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Selected Publications

Mutagenesis & DNA Repair Regulation Group

  1. Swanson RL, Morey NJ, Doetsch PW, Jinks-Robertson SJ. 1999. Overlapping Specificities of Base Excision Repair, Nucleotide Excision Repair, Recombination, and Translesion Synthesis Pathways for DNA Base Damage in Saccharomyces cerevisiae. Mol Cell Biol 19(4):2929-2935. [Abstract Swanson RL, Morey NJ, Doetsch PW, Jinks-Robertson SJ. 1999. Overlapping Specificities of Base Excision Repair, Nucleotide Excision Repair, Recombination, and Translesion Synthesis Pathways for DNA Base Damage in Saccharomyces cerevisiae. Mol Cell Biol 19(4):2929-2935.] 
  2. Viswanathan A, You HJ, Doetsch PW. 1999. Phenotypic Change Caused by Transcriptional Bypass of Uracil in Non-dividing Cells. Science 284(5411):159-162. [Abstract Viswanathan A, You HJ, Doetsch PW. 1999. Phenotypic Change Caused by Transcriptional Bypass of Uracil in Non-dividing Cells. Science 284(5411):159-162.] 
  3. Bregeon D, Doddridge Z, You HJ, Weiss B, Doetsch PW. 2003. Transcriptional Mutagenesis Induced by Uracil and 8-oxoguanine in Escherichia coli. Mol Cell 12(4):959-970. [Abstract Bregeon D, Doddridge Z, You HJ, Weiss B, Doetsch PW. 2003. Transcriptional Mutagenesis Induced by Uracil and 8-oxoguanine in Escherichia coli. Mol Cell 12(4):959-970.] 
  4. Rowe LA, Degtyareva NP, Doetsch PW. 2008. DNA Damage-induced Reactive Oxygen Species (ROS) Stress Response in Saccharomyces cerevisiae. Free Radic Biol Med 45(8):1167-1177. [Abstract Rowe LA, Degtyareva NP, Doetsch PW. 2008. DNA Damage-induced Reactive Oxygen Species (ROS) Stress Response in Saccharomyces cerevisiae. Free Radic Biol Med 45(8):1167-1177.] 
  5. Saxowsky TT, Meadows KL, Klungland A, Doetsch PW. 2008. 8-oxoguanine-mediated Transcriptional Mutagenesis causes Ras Activation in Mammalian Cells. Proc Natl Acad Sci USA 105(48):18877-18882. [Abstract Saxowsky TT, Meadows KL, Klungland A, Doetsch PW. 2008. 8-oxoguanine-mediated Transcriptional Mutagenesis causes Ras Activation in Mammalian Cells. Proc Natl Acad Sci USA 105(48):18877-18882.] 
  6. Degtyareva NP, Heyburn L, Sterling J, Resnick MA, Gordenin DA, Doetsch PW. 2013. Oxidative Stress-Induced Mutagenesis in Single-Strand DNA Occurs Primarily at Cytosines and is DNA Polymerase Zeta-Dependent Only for Adenines and Guanines. Nucleic Acids Res 41(19):8995-9005. [Abstract Degtyareva NP, Heyburn L, Sterling J, Resnick MA, Gordenin DA, Doetsch PW. 2013. Oxidative Stress-Induced Mutagenesis in Single-Strand DNA Occurs Primarily at Cytosines and is DNA Polymerase Zeta-Dependent Only for Adenines and Guanines. Nucleic Acids Res 41(19):8995-9005.] 
