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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.

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Systems Toxicology Branch

Barry S. McIntyre, Ph.D.
Barry S. McIntyre, Ph.D.
Group Leader, Developmental & Reproductive Toxicology Group
Tel 973-670-1759
[email protected]
P.O. Box 12233
Mail Drop K2-12
Durham, NC 27709

Barry McIntyre, Ph.D., D.A.B.T., is a reproductive and developmental toxicologist and leads the Developmental and Reproductive Toxicology Group within the Systems Toxicology Branch of the Division of Translational Toxicology (DTT). Before joining the Toxicology Branch, he led the US- reproductive and developmental toxicology group at the Schering-Plough Research Institute (now Merck). His group was responsible for conducting non-clinical studies that characterized the potential adverse effects of novel drugs and biologics on development and fertility.

After earning his Ph.D. in Pharmacology/Toxicology from Washington State University in 1997, McIntyre was an NIEHS National Research Service Award Postdoctoral Fellow at the Chemical Industry Institute of Toxicology.

Selected Publications

  1. Huang MC, Turner KJ, Vallant M, Robinson VG, Lu Y, Price CJ, Fennell TR, Silinski MA, Waidyanatha S, Ryan KR, Black SR, Fernando RA, McIntyre BS. 2020. Tolerability and age-dependent toxicokinetics following perinatal hydroxyurea treatment in Sprague Dawley rats. J Appl Toxicol; doi: 10.1002/jat.4087 [Online 25 November 2020]. [Abstract Huang MC, Turner KJ, Vallant M, Robinson VG, Lu Y, Price CJ, Fennell TR, Silinski MA, Waidyanatha S, Ryan KR, Black SR, Fernando RA, McIntyre BS. 2020. Tolerability and age-dependent toxicokinetics following perinatal hydroxyurea treatment in Sprague Dawley rats. J Appl Toxicol; doi: 10.1002/jat.4087 [Online 25 November 2020].]
  2. Watson ATD, Sutherland VL, Cunny H, Miller-Pinsler L, Furr J, Hebert C, Collins B, Waidyanatha S, Smith L, Vinke T, Aillon K, Xie G, Shockley KR, McIntyre BS. 2020. Postnatal Effects of Gestational and Lactational Gavage Exposure to Boric Acid in the Developing Sprague Dawley Rat. Toxicol Sci; doi: 10.1093/toxsci/kfaa061 [Online 11 May 2020]. [Abstract Watson ATD, Sutherland VL, Cunny H, Miller-Pinsler L, Furr J, Hebert C, Collins B, Waidyanatha S, Smith L, Vinke T, Aillon K, Xie G, Shockley KR, McIntyre BS. 2020. Postnatal Effects of Gestational and Lactational Gavage Exposure to Boric Acid in the Developing Sprague Dawley Rat. Toxicol Sci; doi: 10.1093/toxsci/kfaa061 [Online 11 May 2020].]
  3. Nakamura N, Vijay V, Desai VG, Hansen DK, Han T, Chang CW, Chen YC, Harrouk W, McIntyre B, Foster PM, Fuscoe JC, Inselman AL. 2019. Rebuttal to the comments by Dr. Yan Xu on the article "Transcript profiling in the testes and prostates of postnatal day 30 Sprague-Dawley rats exposed prenatally and lactationally to 2-hydroxy-4-methoxybenzophenone." Reproductive Toxicology; doi: 10.1016/j.reprotox.2019.07.018 [Online 22 July 2019]. [Abstract Nakamura N, Vijay V, Desai VG, Hansen DK, Han T, Chang CW, Chen YC, Harrouk W, McIntyre B, Foster PM, Fuscoe JC, Inselman AL. 2019. Rebuttal to the comments by Dr. Yan Xu on the article "Transcript profiling in the testes and prostates of postnatal day 30 Sprague-Dawley rats exposed prenatally and lactationally to 2-hydroxy-4-methoxybenzophenone." Reproductive Toxicology; doi: 10.1016/j.reprotox.2019.07.018 [Online 22 July 2019].]
