Inositol Signaling Group

  1. Wang H, Perera L, Jork N, Zong G, Riley AM, Potter BVL, Jessen HJ, Shears SB. A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop. Nat Commun. 2022;13(1):2231. Published 2022 Apr 25. doi:10.1038/s41467-022-29673-y [Abstract Wang H, Perera L, Jork N, Zong G, Riley AM, Potter BVL, Jessen HJ, Shears SB. A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop. Nat Commun. 2022;13(1):2231. Published 2022 Apr 25. doi:10.1038/s41467-022-29673-y]
  2. Marongiu L, Mingozzi F, Cigni C, Marzi R, Di Gioia M, Garrè M, Parazzoli D, Sironi L, Collini M, Sakaguchi R, Morii T, Crosti M, Moro M, Schurmans S, Catelani T, Rotem R, Colombo M, Shears S, Prosperi D, Zanoni I, Granucci F. 2021. Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells. Sci Signal; doi: 10.1126/scisignal.aaz2120 [Online 30 March 2021]. [Abstract Marongiu L, Mingozzi F, Cigni C, Marzi R, Di Gioia M, Garrè M, Parazzoli D, Sironi L, Collini M, Sakaguchi R, Morii T, Crosti M, Moro M, Schurmans S, Catelani T, Rotem R, Colombo M, Shears S, Prosperi D, Zanoni I, Granucci F. 2021. Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells. Sci Signal; doi: 10.1126/scisignal.aaz2120 [Online 30 March 2021].]
  3. Gu C, Liu L, Liu X, Zhang H, Luo J, Wang H, Locasale JW, Shears SB. 2021. Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line. Proc Natl Acad Sci USA; doi: 10.1073/pnas.2020187118 [Online 9 March 2021]. [Abstract Gu C, Liu L, Liu X, Zhang H, Luo J, Wang H, Locasale JW, Shears SB. 2021. Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line. Proc Natl Acad Sci USA; doi: 10.1073/pnas.2020187118 [Online 9 March 2021].]
  4. Zong G, Jork N, Hostachy S, Fiedler D, Jessen HJ, Shears SB, Wang H. 2021. New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1. FASEB J. Feb;35(2):e21275. [Abstract Zong G, Jork N, Hostachy S, Fiedler D, Jessen HJ, Shears SB, Wang H. 2021. New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1. FASEB J. Feb;35(2):e21275.]
  5. Qui D, Wilson MW, Eisenbeis, VB, Harmel RK, Riemer E, Haas TM, Wittwer C, Jork N, Gu C, Shears SB, Schaaf G, Kammerer B, Fiedler D, Saiardi A, Jessen HJ. 2020. Analysis of Inositol Phosphate Metabolism by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry. Nature Communications Nov 27;11(1):6035. doi: 10.1038/s41467-020-19928-x. [Abstract Qui D, Wilson MW, Eisenbeis, VB, Harmel RK, Riemer E, Haas TM, Wittwer C, Jork N, Gu C, Shears SB, Schaaf G, Kammerer B, Fiedler D, Saiardi A, Jessen HJ. 2020. Analysis of Inositol Phosphate Metabolism by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry. Nature Communications Nov 27;11(1):6035. doi: 10.1038/s41467-020-19928-x.]
  6. Wang Z, Jork N, Bittner T, Wang H, Jessen, HJ, Shears, S.B. 2020. Rapid stimulation of cellular Pi uptake by the inositol pyrophosphate InsP8 induced by its photothermal release from lipid nanocarriers using a near infra-red light-emitting diode. Chem Sci 11 10265. [Full Text Wang Z, Jork N, Bittner T, Wang H, Jessen, HJ, Shears, S.B. 2020. Rapid stimulation of cellular Pi uptake by the inositol pyrophosphate InsP8 induced by its photothermal release from lipid nanocarriers using a near infra-red light-emitting diode. Chem Sci 11 10265.]
  7. Shears SB, Wang H. 2020. Metabolism and functions of inositol pyrophosphates: insights gained from the application of synthetic analogues. Molecules; doi: 10.3390/molecules25194515 [Online 2 October 2020]. [Abstract Shears SB, Wang H. 2020. Metabolism and functions of inositol pyrophosphates: insights gained from the application of synthetic analogues. Molecules; doi: 10.3390/molecules25194515 [Online 2 October 2020].]
