Styrene is a colorless, flammable liquid, which has a sweet odor and is highly volatile. Styrene is widely used to make plastics and rubber, which are used to manufacture a variety of products, such as insulation, pipes, automobile parts, printing cartridges, food containers, and carpet backing.
How are people exposed to styrene?
People are exposed to styrene in the workplace and in the environment. Workers in certain occupations are potentially exposed to much higher levels of styrene than the general population. For example, workers who fabricate boats, car and truck parts, tanks, and bath tubs and shower stalls with glass fiber-reinforced polyester composite plastics, may breathe in high levels of styrene in the workplace. Workers may also absorb styrene through the skin. Exposures in the workplace have decreased over time.
People may be exposed to styrene through breathing indoor air that has styrene vapors from building materials, photocopiers, tobacco smoke, and other products.
Smokers are exposed to styrene because it occurs in cigarette smoke.
Living near industrial facilities or hazardous waste sites is another way people may be exposed to styrene.
Styrene may also leach from polystyrene containers used for food products, but levels of styrene in food are very low. Although the National Toxicology Program listed styrene as a reasonably anticipated carcinogen in 2011, the styrene listing was based on studies of workers exposed to high levels of styrene.
Health Effects: Can exposure to styrene cause cancer?
The Report on Carcinogens, prepared by the National Toxicology Program, listed styrene as reasonably anticipated to be a human carcinogen in its 12th Report on Carcinogens (2011).
A report by the National Academy of Sciences in 2014 endorsed this NTP listing of styrene as a reasonably anticipated human carcinogen.
What evidence is there that styrene causes cancer?
The NTP Report on Carcinogens based its listing of formaldehyde as a known human carcinogen using the following evidence:
Human Studies: The limited evidence for cancer from styrene in humans is from occupational studies showing increased risks for lymphohematopoietic cancers, such as leukemia and lymphoma, and genetic damage in the white blood cells, or lymphocytes, of workers exposed to styrene. There is also some evidence for increased risk of cancer in the pancreas or esophagus among some styrene workers, but the evidence is weaker than that for lymphohematopoietic cancers.
Animal Studies: Styrene caused lung tumors in several strains of mice.
Mechanistic Studies: Exactly how styrene causes cancer is not fully understood, but styrene is converted, in laboratory animals and humans, to styrene–7,8–oxide, which is listed in the Report on Carcinogens as reasonably anticipated to be a human carcinogen. Styrene-7,8-oxide causes genetic damage and has been found in the blood of workers exposed to styrene.
What is NIEHS Doing?
The following clinical trials are currently recruiting
In addition to NTP’s work in this area, some NIEHS grantees are also working to understand how occupational exposures to mixtures of chemicals like styrene and butadiene contribute to the development of some cancers.
What are some things I can do to prevent exposure to styrene?
- Stop smoking. Styrene is found in tobacco smoke.
- Limit children’s exposure to tobacco smoke.
- Adhere to federal workplace regulations.
Workers and employers should practice good occupational health behaviors. This may include wearing protective clothing, respirators, and gloves. Work places should be well ventilated.
- Agency for Toxic Substances and Disease Registry (ATSDR) This fact sheet answers the most frequently asked health questions (FAQs) about styrene.
- National Institute for Occupational Safety and Health (NIOSH) Workplace Safety and Health Topics webpage on styrene
- National Toxicology Program Scientific Review of Styrene
- Occupational Safety and Health Administration (OSHA) Safety and Health Topics: Styrene
- Toxic Substances Portal - Styrene information from the ATSRR
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