [Online 5 July 2019].]
  23. Rehder Silinski MA, Fernando RA, Robinson VG, Waidyanatha S. 2019. Development and Validation of an Analytical Method for Quantitation of Monobutylphthalate, a Metabolite of Di-n-Butylphthalate, in Rat Plasma, Amniotic Fluid, Fetuses, and Pups by UPLC-MS/MS. J Anal Toxicol; doi: 10.1093/jat/bkz090 [Online 27 November 2019]. [Abstract Rehder Silinski MA, Fernando RA, Robinson VG, Waidyanatha S. 2019. Development and Validation of an Analytical Method for Quantitation of Monobutylphthalate, a Metabolite of Di-n-Butylphthalate, in Rat Plasma, Amniotic Fluid, Fetuses, and Pups by UPLC-MS/MS. J Anal Toxicol; doi: 10.1093/jat/bkz090 [Online 27 November 2019].]
  24. Mutlu E, Garner CE, Wegerski CJ, McDonald JD, McIntyre BS, Doyle-Eisele M, Waidyanatha S. 2019. Metabolism and disposition of 2-hydroxy-4-methoxybenzophenone, a sunscreen ingredient, in Harlan Sprague Dawley rats and B6C3F1/N mice; a species and route comparison. Xenobiotica; doi: 10.1080/00498254.2019.1680906 [Online 31 October 2019]. [Abstract Mutlu E, Garner CE, Wegerski CJ, McDonald JD, McIntyre BS, Doyle-Eisele M, Waidyanatha S. 2019. Metabolism and disposition of 2-hydroxy-4-methoxybenzophenone, a sunscreen ingredient, in Harlan Sprague Dawley rats and B6C3F1/N mice; a species and route comparison. Xenobiotica; doi: 10.1080/00498254.2019.1680906 [Online 31 October 2019].] 
  25. Waidyanatha, S, Black SR, Fennell TR, Watson SL, Patel PR , Cooper SD, James Blake, Robinson VG, Fernando RA, Blystone CR. 2019. Toxicokinetics and bioavailability of sulfolane, a ground water contaminant, following oral and intravenous administration in rodents: A dose, species, and sex comparison. Toxicol Appl Pharmacol 379:114690. [Abstract Waidyanatha, S, Black SR, Fennell TR, Watson SL, Patel PR , Cooper SD, James Blake, Robinson VG, Fernando RA, Blystone CR. 2019. Toxicokinetics and bioavailability of sulfolane, a ground water contaminant, following oral and intravenous administration in rodents: A dose, species, and sex comparison. Toxicol Appl Pharmacol 379:114690.]
  26. Waidyanatha S, Mutlu E, Gibbs S, Stiffler B , Andre J, Burback B, Rider CV. 2019. Systemic exposure to Ginkgo biloba extract in male F344/NCrl rats: Relevance to humans. Food and Chemical Toxicology 131:110586. [Abstract Waidyanatha S, Mutlu E, Gibbs S, Stiffler B , Andre J, Burback B, Rider CV. 2019. Systemic exposure to Ginkgo biloba extract in male F344/NCrl rats: Relevance to humans. Food and Chemical Toxicology 131:110586.]
  27. Silinski MAR, Uenoyama T, Cooper SD, Fernando RA, Robinson VG, Waidyanatha S. 2019. Development and Validation of an Analytical Method for Quantitation of Sulfolane in Rat and Mouse Plasma by GC-MS. Journal of Analytical Toxicology 43(6):477-481. [Abstract Silinski MAR, Uenoyama T, Cooper SD, Fernando RA, Robinson VG, Waidyanatha S. 2019. Development and Validation of an Analytical Method for Quantitation of Sulfolane in Rat and Mouse Plasma by GC-MS. Journal of Analytical Toxicology 43(6):477-481.]