  4. Catlin N, Waidyanatha S, Mylchreest E, Miller-Pinsler L, Cunny H, Foster P, Sutherland V, McIntyre B. (2018) Response to the letter to the editor for embryo-fetal development studies with the dietary supplement vinpocetine in the rat and rabbit. Birth defects research. Part B, Dev and Reprod Toxicol. 110(18):1374-1375. [Abstract Catlin N, Waidyanatha S, Mylchreest E, Miller-Pinsler L, Cunny H, Foster P, Sutherland V, McIntyre B. (2018) Response to the letter to the editor for embryo-fetal development studies with the dietary supplement vinpocetine in the rat and rabbit. Birth defects research. Part B, Dev and Reprod Toxicol. 110(18):1374-1375.] 
  5. Dere E, Anderson LM, Coulson M, McIntyre BS, Boekelheide K, Chapin RE. (2013). SOT Symposium Highlight: Translatable Indicators of Testicular Toxicity: Inhibin B, MicroRNAs, and Sperm Signatures. Toxicol Sci. Dec;136(2):265-73. doi: 10.1093/toxsci/kft207. Epub 2013 Sep 19. [Abstract Dere E, Anderson LM, Coulson M, McIntyre BS, Boekelheide K, Chapin RE. (2013). SOT Symposium Highlight: Translatable Indicators of Testicular Toxicity: Inhibin B, MicroRNAs, and Sperm Signatures. Toxicol Sci. Dec;136(2):265-73. doi: 10.1093/toxsci/kft207. Epub 2013 Sep 19.]
  6. Enright BP, McIntyre BS, Barat SA, Treinen KA, Kopytek SJ. (2012). Effects of SCH 486757, a nociceptin-1 receptor agonist, on fertility and reproductive hormone levels in female CRL:CD®[SD] Rats. Birth Defects Res B Dev Reprod Toxicol. Feb;95(1):12-22. doi: 10.1002/bdrb.20334. Epub 2011 Sep 15. [Abstract Enright BP, McIntyre BS, Barat SA, Treinen KA, Kopytek SJ. (2012). Effects of SCH 486757, a nociceptin-1 receptor agonist, on fertility and reproductive hormone levels in female CRL:CD®[SD] Rats. Birth Defects Res B Dev Reprod Toxicol. Feb;95(1):12-22. doi: 10.1002/bdrb.20334. Epub 2011 Sep 15.]
  7. Enright BP, Leach MW, Pelletier G, LaBrie F, McIntyre BS, Losco PE. (2010). Effects of an antagonist of neurokinin receptors 1, 2 and 3 on reproductive hormones in male beagle dogs. Birth Defects Res B Dev Reprod Toxicol. Dec;89(6):517-25. doi: 10.1002/bdrb.20274. [Abstract Enright BP, Leach MW, Pelletier G, LaBrie F, McIntyre BS, Losco PE. (2010). Effects of an antagonist of neurokinin receptors 1, 2 and 3 on reproductive hormones in male beagle dogs. Birth Defects Res B Dev Reprod Toxicol. Dec;89(6):517-25. doi: 10.1002/bdrb.20274.]
  8. Enright BP, McIntyre BS, Thackaberry EA, Treinen KA, Kopytek SJ. (2010). Assessment of hydroxypropyl methylcellulose, propylene glycol, polysorbate 80, and hydroxypropyl-?-cyclodextrin for use in developmental and reproductive toxicology studies. Birth Defects Res B Dev Reprod Toxicol. Dec;89(6):504-16. doi: 10.1002/bdrb.20273. [Abstract Enright BP, McIntyre BS, Thackaberry EA, Treinen KA, Kopytek SJ. (2010). Assessment of hydroxypropyl methylcellulose, propylene glycol, polysorbate 80, and hydroxypropyl-?-cyclodextrin for use in developmental and reproductive toxicology studies. Birth Defects Res B Dev Reprod Toxicol. Dec;89(6):504-16. doi: 10.1002/bdrb.20273.]
