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Isoform Usage Two-step Analysis (IUTA)

About IUTA

IUTA is an analysis tool of Illumina paired-end mRNA-seq data for detecting differential usage of gene transcript isoforms. IUTA stands for the Isoform Usage Two-step Analysis. It first uses the EM algorithm to identify the usage of transcript isoforms for each gene, then tests the difference in the isoform usage between two groups based on the method for composition data analysis. Tests on both simulated and read mRNA-seq data showed IUTA can accurately estimate isoform usage and detect usage change between two groups. IUTA is available as an R package freely to the public.

IUTA R Packages

Contact

Please contact Liang Niu, Ph.D. for most issues.

Liang Niu, Ph.D.
Tel (919) 541-0376
Fax (919) 541-4311
niul@niehs.nih.gov
Weichun Huang, Ph.D.
Tel (919) 541-4943
Fax (919) 541-4311
huang6@niehs.nih.gov
David M. Umbach, Ph.D.
Tel (919) 541-4939
Fax (919) 541-4311
umbach@niehs.nih.gov
Leping Li, Ph.D.
Tel (919) 541-5168
Fax (919) 541-4311
li3@niehs.nih.gov

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