  28. Waidyanatha S, Black SR, Aillon K, Collins B, Patel PR, Sutherland V, Robinson VG, Fernando R, Fennell TR. 2019. Toxicokinetics and Bioavailability of Bisphenol AF Following Oral Administration in Rodents: A Dose, Species, and Sex Comparison. Toxicology and Applied Pharmacology 373:39-47. [Abstract Waidyanatha S, Black SR, Aillon K, Collins B, Patel PR, Sutherland V, Robinson VG, Fernando R, Fennell TR. 2019. Toxicokinetics and Bioavailability of Bisphenol AF Following Oral Administration in Rodents: A Dose, Species, and Sex Comparison. Toxicology and Applied Pharmacology 373:39-47.]
  29. Shipkowski KA, Sanders JM, McDonald JD, Garner CE, Doyle-Eisele M, Wegerski CJ, Waidyanatha S. 2019. Comparative Disposition of Dimethylaminoethanol and Choline in Rats and Mice Following Oral or Intravenous Administration. Toxicology and Applied Pharmacology 378:114592. [Abstract Shipkowski KA, Sanders JM, McDonald JD, Garner CE, Doyle-Eisele M, Wegerski CJ, Waidyanatha S. 2019. Comparative Disposition of Dimethylaminoethanol and Choline in Rats and Mice Following Oral or Intravenous Administration. Toxicology and Applied Pharmacology 378:114592.]
  30. Shipkowski KA, Sanders JM, McDonald JD, Walker NJ, Waidyanatha S. 2019. Disposition of Fullerene C60 in Rats Following Intratracheal or Intravenous Administration. Xenobiotica 49(9):1078-1085. [Abstract Shipkowski KA, Sanders JM, McDonald JD, Walker NJ, Waidyanatha S. 2019. Disposition of Fullerene C60 in Rats Following Intratracheal or Intravenous Administration. Xenobiotica 49(9):1078-1085.]
  31. Rider CV, Walker NJ, Waidyanatha S. Getting to the Root of the Matter: Challenges and Recommendations for Assessing the Safety of Botanical Dietary Supplements. Clinical Pharmacology and Therapeutics 2018 104(3):429-431. [Abstract Rider CV, Walker NJ, Waidyanatha S. Getting to the Root of the Matter: Challenges and Recommendations for Assessing the Safety of Botanical Dietary Supplements. Clinical Pharmacology and Therapeutics 2018 104(3):429-431.]
  32. Fennel, TR, Morgan, DL, Watson, SL, Dhungana, S, Waidyanatha, S. Systemic uptake, albumin and hemoglobin binding of [14C]2,3-butanedione administered by intratracheal instillation in male Harlan Sprague Dawley rats and oropharyngeal aspiration in male B6C3F1/N mice. Chem-Biol. Interact. 227, 112-119, 2015. [Abstract Fennel, TR, Morgan, DL, Watson, SL, Dhungana, S, Waidyanatha, S. Systemic uptake, albumin and hemoglobin binding of [14C]2,3-butanedione administered by intratracheal instillation in male Harlan Sprague Dawley rats and oropharyngeal aspiration in male B6C3F1/N mice. Chem-Biol. Interact. 227, 112-119, 2015.]
  33. Waidyanatha S, Gaudette NF , Hong Y, Fennell TR. Formation of epichlorohydrin, a known rodent carcinogen, following oral administration of 1,3-dichloro-2-propanol in rats. Chemical research in toxicology 2014 27(10):1787-1795. [Abstract Waidyanatha S, Gaudette NF , Hong Y, Fennell TR. Formation of epichlorohydrin, a known rodent carcinogen, following oral administration of 1,3-dichloro-2-propanol in rats. Chemical research in toxicology 2014 27(10):1787-1795.]
  34. Waidyanatha S, Ryan K. Disposition of fragrance ingredient [(14)C]1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application. Xenobiotica; the fate of foreign compounds in biological systems 2014 44(8):749-756. [Abstract Waidyanatha S, Ryan K. Disposition of fragrance ingredient [(14)C]1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application. Xenobiotica; the fate of foreign compounds in biological systems 2014 44(8):749-756.]
