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Selected Publications

Inositol Signaling Group

  1. Gu C, Nguyen HN, Ganini D, Chen Z, Jessen HJ, Gu Z, Wang H, Shears SB. KO of 5-InsP7 kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype. Proc Natl Acad Sci U S A. 2017 Oct 25. pii: 201702370. doi: 10.1073/pnas.1702370114 [Abstract] 
  2. Rajasekaran SS, Illies C, Shears SB, Wang H, Ayala TS, Martins JO, Daré E, Berggren PO, Barker CJ. Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity. Cell Signal. 2017 Oct 16;42:127-133. doi: 10.1016/j.cellsig.2017.10.008 [Abstract] 
  3. Wang H, Shears SB. Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities. J Biol Chem. 2017 Sep 7. pii: jbc.M117.801845. doi: 10.1074/jbc.M117.801845. [Abstract] 
  4. Shears, SB. Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling. J Cell Physiol 2017 doi: 10.1002/jcp.26017 [Abstract]
  5. Gu C, Nguyen HN, Hofer A, Jessen HJ, Dai X, Wang H, Shears SB. The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis. J Biol Chem 2017; 292(11):4544-4555. [Abstract]
  6. Gu C, Wilson MSC, Jessen HJ, Saiardi A, Shears SB. Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels. PloS One 2016 11(10):-. [Abstract]
  7. Hager A, Wu M, Wang H, Brown NW, Shears SB, Veiga N, Fiedler D. Cellular Cations Control Conformational Switching of Inositol Pyrophosphate Analogues. Chemistry (Weinheim an der Bergstrasse, Germany) 2016 22(35):12406-12414. [Abstract]
  8. Shears SB. Towards pharmacological intervention in inositol pyrophosphate signaling. Biochem Soc. Trans. 2016; 15:191-196. [Abstract]
  9. Riley AM, Wang H, Shears SB, L Potter BV. Synthetic tools for studying the chemical biology of InsP8. Chem Commun (Camb). 2015; 51(63):12605-12608. [Abstract]
  10. Shears SB. Inositol pyrophosphates: why so many phosphates? Adv Biol Regul. 2015; 57:203-216. [Abstract]
  11. Wang H, Nair VS, Holland AA, Capolicchio S, Jessen HJ, Johnson MK, Shears SB. Asp1 from Schizosaccharomyces pombe Binds a [2Fe-2S](2+) Cluster Which Inhibits Inositol Pyrophosphate 1-Phosphatase Activity. Biochemistry. 2015; 54(42):6462-6474. [Abstract]
  12. Yong ST, Nguyen HN, Choi JH, Bortner CD, Williams J, Pulloor NK, Krishnan MN, Shears SB. Identification of a functional nuclear translocation sequence in hPPIP5K2. BMC cell biology. 2015; 16(1):17-.  [Abstract]
  13. Tsuzuki S, Matsumoto H, Furihata S, Ryuda M, Tanaka H, Sung, EJ, Bird GS, Zhou Y, Shears SB, Hayakawa Y. Switching between humoral and cellular immune responses in Drosophila is guided by the cytokine GBP. Nat Commun. 2014; 5:4628. doi: 10.1038/ncomms5628. [Abstract]
  14. Capolicchio S, Wang H, Thakor DT, Shears SB, Jessen HJ. Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation. Angew Chem Int Ed Engl. 2014; 53(36):9508-9511.  [Abstract]
  15. Wang H, DeRose EF, London RE, Shears SB. IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family. Nat Commun. 2014; 5:4178-. [Abstract]
  16. Wang H, Godage HY, Riley AM, Weaver JD, Shears SB, Potter BV. Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 has a Surface-Mounted Substrate Capture Site that is a Target for Drug Discovery. Chemistry & Biology. 2014; 21(5):689-699. [Abstract]
  17. Stentz, R, Osborne, S, Horn, N, Li, AWH, Hautefort, I, Bongaerts, R, Rouyer, M, Bailey, P, Shears, SB, Hemmings, AM, Brearley, CA, Carding, SR. A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut. Cell Reports. 2014; 6:646-656. [Abstract]
  18. Pulloor, NK, Nair, S, Kostic, AD, Bist, P, Weaver, JD, Riley, AM, Tyag, R, Uchil, PD, York, JD, Snyder, SH, Garc─▒a-Sastre, A, Potter, BVL, Lin, R, Shears, SB, Xavier, RJ, Krishnan, MN. Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response. PlOS Pathogens. 2014; 10(2): e1003981. doi:10.1371/journal.ppat.1003981 [Open Access]
  19. Wang, LD, Bi, X, Song, X, Pohl, NM, Cheng, Y, Zhou, Y, Shears, SB, Ansong, E, Xing, M, Wang, S, Xu, XC, Huang, P, Xu, L, Wang, L, Fan, Z, Zhao, X, Dong, H, Meltzer, SJ, Ding, I, Yang, W. A Sequence Variant in the Phospholipase C epsilon C2 Domain Is Associated with Esophageal Carcinoma and Esophagitis. Molecular Carcinogenesis. 2013; 52:80-86. [Abstract]
  20. Weaver JD, Wang H, Shears SB. The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment. Bioscience Reports. 2013; 33(2):229-241 [Abstract]
  21. Brehm, MA, Williams, J, Wunderberg, T, Mayr, GW, Shears, SB. A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA. J Cell Sci. 2013; 126(Pt 2):437-44. [Abstract]
  22. Kilari, RS, Weaver, JD, Shears, SB, Safrany, ST. Understanding inositol pyrophosphate metabolism and function: Kinetic characterization of the DIPPs. FEBS letters. 2013; 587(21):3464-3470. [Abstract]
  23. Gokhale N, Zaremba A, Janoshazi, AK, Weaver JD, Shears SB. PPIP5K1 Modulates Ligand Competition Between Diphosphoinositol Polyphosphates and PtdIns(3,4,5)P3 for Polyphosphoinositide-Binding Domains. The Biochemical journal. 2013; 453(3):413-426. [Abstract]
  24. Ganapathi, SB, Wei, SG, Zaremba, A, Lamb, FS, Shears, SB. Functional Regulation of ClC-3 in the Migration of Vascular Smooth Muscle Cells. Hypertension. 2013; 61(1):174-179. [Abstract]
  25. Riley, AM, Wang, H, Weaver, JD, Shears, SB, Potter, BV. First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase. Chem. Commun. 2012; 48:11292-11294. [Abstract]
  26. Wang H, Falck JR, Hall, TM, Shears SB. Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nature Chemical Biology. 2011; 8(1):111-6. [Abstract]