  8. Sahu S, Wang Z, Jiao X, Gu C, Jork N, Wittwer C, Li X, Hostachy S, Fiedler D, Wang H, Jessen HJ, Kiledjian M, Shears SB. 2020. InsP 7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics. Proc Natl Acad Sci U S A; doi: 10.1073/pnas.1922284117 [Online 29 July 2020]. [Abstract Sahu S, Wang Z, Jiao X, Gu C, Jork N, Wittwer C, Li X, Hostachy S, Fiedler D, Wang H, Jessen HJ, Kiledjian M, Shears SB. 2020. InsP 7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics. Proc Natl Acad Sci U S A; doi: 10.1073/pnas.1922284117 [Online 29 July 2020].]
  9. Randall TA, Gu C, Li X, Wang H, Shears SB. 2020. A two-way switch for inositol pyrophosphate signaling: Evolutionary history and biological significance of a unique, bifunctional kinase/phosphatase. Adv Biol Regul 75:100674. [Abstract Randall TA, Gu C, Li X, Wang H, Shears SB. 2020. A two-way switch for inositol pyrophosphate signaling: Evolutionary history and biological significance of a unique, bifunctional kinase/phosphatase. Adv Biol Regul 75:100674.]
  10. Li X, Gu C, Hostachy S, Sahu S, Fiedler D, Wang H, Shears SB. 2020. Control of XPR1-dependent cellular phosphate efflux by InsP8 is an exemplar for functionally-exclusive inositol pyrophosphate signaling. Proc Natl Acad Sci U S A 117(7):3568-3574. [Abstract Li X, Gu C, Hostachy S, Sahu S, Fiedler D, Wang H, Shears SB. 2020. Control of XPR1-dependent cellular phosphate efflux by InsP8 is an exemplar for functionally-exclusive inositol pyrophosphate signaling. Proc Natl Acad Sci U S A 117(7):3568-3574.]
  11. Khaled ML, Bykhovskaya Y, Gu C, Liu A, Drewry MD, Chen Z, Mysona BA, Parker E, McNabb RP, Yu H, Lu X, Wang J, Li X, Al-Muammar A, Rotter JI, Porter LF, Estes A, Watsky MA, Smith SB, Xu H, Abu-Amero KK, Kuo A, Shears SB, Rabinowitz YS, Liu Y. 2019. PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus. Sci Rep 9(1):19406. [Abstract Khaled ML, Bykhovskaya Y, Gu C, Liu A, Drewry MD, Chen Z, Mysona BA, Parker E, McNabb RP, Yu H, Lu X, Wang J, Li X, Al-Muammar A, Rotter JI, Porter LF, Estes A, Watsky MA, Smith SB, Xu H, Abu-Amero KK, Kuo A, Shears SB, Rabinowitz YS, Liu Y. 2019. PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus. Sci Rep 9(1):19406.]
  12. Riley AM, Wang H, Shears SB, Potter BVL. Synthesis of an α-phosphono-α,α-difluoroacetamide Analogue of the Diphosphoinositol Pentakisphosphate 5-InsP7. MedChemComm 2019 10(7):1165-1172. [Abstract Riley AM, Wang H, Shears SB, Potter BVL. Synthesis of an α-phosphono-α,α-difluoroacetamide Analogue of the Diphosphoinositol Pentakisphosphate 5-InsP7. MedChemComm 2019 10(7):1165-1172.]
  13. Gu C, Stashko MA, Puhl-Rubio AC, Chakraborty M, Chakraborty A, Frye SV, Pearce KH, Wang X, Shears SB, Wang H. Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure/Activity Analysis. Journal of Medicinal Chemistry 2019 62(3):1443-1454. [Abstract Gu C, Stashko MA, Puhl-Rubio AC, Chakraborty M, Chakraborty A, Frye SV, Pearce KH, Wang X, Shears SB, Wang H. Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure/Activity Analysis. Journal of Medicinal Chemistry 2019 62(3):1443-1454.]
