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Your Environment. Your Health.

John S. House, Ph.D.

Biostatistics & Computational Biology Branch

John House, Ph.D.
John House, Ph.D.
Staff Scientist
Tel 984-287-3581
john.house@nih.gov
P.O. Box 12233
Mail Drop A3-03
Durham, N.C. 27709

Research Summary

John House, Ph.D., is a staff scientist in the Biostatistics and Computational Biology Branch who conducts research in the exposures and Omics space. John is an interdisciplinary scientist with experience in statistics, computational biology, epidemiology and molecular biology who maintains active collaborations with investigators across the country. The overarching theme of John’s research is to understanding and characterize how human health and disease susceptibility are affected by the intersection of environmental exposures and inter-individual variation in the Omics space.

A current research focus is mapping exposure and genetic determinants of disease in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) clinical trial and in the Personalized Environmental Gene Study (PEGS - formally Environmental Polymorphisms Registry). This work includes development of new pipelines for the analysis and visualization of the ever-increasing amount of biological data being generated with DNA/RNA sequencing, epigenetic characterization, proteomics, and metabolomics.

Selected Publications

  1. Marvel SW, House JS, Wheeler M, Song K, Zhou YH, Wright FA, Chiu WA, Rusyn I, Motsinger-Reif A, Reif DM. 2021. The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring county-level vulnerability using visualization, statistical modeling, and machine learning. Environ Health Perspect 129(1):17701. [Abstract Marvel SW, House JS, Wheeler M, Song K, Zhou YH, Wright FA, Chiu WA, Rusyn I, Motsinger-Reif A, Reif DM. 2021. The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring county-level vulnerability using visualization, statistical modeling, and machine learning. Environ Health Perspect 129(1):17701.]
  2. House JS, Grimm FA, Klaren WD, Dalzell A, Kuchi S, Zhang S-D, et al. 2021. Grouping of UVCB substances with new approach methodologies (NAMs) data. Altex 38(1):123-137. Epub 2020 Oct 9. [Abstract House JS, Grimm FA, Klaren WD, Dalzell A, Kuchi S, Zhang S-D, et al. 2021. Grouping of UVCB substances with new approach methodologies (NAMs) data. Altex 38(1):123-137. Epub 2020 Oct 9.]
  3. Nichols CE, House JS, Li H, Ward JM, Wyss A, Williams JG, et al. 2021. Lrp1 Regulation of Pulmonary Function. Follow-up of Human GWAS in Mice. Am J Respir Cell Mol Biol Mar;64(3):368-378. [Abstract Nichols CE, House JS, Li H, Ward JM, Wyss A, Williams JG, et al. 2021. Lrp1 Regulation of Pulmonary Function. Follow-up of Human GWAS in Mice. Am J Respir Cell Mol Biol Mar;64(3):368-378.]
  4. Sakolish C, House JS, Chramiec A, Liu Y, Chen Z, Halligan SP, et al. 2020. Tissue-engineered Bone Tumor as a Reproducible Human in Vitro Model for Studies of Anticancer Drugs. Toxicol Sci Jan 1;173(1):65-76. [Abstract Sakolish C, House JS, Chramiec A, Liu Y, Chen Z, Halligan SP, et al. 2020. Tissue-engineered Bone Tumor as a Reproducible Human in Vitro Model for Studies of Anticancer Drugs. Toxicol Sci Jan 1;173(1):65-76.]
  5. Maguire RL, House JS, Lloyd DT, Skinner HG, Allen TK, Raffi AM, et al. 2020. Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort. Pediatr Obes Dec 30;e12763. [Abstract Maguire RL, House JS, Lloyd DT, Skinner HG, Allen TK, Raffi AM, et al. 2020. Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort. Pediatr Obes Dec 30;e12763.]
  6. House JS, Bouzos E, Fahy KM, Francisco VM, Lloyd DT, Wright FA, et al. 2020. Low-dose Silver Nanoparticle Surface Chemistry and Temporal Effects on Gene Expression in Human Liver Cells. Small May;16(21):e2000299. [Abstract House JS, Bouzos E, Fahy KM, Francisco VM, Lloyd DT, Wright FA, et al. 2020. Low-dose Silver Nanoparticle Surface Chemistry and Temporal Effects on Gene Expression in Human Liver Cells. Small May;16(21):e2000299.]
  7. House JS, Motsinger-Reif AA. 2020. Fibrate Pharmacogenomics: Expanding Past the Genome. Pharmacogenomics 21(4):293-306. [Abstract House JS, Motsinger-Reif AA. 2020. Fibrate Pharmacogenomics: Expanding Past the Genome. Pharmacogenomics 21(4):293-306.]
  8. Gonzalez-Nahm S, Nihlani K, S House J, L Maguire R, G Skinner H, Hoyo C. 2020. Associations Between Maternal Cadmium Exposure with Risk of Preterm Birth and Low after Birth Weight Effect of Mediterranean Diet Adherence on Affected Prenatal Outcomes. Toxics 2020 Oct 20;8(4):90. [Abstract Gonzalez-Nahm S, Nihlani K, S House J, L Maguire R, G Skinner H, Hoyo C. 2020. Associations Between Maternal Cadmium Exposure with Risk of Preterm Birth and Low after Birth Weight Effect of Mediterranean Diet Adherence on Affected Prenatal Outcomes. Toxics 2020 Oct 20;8(4):90.]
  9. House JS, Mendez M, Maguire RL, Gonzalez-Nahm S, Huang Z, Daniels J, et al. 2018. Periconceptional Maternal Mediterranean Diet Is Associated With Favorable Offspring Behaviors and Altered CpG Methylation of Imprinted Genes. Front Cell Dev Biol Sep 7;6:107. [Abstract House JS, Mendez M, Maguire RL, Gonzalez-Nahm S, Huang Z, Daniels J, et al. 2018. Periconceptional Maternal Mediterranean Diet Is Associated With Favorable Offspring Behaviors and Altered CpG Methylation of Imprinted Genes. Front Cell Dev Biol Sep 7;6:107.]
  10. House JS, Wyss AB, Hoppin JA, Richards M, Long S, Umbach DM, et al. 2017. Early-life farm exposures and adult asthma and atopy in the Agricultural Lung Health Study. J Allergy Clin Immunol Jul;140(1):249-256.e14. [Abstract House JS, Wyss AB, Hoppin JA, Richards M, Long S, Umbach DM, et al. 2017. Early-life farm exposures and adult asthma and atopy in the Agricultural Lung Health Study. J Allergy Clin Immunol Jul;140(1):249-256.e14.]
  11. House JS, Grimm FA, Jima DD, Zhou Y-H, Rusyn I, Wright FA. 2017. A Pipeline for High-throughput Concentration Response Modeling of Gene Expression for Toxicogenomics. Front Genet Nov 1;8:168. [Abstract House JS, Grimm FA, Jima DD, Zhou Y-H, Rusyn I, Wright FA. 2017. A Pipeline for High-throughput Concentration Response Modeling of Gene Expression for Toxicogenomics. Front Genet Nov 1;8:168.]
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