Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Report on Carcinogens
Bevin Blake, Ph.D. is a Staff Scientist in the Integrative Health Assessments Branch (IHAB) at the National Institute of Environmental Health Sciences with the Report on Carcinogens (RoC) group. She conducts hazard evaluations and provides toxicological expertise for the Report on Carcinogens (RoC), a congressionally mandated report that identifies substances or exposure circumstances that may pose a cancer hazard to human health.
Prior to joining DTT in 2026, Blake worked at the U.S. Environmental Protection Agency (EPA) where she contributed toxicology expertise in both human health risk assessment and research-based roles in the Office of Research and Development and the Office of Water. Blake led research projects evaluating the reproductive and developmental toxicity of per- and polyfluorinated substances (PFAS) and contributed to toxicological assessments on metals, polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and PFAS.
Blake received her Ph.D. in toxicology and environmental medicine from the University of North Carolina at Chapel Hill, where her dissertation research utilized transdisciplinary science to evaluate the human health effects associated with exposure to PFAS, with a focus on gestational exposure and placental toxicity. She went on to receive postdoctoral training at the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) before completing a postdoctoral fellowship at the U.S. EPA where she received human health risk assessment training in the Integrated Risk Information System (IRIS) program. Her current research interests include reproductive and developmental toxicity, developmental origins of health and disease, placental toxicity and placental origins of disease, and the integration of transdisciplinary tools into research and risk assessment, including new approach methodologies.
Recent Publications
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Foley J, Picut C, Chappell V, Miller C, Fenton S, Blake B. Placental Lesions in CD-1 Mouse Placenta Following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX).
Toxicologic pathology.
2026 May 14 [Epub ahead of print].
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AbstractFoley J, Picut C, Chappell V, Miller C, Fenton S, Blake B. Placental Lesions in CD-1 Mouse Placenta Following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX). Toxicologic pathology. 2026 May 14
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Foster C, Wignall J, Kovach S, Choksi N, Allen D, Trgovcich J, Rochester J, Ceger P, Daniel A, Hamm J, Truax J, Blake B, McIntyre B, Sutherland V, Stout M, Kleinstreuer N. Standardizing Extracted Data Using Automated Application of Controlled Vocabularies.
Environmental health perspectives.
2024 Feb;132(2):27006.
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AbstractFoster C, Wignall J, Kovach S, Choksi N, Allen D, Trgovcich J, Rochester J, Ceger P, Daniel A, Hamm J, Truax J, Blake B, McIntyre B, Sutherland V, Stout M, Kleinstreuer N. Standardizing Extracted Data Using Automated Application of Controlled Vocabularies. Environmental health perspectives. 2024 Feb
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Blake B, Rickard B, Fenton S. A High-Throughput Toxicity Screen of 42 Per- and Polyfluoroalkyl Substances (PFAS) and Functional Assessment of Migration and Gene Expression in Human Placental Trophoblast Cells.
Frontiers in toxicology.
2022;4:881347.
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AbstractBlake B, Rickard B, Fenton S. A High-Throughput Toxicity Screen of 42 Per- and Polyfluoroalkyl Substances (PFAS) and Functional Assessment of Migration and Gene Expression in Human Placental Trophoblast Cells. Frontiers in toxicology. 2022
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Blake B, Miller C, Nguyen H, Chappell V, Phan T, Phadke D, Balik-Meisner M, Mav D, Shah R, Fenton S. Transcriptional pathways linked to fetal and maternal hepatic dysfunction caused by gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) in CD-1 mice.
Ecotoxicology and environmental safety.
2022 Dec 15;248:114314.
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AbstractBlake B, Miller C, Nguyen H, Chappell V, Phan T, Phadke D, Balik-Meisner M, Mav D, Shah R, Fenton S. Transcriptional pathways linked to fetal and maternal hepatic dysfunction caused by gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) in CD-1 mice. Ecotoxicology and environmental safety. 2022 Dec 15
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Karmaus A, Mansouri K, To K, Blake B, Fitzpatrick J, Strickland J, Patlewicz G, Allen D, Casey W, Kleinstreuer N. Evaluation of Variability Across Rat Acute Oral Systemic Toxicity Studies.
Toxicological sciences : an official journal of the Society of Toxicology.
2022 Jun 28;188(1):34-47.
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AbstractKarmaus A, Mansouri K, To K, Blake B, Fitzpatrick J, Strickland J, Patlewicz G, Allen D, Casey W, Kleinstreuer N. Evaluation of Variability Across Rat Acute Oral Systemic Toxicity Studies. Toxicological sciences : an official journal of the Society of Toxicology. 2022 Jun 28
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