Chief, Biostatistics & Computational Biology Branch and Principal Investigator
Deputy Chief, Biostatistics & Computational Biology Branch and Principal Investigator
Research Summary The Biostatistics and Computational Biology Branch carries out basic and applied research dealing with statistical issues of relevance to environmental health. The branch's members develop new methodologies and apply existing techniques in novel ways to address environmental health problems. Members of the branch also advise institute scientists on computational, study design, database and statistical issues via both long-term and short-term collaboration in research projects throughout NIEHS. The branch also offers training at regular intervals.
Research in the Biostatistics and Computational Biology Branch focuses on several areas:
Design and analysis of laboratory animal toxicology/carcinogenicity experiments and development of improved statistical methods Application and development of methodology for epidemiological and clinical human studies Application and development of new bioinformatics techniques for harvesting information from high-dimensional genomic, gene expression and proteomic data Development of new design and analysis approaches in statistical genetics Development of broadly applicable statistical approaches
Biostatistics & Computational Biology Branch Software
See
Software to access the data or computer instructions developed by members of the NIEHS Biostatistics & Computational Biology Branch.
Recent Publications
Hill B, Karmaus A, Hull V, Unnikrishnan A, Kleinstreuer N, Hogberg H. Enhancing toxicological interpretation and reporting of in vitro high-throughput screening data.
Frontiers in toxicology .
2026;8:1886801.
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AbstractHill B, Karmaus A, Hull V, Unnikrishnan A, Kleinstreuer N, Hogberg H. Enhancing toxicological interpretation and reporting of in vitro high-throughput screening data. Frontiers in toxicology. 2026
]
Angarita-Rodríguez A, Vargas-López V, Pinzón A, Sandoval-Hernandez A, Kang K, Li L, Papin J, Puentes-Rozo P, Felipe Aristizábal A, González J. Correction: Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer's disease progression.
Frontiers in bioinformatics .
2026;6:1953979.
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AbstractAngarita-Rodríguez A, Vargas-López V, Pinzón A, Sandoval-Hernandez A, Kang K, Li L, Papin J, Puentes-Rozo P, Felipe Aristizábal A, González J. Correction: Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer's disease progression. Frontiers in bioinformatics. 2026
]
Hasan M, Umbach D, Shi M, Gu C, Yeung D, Talukder A, Fan Z, Li L. Seasonal variation in sleep apnea and other sleep parameters from diagnostic polysomnography data, 2003-2024.
Communications health .
2026;1(1):15.
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AbstractHasan M, Umbach D, Shi M, Gu C, Yeung D, Talukder A, Fan Z, Li L. Seasonal variation in sleep apnea and other sleep parameters from diagnostic polysomnography data, 2003-2024. Communications health. 2026
]
Sauty S, Hsiao Y, Klimczak L, Gordenin D. Motif-centered analyses reveal universal and tissue-specific mutagenic mechanisms operating in the human body.
NAR cancer .
2026 Sep;8(3):zcag024.
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AbstractSauty S, Hsiao Y, Klimczak L, Gordenin D. Motif-centered analyses reveal universal and tissue-specific mutagenic mechanisms operating in the human body. NAR cancer. 2026 Sep
]
Cosey T, Leighton G, De Diavoukana E, Shi M, Foo A, Pomés A, Nesbit J, Gipson S, Creeks P, Zhang J, Peebles R, Maleki S, Croote D, Smith S, Mueller G. Human IgE Antibodies Recognize the Vicilin and Alpha-Hairpinin Domains of Peanut Allergen Ara h 1.
Allergy .