  7. Marullo R, Werner E, Degtyareva N, Moore B, Altavilla G, Ramalingam SS, Doetsch PW. 2013. Cisplatin Induces a Mitochondrial-ROS Response that Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions [Abstract Marullo R, Werner E, Degtyareva N, Moore B, Altavilla G, Ramalingam SS, Doetsch PW. 2013. Cisplatin Induces a Mitochondrial-ROS Response that Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions]Limpose KL, Trego K, Li Z, Leung SW, Sarkar A, Shah JA, Ramalingam SS, Werner EM, Dynan W, Cooper PK, Corbett AH, Doetsch PW. 2018. Overexpression of the Base Excision Repair NTHL1 Glycosylase Causes Genomic Instability and Early Cellular Hallmarks of Cancer. Nucleic Acids Res 46(9):4515-4532. [Abstract Limpose KL, Trego K, Li Z, Leung SW, Sarkar A, Shah JA, Ramalingam SS, Werner EM, Dynan W, Cooper PK, Corbett AH, Doetsch PW. 2018. Overexpression of the Base Excision Repair NTHL1 Glycosylase Causes Genomic Instability and Early Cellular Hallmarks of Cancer. Nucleic Acids Res 46(9):4515-4532.]  
  8. Morreall J, Kim A, Liu Y, Degtyareva N, Weiss B, Doetsch PW. 2015. Evidence for Retromutagenesis as a Mechanism for Adaptive Mutation in Escherichia coli. PLoS Genet 11(8):e1005477. [Abstract Morreall J, Kim A, Liu Y, Degtyareva N, Weiss B, Doetsch PW. 2015. Evidence for Retromutagenesis as a Mechanism for Adaptive Mutation in Escherichia coli. PLoS Genet 11(8):e1005477.] 
  9. Chen G, Magis AT, Xu K, Park D, Yu DS, Owonikoko TK, Sica GL, Ramalingam SS, Curran WJ, Doetsch PW, Deng X. 2018. Targeting Mcl-1 to Enhance DNA Replication Stress Sensitivity for Cancer Therapy. J Clin Invest 128(1):500-516. [Abstract Chen G, Magis AT, Xu K, Park D, Yu DS, Owonikoko TK, Sica GL, Ramalingam SS, Curran WJ, Doetsch PW, Deng X. 2018. Targeting Mcl-1 to Enhance DNA Replication Stress Sensitivity for Cancer Therapy. J Clin Invest 128(1):500-516.] 
  10. Limpose KL, Trego K, Li Z, Leung SW, Sarkar A, Shah JA, Ramalingam SS, Werner EM, Dynan W, Cooper PK, Corbett AH, Doetsch PW. 2018. Overexpression of the Base Excision Repair NTHL1 Glycosylase Causes Genomic Instability and Early Cellular Hallmarks of Cancer. Nucleic Acids Res 46(9):4515-4532. [Abstract Limpose KL, Trego K, Li Z, Leung SW, Sarkar A, Shah JA, Ramalingam SS, Werner EM, Dynan W, Cooper PK, Corbett AH, Doetsch PW. 2018. Overexpression of the Base Excision Repair NTHL1 Glycosylase Causes Genomic Instability and Early Cellular Hallmarks of Cancer. Nucleic Acids Res 46(9):4515-4532.]
  11. Degtyareva N, Saini N, Sterling JF, Placentra VC, Klimczak LJ, Gordenin DA, Doetsch PW. 2019. Mutational Signatures of Redox Stress in Yeast Single-strand DNA and of Aging in Human Mitochondrial DNA Share a Common Feature. PLoS Biology 17(5):-. [Abstract Degtyareva N, Saini N, Sterling JF, Placentra VC, Klimczak LJ, Gordenin DA, Doetsch PW. 2019. Mutational Signatures of Redox Stress in Yeast Single-strand DNA and of Aging in Human Mitochondrial DNA Share a Common Feature. PLoS Biology 17(5):-.]
  12. Chen G, Luo Y, Warncke K, Sun Y, Yu DS, Fu H, Behera M, Ramalingam SS, Doetsch PW, Duong DM, Lammers M, Curran WJ, Deng X. 2019. Acetylation Regulates Ribonucleotide Reductase Activity and Cancer Cell Growth. Nature Communications 10(1):3213. [Abstract Chen G, Luo Y, Warncke K, Sun Y, Yu DS, Fu H, Behera M, Ramalingam SS, Doetsch PW, Duong DM, Lammers M, Curran WJ, Deng X. 2019. Acetylation Regulates Ribonucleotide Reductase Activity and Cancer Cell Growth. Nature Communications 10(1):3213.]
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