  9. Enright BP, Gu YZ, Snyder RD, Dugyala RR, Obert LA, Treinen KA, McIntyre BS, Veneziale RW. (2010). Effects of the histamine H1 antagonist chlorcyclizine on rat fetal palate development. Birth Defects Res B Dev Reprod Toxicol. Dec;89(6):474-84. doi: 10.1002/bdrb.20261. [Abstract Enright BP, Gu YZ, Snyder RD, Dugyala RR, Obert LA, Treinen KA, McIntyre BS, Veneziale RW. (2010). Effects of the histamine H1 antagonist chlorcyclizine on rat fetal palate development. Birth Defects Res B Dev Reprod Toxicol. Dec;89(6):474-84. doi: 10.1002/bdrb.20261.]
  10. Enright B.P., Compton D.R., Collins N., Davis T., and B.S. McIntyre. (2009). Comparative effects of interferon alpha-2b and pegylated interferon alpha-2b on menstrual cycles and ovarian hormones in cynomolgus monkeys. Birth Defects Res B Dev Reproductive Toxicology. Feb;86(1):29. [Abstract Enright B.P., Compton D.R., Collins N., Davis T., and B.S. McIntyre. (2009). Comparative effects of interferon alpha-2b and pegylated interferon alpha-2b on menstrual cycles and ovarian hormones in cynomolgus monkeys. Birth Defects Res B Dev Reproductive Toxicology. Feb;86(1):29.]  
  11. Chapin R.E., Adams J., Boekelheide K., Gray L.E. Jr, Hayward S.W., Lees P.S., McIntyre B.S., Portier K.M., Schnorr T.M., Selevan S.G., Vandenbergh J.G., Woskie S.R. (2008). NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A. Birth Defects Research B Developmental Reproductive Toxicology. 83(3):157-395. [Abstract Chapin R.E., Adams J., Boekelheide K., Gray L.E. Jr, Hayward S.W., Lees P.S., McIntyre B.S., Portier K.M., Schnorr T.M., Selevan S.G., Vandenbergh J.G., Woskie S.R. (2008). NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A. Birth Defects Research B Developmental Reproductive Toxicology. 83(3):157-395.]  
  12. Barlow, N.J., McIntyre, B.S., and P.M.D. Foster. (2004). Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl)phthalate Toxicological Pathology 32: 79-90. [Abstract Barlow, N.J., McIntyre, B.S., and P.M.D. Foster. (2004). Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl)phthalate Toxicological Pathology 32: 79-90.]  
  13. McIntyre, B.S., Vancutsem, P.M., Treinen, K.A., and R.E. Morrissey. (2003). Effects of perinatal loratadine exposure on male rat reproductive organ development. Reproductive Toxicology 17: 691-697. [Abstract McIntyre, B.S., Vancutsem, P.M., Treinen, K.A., and R.E. Morrissey. (2003). Effects of perinatal loratadine exposure on male rat reproductive organ development. Reproductive Toxicology 17: 691-697.]  
  14. Turner, K.J., McIntyre, B.S., Phillips, S.L., Barlow, N.J., Bowman, C.J. and P.M.D. Foster. (2003). Altered gene expression during rat Wolffian duct development in response to in utero exposure to the antiandrogen linuron. Toxicological Sciences 74:114-28. [Abstract Turner, K.J., McIntyre, B.S., Phillips, S.L., Barlow, N.J., Bowman, C.J. and P.M.D. Foster. (2003). Altered gene expression during rat Wolffian duct development in response to in utero exposure to the antiandrogen linuron. Toxicological Sciences 74:114-28.]  
