Office of Program Operations

Brad Collins, M.S.P.H.
Brad Collins, M.S.P.H.
Chemist
Tel 984-287-3121
[email protected]

Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.

Visit the NTP Website

Bradley Collins is a chemist and serves as a project officer in the Office of Program Operations for the Division of Translational Toxicology (DTT). He manages contracted chemistry efforts in support of NTP toxicology studies and has served on study design teams and interagency working groups to provide technical assistance in the areas of chemistry and toxicokinetics. Collins also provides NTP with expertise in the design, direction and interpretation of toxicokinetic studies for AIDS therapeutics and other test articles and provides cheminformatics support to the NTP high throughput toxicology-screening program.

As a chemist, Collins is involved in the design, conduct, interpretation and reporting of NTP research and testing activities that investigate the toxicology of a variety of chemicals including high production volume chemicals, dietary supplements and nanoparticles. Over the past 20 years, Collins has served as the Project Officer for NTP chemistry support activities, which include chemical procurement, characterization and toxicokinetics. As part of those activities, Collins worked with the chemistry support contractor to develop the dose analysis method validation protocol currently used by the NTP.

Collins received his B.S. in Science and Environmental Change from the University of Wisconsin-Green Bay in 1979 and his M.S.P.H. in Environmental Chemistry from the University of North Carolina at Chapel Hill in 1984. In addition to his scientific duties, he has also served as Chair of the NIEHS Diversity Council, served on the NIEHS Quality Council and the on the Environmental Awareness Advisory Committee.

