Signal Transduction Laboratory
John A. Cidlowski, Ph.D.
Chief, Signal Transduction Laboratory and Principal Investigator
David S. Miller, Ph.D.
Deputy Chief, Signal Transduction Laboratory and Principal Investigator
The overall goal of the Signal Transduction Laboratory is to define the mechanisms that cells, tissues and organisms use to respond to physiological and environmental stimuli. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer.
The delineation of the signal transduction pathways affected in these and other complex human diseases is likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms. The Signal Transduction Laboratory seeks to achieve this goal through cutting edge basic research and training of junior scientists in aspects of environmental health related science that are critical to the mission of NIEHS. It is anticipated that research in signal transduction will have a central role in environmental human health in the post-genomic era.
The Signal Transduction Laboratory investigates the following topics:
- Glucocorticoid receptors and their actions on the immune system because they reflect the primary response to environmental stress
- Mechanisms involved in the regulation of apoptosis in normal and neoplastic cells
- Intracellular Ca2+ pools involved in cellular signaling, and the basis for intracellular [Ca2+]i oscillations
- Inositol phosphate family of intracellular signals. These compounds play a number of important "second messenger" roles
- Identification of environmental cues that sirtuins sense and determination of how they affect the progress of aging and age-associated diseases
- The roles of a small family of protein kinase C substrate proteins in the normal development of the brain and retina, and the roles of another small family of CCCH tandem zinc finger proteins in the physiological regulation of mRNA turnover
- Molecular mechanisms governing eukaryotic ribosome biogenesis
Scientific Support Staff
Pinkney Wilder III
Tel (919) 541-3332
Fax (919) 541-1898
Tamika Christine Johnson-Traynham
Tel (919) 541-3339
Fax (301) 480-3576