This year marks the 40th anniversary of the Superfund Amendments and Reauthorization Act, the legislation that established the Superfund Research Program (SRP) within NIEHS. A cornerstone of the SRP is the P42 multiproject center grant program, which funds research at universities nationwide. SRP Centers investigate how environmental exposures affect human health, design strategies to reduce exposures, and identify opportunities to protect health by bringing together researchers from different fields.