  14. Shears SB, Hayakawa Y. Functional Multiplicity of an Insect Cytokine Family Assists Defense Against Environmental Stress. Front Physiol 10:222; 2019. [Abstract Shears SB, Hayakawa Y. Functional Multiplicity of an Insect Cytokine Family Assists Defense Against Environmental Stress. Front Physiol 10:222; 2019.]
  15. Yi A, Jessen H, Wang H, Shears SB, Kireev D. Dynamics of Substrate Processing by PPIP5K2, a Versatile Catalytic Machine. Structure. 2019 27(6):1022-1028.e2 [Abstract Yi A, Jessen H, Wang H, Shears SB, Kireev D. Dynamics of Substrate Processing by PPIP5K2, a Versatile Catalytic Machine. Structure. 2019 27(6):1022-1028.e2]
  16. Puhl-Rubio AC, Stashko MA, Wang H, Hardy PB, Tyagi V, Li B, Wang X, Kireev D, Jessen HJ, Frye SV, Shears SB, Pearce KH. Use of protein kinase-focused compound libraries for the discovery of new inositol phosphate kinase inhibitors. SLAS Discov. 2018 May 1:2472555218775323. doi: 10.1177/2472555218775323 [Abstract Puhl-Rubio AC, Stashko MA, Wang H, Hardy PB, Tyagi V, Li B, Wang X, Kireev D, Jessen HJ, Frye SV, Shears SB, Pearce KH. Use of protein kinase-focused compound libraries for the discovery of new inositol phosphate kinase inhibitors. SLAS Discov. 2018 May 1:2472555218775323. doi: 10.1177/2472555218775323]
  17. Yousaf R, Gu C, Ahmed ZM, Khan SN, Friedman TB, Riazuddin S, Shears SB, Riazuddin S. Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse. PLoS Genet. 2018 Mar 28;14(3):e1007297. doi: 10.1371/journal.pgen.1007297 [Abstract Yousaf R, Gu C, Ahmed ZM, Khan SN, Friedman TB, Riazuddin S, Shears SB, Riazuddin S. Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse. PLoS Genet. 2018 Mar 28;14(3):e1007297. doi: 10.1371/journal.pgen.1007297]
  18. Wang H, Gu C, Rolfes RJ, Jessen HJ, Shears SB. Structural and biochemical characterization of Siw14: a protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates. 2018 J.Biol.Chem. Mar 14. pii: jbc.RA117.001670. doi: 10.1074/jbc.RA117.001670 [Abstract Wang H, Gu C, Rolfes RJ, Jessen HJ, Shears SB. Structural and biochemical characterization of Siw14: a protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates. 2018 J.Biol.Chem. Mar 14. pii: jbc.RA117.001670. doi: 10.1074/jbc.RA117.001670]
  19. Rajasekaran SS, Kim J, Gaboardi GC, Gromada J, Shears SB, Dos Santos KT, Nolasco EL, Ferreira SS, Illies C, Köhler M, Gu C, Ryu SH, Martins JO, Darè E, Barker CJ, Berggren PO. Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells. 2018 Cell Signal. 2018 46:120-128. doi: 10.1016/j.cellsig.2018.03.001. [Abstract Rajasekaran SS, Kim J, Gaboardi GC, Gromada J, Shears SB, Dos Santos KT, Nolasco EL, Ferreira SS, Illies C, Köhler M, Gu C, Ryu SH, Martins JO, Darè E, Barker CJ, Berggren PO. Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells. 2018 Cell Signal. 2018 46:120-128. doi: 10.1016/j.cellsig.2018.03.001.]
  20. Nair VS, Gu C, Janoshazi AK, Jessen HJ, Wang H, Shears SB. Inositol Pyrophosphate Synthesis by Diphosphoinositol Pentakisphosphate Kinase-1 is Regulated by Phosphatidylinositol(4,5)bisphosphate. Biosci Rep. 2018 Feb 19. pii: BSR20171549. doi: 10.1042/BSR20171549. [Abstract Nair VS, Gu C, Janoshazi AK, Jessen HJ, Wang H, Shears SB. Inositol Pyrophosphate Synthesis by Diphosphoinositol Pentakisphosphate Kinase-1 is Regulated by Phosphatidylinositol(4,5)bisphosphate. Biosci Rep. 2018 Feb 19. pii: BSR20171549. doi: 10.1042/BSR20171549.]