  15. McIntyre, B.S., Barlow, N.J., Sar, M., Wallace, D.G., and P.M.D. Foster. (2002). Effects of in utero linuron exposure on rat Wolffian duct development. Reproductive Toxicology 16:131-139. [Abstract McIntyre, B.S., Barlow, N.J., Sar, M., Wallace, D.G., and P.M.D. Foster. (2002). Effects of in utero linuron exposure on rat Wolffian duct development. Reproductive Toxicology 16:131-139.]  
  16. You, L., Sar, M., Bartolucci, E., McIntyre, B.S., and R Sriperumbudur. (2002). Modulation of mammary gland development in prepubertal male rats exposed to genistein and methoxychlor. Toxicological Sciences 66: 216-225. [Abstract You, L., Sar, M., Bartolucci, E., McIntyre, B.S., and R Sriperumbudur. (2002). Modulation of mammary gland development in prepubertal male rats exposed to genistein and methoxychlor. Toxicological Sciences 66: 216-225.]  
  17. Foster P.M.D and B.S. McIntyre. (2002). Endocrine active agents: implications of adverse and non-adverse changes. Toxicological Pathology 30: 59-65. [Abstract Foster P.M.D and B.S. McIntyre. (2002). Endocrine active agents: implications of adverse and non-adverse changes. Toxicological Pathology 30: 59-65.]  
  18. McIntyre, B.S., Barlow, N.J., and P.M.D Foster. (2002). Male rats exposed to linuron in utero exhibit permanent changes in anogenital distance, nipple retention, and epididymal malformations that results in subsequent testicular atrophy Toxicological Sciences 65: 62-70. [Abstract McIntyre, B.S., Barlow, N.J., and P.M.D Foster. (2002). Male rats exposed to linuron in utero exhibit permanent changes in anogenital distance, nipple retention, and epididymal malformations that results in subsequent testicular atrophy Toxicological Sciences 65: 62-70.]  
  19. Sylvester, P.W., McIntyre, B.S., Gapor, A., and K.P. Briski. (2001). Vitamin E inhibition of normal mammary epithelial cell proliferation is associated with a reduction in Protein Kinase C activation. Cell Proliferation 34: 347-358. [Abstract Sylvester, P.W., McIntyre, B.S., Gapor, A., and K.P. Briski. (2001). Vitamin E inhibition of normal mammary epithelial cell proliferation is associated with a reduction in Protein Kinase C activation. Cell Proliferation 34: 347-358.]  
  20. McIntyre, B.S., Barlow, N.J., and P.M.D Foster. (2001). Androgen-mediated development in male rat offspring exposed to flutamide in utero: Permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues. Toxicological Sciences 62: 236-249. [Abstract McIntyre, B.S., Barlow, N.J., and P.M.D Foster. (2001). Androgen-mediated development in male rat offspring exposed to flutamide in utero: Permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues. Toxicological Sciences 62: 236-249.]  
  21. McIntyre, B.S., Barlow, N.J., Wallace, D.G., Maness, S. C., Gaido, K.W., and P.M.D Foster. (2000). Effects of in utero exposure to linuron on androgen-dependent reproductive development in the male Crl:CD(SD)BR rat. Toxicology and Applied Pharmacology 167: 87-99. [Abstract McIntyre, B.S., Barlow, N.J., Wallace, D.G., Maness, S. C., Gaido, K.W., and P.M.D Foster. (2000). Effects of in utero exposure to linuron on androgen-dependent reproductive development in the male Crl:CD(SD)BR rat. Toxicology and Applied Pharmacology 167: 87-99.]  
  22. McIntyre, B.S., Briski, K.P., Gapor, A., and P.W. Sylvester. (2000). Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mammary epithelial cells. Proceedings of the Society for Experimental Biology and Medicine 224: 292-301. [Abstract McIntyre, B.S., Briski, K.P., Gapor, A., and P.W. Sylvester. (2000). Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mammary epithelial cells. Proceedings of the Society for Experimental Biology and Medicine 224: 292-301.]  