Selected Publications

  1. Collins BJ, Kerns SP, Aillon K, Mueller G, Rider CV, DeRose EF, London RE, Harnly JM, Waidyanatha S. 2020. Comparison of phytochemical composition of Ginkgo biloba extracts using a combination of non-targeted and targeted analytical approaches. Anal Bioanal Chem 412(25):6789-6809. [Abstract Collins BJ, Kerns SP, Aillon K, Mueller G, Rider CV, DeRose EF, London RE, Harnly JM, Waidyanatha S. 2020. Comparison of phytochemical composition of Ginkgo biloba extracts using a combination of non-targeted and targeted analytical approaches. Anal Bioanal Chem 412(25):6789-6809.]
  2. Collins BJ, Slade D, Ryan K, Mathias R, Shan A, Algaier J, Aillon K, Waidyanatha S. Development and Validation of an Analytical Method to Quantitate Tris (chloroisopropyl) phosphate in Rat and Mouse Plasma using Gas Chromatography with Flame Photometric Detection. Journal of Analytical Toxicology 2018 ():-. [Abstract Collins BJ, Slade D, Ryan K, Mathias R, Shan A, Algaier J, Aillon K, Waidyanatha S. Development and Validation of an Analytical Method to Quantitate Tris (chloroisopropyl) phosphate in Rat and Mouse Plasma using Gas Chromatography with Flame Photometric Detection. Journal of Analytical Toxicology 2018 ():-.]
  3. Levine KE, Han L, McWilliams AC, Essader AS, Amato KE, Fernando RA, Browning DB, Greene LC, Ensor DS, Walker NJ, Robinson VG, Collins BJ. Characterization of an assortment of commercially available multiwalled carbon nanotubes. Microchimica Acta 2014 181(1-2):171-179. [Abstract Levine KE, Han L, McWilliams AC, Essader AS, Amato KE, Fernando RA, Browning DB, Greene LC, Ensor DS, Walker NJ, Robinson VG, Collins BJ. Characterization of an assortment of commercially available multiwalled carbon nanotubes. Microchimica Acta 2014 181(1-2):171-179.]
  4. Surh I, Brix A, French JE, Collins BJ, Sanders M, Vallant M, Dunnick JK. Toxicology and Carcinogenesis Study of Senna in C3B6.129F1-Trp53 tm1Brd N12 Haploinsufficient Mice. Toxicologic pathology 2013 41(5):770-778.  [Abstract Surh I, Brix A, French JE, Collins BJ, Sanders M, Vallant M, Dunnick JK. Toxicology and Carcinogenesis Study of Senna in C3B6.129F1-Trp53 tm1Brd N12 Haploinsufficient Mice. Toxicologic pathology 2013 41(5):770-778. ]
  5. Collins BJ, Stout MD, Levine KE, Kissling GE, Melnick RL, Fennell TR, Abdo K, Pritchard JB, Walden R, Fernando RA, Burka LT, Hooth MJ. Hexavalent chromium in drinking water (reply to comment). Toxicological Sciences 119(2):425-, (2011). [Abstract Collins BJ, Stout MD, Levine KE, Kissling GE, Melnick RL, Fennell TR, Abdo K, Pritchard JB, Walden R, Fernando RA, Burka LT, Hooth MJ. Hexavalent chromium in drinking water (reply to comment). Toxicological Sciences 119(2):425-, (2011).]
  6. Collins BJ, Stout MD, Levine KE, Kissling GE, Melnick RL, Fennell TR, Walden R, Abdo K, Pritchard JB, Fernando RA, Burka LT, Hooth MJ. Exposure to hexavalent chromium resulted in significantly higher tissue chromium burden compared to trivalent chromium following similar oral doses to male F344/N rats and female B6C3F1 mice. Toxicol Sci 118(2):368-379, (2010) [Abstract Collins BJ, Stout MD, Levine KE, Kissling GE, Melnick RL, Fennell TR, Walden R, Abdo K, Pritchard JB, Fernando RA, Burka LT, Hooth MJ. Exposure to hexavalent chromium resulted in significantly higher tissue chromium burden compared to trivalent chromium following similar oral doses to male F344/N rats and female B6C3F1 mice. Toxicol Sci 118(2):368-379, (2010)]
  7. Levine, KE, Ross, GT, Essader, AS, Perlmutter, JM, Grohse, PM, Fernando, RA, Lang, M, Collins, BJ. Validation of a method for the determination of chromium in rat feces by inductively coupled plasma optical emission spectrometry. Analytical letters 42(17):2729-2746, (2009). [Abstract Levine, KE, Ross, GT, Essader, AS, Perlmutter, JM, Grohse, PM, Fernando, RA, Lang, M, Collins, BJ. Validation of a method for the determination of chromium in rat feces by inductively coupled plasma optical emission spectrometry. Analytical letters 42(17):2729-2746, (2009).]
  8. Stout MD, Herbert RA, Kissling GE, Collins BJ, Travlos GS, Witt KL, Melnick RL, Malarkey DE, Hooth MJ. (2009) Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure. Environmental health perspectives 117(5):716-722. [Abstract Stout MD, Herbert RA, Kissling GE, Collins BJ, Travlos GS, Witt KL, Melnick RL, Malarkey DE, Hooth MJ. (2009) Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure. Environmental health perspectives 117(5):716-722.]
  9. Lodge, JW, Fletcher, BL, Brown, SS, Parham, AJ, Fernando, RA, Collins, BJ. Determination of lovastatin hydroxy acid in female B6C3F1 mouse serum. Journal of analytical toxicology. 32(3):248-252, (2008). [Abstract Lodge, JW, Fletcher, BL, Brown, SS, Parham, AJ, Fernando, RA, Collins, BJ. Determination of lovastatin hydroxy acid in female B6C3F1 mouse serum. Journal of analytical toxicology. 32(3):248-252, (2008).]
  10. Weber, HA, Hodges, AE, Guthrie, JR, O’Brien, BM, Robaugh, D, Clark, AP, Harris, RK, Algaier, JW, Smith, CS. Comparison of Proanthocyanidins in Commercial Antioxidants: Grape Seed and Pine Bark Extracts. J. Agric. Food Chem. 55(1) 148, (2007). [Abstract Weber, HA, Hodges, AE, Guthrie, JR, O’Brien, BM, Robaugh, D, Clark, AP, Harris, RK, Algaier, JW, Smith, CS. Comparison of Proanthocyanidins in Commercial Antioxidants: Grape Seed and Pine Bark Extracts. J. Agric. Food Chem. 55(1) 148, (2007).]
  11. Collins BJ, Dix KJ, Grizzle TB, Dunnick JK. Toxicokinetics of phenolphthalein (PTH) in male and female rats and mice. Toxicol Sci 56(2):271-281, (2000). [Abstract Collins BJ, Dix KJ, Grizzle TB, Dunnick JK. Toxicokinetics of phenolphthalein (PTH) in male and female rats and mice. Toxicol Sci 56(2):271-281, (2000).]
  12. Chapin RE, Harris MW, Davis BJ, Ward SM, Wilson RE, Mauney MA, Lockhart AC, Smialowicz RJ, Moser VC, Burka LT, Collins BJ, Haskins EA, Allen JD, Judd L, Purdie WA, Harris HL, Lee CA, Corniffe GM. The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous immune and reproductive system function. Fundam Appl Toxicol 40(1):138-157, (1997). [Abstract Chapin RE, Harris MW, Davis BJ, Ward SM, Wilson RE, Mauney MA, Lockhart AC, Smialowicz RJ, Moser VC, Burka LT, Collins BJ, Haskins EA, Allen JD, Judd L, Purdie WA, Harris HL, Lee CA, Corniffe GM. The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous immune and reproductive system function. Fundam Appl Toxicol 40(1):138-157, (1997).]
  13. Rey C, Collins B, Goehl T, Dickson IR, Glimcher MJ. The carbonate environment in bone mineral. A resolution-enhanced Fourier transform infrared spectroscopy study. Calcif Tissue Int 45(3):157-164, (1989). [Abstract Rey C, Collins B, Goehl T, Dickson IR, Glimcher MJ. The carbonate environment in bone mineral. A resolution-enhanced Fourier transform infrared spectroscopy study. Calcif Tissue Int 45(3):157-164, (1989).]