  21. Shears SB, Hayakawa Y. The Drosophila cytokine, GBP: A model that illuminates the yin-yang of inflammation and longevity in humans?  Cytokine. 2018 Feb 15. pii: S1043-4666(18)30056-5. doi: 10.1016/j.cyto.2018.02.016. [Abstract Shears SB, Hayakawa Y. The Drosophila cytokine, GBP: A model that illuminates the yin-yang of inflammation and longevity in humans?  Cytokine. 2018 Feb 15. pii: S1043-4666(18)30056-5. doi: 10.1016/j.cyto.2018.02.016.]
  22. Rajasekaran SS, Illies C, Shears SB, Wang H, Ayala TS, Martins JO, Daré E, Berggren PO, Barker CJ. Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity. Cell Signal. 2018 42: 127-133. [Abstract Rajasekaran SS, Illies C, Shears SB, Wang H, Ayala TS, Martins JO, Daré E, Berggren PO, Barker CJ. Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity. Cell Signal. 2018 42: 127-133.] 
  23. Sung EJ, Ryuda M, Matsumoto H, Uryu O, Ochiai M, Cook ME, Yi NY, Wang H, Putney JW, Bird GS, Shears SB, Hayakawa Y. Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13786-13791. [Abstract Sung EJ, Ryuda M, Matsumoto H, Uryu O, Ochiai M, Cook ME, Yi NY, Wang H, Putney JW, Bird GS, Shears SB, Hayakawa Y. Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13786-13791.]
  24. Gu C, Nguyen HN, Ganini D, Chen Z, Jessen HJ, Gu Z, Wang H, Shears SB. KO of 5-InsP7 kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype. Proc Natl Acad Sci U S A. 2017 114: 11968-11973. [Abstract Gu C, Nguyen HN, Ganini D, Chen Z, Jessen HJ, Gu Z, Wang H, Shears SB. KO of 5-InsP7 kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype. Proc Natl Acad Sci U S A. 2017 114: 11968-11973.] 
  25. Wang H, Shears SB. Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities. J Biol Chem. 2017 292 (44) 18192-18202. [Abstract Wang H, Shears SB. Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities. J Biol Chem. 2017 292 (44) 18192-18202.] 
  26. Shears, SB. Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling. J Cell Physiol 2018 233: 1897-1912 [Abstract Shears, SB. Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling. J Cell Physiol 2018 233: 1897-1912]
  27. Gu C, Nguyen HN, Hofer A, Jessen HJ, Dai X, Wang H, Shears SB. The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis. J Biol Chem 2017; 292(11):4544-4555. [Abstract Gu C, Nguyen HN, Hofer A, Jessen HJ, Dai X, Wang H, Shears SB. The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis. J Biol Chem 2017; 292(11):4544-4555.]
  28. Gu C, Wilson MSC, Jessen HJ, Saiardi A, Shears SB. Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels. PloS One 2016 11(10):-. [Abstract Gu C, Wilson MSC, Jessen HJ, Saiardi A, Shears SB. Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels. PloS One 2016 11(10):-.]
  29. Hager A, Wu M, Wang H, Brown NW, Shears SB, Veiga N, Fiedler D. Cellular Cations Control Conformational Switching of Inositol Pyrophosphate Analogues. Chemistry (Weinheim an der Bergstrasse, Germany) 2016 22(35):12406-12414. [Abstract Hager A, Wu M, Wang H, Brown NW, Shears SB, Veiga N, Fiedler D. Cellular Cations Control Conformational Switching of Inositol Pyrophosphate Analogues. Chemistry (Weinheim an der Bergstrasse, Germany) 2016 22(35):12406-12414.]
  30. Shears SB. Towards pharmacological intervention in inositol pyrophosphate signaling. Biochem Soc. Trans. 2016; 15:191-196. [Abstract Shears SB. Towards pharmacological intervention in inositol pyrophosphate signaling. Biochem Soc. Trans. 2016; 15:191-196.]