  23. McIntyre, B.S., Briski, K.P., Tirmenstein, M., Gapor, A., Fariss M. W., and P.W. Sylvester. (2000). Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary epithelial cells. Lipids 35: 171-180. [Abstract McIntyre, B.S., Briski, K.P., Tirmenstein, M., Gapor, A., Fariss M. W., and P.W. Sylvester. (2000). Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary epithelial cells. Lipids 35: 171-180.]  
  24. Mealey, K.L., Barhoumi, R., Burghardt, R.C., McIntyre, B.S., Sylvester, P.W., Hosick, H.L., and D.T. Kochevar. (1999). Immunosuppressant inhibition of P-glycoprotein is independent of drug-induced suppression of peptide-prolyl isomerase and calcineurin activity. Cancer Chemotherapy and Pharmacology 44: 152-158. [Abstract Mealey, K.L., Barhoumi, R., Burghardt, R.C., McIntyre, B.S., Sylvester, P.W., Hosick, H.L., and D.T. Kochevar. (1999). Immunosuppressant inhibition of P-glycoprotein is independent of drug-induced suppression of peptide-prolyl isomerase and calcineurin activity. Cancer Chemotherapy and Pharmacology 44: 152-158.]  
  25. McIntyre, B.S. and P.W. Sylvester. (1998). Genistein and erbstatin inhibition of normal mammary epithelial cell proliferation is associated with EGF-receptor downregulation. Cell Proliferation 31: 35-46. [Abstract McIntyre, B.S. and P.W. Sylvester. (1998). Genistein and erbstatin inhibition of normal mammary epithelial cell proliferation is associated with EGF-receptor downregulation. Cell Proliferation 31: 35-46.]  
  26. McIntyre, B.S., Briski, K.P., Hosick, H.L., and P.W. Sylvester. (1998). Effects of tyrosine phosphatase inhibitors on EGF- and insulin-dependent mammary epithelial cell growth. Proceedings of the Society for Experimental Biology and Medicine 217: 180-187. [Abstract McIntyre, B.S., Briski, K.P., Hosick, H.L., and P.W. Sylvester. (1998). Effects of tyrosine phosphatase inhibitors on EGF- and insulin-dependent mammary epithelial cell growth. Proceedings of the Society for Experimental Biology and Medicine 217: 180-187.]  
  27. Birkenfeld, H.P., McIntyre, B.S., Briski K.P., and P.W. Sylvester. (1996). Protein kinase C isoenzyme expression in normal mouse mammary epithelial cells grown in primary culture. Proceedings of the Society for Experimental Biology and Medicine 213: 65-70. [Abstract Birkenfeld, H.P., McIntyre, B.S., Briski K.P., and P.W. Sylvester. (1996). Protein kinase C isoenzyme expression in normal mouse mammary epithelial cells grown in primary culture. Proceedings of the Society for Experimental Biology and Medicine 213: 65-70.]  
  28. Birkenfeld H.P., McIntyre, B.S., Briski K.P., and P.W. Sylvester. (1996). Role of protein kinase C in modulating epidermal growth factor-and phorbol ester-induced mammary epithelial cell growth in vitro. Experimental Cell Research 223: 183-191. [Abstract Birkenfeld H.P., McIntyre, B.S., Briski K.P., and P.W. Sylvester. (1996). Role of protein kinase C in modulating epidermal growth factor-and phorbol ester-induced mammary epithelial cell growth in vitro. Experimental Cell Research 223: 183-191.]  
  29. McIntyre, B.S., Birkenfeld H.P., and P.W. Sylvester. (1995). Relationship between epidermal growth factor receptor levels, autophosphorylation, and mitogenic-responsiveness in normal mouse mammary epithelial cells in vitro. Cell Proliferation 28: 45-56. [Abstract McIntyre, B.S., Birkenfeld H.P., and P.W. Sylvester. (1995). Relationship between epidermal growth factor receptor levels, autophosphorylation, and mitogenic-responsiveness in normal mouse mammary epithelial cells in vitro. Cell Proliferation 28: 45-56.]