Reproductive Medicine Group

1. Stein P, Emori C, Padilla-Banks E, Radonova L, Gruzdev A, Ikawa M, Williams CJ. 2026. Beware of your "oocyte specific" Cre line: somatic cell Cre expression in several Zp3-Cre lines and the Gdf9-iCre transgenic line. Biol Reprod ioag093. doi: 10.1093/biolre/ioag093. doi: 10.1093/biolre/ioag093. Epub ahead of print. PMID: 42059582. [ Abstract Stein P, Emori C, Padilla-Banks E, Radonova L, Gruzdev A, Ikawa M, Williams CJ. 2026. Beware of your "oocyte specific" Cre line: somatic cell Cre expression in several Zp3-Cre lines and the Gdf9-iCre transgenic line. Biol Reprod ioag093. doi: 10.1093/biolre/ioag093. doi: 10.1093/biolre/ioag093. Epub ahead of print. PMID: 42059582. ]
2. Stein P, Glodowski CR, Williams CJ, Bernhardt ML. 2025. Mt1 expression artifacts: a caution to Cre users. Biol Reprod 113(4):714-716. doi: 10.1093/biolre/ioaf200. PMID: 40884477. PMCID: PMC12527227. [ Abstract Stein P, Glodowski CR, Williams CJ, Bernhardt ML. 2025. Mt1 expression artifacts: a caution to Cre users. Biol Reprod 113(4):714-716. doi: 10.1093/biolre/ioaf200. PMID: 40884477. PMCID: PMC12527227. ]
3. Jefferson WN, Wang T, Padilla-Banks E, Williams CJ. 2024. Unexpected nuclear hormone receptor and chromatin dynamics regulate estrous cycle dependent gene expression. Nucleic Acids Res. 52(18):10897-10917. doi: 10.1093/nar/gkae714. PMID: 39166489. PMCID: PMC11472041. [ Abstract Jefferson WN, Wang T, Padilla-Banks E, Williams CJ. 2024. Unexpected nuclear hormone receptor and chromatin dynamics regulate estrous cycle dependent gene expression. Nucleic Acids Res. 52(18):10897-10917. doi: 10.1093/nar/gkae714. PMID: 39166489. PMCID: PMC11472041. ]
4. Vega-Sendino M, Lüttmann FF, Olbrich T, Chen Y, Kuenne C, Stein P, Tillo D, Carey GI, Zhong J, Savy V, Radonova L, Lu T, Saykali B, Kim KP, Domingo CN, Schüler L, Günther S, Bentsen M, Bosnakovski D, Schöler H, Kyba M, Maity TK, Jenkins LM, Looso M, Williams CJ, Kim J, Ruiz S. 2024. The homeobox transcription factor DUXBL controls exit from totipotency. Nat Genet 56(4):697-709. doi: 10.1038/s41588-024-01692-z. Epub 2024 Mar 20. PMID: 38509386. PMCID: PMC11149696. [ Abstract Vega-Sendino M, Lüttmann FF, Olbrich T, Chen Y, Kuenne C, Stein P, Tillo D, Carey GI, Zhong J, Savy V, Radonova L, Lu T, Saykali B, Kim KP, Domingo CN, Schüler L, Günther S, Bentsen M, Bosnakovski D, Schöler H, Kyba M, Maity TK, Jenkins LM, Looso M, Williams CJ, Kim J, Ruiz S. 2024. The homeobox transcription factor DUXBL controls exit from totipotency. Nat Genet 56(4):697-709. doi: 10.1038/s41588-024-01692-z. Epub 2024 Mar 20. PMID: 38509386. PMCID: PMC11149696. ]
5. Gupta N, Soriano-Úbeda C, Stein P, Savy V, Papas BN, Ardestani G, Carvacho I, Alfandari D, Williams CJ, Fissore RA. 2023. Essential role of Mg2+ in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes. Cell Rep 42(10):113232. doi: 10.1016/j.celrep.2023.113232. Epub 2023 Oct 11. PMID: 37824328. PMCID: PMC10842026. [ Abstract Gupta N, Soriano-Úbeda C, Stein P, Savy V, Papas BN, Ardestani G, Carvacho I, Alfandari D, Williams CJ, Fissore RA. 2023. Essential role of Mg2+ in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes. Cell Rep 42(10):113232. doi: 10.1016/j.celrep.2023.113232. Epub 2023 Oct 11. PMID: 37824328. PMCID: PMC10842026. ]
