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Microphysiological Systems (MPS)
A feature article published in July 2021 in Drug Discovery Today reviews MPSCoRe activities in the context of the broader effort to apply MPS to the development of therapies for ...
https://ntp.niehs.nih.gov/whatwestudy/niceatm/test-method-evaluations/mps -
Agenda: Draft Monograph on Developmental Effects and Pregnancy...
Topoisomerase II Inhibitor Oxygen-free Radical Generator Targeted Therapies Presentation on each mechanism Peer review comments on each agent Panel discussion on each agent Dr. ...
Size: 56KB https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2012/october/agenda20121002_508.pdf -
RoC Profile: Diethylstilbestrol; 15th RoC 2021
... also occurred in the past through the use of diethylstilbestrol to prevent miscarriages, as hormone replacement therapy, to treat prostate cancer, and in other medical therapies. ...
Size: 141KB https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/diethylstilbestrol.pdf -
RoC Profile: Estrogens, Steroidal; 15th RoC 2021
... These replace- ment therapies are used to treat symptoms of menopause, including menopause ... used in typical estrogen therapies, particularly in some oral contraceptive formulations. ...
Size: 161KB https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/estrogenssteroidal.pdf -
RoC Background Document: Steroidal Estrogens; Dec. 13-14, 2000
... between the effects of estrogen- only and estrogen-progestin combination therapies. ... combination therapies; however, others have not had adequate information to do so. ...
Size: 1.7MB https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc10/se_no_appendices_508be.pdf -
Public Comment: Cobalt and Certain Cobalt Compounds; Andrew Monnot...
... Individuals may have elevated Co exposures due to (1) occupational Co exposures, (2) prescribed medical Co therapies, (3) voluntary ingestion of vitamin B12 and other Co-containing ...
Size: 491KB https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/thirteenth/publiccomm/monnot20131018_508.pdf -
Notices
... of Vaccine With Adoptive Cell Therapies Made at NCI for the Treatment of Solid ... The trial would involve the combination of NCI- engineered cell therapies with a vaccine ...
Size: 218KB https://ntp.niehs.nih.gov/sites/default/files/2024-08/2024-17099.pdf -
RoC Profile: Aristolochic Acids; 15th RoC 2021
... In contemporary medicine, Aristolochia plant extracts have been used in therapies for arthritis, gout, rheu- matism, and festering wounds, but these uses were discontinued in ...
Size: 182KB https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/aristolochicacids.pdf -
NTP Monograph: Developmental Effects and Pregnancy Outcomes Associated...
... gestational exposure to targeted therapies ......and the fact that combination therapies employ agents with various mechanisms of action. ...
Size: 23.8MB https://ntp.niehs.nih.gov/go/mgraph02 -
ICCVAM PF 2023 _230511_JM EB
... National Cancer Institute CAR-T cell therapies are ground-breaking, life-saving ... methods to evaluate the safety of these therapies, that have extraordinarily high risk for ...
Size: 191KB https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2023/pubcmts/pcrm20230512_508.pdf
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