2026 Aug 27 [Epub ahead of print].
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AbstractCosey T, Leighton G, De Diavoukana E, Shi M, Foo A, Pomés A, Nesbit J, Gipson S, Creeks P, Zhang J, Peebles R, Maleki S, Croote D, Smith S, Mueller G. Human IgE Antibodies Recognize the Vicilin and Alpha-Hairpinin Domains of Peanut Allergen Ara h 1. Allergy. 2026 Aug 27
]
Principal Investigators Applied Statistics
Deputy Chief, Biostatistics & Computational Biology Branch and Principal Investigator
Bioinformatics
Integrative Bioinformatics Support
Director, Integrative Bioinformatics Support Group
Statistical Methods and Applications in Epidemiology
Publications
Recent Publications
Li L, Huang H, Wang H, Pan Y, Tao H, Zhang S, Karmaus P, Fessler M, Sleasman J, Zhong X. DGKα and ζ deficiency causes regulatory T-cell dysregulation, destabilization, and conversion to pathogenic T-follicular helper cells to trigger IgG1-predominant autoimmunity.
eLife .
2026 Sep 18;14:.
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AbstractLi L, Huang H, Wang H, Pan Y, Tao H, Zhang S, Karmaus P, Fessler M, Sleasman J, Zhong X. DGKα and ζ deficiency causes regulatory T-cell dysregulation, destabilization, and conversion to pathogenic T-follicular helper cells to trigger IgG1-predominant autoimmunity. eLife. 2026 Sep 18
]
Zhou X, Bird G, Yu M, Li J, Solone X, Chung M, Guan J, Walensky L, Wu L. Targeting LKB1-inactivated lung cancers with a stapled peptide inhibitor of the CRTC-CREB pathway.
Molecular therapy. Oncology .
2026 Sep 17;34(3):201331.
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AbstractZhou X, Bird G, Yu M, Li J, Solone X, Chung M, Guan J, Walensky L, Wu L. Targeting LKB1-inactivated lung cancers with a stapled peptide inhibitor of the CRTC-CREB pathway. Molecular therapy. Oncology. 2026 Sep 17
]
Horton M, Johnson D, Overdahl K, Nititham J, Taylor K, Katz P, Chun J, Yazdany J, Dall'Era M, Barcellos L, Li J, Jarmusch A, Criswell L, Lanata C. Integrated metabolomics and DNA methylation signatures and their association with flare remission in SLE.
Lupus science & medicine .
2026 Sep 12;13(2):.
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AbstractHorton M, Johnson D, Overdahl K, Nititham J, Taylor K, Katz P, Chun J, Yazdany J, Dall'Era M, Barcellos L, Li J, Jarmusch A, Criswell L, Lanata C. Integrated metabolomics and DNA methylation signatures and their association with flare remission in SLE. Lupus science & medicine. 2026 Sep 12
]
Li J, Chen C, Zhou Y, Li C, Zhang W, Liu Q, Liang Y, Fang J, Wang Y, Wang J, Mao C, Shi X. [Joint effects of short term exposure to heat and ozone on circulatory disease mortality in Beijing-Tianjin-Hebei region and surrounding areas].
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi .
2026 Sep 10;47(9):1576-1583.
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AbstractLi J, Chen C, Zhou Y, Li C, Zhang W, Liu Q, Liang Y, Fang J, Wang Y, Wang J, Mao C, Shi X. [Joint effects of short term exposure to heat and ozone on circulatory disease mortality in Beijing-Tianjin-Hebei region and surrounding areas]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi. 2026 Sep 10
]
Liu Q, Chen C, Fang J, Zhang W, Li J, Li C, Wang J, Wang Y, Shi X. [Association of exposure to fine particulate matter and its components with frailty in middle-aged and older adults in Beijing-Tianjin-Hebei region and surrounding areas].
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi .
2026 Sep 10;47(9):1569-1575.
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AbstractLiu Q, Chen C, Fang J, Zhang W, Li J, Li C, Wang J, Wang Y, Shi X. [Association of exposure to fine particulate matter and its components with frailty in middle-aged and older adults in Beijing-Tianjin-Hebei region and surrounding areas]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi. 2026 Sep 10
]