6. Padilla-Banks E, Jefferson WN, Papas BN, Suen AA, Xu X, Carreon DV, Willson CJ, Quist EM, Williams CJ. 2023. Developmental estrogen exposure in mice disrupts uterine epithelial cell differentiation and causes adenocarcinoma via Wnt/β-catenin and PI3K/AKT signaling. PLoS Biol 21(10):e3002334. doi: 10.1371/journal.pbio.3002334. PMID: 37856394. PMCID: PMC10586657. [ Abstract Padilla-Banks E, Jefferson WN, Papas BN, Suen AA, Xu X, Carreon DV, Willson CJ, Quist EM, Williams CJ. 2023. Developmental estrogen exposure in mice disrupts uterine epithelial cell differentiation and causes adenocarcinoma via Wnt/β-catenin and PI3K/AKT signaling. PLoS Biol 21(10):e3002334. doi: 10.1371/journal.pbio.3002334. PMID: 37856394. PMCID: PMC10586657. ]
7. Ji S, Chen F, Stein P, Wang J, Zhou Z, Wang L, Zhao Q, Lin Z, Liu B, Xu K, Lai F, Xiong Z, Hu X, Kong T, Kong F, Huang B, Wang Q, Xu Q, Fan Q, Liu L, Williams CJ, Schultz RM, Xie W. 2023. OBOX regulates mouse zygotic genome activation and early development. Nature 620(7976):1047-1053. doi: 10.1038/s41586-023-06428-3. Epub 2023 Jul 17. PMID: 37459895. PMCID: PMC10528489. [ Abstract Ji S, Chen F, Stein P, Wang J, Zhou Z, Wang L, Zhao Q, Lin Z, Liu B, Xu K, Lai F, Xiong Z, Hu X, Kong T, Kong F, Huang B, Wang Q, Xu Q, Fan Q, Liu L, Williams CJ, Schultz RM, Xie W. 2023. OBOX regulates mouse zygotic genome activation and early development. Nature 620(7976):1047-1053. doi: 10.1038/s41586-023-06428-3. Epub 2023 Jul 17. PMID: 37459895. PMCID: PMC10528489. ]
8. Savy V, Stein P, Shi M, Williams CJ. 2022. PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth. Biol Reprod 107(6):1439-1451. doi: 10.1093/biolre/ioac180. PMID: 36130203. PMCID: PMC10144700. [ Abstract Savy V, Stein P, Shi M, Williams CJ. 2022. PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth. Biol Reprod 107(6):1439-1451. doi: 10.1093/biolre/ioac180. PMID: 36130203. PMCID: PMC10144700. ]
9. Suen AA, Kenan AC, Williams CJ. 2022. Developmental exposure to phytoestrogens found in soy: New findings and clinical implications. Biochem Pharmacol 195:114848. doi: 10.1016/j.bcp.2021.114848. Epub 2021 Nov 18. PMID: 34801523. PMCID: PMC8712417. [ Abstract Suen AA, Kenan AC, Williams CJ. 2022. Developmental exposure to phytoestrogens found in soy: New findings and clinical implications. Biochem Pharmacol 195:114848. doi: 10.1016/j.bcp.2021.114848. Epub 2021 Nov 18. PMID: 34801523. PMCID: PMC8712417. ]
10. Savy V, Stein P, Shi M, Williams CJ. 2021. Superovulation Does Not Alter Calcium Oscillations Following Fertilization. Front Cell Dev Biol 9:762057. doi: 10.3389/fcell.2021.762057. PMID: 34805168. PMCID: PMC8601230. [ Abstract Savy V, Stein P, Shi M, Williams CJ. 2021. Superovulation Does Not Alter Calcium Oscillations Following Fertilization. Front Cell Dev Biol 9:762057. doi: 10.3389/fcell.2021.762057. PMID: 34805168. PMCID: PMC8601230. ]