  31. Riley AM, Wang H, Shears SB, L Potter BV. Synthetic tools for studying the chemical biology of InsP8. Chem Commun (Camb). 2015; 51(63):12605-12608. [Abstract Riley AM, Wang H, Shears SB, L Potter BV. Synthetic tools for studying the chemical biology of InsP8. Chem Commun (Camb). 2015; 51(63):12605-12608.]
  32. Shears SB. Inositol pyrophosphates: why so many phosphates? Adv Biol Regul. 2015; 57:203-216. [Abstract Shears SB. Inositol pyrophosphates: why so many phosphates? Adv Biol Regul. 2015; 57:203-216.]
  33. Wang H, Nair VS, Holland AA, Capolicchio S, Jessen HJ, Johnson MK, Shears SB. Asp1 from Schizosaccharomyces pombe Binds a [2Fe-2S](2+) Cluster Which Inhibits Inositol Pyrophosphate 1-Phosphatase Activity. Biochemistry. 2015; 54(42):6462-6474. [Abstract Wang H, Nair VS, Holland AA, Capolicchio S, Jessen HJ, Johnson MK, Shears SB. Asp1 from Schizosaccharomyces pombe Binds a [2Fe-2S](2+) Cluster Which Inhibits Inositol Pyrophosphate 1-Phosphatase Activity. Biochemistry. 2015; 54(42):6462-6474.]
  34. Yong ST, Nguyen HN, Choi JH, Bortner CD, Williams J, Pulloor NK, Krishnan MN, Shears SB. Identification of a functional nuclear translocation sequence in hPPIP5K2. BMC cell biology. 2015; 16(1):17-.  [Abstract Yong ST, Nguyen HN, Choi JH, Bortner CD, Williams J, Pulloor NK, Krishnan MN, Shears SB. Identification of a functional nuclear translocation sequence in hPPIP5K2. BMC cell biology. 2015; 16(1):17-. ]
  35. Tsuzuki S, Matsumoto H, Furihata S, Ryuda M, Tanaka H, Sung, EJ, Bird GS, Zhou Y, Shears SB, Hayakawa Y. Switching between humoral and cellular immune responses in Drosophila is guided by the cytokine GBP. Nat Commun. 2014; 5:4628. doi: 10.1038/ncomms5628. [Abstract Tsuzuki S, Matsumoto H, Furihata S, Ryuda M, Tanaka H, Sung, EJ, Bird GS, Zhou Y, Shears SB, Hayakawa Y. Switching between humoral and cellular immune responses in Drosophila is guided by the cytokine GBP. Nat Commun. 2014; 5:4628. doi: 10.1038/ncomms5628.]
  36. Capolicchio S, Wang H, Thakor DT, Shears SB, Jessen HJ. Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation. Angew Chem Int Ed Engl. 2014; 53(36):9508-9511.  [Abstract Capolicchio S, Wang H, Thakor DT, Shears SB, Jessen HJ. Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation. Angew Chem Int Ed Engl. 2014; 53(36):9508-9511. ]
  37. Wang H, DeRose EF, London RE, Shears SB. IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family. Nat Commun. 2014; 5:4178-. [Abstract Wang H, DeRose EF, London RE, Shears SB. IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family. Nat Commun. 2014; 5:4178-.]
  38. Wang H, Godage HY, Riley AM, Weaver JD, Shears SB, Potter BV. Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 has a Surface-Mounted Substrate Capture Site that is a Target for Drug Discovery. Chemistry & Biology. 2014; 21(5):689-699. [Abstract Wang H, Godage HY, Riley AM, Weaver JD, Shears SB, Potter BV. Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 has a Surface-Mounted Substrate Capture Site that is a Target for Drug Discovery. Chemistry & Biology. 2014; 21(5):689-699.]
  39. Stentz, R, Osborne, S, Horn, N, Li, AWH, Hautefort, I, Bongaerts, R, Rouyer, M, Bailey, P, Shears, SB, Hemmings, AM, Brearley, CA, Carding, SR. A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut. Cell Reports. 2014; 6:646-656. [Abstract Stentz, R, Osborne, S, Horn, N, Li, AWH, Hautefort, I, Bongaerts, R, Rouyer, M, Bailey, P, Shears, SB, Hemmings, AM, Brearley, CA, Carding, SR. A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut. Cell Reports. 2014; 6:646-656.]
