2002
Two New Lines of Genetically Altered Mice Developed to Study Cancer
NIEHS researchers produced two lines of genetically altered mice that have a significant impact on the study of cancer development. Research with these mice showed that removal of two genes, COX-1 and COX-2, lead to a significant decrease in development of colon, skin, and intestinal cancers in laboratory animals.
Citation:
Tiano HF, Loftin CD, Akunda J, Lee CA, Spalding J, Sessoms A, Dunson DB, Rogan EG, Morham SG, Smart RC, Langenbach R. 2002. Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res 62(12):3395-3401. [Abstract] [Full Text]
More Information:
NTP Initiatives:
- National Toxicology Program (NTP)
- NTP Interagency Center for the Evaluation of Alternative Toxicological Methods
News Release:
- 2007: Mouse Genome Will Help Identify Causes of Environmental Disease