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Department of Health and Human Services (DHHS)
National Institutes of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Intramural Research Division (DIR)
Molecular & Cellular Biology Laboratory
Metabolism, Genes, and Environment Group
Research Triangle Park, North Carolina

Job Description

Postdoctoral Fellow – Metabolic and Epigenetic Regulation of Adaptation to the Environment

Organization

The Division of Intramural Research at the National Institute of Environmental Health Sciences (NIEHS), NIH, is seeking a highly motivated postdoctoral fellow to join an interdisciplinary research program focused on metabolic and epigenetic regulation of cellular functions and animal physiology in response to environmental changes.

About the Position

This position is within the Metabolism, Genes, and Environment Group, with a goal to study how cellular metabolism interacts with epigenetic modification enzymes to mediate environmental influences on cellular functions, and to further investigate how dysregulation of this interplay contributes to pathogenesis of human diseases and aging. The group has two major research directions. The first direction is focused on SIRT1, a highly conserved NAD+-dependent protein deacetylase/deacylase important for epigenetic and transcriptional regulation of gene expression. Utilizing genetically modified mice and cultured cells as model systems, the group combines molecular, cellular, and genetic approaches to study the role of NAD+ metabolism, SIRT1, and protein acetylation/acylation in mediating environmental influence on aging, development, and metabolic diseases. The second direction aims to understand the impact of dietary methionine intervention on cancer and anti-cancer immunity. The ultimate goal of this research is to provide the molecular basis for the development of novel therapeutic targets and dietary interventions for human diseases.

Research Focus

  • Host-microbe interactions in regulation host NAD+ metabolism and associated physiological and pathological processes
  • Host regulation of gut microbiota in intestinal tissue homeostasis, inflammation, and tumorigenesis
  • Metabolic and epigenetic regulation of stem cell function and tumorigenesis

Collaborative Environment

The fellow will be immersed in a collaborative, multidisciplinary environment with exceptional facilities and resources. They will engage in cutting-edge research and receive outstanding professional development that prepares them for independent career.

Qualifications

  • Ph.D., or equivalent in biomedical sciences (e.g., molecular and cell biology, biochemistry, physiology, or related field), preferably within one-year of graduation
  • Strong training in epigenetics, chromatin remodeling, and transcriptional regulation
  • Demonstrated interest in metabolism
  • Background in gastroenterology, particularly gut microbiome and tumorigenesis, is a plus

Application

Email the following documents to Xiaoling Li, Ph.D. 

  • Curriculum vitae or Résumé
  • Contact information for 3 references
  • A short statement (max 2 pages) detailing your research interests and skill set

Contact:  Xiaoling Li, Ph.D. ([email protected])

DO NOT INCLUDE YOUR BIRTHDATE OR SOCIAL SECURITY NUMBER (SSN) ON APPLICATION MATERIALS.
DHHS, NIH, AND NIEHS ARE EQUAL OPPORUNITY EMPLOYERS.
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