Children’s Environmental Health Clinic (ChEHC) WHO CC in CEH Department of Pediatrics, University of Alberta Canada

Network of WHO Collaborating Centres for Children’s Environmental Health

The Children’s Environmental Health Clinic (ChEHC) WHO CC in CEH Department of Pediatrics, University of Alberta Canada addresses the impacts of environmental exposures (chemical, biological, physical and social) on children’s health. Our interdisciplinary team addresses clinical concerns by integrating clinical, research and educational components. ChEHC synthesizes existing knowledge and collects new data to be used in patient care, education as well as advancement of CHE in the global community.

Centre Contacts	Lesley Brennan, Ph.D., M.P.H. Children’s Environmental Health Clinic (ChEHC); Department of Pediatrics, University of Alberta Tel 780-735-2443 Lesley.Brennan@covenanthealth.ca
Mail Address	Child Health Clinic Mother Rosalie Health Services Centre 231-16930 87 Avenue NW Edmonton AB T5R 4H5
Website Links	https://sites.google.com/ualberta.ca/chehc
Collaborators	Pediatric Environmental Health Specialty Units Health Canada Department of Environmental and Occupational Health Rutgers School of Public Health Environmental Health Sciences, University of Michigan, School of Public Health Universidad Nacional Autónoma de México, México Universidad Industrial de Santander, Colombia Colectivo Ecologista de Jalisco, México Canadian Partnership for Children's Health & Environment
Chemicals/Exposures Studied	Air pollutants, metals and other chemicals, mold, allergens
Health or Social Effects Studied	Respiratory diseases, cancers, cognitive/neurodevelopmental effects, prenatal impacts and birth outcomes, socioeconomic status
Population(s) Studied	Children

