Skip Navigation
 

Software


Biostatistics

  • ACANA
    ACANA is an accurate and consistent alignment tool for DNA sequences.
  • Analysis of Genetic Associations for Shared Controls Design
    ("/Rhythmyx/assembler/render?sys_contentid=35154&sys_revision=8&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35154" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35154" sys_siteid="" sys_folderid="")P-value based analysis for shared controls design in genome-wide association studies.
  • ART ("/Rhythmyx/assembler/render?sys_contentid=34834&sys_revision=9&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="34834" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="34834" sys_siteid="" sys_folderid="")
    ART is a set of simulation tools to generate synthetic next-generation sequencing reads. ART simulates sequencing reads by mimicking real sequencing process with empirical error models or quality profiles summarized from large recalibrated sequencing data.
  • Case Control
    ("/Rhythmyx/assembler/render?sys_contentid=56407&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="56407" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="56407" sys_siteid="" sys_folderid="")This archive provides information for fitting log-linear models and carrying out statistical tests for a design that includes two samples from the same population: one sample of affected individuals and their mothers and a second sample of unaffected individuals and their mothers.
  • Circular FSA
    ("/Rhythmyx/assembler/render?sys_contentid=51492&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="51492" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="51492" sys_siteid="" sys_folderid="")A SAS extention that tests whether the orthologs {B1,B2,...,BG} satisfy the same relative order as the genes { A1,A2,...,AG }.
  • coMotif ("/Rhythmyx/assembler/render?sys_contentid=34836&sys_revision=3&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="34836" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="34836" sys_siteid="" sys_folderid="")
    A three-component mixture framework to model the joint distribution of two motifs as well as the situation where some sequences contain only one or none of the motifs.
  • Correlation-Based Tests
    ("/Rhythmyx/assembler/render?sys_contentid=35146&sys_revision=5&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35146" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35146" sys_siteid="" sys_folderid="")Correlation-based inference for linkage disequilibrium with multiple alleles.
  • Ctrl-mom-hybrid
    ("/Rhythmyx/assembler/render?sys_contentid=56408&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="56408" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="56408" sys_siteid="" sys_folderid="")This archive provides information for fitting log-linear models and carrying out statistical tests for a hybrid design that includes a sample of affected individuals and their parents and a sample of unaffected individuals and their mothers (case-parent triad/control-mother dyad design).
  • EagleView
    EagleView is an information-rich viewer for next-generation genome assembles with data integration capability.
  • EpiCenter
    ("/Rhythmyx/assembler/render?sys_contentid=34838&sys_revision=3&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="34838" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="34838" sys_siteid="" sys_folderid="")EpiCenter is a powerful analysis tool of genome-wide mRNA-seq or ChIP-seq data for detecting differentially expressed genes or identifying changes in epigenetic modifications.
  • Expression Predictor (ExP)
    ("/Rhythmyx/assembler/render?sys_contentid=34881&sys_revision=4&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="34881" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="34881" sys_siteid="" sys_folderid="")A desktop application developed with Java programming language for classifying and predicting samples based on gene expression data using a simplified fuzzy adaptive resonance theory map (SFAM) neural network architecture.
  • Extracting Patterns and Identifying co-expressed Genes (EPIG)
    ("/Rhythmyx/assembler/render?sys_contentid=34840&sys_revision=5&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="34840" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="34840" sys_siteid="" sys_folderid="")A method for Extracting microarray gene expression Patterns and Identifying co-expressed Genes.
  • fdrMotif
    ("/Rhythmyx/assembler/render?sys_contentid=34887&sys_revision=3&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="34887" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="34887" sys_siteid="" sys_folderid="")Determines the number of binding sites in each sequence of a probability model by performing statistical tests.
  • GA/KNN
    ("/Rhythmyx/assembler/render?sys_contentid=34892&sys_revision=3&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="34892" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="34892" sys_siteid="" sys_folderid="")Selects the most discriminative variables for sample classification and may be used for analysis of microarray gene expression data, proteomic data or other high-dimensional data.
  • GADEM ("/Rhythmyx/assembler/render?sys_contentid=34890&sys_revision=3&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="34890" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="34890" sys_siteid="" sys_folderid="")
    An unbiased de novo motif discovery tool implementing an expectation-maximization (EM) algorithm.
  • GEI-TRIMM
    ("/Rhythmyx/assembler/render?sys_contentid=56417&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="56417" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="56417" sys_siteid="" sys_folderid="")This package includes the program GEI-TRIMM, which implements the method described in the manuscript Shi M, Umbach DM, Weinberg CR 2010 "Testing Haplotype-Environment Interactions Using Case-parent Triads."
  • Genetic Algorithm Method for Optimizing a Position Weight Matrix
    ("/Rhythmyx/assembler/render?sys_contentid=34945&sys_revision=4&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="34945" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="34945" sys_siteid="" sys_folderid="")Implements a simple method to improve a poorly estimated position weight matrix using chromatin immunoprecipitation data.