11. Grow EJ, Weaver BD, Smith CM, Guo J, Stein P, Shadle SC, Hendrickson PG, Johnson NE, Butterfield RJ, Menafra R, Kloet SL, van der Maarel SM, Williams CJ, Cairns BR. 2021. p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models. Nat Genet 53(8):1207-1220. doi: 10.1038/s41588-021-00893-0. Epub 2021 Jul 15. PMID: 34267371. PMCID: PMC8513633. [ Abstract Grow EJ, Weaver BD, Smith CM, Guo J, Stein P, Shadle SC, Hendrickson PG, Johnson NE, Butterfield RJ, Menafra R, Kloet SL, van der Maarel SM, Williams CJ, Cairns BR. 2021. p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models. Nat Genet 53(8):1207-1220. doi: 10.1038/s41588-021-00893-0. Epub 2021 Jul 15. PMID: 34267371. PMCID: PMC8513633. ]
12. Gambini A, Stein P, Savy V, Grow EJ, Papas BN, Zhang Y, Kenan AC, Padilla-Banks E, Cairns BR, Williams CJ. 2020. Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation. Dev Cell 53(5):545-560.e7. doi: 10.1016/j.devcel.2020.04.018. Epub 2020 May 21. PMID: 32442396. PMCID: PMC7335218. [ Abstract Gambini A, Stein P, Savy V, Grow EJ, Papas BN, Zhang Y, Kenan AC, Padilla-Banks E, Cairns BR, Williams CJ. 2020. Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation. Dev Cell 53(5):545-560.e7. doi: 10.1016/j.devcel.2020.04.018. Epub 2020 May 21. PMID: 32442396. PMCID: PMC7335218. ]
13. Stein P, Savy V, Williams AM, Williams CJ. 2020. Modulators of calcium signalling at fertilization. Open Biol 10(7):200118. doi: 10.1098/rsob.200118. Epub 2020 Jul 15. PMID: 32673518. PMCID: PMC7574550. [ Abstract Stein P, Savy V, Williams AM, Williams CJ. 2020. Modulators of calcium signalling at fertilization. Open Biol 10(7):200118. doi: 10.1098/rsob.200118. Epub 2020 Jul 15. PMID: 32673518. PMCID: PMC7574550. ]
14. Jefferson WN, Padilla-Banks E, Suen AA, Royer LJ, Zeldin SM, Arora R, Williams CJ. 2020. Uterine Patterning, Endometrial Gland Development, and Implantation Failure in Mice Exposed Neonatally to Genistein. Environ Health Perspect 128(3):37001. doi: 10.1289/EHP6336. Epub 2020 Mar 18. PMID: 32186404. PMCID: PMC7138129. [ Abstract Jefferson WN, Padilla-Banks E, Suen AA, Royer LJ, Zeldin SM, Arora R, Williams CJ. 2020. Uterine Patterning, Endometrial Gland Development, and Implantation Failure in Mice Exposed Neonatally to Genistein. Environ Health Perspect 128(3):37001. doi: 10.1289/EHP6336. Epub 2020 Mar 18. PMID: 32186404. PMCID: PMC7138129. ]
15. Bernhardt ML, Stein P, Carvacho I, Krapp C, Ardestani G, Mehregan A, Umbach DM, Bartolomei MS, Fissore RA, Williams CJ. 2018. TRPM7 and CaV3.2 channels mediate Ca2+ influx required for egg activation at fertilization. Proc Natl Acad Sci U S A 115(44):E10370-E10378. doi: 10.1073/pnas.1810422115. Epub 2018 Oct 15. PMID: 30322909. PMCID: PMC6217414. [ Abstract Bernhardt ML, Stein P, Carvacho I, Krapp C, Ardestani G, Mehregan A, Umbach DM, Bartolomei MS, Fissore RA, Williams CJ. 2018. TRPM7 and CaV3.2 channels mediate Ca2+ influx required for egg activation at fertilization. Proc Natl Acad Sci U S A 115(44):E10370-E10378. doi: 10.1073/pnas.1810422115. Epub 2018 Oct 15. PMID: 30322909. PMCID: PMC6217414. ]

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