Publications

2017

• Nielsen CC, Amrhein CG, Osornio-Vargas AR, the DoMiNO Team. Mapping outdoor habitat and abnormally small newborns to develop an ambient health hazard index. International Journal of Health Geographics, 2017 Nov 28;16(1):43. doi: 10.1186/s12942-017-0117-5. [Abstract Nielsen CC, Amrhein CG, Osornio-Vargas AR, the DoMiNO Team. Mapping outdoor habitat and abnormally small newborns to develop an ambient health hazard index. International Journal of Health Geographics, 2017 Nov 28;16(1):43. doi: 10.1186/s12942-017-0117-5.] [Full Text Nielsen CC, Amrhein CG, Osornio-Vargas AR, the DoMiNO Team. Mapping outdoor habitat and abnormally small newborns to develop an ambient health hazard index. International Journal of Health Geographics, 2017 Nov 28;16(1):43. doi: 10.1186/s12942-017-0117-5.]
• Bellinger C, Mohomed Jabbar MS, Zaïane O, Osornio-Vargas A. A systematic review of data mining and machine learning for air pollution epidemiology. BMC Public Health, 2017 Nov 28;17(1):907. doi: 10.1186/s12889-017-4914-3. [Abstract Bellinger C, Mohomed Jabbar MS, Zaïane O, Osornio-Vargas A. A systematic review of data mining and machine learning for air pollution epidemiology. BMC Public Health, 2017 Nov 28;17(1):907. doi: 10.1186/s12889-017-4914-3.] [Full Text Bellinger C, Mohomed Jabbar MS, Zaïane O, Osornio-Vargas A. A systematic review of data mining and machine learning for air pollution epidemiology. BMC Public Health, 2017 Nov 28;17(1):907. doi: 10.1186/s12889-017-4914-3.]
• Santibáñez-Andrade M, Quezada-Maldonado EM, Osornio-Vargas Á, Sánchez-Pérez Y, García-Cuellar C. Air pollution and genomic instability: The role of particulate matter in lung carcinogens. Environmental Pollution, 2017 Oct;229:412-422. doi: 10.1016/j.envpol.2017.06.019. Epub 2017 Jun 13. [Abstract Santibáñez-Andrade M, Quezada-Maldonado EM, Osornio-Vargas Á, Sánchez-Pérez Y, García-Cuellar C. Air pollution and genomic instability: The role of particulate matter in lung carcinogens. Environmental Pollution, 2017 Oct;229:412-422. doi: 10.1016/j.envpol.2017.06.019. Epub 2017 Jun 13.] [Full Text Santibáñez-Andrade M, Quezada-Maldonado EM, Osornio-Vargas Á, Sánchez-Pérez Y, García-Cuellar C. Air pollution and genomic instability: The role of particulate matter in lung carcinogens. Environmental Pollution, 2017 Oct;229:412-422. doi: 10.1016/j.envpol.2017.06.019. Epub 2017 Jun 13.]
• Falcon-Rodriguez CI, De Vizcaya-Ruiz A, Rosas-Pérez IA, Osornio-Vargas ÁR, Segura-Medina P. Inhalation of concentrated PM2.5 from Mexico City acts as an adjuvant in a guinea pig model of allergic asthma. Environmental Pollution, 2017 Sep;228:474-483. doi: 10.1016/j.envpol.2017.05.050. Epub 2017 May 29. [Abstract Falcon-Rodriguez CI, De Vizcaya-Ruiz A, Rosas-Pérez IA, Osornio-Vargas ÁR, Segura-Medina P. Inhalation of concentrated PM2.5 from Mexico City acts as an adjuvant in a guinea pig model of allergic asthma. Environmental Pollution, 2017 Sep;228:474-483. doi: 10.1016/j.envpol.2017.05.050. Epub 2017 May 29.] [Full Text Falcon-Rodriguez CI, De Vizcaya-Ruiz A, Rosas-Pérez IA, Osornio-Vargas ÁR, Segura-Medina P. Inhalation of concentrated PM2.5 from Mexico City acts as an adjuvant in a guinea pig model of allergic asthma. Environmental Pollution, 2017 Sep;228:474-483. doi: 10.1016/j.envpol.2017.05.050. Epub 2017 May 29.]
• Chirino YI, García-Cuellar CM, García-García C, Soto-Reyes E, Osornio-Vargas ÁR, Herrera LA, López-Saavedra A, Miranda J, Quintana-Belmares R, Pérez IR, Sánchez-Pérez Y. Airborne particulate matter in vitro exposure induces cytoskeleton remodeling through activation of the ROCK-MYPT1-MLC pathway in A549 epithelial lung cells. Toxicology Letters, 2017 Apr 15;272:29-37. doi: 10.1016/j.toxlet.2017.03.002. Epub 2017 Mar 6. [Abstract Chirino YI, García-Cuellar CM, García-García C, Soto-Reyes E, Osornio-Vargas ÁR, Herrera LA, López-Saavedra A, Miranda J, Quintana-Belmares R, Pérez IR, Sánchez-Pérez Y. Airborne particulate matter in vitro exposure induces cytoskeleton remodeling through activation of the ROCK-MYPT1-MLC pathway in A549 epithelial lung cells. Toxicology Letters, 2017 Apr 15;272:29-37. doi: 10.1016/j.toxlet.2017.03.002. Epub 2017 Mar 6.] [Full Text Chirino YI, García-Cuellar CM, García-García C, Soto-Reyes E, Osornio-Vargas ÁR, Herrera LA, López-Saavedra A, Miranda J, Quintana-Belmares R, Pérez IR, Sánchez-Pérez Y. Airborne particulate matter in vitro exposure induces cytoskeleton remodeling through activation of the ROCK-MYPT1-MLC pathway in A549 epithelial lung cells. Toxicology Letters, 2017 Apr 15;272:29-37. doi: 10.1016/j.toxlet.2017.03.002. Epub 2017 Mar 6.]

