May 24 - 25, 2022 • 11:00 a.m. - 4:00 p.m. EDT
May 26, 2022 • 11:00 a.m. - 4:30 p.m. EDT

Virtual Event

Workshop Purpose

This jointly supported NIEHS/NHGRI virtual workshop was convened to determine the current capabilities, needs, and prospects for comprehensive characterization and understanding of the true diversity of all RNAs and their modifications at a chemical and structural level in relation to normal and disease states.

Workshop Goals

1. To explore the need for “RNomics” in genomics.
2. To identify what technologies are needed to sequence full-length RNAs directly capturing molecular diversity and cellular context.
3. To determine what infrastructure, bioinformatics, and other resources are needed to support technology development, utilization, and validation.
4. To consider the steps needed to facilitate rapid adoption of these technologies by the wider scientific community.

Workshop Topics and Recordings

Click on the session title to view recording.

• Opening Remarks
• Session 1: Setting the Stage
• Session 2: Impact on RNA Structure and Biological Roles
  • Breakout 2A: Association With RBPs
  • Breakout 2B: Impact of Cellular Stress
  • Breakout 2C: Influences of Modifications on RNA Structure and Dynamics
• Session 3: RNomics Applications from Research to Clinic
  • Breakout 3A: RNA Therapeutics
  • Breakout 3B: RNA Diagnostics
  • Breakout 3C: Viral RNome
• Session 4: Technologies for Direct Sequencing
  • Breakout 4A: Technologies on the Horizon
  • Breakout 4B: Leveraging Existing Technologies – Opportunities for Further Innovation
  • Breakout 4C: Unmet Challenges and Needs
• Session 5: Infrastructure, Bioinformatics, and Critical Resources: What is Needed?
  • Breakout 5A: Infrastructure and Bioinformatics
  • Breakout 5B: Critical Computational Resources
  • Breakout 5C: Critical Biological Resources
• Session 6: Facilitating Technology Dissemination and Adoption
  • Breakout 6A: Technology Dissemination and Adoption
  • Breakout 6B: Training
• Wrap-up Session

Contact

For questions on the workshop content, please contact Fred Tyson, 984-287-3334.