Shared and Core Facilities
The following NIEHS facilities provide state-of-the-art equipment and expertise, which support in-house (intramural) research activities at the institute. These shared and core services are available to NIH employees only.
Clinical Research Branch
The Clinical Research Branch provides the following service functions to NIEHS scientists.
- Clinical Research Unit (CRU)
Under the guidance of Medical Director Stavros Garantziotis, M.D., the core permits NIEHS scientists to conduct on-site studies on how the environment affects human health and disease. The CRU is situated adjacent to NIEHS building 101.
- Office of Human Research Compliance (OHRC)
OHRC Director Joan Packenham, Ph.D., and her staff protect human volunteers participating in NIEHS clinical research. The office is located in CRU-110.
Epigenetics and Stem Cell Biology Laboratory
The Epigenetics and Stem Cell Biology Laboratory provides the following service functions to NIEHS scientists.
- DNA Sequencing Core Laboratory
Directed by Gregory G. Solomon, the core uses biochemical methods to determine the order of nucleotide bases — adenine, guanine, cytosine, and thymine — in a DNA sample. The DNA Sequencing Core Laboratory can also help researchers in DNA construct design for gene expression, primer design, and data analysis. The Core staff will assist in training on variety of molecular biology related topics.
- Epigenomics Core Laboratory
Led by the Deputy Chief of the Epigenetics and Stem Cells Biology Laboratory Paul Wade, Ph.D., and managed by Core Manager Gregory G. Solomon, the core produces 100's of millions of short sequence reads of individual DNA molecules using the Illumina NextSeq 500 or Illumina's MiSeq platforms. Only NIEHS scientists may request NextGen Sequencing from the core.
- Integrative Bioinformatics Support Group
Led by Jianliang Li, Ph.D., the group promotes and develops bioinformatics tools and resources that empower NIEHS research. It is located in Room A-037.
- Mass Spectrometry Research and Support Group
Led by Leesa Deterding, Ph.D., and Jason Williams, Ph.D., the group specializes in a large number of mass spectrometry approaches, including qualitative and quantitative analyses. It is located in F-008.
Genome Integrity and Structural Biology Laboratory
The Genome Integrity and Structural Biology Laboratory provides the following service functions to NIEHS scientists.
- Computational Chemistry and Molecular Modeling Support Group
Guided by Lalith Perera, Ph.D., the group aids NIEHS researchers with evaluations, docking, molecular modeling, mutation analysis, energetics, reaction path calculations, and graphic visualizations. It is located in F-019.
- Molecular Microscopy Consortium (MMC)
Led by Mario Borgnia, Ph.D., the facility uses cryo-electron microscopy to determine the structure of macromolecules at the atomic level. NIEHS, the University of North Carolina at Chapel Hill, and Duke University are collaborative partners in the endeavor.
- Protein Expression Core Laboratory
Headed by Robert Petrovich, Ph.D., the facility assists NIEHS researchers with their protein expression needs. It is located in Room F-145.
- X-ray Crystallography Core Laboratory
Led by Lars Pedersen, Ph.D., the facility works with NIEHS laboratories to aid in the determination of crystal structures of macromolecules using X-ray crystallography. It is located in Rooms F-338 and F-340.
National Toxicology Program
The National Toxicology Program (NTP) is a U.S. Department of Health and Human Services interagency program dedicated to testing and evaluating substances in the environment. It provides the following services for NTP and NIEHS scientists through the Cellular and Molecular Pathology Branch, headed by Robert Sills, Ph.D.
- Clinical Pathology Core Laboratory
Led by Greg Travlos, D.V.M., the facility provides services in hematology, clinical chemistry, immunoassay, and urinalysis.
- Image Analysis Group
Headed by Robert Sills, D.V.M., Ph.D., the group helps institute researchers acquire high quality digital images for use in publications and presentations.
- Laser Capture Microdissection
Offered through the Molecular Pathology Group, which is led by Arun Pandiri, B.V.Sc., M.S., Ph.D., the service isolates specific cells from a mixed population of cells.
- Mouse Embryo Phenotyping Group
Guided by Susan Elmore, M.S., D.V.M, D.A.B.T, D.A.C.V.P., the group provides expertise for evaluating pathology phenotypes of genetically altered mice.
- Pathology Support Core Laboratory
Led by Ron Herbert, D.V.M., Ph.D., the facility renders technical, collaborative and consultative pathology support through these four services: Electron Microscopy, Histology, Immunohistochemistry, and Necropsy.
The Neurobiology Laboratory provides the following service functions to NIEHS scientists.
- Neurobehavioral Core Laboratory
Led by Chief of the Neurobiology Laboratory Jerry Yakel, Ph.D., the core allows NIEHS researchers to study rodent responses to internal and external stimuli with the goal of understanding human behavior associated with psychological syndromes. It is located in Room D-030.
- Viral Vector Core Laboratory
With Acting Head Negin Martin, Ph.D., the facility provides NIEHS researchers with training and expertise in the design, production, and validation of viral vectors. It is located in Room F-190.
Reproductive and Developmental Biology Laboratory
The Reproductive and Developmental Biology Laboratory provides the following service function to NIEHS scientists.
- Knockout Mouse Core Laboratory
Led by Manas Ray, Ph.D., the facility provides NIEHS researchers with expertise in generating transgenic mouse models (conventional, conditional, knock-in, etc.). It is located in Room E-408.
Signal Transduction Laboratory
The Signal Transduction Laboratory provides the following service functions to NIEHS scientists.
- Flow Cytometry Center
Directed by Carl Bortner, Ph.D., the core provides state of the art instrumentation and resources for fluorescent analysis of cells at the single cell level, including high-speed fluorescence-activated cell sorting. It is located in Rooms F-360 and F-367.
- Fluorescence Microscopy and Imaging Center
Led by Charles (Jeff) Tucker, the core assists in obtaining and analyzing high quality, biologically accurate images of cells and tissue using fluorescence and light microscopy. It is located in F-222.
- Molecular Genomics Core Laboratory
Led by Acting Director Kevin Gerrish, Ph.D., the core provides Nanostring, genotyping, microarray, and sequencing services. It is located in Room D-216A.