2016

• Weinstangel H, Buka I, Campbell S. 2016. Environmental pediatrics: an introduction and evaluation of online resources. Reviews on Environmental Health, 2016 Dec 1;31(4):435-446. doi: 10.1515/reveh-2016-0019 [Abstract Weinstangel H, Buka I, Campbell S. 2016. Environmental pediatrics: an introduction and evaluation of online resources. Reviews on Environmental Health, 2016 Dec 1;31(4):435-446. doi: 10.1515/reveh-2016-0019] [Full Text Weinstangel H, Buka I, Campbell S. 2016. Environmental pediatrics: an introduction and evaluation of online resources. Reviews on Environmental Health, 2016 Dec 1;31(4):435-446. doi: 10.1515/reveh-2016-0019] 
• Heacock M, Kelly CB, Asante KA, Birnbaum LS, Bergman ÅL, Bruné MN, Buka I, Carpenter DO, Chen A, Huo X, Kamel M, Landrigan PJ, Magalini F, Diaz-Barriga F, Neira M, Omar M, Pascale A, Ruchirawat M, Sly L, Sly PD, Van den Berg M, Suk WA. 2016. E-Waste and Harm to Vulnerable Populations: A Growing Global Problem. Environ Health Perspect 124(5):550-5 [Abstract Heacock M, Kelly CB, Asante KA, Birnbaum LS, Bergman ÅL, Bruné MN, Buka I, Carpenter DO, Chen A, Huo X, Kamel M, Landrigan PJ, Magalini F, Diaz-Barriga F, Neira M, Omar M, Pascale A, Ruchirawat M, Sly L, Sly PD, Van den Berg M, Suk WA. 2016. E-Waste and Harm to Vulnerable Populations: A Growing Global Problem. Environ Health Perspect 124(5):550-5] 
• Rodríguez-Villamizar LA, Berney C, Villa-Roel C, Ospina MB, Osornio-Vargas A, Rowe BH. The role of socioeconomic position as an effect-modifier of the association between outdoor air pollution and children's asthma exacerbations: an equity-focused systematic review. Reviews on Environmental Health, 2016 Sep 1;31(3):297-309. doi: 10.1515/reveh-2016-0005 [Abstract Rodríguez-Villamizar LA, Berney C, Villa-Roel C, Ospina MB, Osornio-Vargas A, Rowe BH. The role of socioeconomic position as an effect-modifier of the association between outdoor air pollution and children's asthma exacerbations: an equity-focused systematic review. Reviews on Environmental Health, 2016 Sep 1;31(3):297-309. doi: 10.1515/reveh-2016-0005] [Full Text Rodríguez-Villamizar LA, Berney C, Villa-Roel C, Ospina MB, Osornio-Vargas A, Rowe BH. The role of socioeconomic position as an effect-modifier of the association between outdoor air pollution and children's asthma exacerbations: an equity-focused systematic review. Reviews on Environmental Health, 2016 Sep 1;31(3):297-309. doi: 10.1515/reveh-2016-0005] 
• Reyes-Zárate E, Sánchez-Pérez Y, Gutiérrez-Ruiz MC, Chirino YI, Osornio-Vargas ÁR, Morales-Bárcenas R, Souza-Arroyo V, García-Cuellar CM. Atmospheric particulate matter (PM10) exposure-induced cell cycle arrest and apoptosis evasion through STAT3 activation via PKCζ and Src kinases in lung cells. Environmental Pollution, 2016 Jul;214:646-656. doi: 10.1016/j.envpol.2016.04.072. Epub 2016 Apr 29. [Abstract Reyes-Zárate E, Sánchez-Pérez Y, Gutiérrez-Ruiz MC, Chirino YI, Osornio-Vargas ÁR, Morales-Bárcenas R, Souza-Arroyo V, García-Cuellar CM. Atmospheric particulate matter (PM10) exposure-induced cell cycle arrest and apoptosis evasion through STAT3 activation via PKCζ and Src kinases in lung cells. Environmental Pollution, 2016 Jul;214:646-656. doi: 10.1016/j.envpol.2016.04.072. Epub 2016 Apr 29.] [Full Text Reyes-Zárate E, Sánchez-Pérez Y, Gutiérrez-Ruiz MC, Chirino YI, Osornio-Vargas ÁR, Morales-Bárcenas R, Souza-Arroyo V, García-Cuellar CM. Atmospheric particulate matter (PM10) exposure-induced cell cycle arrest and apoptosis evasion through STAT3 activation via PKCζ and Src kinases in lung cells. Environmental Pollution, 2016 Jul;214:646-656. doi: 10.1016/j.envpol.2016.04.072. Epub 2016 Apr 29.] 
• Manzano-León N, Serrano-Lomelin J, Sánchez BN, Quintana-Belmares R, Vega E, Vázquez-López I, Rojas-Bracho L, López-Villegas MT, Vadillo-Ortega F, De Vizcaya-Ruiz A, Rosas Perez I, O’Neill MS, Osornio-Vargas AR. TNFα and IL-6 responses to particulate matter in vitro: variation according to PM size, season, and polycyclic aromatic hydrocarbon and soil content. Environmental Health Perspectives, 2016 Apr;124(4):406-12. doi: 10.1289/ehp.1409287. Epub 2015 Sep 15 [Abstract Manzano-León N, Serrano-Lomelin J, Sánchez BN, Quintana-Belmares R, Vega E, Vázquez-López I, Rojas-Bracho L, López-Villegas MT, Vadillo-Ortega F, De Vizcaya-Ruiz A, Rosas Perez I, O’Neill MS, Osornio-Vargas AR. TNFα and IL-6 responses to particulate matter in vitro: variation according to PM size, season, and polycyclic aromatic hydrocarbon and soil content. Environmental Health Perspectives, 2016 Apr;124(4):406-12. doi: 10.1289/ehp.1409287. Epub 2015 Sep 15] [Full Text Manzano-León N, Serrano-Lomelin J, Sánchez BN, Quintana-Belmares R, Vega E, Vázquez-López I, Rojas-Bracho L, López-Villegas MT, Vadillo-Ortega F, De Vizcaya-Ruiz A, Rosas Perez I, O’Neill MS, Osornio-Vargas AR. TNFα and IL-6 responses to particulate matter in vitro: variation according to PM size, season, and polycyclic aromatic hydrocarbon and soil content. Environmental Health Perspectives, 2016 Apr;124(4):406-12. doi: 10.1289/ehp.1409287. Epub 2015 Sep 15] 