  35. Waidyanatha S, Johnson JD, Hong SP, Robinson VG, Gibbs S, Graves SW, Hooth MJ, Smith CS. Toxicokinetics of α-thujone following intravenous and gavage administration of α-thujone or α- and β-thujone mixture in male and female F344/N rats and B6C3F1 mice. Toxicology and applied pharmacology 2013 271(2):216-228. [Abstract Waidyanatha S, Johnson JD, Hong SP, Robinson VG, Gibbs S, Graves SW, Hooth MJ, Smith CS. Toxicokinetics of α-thujone following intravenous and gavage administration of α-thujone or α- and β-thujone mixture in male and female F344/N rats and B6C3F1 mice. Toxicology and applied pharmacology 2013 271(2):216-228.]
  36. Matthews JM, Brown SS, Patel PR, Black SR, Banks TT, Etheridge AS, Fennell TR, Snyder RW, Blystone CR, Waidyanatha S. Metabolism and disposition of [14C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application. Xenobiotica; the fate of foreign compounds in biological systems 2013 43(2):169-181. [Abstract Matthews JM, Brown SS, Patel PR, Black SR, Banks TT, Etheridge AS, Fennell TR, Snyder RW, Blystone CR, Waidyanatha S. Metabolism and disposition of [14C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application. Xenobiotica; the fate of foreign compounds in biological systems 2013 43(2):169-181.]
  37. Hong S.P., Fuciarelli A.F., Johnson J.D., Graves S.W., Bates D.J., Waidyanatha S., Smith C.S. (2012) Toxicokinetics of methyleugenol in F344 rats and B6C3F(1) mice. Xenobiotica, 43(3):293-302. [Abstract Hong S.P., Fuciarelli A.F., Johnson J.D., Graves S.W., Bates D.J., Waidyanatha S., Smith C.S. (2012) Toxicokinetics of methyleugenol in F344 rats and B6C3F(1) mice. Xenobiotica, 43(3):293-302.]
  38. Mathews J.M., Brown S.S., Patel P.R., Black S.R., Banks T.T., Etheridge A.S., Fennell T.R., Snyder R.W., Blystone C.R., Waidyanatha S. (2012) Metabolism and disposition of [(14)C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application. Xenobiotica, 43(2):169-181. [Abstract Mathews J.M., Brown S.S., Patel P.R., Black S.R., Banks T.T., Etheridge A.S., Fennell T.R., Snyder R.W., Blystone C.R., Waidyanatha S. (2012) Metabolism and disposition of [(14)C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application. Xenobiotica, 43(2):169-181.]
  39. Mathews J.M., Zhan Q., Etheridge A.S., Patel P.R., Black S.R., Banks T.T., Fennell T.R., Snyder R.W., Burgess J.P., Warren S.D., Surh I., Waidyanatha S. (2012) Metabolism and disposition of 2-methoxy-4-nitroaniline in male and female Harlan Sprague Dawley rats and B6C3F1/N mice. Xenobiotica, 42(12):1213-1224. [Abstract Mathews J.M., Zhan Q., Etheridge A.S., Patel P.R., Black S.R., Banks T.T., Fennell T.R., Snyder R.W., Burgess J.P., Warren S.D., Surh I., Waidyanatha S. (2012) Metabolism and disposition of 2-methoxy-4-nitroaniline in male and female Harlan Sprague Dawley rats and B6C3F1/N mice. Xenobiotica, 42(12):1213-1224.]
  40. Pleil J.D., Blount B.C., Waidyanatha S., Harper M. (2012) Establishing exposure science as a distinct scientific discipline. J Expo Sci Environ Epidemiol, 22(4):317-319. [Abstract Pleil J.D., Blount B.C., Waidyanatha S., Harper M. (2012) Establishing exposure science as a distinct scientific discipline. J Expo Sci Environ Epidemiol, 22(4):317-319.]
  41. Fennell T., Watson S., Snyder R., Jeffcoat R., Waidyanatha S. (2011) Disposition and Metabolism of N,N-dimethylacetoacetamide in male F344 rats and Wistar-Han rats and female B6C3F1 mice. Xenobiotica, 41(11):1013-1020. [Abstract Fennell T., Watson S., Snyder R., Jeffcoat R., Waidyanatha S. (2011) Disposition and Metabolism of N,N-dimethylacetoacetamide in male F344 rats and Wistar-Han rats and female B6C3F1 mice. Xenobiotica, 41(11):1013-1020.]
