Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Mechanistic Toxicology Branch
Ryan Olsen, Ph.D., is a Biologist within the Mechanistic Toxicology Branch (MTB) at the National Institute of Environmental Health Sciences (NIEHS). Working in the laboratory of Eric Tokar, Ph.D., his research is at the forefront of modernizing environmental toxicology and regulatory safety science. His work primarily focuses on the development and implementation of New Approach Methodologies (NAMs) to advance hazard identification and reduce reliance on traditional animal models.
Prior to joining NIEHS in 2026, Olsen was a Lead Research Scientist at QPS, LLC, where he managed preclinical in vitro DMPK study portfolios for small-molecule and oligonucleotide therapeutics. He completed his doctoral work at the University of Nevada, Reno, which included high-impact NIH-funded drug discovery projects for Hepatitis B Virus (HBV) and collaborations with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) on thyroid therapeutics.
Recent Publications
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Christopoulos A, Changeux J, Catterall W, Fabbro D, Burris T, Cidlowski J, Olsen R, Peters J, Neubig R, Pin J, Sexton P, Kenakin T, Ehlert F, Spedding M, Langmead C. International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.
Pharmacological reviews.
2014 Oct;66(4):918-47.
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AbstractChristopoulos A, Changeux J, Catterall W, Fabbro D, Burris T, Cidlowski J, Olsen R, Peters J, Neubig R, Pin J, Sexton P, Kenakin T, Ehlert F, Spedding M, Langmead C. International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands. Pharmacological reviews. 2014 Oct
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