2015

• Chirino YL, Sánchez-Pérez Y, Román Osornio-Vargas A, Rosas I, and García-Cuellar CM. Sampling and composition of airborne particulate matter (PM10) from two locations of Mexico City. Data Brief, 2015 Jul 2;4:353-6. doi: 10.1016/j.dib.2015.06.017. eCollection 2015 Sep. [Abstract Chirino YL, Sánchez-Pérez Y, Román Osornio-Vargas A, Rosas I, and García-Cuellar CM. Sampling and composition of airborne particulate matter (PM10) from two locations of Mexico City. Data Brief, 2015 Jul 2;4:353-6. doi: 10.1016/j.dib.2015.06.017. eCollection 2015 Sep.] [Full Text Chirino YL, Sánchez-Pérez Y, Román Osornio-Vargas A, Rosas I, and García-Cuellar CM. Sampling and composition of airborne particulate matter (PM10) from two locations of Mexico City. Data Brief, 2015 Jul 2;4:353-6. doi: 10.1016/j.dib.2015.06.017. eCollection 2015 Sep.] 
• Chan E, Serrano J, Chen L, Stieb DM, Jerrett M, and Osornio Vargas A. Development of a Canadian socioeconomic status index for the study of health outcomes related to environmental pollution. BMC Public Health, 2015 Jul 28;15:714. doi: 10.1186/s12889-015-1992-y. [Abstract Chan E, Serrano J, Chen L, Stieb DM, Jerrett M, and Osornio Vargas A. Development of a Canadian socioeconomic status index for the study of health outcomes related to environmental pollution. BMC Public Health, 2015 Jul 28;15:714. doi: 10.1186/s12889-015-1992-y.] [Full Text Chan E, Serrano J, Chen L, Stieb DM, Jerrett M, and Osornio Vargas A. Development of a Canadian socioeconomic status index for the study of health outcomes related to environmental pollution. BMC Public Health, 2015 Jul 28;15:714. doi: 10.1186/s12889-015-1992-y.] 
• Morales-Bárcenas R, Chirino YI, Sánchez-Pérez Y, Osornio-Vargas ÁR, Melendez-Zajgla J, Rosas I, García-Cuellar CM. Particulate matter (PM₁₀) induces metalloprotease activity and invasion in airway epithelial cells. Toxicology Letters, 2015 Sep 17;237(3):167-73. doi: 10.1016/j.toxlet.2015.06.001. Epub 2015 Jun 3. [Abstract Morales-Bárcenas R, Chirino YI, Sánchez-Pérez Y, Osornio-Vargas ÁR, Melendez-Zajgla J, Rosas I, García-Cuellar CM. Particulate matter (PM₁₀) induces metalloprotease activity and invasion in airway epithelial cells. Toxicology Letters, 2015 Sep 17;237(3):167-73. doi: 10.1016/j.toxlet.2015.06.001. Epub 2015 Jun 3.] [Full Text Morales-Bárcenas R, Chirino YI, Sánchez-Pérez Y, Osornio-Vargas ÁR, Melendez-Zajgla J, Rosas I, García-Cuellar CM. Particulate matter (PM₁₀) induces metalloprotease activity and invasion in airway epithelial cells. Toxicology Letters, 2015 Sep 17;237(3):167-73. doi: 10.1016/j.toxlet.2015.06.001. Epub 2015 Jun 3.] 
• Rodriguez-Villamizar LA, Magico A, Osornio-Vargas A, Rowe BH. The effects of outdoor air pollution on the respiratory health of Canadian children: A systematic review of epidemiological studies. Canadian Respiratory Journal: Journal of the Canadian Thoracic Society, 2015 Sep-Oct;22(5):282-92. Epub 2015 May 11. [Abstract Rodriguez-Villamizar LA, Magico A, Osornio-Vargas A, Rowe BH. The effects of outdoor air pollution on the respiratory health of Canadian children: A systematic review of epidemiological studies. Canadian Respiratory Journal: Journal of the Canadian Thoracic Society, 2015 Sep-Oct;22(5):282-92. Epub 2015 May 11.] [Full Text Rodriguez-Villamizar LA, Magico A, Osornio-Vargas A, Rowe BH. The effects of outdoor air pollution on the respiratory health of Canadian children: A systematic review of epidemiological studies. Canadian Respiratory Journal: Journal of the Canadian Thoracic Society, 2015 Sep-Oct;22(5):282-92. Epub 2015 May 11.] 