  42. Waidyanatha, S., Johnson, J.D., Hong, S.P., Godfrey-Robinson, V.D., Graves, S.W., Cristy, T., Dunnick, J.K., and  Smith, C. (2011) Toxicokinetics of Bis(2-chloroethoxy)methane Following Intravenous Administration and Dermal Application in Male and Female F344/N Rats and B6C3F1 Mice. Toxicology letters,  205(2):215-226. [Abstract Waidyanatha, S., Johnson, J.D., Hong, S.P., Godfrey-Robinson, V.D., Graves, S.W., Cristy, T., Dunnick, J.K., and  Smith, C. (2011) Toxicokinetics of Bis(2-chloroethoxy)methane Following Intravenous Administration and Dermal Application in Male and Female F344/N Rats and B6C3F1 Mice. Toxicology letters,  205(2):215-226.]
  43. Xing C., Marchetti F., Li G., Weldon R.H., Kurtovich E., Young S., Schmid T.E., Zhang L., Rappaport S., Waidyanatha S., Wyrobek A.J., Eskenazi B. (2010) Benzene exposure near the U.S. permissible limit is associated with sperm aneuploidy. Environ Health Perspect 118(6):833-839. [Abstract Xing C., Marchetti F., Li G., Weldon R.H., Kurtovich E., Young S., Schmid T.E., Zhang L., Rappaport S., Waidyanatha S., Wyrobek A.J., Eskenazi B. (2010) Benzene exposure near the U.S. permissible limit is associated with sperm aneuploidy. Environ Health Perspect 118(6):833-839.]
  44. Rappaport S.M., Kim S., Lan Q., Vermeulen R., Waidyanatha S., Zhang L., Li G., Yin S., Hayes R.B., Rothman N., Smith M.T. (2009) Evidence that humans metabolize benzene via two pathways. Environ Health Perspect 117(6):946-952. [Abstract Rappaport S.M., Kim S., Lan Q., Vermeulen R., Waidyanatha S., Zhang L., Li G., Yin S., Hayes R.B., Rothman N., Smith M.T. (2009) Evidence that humans metabolize benzene via two pathways. Environ Health Perspect 117(6):946-952.]
  45. Onyemauwa F, Rappaport SM, Sobus JR, Gajdosová D, Wu R, Waidyanatha S. (2009) Using liquid chromatography-tandem mass spectrometry to quantify monohydroxylated metabolites of polycyclic aromatic hydrocarbons in urine. J Chromatogr B Analyt Technol Biomed Life Sci 877(11-12):1117-1125. [Abstract Onyemauwa F, Rappaport SM, Sobus JR, Gajdosová D, Wu R, Waidyanatha S. (2009) Using liquid chromatography-tandem mass spectrometry to quantify monohydroxylated metabolites of polycyclic aromatic hydrocarbons in urine. J Chromatogr B Analyt Technol Biomed Life Sci 877(11-12):1117-1125.]
  46. Sobus J.R., Waidyanatha S., McClean M.D., Herrick R.F., Smith T.J., Garshick E., Laden F., Hart J.E., Zheng Y., Rappaport S.M. (2009) Urinary naphthalene and phenanthrene as biomarkers of occupational exposure to polycyclic aromatic hydrocarbons. Occup Environ Med 66(2):99-104. [Abstract Sobus J.R., Waidyanatha S., McClean M.D., Herrick R.F., Smith T.J., Garshick E., Laden F., Hart J.E., Zheng Y., Rappaport S.M. (2009) Urinary naphthalene and phenanthrene as biomarkers of occupational exposure to polycyclic aromatic hydrocarbons. Occup Environ Med 66(2):99-104.]
  47. Funk, W.E., Waidyanatha, S., Chaing, S.H. and Rappaport, S.M. (2008) Hemoglobin adducts of benzene oxide in neonatal and adult dried blood spots. Cancer Epidemiol. Biomarkers Prev., 17: 1896-1901. [Abstract Funk, W.E., Waidyanatha, S., Chaing, S.H. and Rappaport, S.M. (2008) Hemoglobin adducts of benzene oxide in neonatal and adult dried blood spots. Cancer Epidemiol. Biomarkers Prev., 17: 1896-1901.]
