The NIH intramural research program has shifted all non-mission-critical laboratory operations to a maintenance phase in order to promote physical distancing and diminished transmission risk of COVID-19. Effective Monday, March 23, 2020, only mission-critical functions within NIH research laboratories will be supported.
The following NIEHS facilities provide state-of-the-art equipment and expertise, which support in-house (intramural) research activities at the institute. These shared and core services are available to NIH employees only.
Clinical Research Branch
The Clinical Research Branch provides the following service functions to NIEHS scientists.
- Clinical Research Unit (CRU)
Under the guidance of Medical Director Stavros Garantziotis, M.D., the core permits NIEHS scientists to conduct on-site studies on how the environment affects human health and disease. The CRU is situated adjacent to NIEHS building 101.
- Office of Human Research Compliance (OHRC)
OHRC Director Joan Packenham, Ph.D., and her staff protect human volunteers participating in NIEHS clinical research. The office is located in CRU-110.
Epigenetics and Stem Cell Biology Laboratory
The Epigenetics and Stem Cell Biology Laboratory provides the following service functions to NIEHS scientists.
- Epigenomics and DNA Sequencing Core Facility
Led by Guang Hu, Ph.D., and Gregory Solomon, the core provides NextGen Sequencing (NGS) and Sanger Sequencing services. It helps NIEHS researchers develop DNA constructs for gene expression, primer design, and perform data analysis. Core staff members also provide training on a variety of molecular biology-related topics.
- Integrative Bioinformatics Support Group
Led by Jianliang Li, Ph.D., the group promotes and develops bioinformatics tools and resources that empower NIEHS research. It is located in Room A-037.
- Mass Spectrometry Research and Support Group
Led by Leesa Deterding, Ph.D., and Jason Williams, Ph.D., the group specializes in a large number of mass spectrometry approaches, including qualitative and quantitative analyses. It is located in F-008.
Genome Integrity and Structural Biology Laboratory
The Genome Integrity and Structural Biology Laboratory provides the following service functions to NIEHS scientists.
- Computational Chemistry and Molecular Modeling Support Group
Guided by Lalith Perera, Ph.D., the group aids NIEHS researchers with evaluations, docking, molecular modeling, mutation analysis, energetics, reaction path calculations, and graphic visualizations. It is located in F-019.
- Molecular Microscopy Consortium (MMC)
Led by Mario Borgnia, Ph.D., the facility uses cryo-electron microscopy to determine the structure of macromolecules at the atomic level. NIEHS, the University of North Carolina at Chapel Hill, and Duke University are collaborative partners in the endeavor.
- Stuctural Biology Core Facility
Headed by Robert Petrovich, Ph.D., and Lars Pedersen, Ph.D., the facility assists in construct design and cloning, protein expression and purification, and structure determination by X-ray crystallography.
National Toxicology Program
The National Toxicology Program (NTP) is a U.S. Department of Health and Human Services interagency program dedicated to testing and evaluating substances in the environment. It provides the following services for NTP and NIEHS scientists through the Cellular and Molecular Pathology Branch, headed by Robert Sills, Ph.D.
- Clinical Pathology Core Group
Led by Greg Travlos, D.V.M., the facility provides services in hematology, clinical chemistry, immunoassay, and urinalysis.
- Laser Capture Microdissection
Offered through the Molecular Pathology Group, which is led by Arun Pandiri, B.V.Sc., M.S., Ph.D., the service isolates specific cells from a mixed population of cells.
- Mouse Embryo Phenotyping Group
Guided by Susan Elmore, M.S., D.V.M, D.A.B.T, D.A.C.V.P., the group provides expertise for evaluating pathology phenotypes of genetically altered mice.
- Pathology Image Analysis Group
Headed by Robert Sills, D.V.M., Ph.D., the group helps institute researchers acquire high quality digital images for use in publications and presentations.
- Pathology Support Core Group
Led by Ron Herbert, D.V.M., Ph.D., the facility renders technical, collaborative and consultative pathology support through these four services: Electron Microscopy, Histology, Immunohistochemistry, and Necropsy.
The Neurobiology Laboratory provides the following service functions to NIEHS scientists.
- Neurobehavioral Core Facility
Led by Chief of the Neurobiology Laboratory Jerry Yakel, Ph.D., the core allows NIEHS researchers to study rodent responses to internal and external stimuli with the goal of understanding human behavior associated with psychological syndromes. It is located in Room D-030.
- Viral Vector Core Facility
Directed by Negin Martin, Ph.D., the facility provides NIEHS researchers with training and expertise in the design, production, and validation of viral vectors. It is located in Room F-190.
Reproductive and Developmental Biology Laboratory
The Reproductive and Developmental Biology Laboratory provides the following service function to NIEHS scientists.
- Knockout Mouse Core Facility
Led by Manas Ray, Ph.D., the facility provides NIEHS researchers with expertise in generating transgenic mouse models (conventional, conditional, knock-in, etc.). It is located in Room E-408.
Signal Transduction Laboratory
The Signal Transduction Laboratory provides the following service functions to NIEHS scientists.
- Flow Cytometry Center
Directed by Carl Bortner, Ph.D., the core provides state of the art instrumentation and resources for fluorescent analysis of cells at the single cell level, including high-speed fluorescence-activated cell sorting. It is located in Rooms F-360 and F-367.
- Fluorescence Microscopy and Imaging Center
Led by Charles (Jeff) Tucker, the core assists in obtaining and analyzing high quality, biologically accurate images of cells and tissue using fluorescence and light microscopy. It is located in F-222.
- Molecular Genomics Core Facility
Led by Acting Director Kevin Gerrish, Ph.D., the core provides Nanostring, genotyping, microarray, and sequencing services. It is located in Room D-216A.