Many women develop irregular menstrual cycles which may make it difficult to become pregnant and increase the risk of osteoporosis. Why do exercise and diet have this effect in some women but not others? This study will help us understand how nutrition, exercise, and the environment affect women's reproductive cycles.
Participants will track three consecutive menstrual cycles and come in for 9-10 visits on specific days. Participants will undergo two 5-day exercise and diet regimens provided by the study. Procedures include a physical exam, fitness testing, measurement of body fat and bone density, blood sampling, and daily at home blood & urine tests.
- This study is no longer recruiting participants
- Study participants: women, 18–28 years old
- Reported menarche between the ages of 11–14 years
- A history of self-reported regular menstrual cycles when not on contraceptive medication of between 25 and 35 days (inclusive) at prescreen and knowledge of date of onset of menses before the screening visit
- A BMI of 18.5 to 27 kg (Summation)m(2) and a weight >= 93 lbs.
- Agrees to use barrier contraception method for the duration of the study
- Agrees to abstain from alcohol consumption during both 5-day diet/exercise study interventions
- Agrees to abstain from donating blood during the study and within 30 days of completing the study
Janet E. Hall, M.D., M.S.
Clinical Director and Senior Investigator;
Chair - Clinical Advisory Committee (CAC)
P.O. Box 12233Mail Drop A2-03Durham, N.C. 27709
Abbie Smith-Ryan, Ph.D.
Department of Exercise & Sport Science
University of North Carolina at Chapel Hill