  48. Fustinoni, S., Campo, L., Manini, P., Buratti, M., Waidyanatha, S., DePalma, G., Mutti, A., Foa, V., Colombi, A. and Rappaport, S.M. (2008) An integrated approach to biomonitoring exposure to styrene and styrene-(7,8)-oxide using repeated measurements sampling design. Biomarkers, 15: 1-19. [Abstract Fustinoni, S., Campo, L., Manini, P., Buratti, M., Waidyanatha, S., DePalma, G., Mutti, A., Foa, V., Colombi, A. and Rappaport, S.M. (2008) An integrated approach to biomonitoring exposure to styrene and styrene-(7,8)-oxide using repeated measurements sampling design. Biomarkers, 15: 1-19.]
  49. Waidyanatha, S. and Rappaport, S.M. (2008) Hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2- and 1,4-naphthoquinone in Swiss Webster mice. Chem-Biol. Intercat., 172:105-114. [Abstract Waidyanatha, S. and Rappaport, S.M. (2008) Hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2- and 1,4-naphthoquinone in Swiss Webster mice. Chem-Biol. Intercat., 172:105-114.]
  50. Kim, S., Lan, Q., Waidyanatha, S., Chanock, S., Johnson, B.A., Vermeulen, R., Smith, M.T., Zhang, L., Li, G., Shen, M., Yin, S., Rothman, N., and Rappaport, S.M. (2007) Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations. Pharmacogenet. Genomics. 17, 789-801. [Abstract Kim, S., Lan, Q., Waidyanatha, S., Chanock, S., Johnson, B.A., Vermeulen, R., Smith, M.T., Zhang, L., Li, G., Shen, M., Yin, S., Rothman, N., and Rappaport, S.M. (2007) Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations. Pharmacogenet. Genomics. 17, 789-801.]
  51. Lin, Y.S., Vermeulen, R., Tsai, C.H., Waidyanatha, S., Lan, Q., Rothman, N., Smith, M.T., Zhang, L., Shen, M., Li, G.,Yin, S., Kim, S. and Rappaport, S.M. (2007) Albumin adducts of electrophilic benzene metabolites in benzene exposed and control workers. Environ. Health Perspect., 115:28-34. [Abstract Lin, Y.S., Vermeulen, R., Tsai, C.H., Waidyanatha, S., Lan, Q., Rothman, N., Smith, M.T., Zhang, L., Shen, M., Li, G.,Yin, S., Kim, S. and Rappaport, S.M. (2007) Albumin adducts of electrophilic benzene metabolites in benzene exposed and control workers. Environ. Health Perspect., 115:28-34.]
  52. Kim, S., Vermeulen, R., Waidyanatha, S., Johnson, B., Lan, Q., Rothman, N., Smith, M.T., Zhang, L., Li, G., Shen, M., Yin, S. and Rappaport, S.M. (2006) Modeling human metabolism of benzene following occupational and environmental exposures. Cancer Epidemiol. Biomarkers Prev., 15:2246-2252. [Abstract Kim, S., Vermeulen, R., Waidyanatha, S., Johnson, B., Lan, Q., Rothman, N., Smith, M.T., Zhang, L., Li, G., Shen, M., Yin, S. and Rappaport, S.M. (2006) Modeling human metabolism of benzene following occupational and environmental exposures. Cancer Epidemiol. Biomarkers Prev., 15:2246-2252.]
  53. Kim, S., Vermeulen, R., Waidyanatha, S., Johnson, B., Lan, Q., Rothman, N., Smith, M.T., Zhang, L., Li, G., Shen, M., Yin, S. and Rappaport, S.M. (2006) Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism. Carcinogenesis, 27:772-781. [Abstract Kim, S., Vermeulen, R., Waidyanatha, S., Johnson, B., Lan, Q., Rothman, N., Smith, M.T., Zhang, L., Li, G., Shen, M., Yin, S. and Rappaport, S.M. (2006) Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism. Carcinogenesis, 27:772-781.]