• Rivera-González LO, Zhang Z, Sánchez BN, Zhang K, Brown DG, Rojas-Bracho L, Osornio-Vargas A, Vadillo-Ortega F, O’Neill M. An Assessment of Air Pollutant Exposure Methods in Mexico City, Mexico. Journal of the Air & Waste Management Association, 2015 May;65(5):581-91. doi: 10.1080/10962247.2015.1020974. [Abstract Rivera-González LO, Zhang Z, Sánchez BN, Zhang K, Brown DG, Rojas-Bracho L, Osornio-Vargas A, Vadillo-Ortega F, O’Neill M. An Assessment of Air Pollutant Exposure Methods in Mexico City, Mexico. Journal of the Air & Waste Management Association, 2015 May;65(5):581-91. doi: 10.1080/10962247.2015.1020974.] [Full Text Rivera-González LO, Zhang Z, Sánchez BN, Zhang K, Brown DG, Rojas-Bracho L, Osornio-Vargas A, Vadillo-Ortega F, O’Neill M. An Assessment of Air Pollutant Exposure Methods in Mexico City, Mexico. Journal of the Air & Waste Management Association, 2015 May;65(5):581-91. doi: 10.1080/10962247.2015.1020974.] 
• Salcido-Neyoy ME, Sánchez-Pérez Y, Osornio-Vargas AR, Gonsebatt ME, Meléndez-Zajgla J, Morales-Bárcenas R, Petrosyan P, Molina-Servin ED, Vega E, Manzano-León N, García-Cuellar CM. Induction of c-Jun by air particulate matter (PM₁₀) of Mexico City: Participation of polycyclic aromatic hydrocarbons. Environmental Pollution, 2015 Aug;203:175-82. doi: 10.1016/j.envpol.2015.03.051. Epub 2015 Apr 20. [Abstract Salcido-Neyoy ME, Sánchez-Pérez Y, Osornio-Vargas AR, Gonsebatt ME, Meléndez-Zajgla J, Morales-Bárcenas R, Petrosyan P, Molina-Servin ED, Vega E, Manzano-León N, García-Cuellar CM. Induction of c-Jun by air particulate matter (PM₁₀) of Mexico City: Participation of polycyclic aromatic hydrocarbons. Environmental Pollution, 2015 Aug;203:175-82. doi: 10.1016/j.envpol.2015.03.051. Epub 2015 Apr 20.] [Full Text Salcido-Neyoy ME, Sánchez-Pérez Y, Osornio-Vargas AR, Gonsebatt ME, Meléndez-Zajgla J, Morales-Bárcenas R, Petrosyan P, Molina-Servin ED, Vega E, Manzano-León N, García-Cuellar CM. Induction of c-Jun by air particulate matter (PM₁₀) of Mexico City: Participation of polycyclic aromatic hydrocarbons. Environmental Pollution, 2015 Aug;203:175-82. doi: 10.1016/j.envpol.2015.03.051. Epub 2015 Apr 20.] 
• Rivas-Santiago CE, Sarkar S, Cantarella P, Osornio-Vargas Á, Quintana-Belmares R, Meng Q, Kirn TJ, Ohman Strickland P, Chow JC, Watson JG, Torres M, Schwander S. Air Pollution Particulate Matter Alters Antimycobacterial Respiratory Epithelium Innate Immunity. Infection and Immunity, 2015 Jun;83(6):2507-17. doi: 10.1128/IAI.03018-14. Epub 2015 Apr 6. [Abstract Rivas-Santiago CE, Sarkar S, Cantarella P, Osornio-Vargas Á, Quintana-Belmares R, Meng Q, Kirn TJ, Ohman Strickland P, Chow JC, Watson JG, Torres M, Schwander S. Air Pollution Particulate Matter Alters Antimycobacterial Respiratory Epithelium Innate Immunity. Infection and Immunity, 2015 Jun;83(6):2507-17. doi: 10.1128/IAI.03018-14. Epub 2015 Apr 6.] [Full Text Rivas-Santiago CE, Sarkar S, Cantarella P, Osornio-Vargas Á, Quintana-Belmares R, Meng Q, Kirn TJ, Ohman Strickland P, Chow JC, Watson JG, Torres M, Schwander S. Air Pollution Particulate Matter Alters Antimycobacterial Respiratory Epithelium Innate Immunity. Infection and Immunity, 2015 Jun;83(6):2507-17. doi: 10.1128/IAI.03018-14. Epub 2015 Apr 6.]