  • Hill Viewer
    ("/Rhythmyx/assembler/render?sys_contentid=34951&sys_revision=4&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="34951" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="34951" sys_siteid="" sys_folderid="")Used to visualize dose-response curves and relative potency functions based on two sets of Hill model parameters.
  • Hybrid Design
    ("/Rhythmyx/assembler/render?sys_contentid=34981&sys_revision=3&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="34981" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="34981" sys_siteid="" sys_folderid="")Provides information for fitting log-linear models and carrying out statistical tests.
  • LEM scripts
    ("/Rhythmyx/assembler/render?sys_contentid=56421&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="56421" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="56421" sys_siteid="" sys_folderid="")This archive provides information for fitting log-linear models and carrying out statistical tests for preterm birth study.
  • Modk-Prototypes
    ("/Rhythmyx/assembler/render?sys_contentid=35062&sys_revision=4&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35062" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35062" sys_siteid="" sys_folderid="")Clusters biological samples by simultaneously considering microarray gene expression data and classes of known phenotypic variables such as clinical chemistry evaluations and histopathologic observations.
  • OMiMa
    The OMiMa System is a computational tool for identifying functional motifs in DNA or protein sequences.
  • ORIOGEN v 3 - Order Restricted Inference for Ordered Gene Expression
    ("/Rhythmyx/assembler/render?sys_contentid=35065&sys_revision=8&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35065" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35065" sys_siteid="" sys_folderid="")Analyzes gene expression data obtained from time-course/dose-response studies.
  • PCA-based Gene Filtering
    ("/Rhythmyx/assembler/render?sys_contentid=35076&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35076" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35076" sys_siteid="" sys_folderid="")A new filtering statistic for Affymetrix GeneChips, based on principle component analysis (PCA) on the probe-level gene expression data.
  • Phase-shifted Analysis of Gene Expression (PAGE)
    ("/Rhythmyx/assembler/render?sys_contentid=35110&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35110" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35110" sys_siteid="" sys_folderid="")An interactive tool that uses a line graph to dynamically illustrate the phase-shifted patterns of gene expressions based on the q-Cluster selected by the users.
  • Principal Variance Component Analysis ("/Rhythmyx/assembler/render?sys_contentid=35299&sys_revision=3&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35299" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35299" sys_siteid="" sys_folderid="")
    A hybrid approach using principal components analysis and variance component analysis as a methodology to determine and quantify sources of variability most prominent in microarray gene expression data.
  • PSPE
    PSPE is a computational tool specifically designed for simulating evolution of non-coding DNA sequences, in particular promoter sequences.
  • R code for fitting Random Periods Model ("/Rhythmyx/assembler/render?sys_contentid=51500&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="51500" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="51500" sys_siteid="" sys_folderid="")
    Software for fitting the Random Periods Model (RPM) for cell cycle genes.
  • Rankings of causal loci in GWAS
    ("/Rhythmyx/assembler/render?sys_contentid=35144&sys_revision=4&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35144" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35144" sys_siteid="" sys_folderid="")Novel rank-based approaches for discovery and replication in genome wide association studies.
  • R-SCRIPTS
    ("/Rhythmyx/assembler/render?sys_contentid=56430&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="56430" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="56430" sys_siteid="" sys_folderid="")This package contains two R scripts for generating scenarios 1-4 described in the manuscript Shi M, Weinberg CR 2011 "How much are we missing in SNP-by-SNP analyses of GWAS?"
  • SA-Modk-Prototypes
    ("/Rhythmyx/assembler/render?sys_contentid=35617&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35617" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35617" sys_siteid="" sys_folderid="")For simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations using simulated annealing.
  • SAS Code to Fit Genetic Models
    ("/Rhythmyx/assembler/render?sys_contentid=56439&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="56439" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="56439" sys_siteid="" sys_folderid="")Various SAS code for identifying genes related to a quantitative trait, incorporating multiple siblings and missing parents.
  • Systematic Variation Normalization (SVN)
    ("/Rhythmyx/assembler/render?sys_contentid=35622&sys_revision=3&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35622" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35622" sys_siteid="" sys_folderid="")A procedure for removing systematic variation in microarray gene expression data.
  • TRIad Multi-Marker
    ("/Rhythmyx/assembler/render?sys_contentid=35906&sys_revision=3&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35906" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35906" sys_siteid="" sys_folderid="")Performs association tests for a child's or mother's genetic effects using multiple markers from triad families.
  • TRIMMEST
    ("/Rhythmyx/assembler/render?sys_contentid=56435&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="56435" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="56435" sys_siteid="" sys_folderid="")This package contains programs that fit log-linear models to estimate the relative risk associated with a candidate risk haplotype in a triad-based association study.