  54. Lin, Y.S., McKelvey, W., Waidyanatha, S. and Rappaport, S.M. (2006) Variability of albumin adducts of 1,4-benzoquinone, a toxic metabolite of benzene, in human volunteers. Biomarkers, 11: 14-27. [Abstract Lin, Y.S., McKelvey, W., Waidyanatha, S. and Rappaport, S.M. (2006) Variability of albumin adducts of 1,4-benzoquinone, a toxic metabolite of benzene, in human volunteers. Biomarkers, 11: 14-27.]
  55. Yokley, K., Tran, H.T., Pekari, K., Rappaport, S., Riihimaki, V., Rothman, N., Waidyanatha, S. and Schlosser, P.M. (2006) Physiologically-based pharmacokinetic modeling of benzene in humans: a Bayesian approach. Risk. Anal., 26, 925-943. [Abstract Yokley, K., Tran, H.T., Pekari, K., Rappaport, S., Riihimaki, V., Rothman, N., Waidyanatha, S. and Schlosser, P.M. (2006) Physiologically-based pharmacokinetic modeling of benzene in humans: a Bayesian approach. Risk. Anal., 26, 925-943.]
  56. Wu, R., Waidyanatha, S., Henderson, A.P., Serdar, B., Zheng, Y. and Rappaport, S.M. (2005) Determination of dihydroxynaphthalenes in human urine by gas chromatography-mass spectrometry. Journal of Chromatography (B), 826:206-213. [Abstract Wu, R., Waidyanatha, S., Henderson, A.P., Serdar, B., Zheng, Y. and Rappaport, S.M. (2005) Determination of dihydroxynaphthalenes in human urine by gas chromatography-mass spectrometry. Journal of Chromatography (B), 826:206-213.]
  57. Waidyanatha, S., Sangaiah, R.and Rappaport, S.M. 2005. Characterization and quantification of cysteinyl adducts of benzene diol epoxide. Chem. Res. Toxicol., 18:1178-1185. [Abstract Waidyanatha, S., Sangaiah, R.and Rappaport, S.M. 2005. Characterization and quantification of cysteinyl adducts of benzene diol epoxide. Chem. Res. Toxicol., 18:1178-1185.]
  58. Henderson, A.P.,Waidyanatha, S., Delany, K., Lindstrom, A.B., Bleasdale, C., Watson, W.P., Golding, B.T. and Rappaport, S.M. (2005) Evidence for the formation of Michael adducts from (E,E)-muconaldehyde with glutathione and other thiols. Biorganic Chem., 33: 363-373. [Abstract Henderson, A.P.,Waidyanatha, S., Delany, K., Lindstrom, A.B., Bleasdale, C., Watson, W.P., Golding, B.T. and Rappaport, S.M. (2005) Evidence for the formation of Michael adducts from (E,E)-muconaldehyde with glutathione and other thiols. Biorganic Chem., 33: 363-373.]
  59. Rappaport, S.M., Waidyanatha, S., Yeowell-O'Connell1, K., Rothman, N., Smith, M.T., Zhang, L., Qu, Q., Shore, R., Li, G. and Yin, S. (2005) Protein adducts as biomarkers of human benzene metabolism. Chem-Bio.l Interact., 153-154: 103-109. [Abstract Rappaport, S.M., Waidyanatha, S., Yeowell-O'Connell1, K., Rothman, N., Smith, M.T., Zhang, L., Qu, Q., Shore, R., Li, G. and Yin, S. (2005) Protein adducts as biomarkers of human benzene metabolism. Chem-Bio.l Interact., 153-154: 103-109.]
  60. Waidyanatha, S. and Rappaport, S.M. (2005) Investigation of cysteinyl protein adducts of benzene diol epoxide. Chem-Bio.l Interact., 153-154: 261-266. [Abstract Waidyanatha, S. and Rappaport, S.M. (2005) Investigation of cysteinyl protein adducts of benzene diol epoxide. Chem-Bio.l Interact., 153-154: 261-266.]
