Purpose

Suppose A and B are two species of organisms where { A₁,A₂,...,A_G } is a set of cell cycle genes of species A and { B₁,B₂,...,B_G } is the set of corresponding orthologs of species B. Suppose the phase angles of the set {A₁,A₂,...,A_G} satisfy the following relative order around the unit circle: A₁ < A₂ < A₃ < ... < A_G < A₁, where the notation A₁ < A₂ refers to "gene A₂ follows gene A₁ in its time to peak expression", then the program Circular_FSA.sas tests whether the orthologs {B₁,B₂,...,B_G} satisfy the same relative order as the genes { A₁,A₂,...,A_G }, i.e., it tests the null hypothesis B₁ < B₂ < B₃ < ... < B_G < B₁ against the alternative that the order is not satisfied. If the null hypothesis is rejected then Circular_FSA.sas identifies the subset of g genes { B_S1,B_S2,...,B_Sg } which have the same relative order of time to peak expression as the corresponding subset { A_S1,A_S2,...,A_Sg } by eliminating genes which are out of order.

Software info

The software is applicable to any version of SAS 9. or better. Details on how to use is provided in the README.pdf file.

Download

circularFSA-sas.zip (35KB)

Contact

Clarice R. Weinberg, Ph.D.
Principal Investigator

Tel 984-287-3697
[email protected]