Back to top Back to top

Epidemiology

  • mPopTag
    ("/Rhythmyx/assembler/render?sys_contentid=35063&sys_revision=6&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35063" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35063" sys_siteid="" sys_folderid="")A tool used to select or evaluate linkage disequilibrium tag SNPs for multiple populations.
  • TAGster ("/Rhythmyx/assembler/render?sys_contentid=35267&sys_revision=3&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35267" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35267" sys_siteid="" sys_folderid="")
    A tool to select, evaluate and visualize LD tag SNPs for single or multiple populations.


Back to top Back to top

National Toxicology Program

 

  • Forest Plot Viewer program 
    Creates figures using a forest plot display with multiple columns of descriptive text and has the ability to be rapidly modified by the user to display subsets of data based on user-specified filtering criteria.


Back to top Back to top

Respiratory Biology

  • PCR Analyzer
    ("/Rhythmyx/assembler/render?sys_contentid=35098&sys_revision=6&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35098" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35098" sys_siteid="" sys_folderid="")Uses an algorithm that helps researchers examine polymerase chain reaction (PCR) data.


Back to top Back to top

Structural Biology

  • NMR NOE Simulations
    ("/Rhythmyx/assembler/render?sys_contentid=35069&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35069" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35069" sys_siteid="" sys_folderid="")Calculates the time dependence of the diagonal and crosspeaks in a 2D NOESY experiment for a system undergoing chemical exchange using the full relaxation matrix.
  • NMR Scripts
    ("/Rhythmyx/assembler/render?sys_contentid=35071&sys_revision=4&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35071" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35071" sys_siteid="" sys_folderid="")Analyzes multidimensional NMR data.
  • NvAssign
    ("/Rhythmyx/assembler/render?sys_contentid=34773&sys_revision=5&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="34773" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="34773" sys_siteid="" sys_folderid="")Software that aids the process of protein resonance in NMR.


Back to top Back to top

Toxicology & Pharmacology

  • Electron Spin Resonance Software Database
    ("/Rhythmyx/assembler/render?sys_contentid=34873&sys_revision=3&sys_variantid=787&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="787" sys_dependentid="34873" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="34873" sys_siteid="" sys_folderid="")A compilation of details about programs written for Electron Paramagnetic Resonance spectroscopists.
  • Public Electron Paramagnetic Resonance Software Tools
    ("/Rhythmyx/assembler/render?sys_contentid=32797&sys_revision=4&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="32797" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="32797" sys_siteid="" sys_folderid="")Helps researchers analyze Electron Paramagnetic Resonance data.


Back to top Back to top


 
Last Reviewed: December 06, 2011