  61. Lan,Q., Zhang,L., Li,G., Vermeulen,R., Weinberg,R.S., Dosemeci,M., Rappaport,S.M., Shen,M., Alter,B.P., Wu,Y., Kopp,W., Waidyanatha,S., Rabkin,C., Guo,W., Chanock,S., Hayes,R.B., Linet,M., Kim,S., Yin,S., Rothman,N. and Smith,M.T. (2004) Hematotoxicity in workers exposed to low levels of benzene. Science, 306: 1774-1776. [Abstract Lan,Q., Zhang,L., Li,G., Vermeulen,R., Weinberg,R.S., Dosemeci,M., Rappaport,S.M., Shen,M., Alter,B.P., Wu,Y., Kopp,W., Waidyanatha,S., Rabkin,C., Guo,W., Chanock,S., Hayes,R.B., Linet,M., Kim,S., Yin,S., Rothman,N. and Smith,M.T. (2004) Hematotoxicity in workers exposed to low levels of benzene. Science, 306: 1774-1776.]
  62. Rappaport, S.M., Waidyanatha, S. and Serdar, B. (2004) Naphthalene and its biomarkers as measures of occupational exposure to polycyclic aromatic hydrocarbons, J. Environ. Monit., 6:413-416. [Abstract Rappaport, S.M., Waidyanatha, S. and Serdar, B. (2004) Naphthalene and its biomarkers as measures of occupational exposure to polycyclic aromatic hydrocarbons, J. Environ. Monit., 6:413-416.]
  63. Waidyanatha, S., Rothman, N., Li, G., Smith, M.T., Yin, S. and Rappaport, S.M. (2004) Rapid determination of six urinary benzene metabolites in occupationally-exposed and unexposed subjects, Anal. Biochem., 327:184-199. [Abstract Waidyanatha, S., Rothman, N., Li, G., Smith, M.T., Yin, S. and Rappaport, S.M. (2004) Rapid determination of six urinary benzene metabolites in occupationally-exposed and unexposed subjects, Anal. Biochem., 327:184-199.]
  64. Waidyanatha, S., Zheng, Y., Serdar, B., Rappaport, S.M. (2004) Albumin adducts of naphthalene metabolites as biomarkers of exposure to polycyclic aromatic hydrocarbons, Cancer Epidemiol. Biomarkers Prev., 13:117-124. [Abstract Waidyanatha, S., Zheng, Y., Serdar, B., Rappaport, S.M. (2004) Albumin adducts of naphthalene metabolites as biomarkers of exposure to polycyclic aromatic hydrocarbons, Cancer Epidemiol. Biomarkers Prev., 13:117-124.]
  65. Rappaport, S.M., Waidyanatha, S., Qu, Q., Shore, R., Jin, X., Cohen, B., Chen, L.C., Melikian, A.A., Li, G., Yin, S., Yan, H., Xu, B., Mu, R., Li, Y., Zhang, X. and Li, K. (2002) Albumin adducts of benzene oxide and 1,4-benzoquinone as measures of human benzene metabolism, Cancer Research, 62: 1330-1337. [Abstract Rappaport, S.M., Waidyanatha, S., Qu, Q., Shore, R., Jin, X., Cohen, B., Chen, L.C., Melikian, A.A., Li, G., Yin, S., Yan, H., Xu, B., Mu, R., Li, Y., Zhang, X. and Li, K. (2002) Albumin adducts of benzene oxide and 1,4-benzoquinone as measures of human benzene metabolism, Cancer Research, 62: 1330-1337.]
  66. Waidyanatha, S., Rothman, N., Fustinoni, S., Smith, M.T., Hayes, R.B., Bechtold, W., Dosemeci, M., Li, G., Yin, S. and Rappaport, S.M. (2001) Urinary benzene as a biomarker of exposure among occupationally exposed and unexposed subjects, Carcinogenesis, 22: 279-286. [Abstract Waidyanatha, S., Rothman, N., Fustinoni, S., Smith, M.T., Hayes, R.B., Bechtold, W., Dosemeci, M., Li, G., Yin, S. and Rappaport, S.M. (2001) Urinary benzene as a biomarker of exposure among occupationally exposed and unexposed subjects, Carcinogenesis, 22: 279-286.]