  40. Pulloor, NK, Nair, S, Kostic, AD, Bist, P, Weaver, JD, Riley, AM, Tyag, R, Uchil, PD, York, JD, Snyder, SH, Garcıa-Sastre, A, Potter, BVL, Lin, R, Shears, SB, Xavier, RJ, Krishnan, MN. Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response. PlOS Pathogens. 2014; 10(2): e1003981. doi:10.1371/journal.ppat.1003981 [Open Access Pulloor, NK, Nair, S, Kostic, AD, Bist, P, Weaver, JD, Riley, AM, Tyag, R, Uchil, PD, York, JD, Snyder, SH, Garcıa-Sastre, A, Potter, BVL, Lin, R, Shears, SB, Xavier, RJ, Krishnan, MN. Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response. PlOS Pathogens. 2014; 10(2): e1003981. doi:10.1371/journal.ppat.1003981]
  41. Wang, LD, Bi, X, Song, X, Pohl, NM, Cheng, Y, Zhou, Y, Shears, SB, Ansong, E, Xing, M, Wang, S, Xu, XC, Huang, P, Xu, L, Wang, L, Fan, Z, Zhao, X, Dong, H, Meltzer, SJ, Ding, I, Yang, W. A Sequence Variant in the Phospholipase C epsilon C2 Domain Is Associated with Esophageal Carcinoma and Esophagitis. Molecular Carcinogenesis. 2013; 52:80-86. [Abstract Wang, LD, Bi, X, Song, X, Pohl, NM, Cheng, Y, Zhou, Y, Shears, SB, Ansong, E, Xing, M, Wang, S, Xu, XC, Huang, P, Xu, L, Wang, L, Fan, Z, Zhao, X, Dong, H, Meltzer, SJ, Ding, I, Yang, W. A Sequence Variant in the Phospholipase C epsilon C2 Domain Is Associated with Esophageal Carcinoma and Esophagitis. Molecular Carcinogenesis. 2013; 52:80-86.]
  42. Weaver JD, Wang H, Shears SB. The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment. Bioscience Reports. 2013; 33(2):229-241 [Abstract Weaver JD, Wang H, Shears SB. The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment. Bioscience Reports. 2013; 33(2):229-241]
  43. Brehm, MA, Williams, J, Wunderberg, T, Mayr, GW, Shears, SB. A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA. J Cell Sci. 2013; 126(Pt 2):437-44. [Abstract Brehm, MA, Williams, J, Wunderberg, T, Mayr, GW, Shears, SB. A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA. J Cell Sci. 2013; 126(Pt 2):437-44.]
  44. Kilari, RS, Weaver, JD, Shears, SB, Safrany, ST. Understanding inositol pyrophosphate metabolism and function: Kinetic characterization of the DIPPs. FEBS letters. 2013; 587(21):3464-3470. [Abstract Kilari, RS, Weaver, JD, Shears, SB, Safrany, ST. Understanding inositol pyrophosphate metabolism and function: Kinetic characterization of the DIPPs. FEBS letters. 2013; 587(21):3464-3470.]
  45. Gokhale N, Zaremba A, Janoshazi, AK, Weaver JD, Shears SB. PPIP5K1 Modulates Ligand Competition Between Diphosphoinositol Polyphosphates and PtdIns(3,4,5)P3 for Polyphosphoinositide-Binding Domains. The Biochemical journal. 2013; 453(3):413-426. [Abstract Gokhale N, Zaremba A, Janoshazi, AK, Weaver JD, Shears SB. PPIP5K1 Modulates Ligand Competition Between Diphosphoinositol Polyphosphates and PtdIns(3,4,5)P3 for Polyphosphoinositide-Binding Domains. The Biochemical journal. 2013; 453(3):413-426.]
  46. Ganapathi, SB, Wei, SG, Zaremba, A, Lamb, FS, Shears, SB. Functional Regulation of ClC-3 in the Migration of Vascular Smooth Muscle Cells. Hypertension. 2013; 61(1):174-179. [Abstract Ganapathi, SB, Wei, SG, Zaremba, A, Lamb, FS, Shears, SB. Functional Regulation of ClC-3 in the Migration of Vascular Smooth Muscle Cells. Hypertension. 2013; 61(1):174-179.]