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Developmental & Reproductive Toxicity (DART) Reports
Treatment of AIDS generally involves combination therapies of antiretroviral agents with ... These evaluations included single therapeutic agents or combination therapies when the ...
https://ntp.niehs.nih.gov/publications/reports/dart -
RoC Profile: Nitrosourea Chemotherapeutic Agents; 15th RoC 2021
... use with other anti- cancer therapies in the treatment of preexisting cancer (IARC 1987). ... nonlymphocytic leukemia among 1,566 patients given other therapies (Boice et al. 1983). ...
Size: 215KB https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/nitrosoureachemotherapeuticagents.pdf -
RoC Profile: Norethisterone; 15th RoC 2021
... and dysmenorrhea, and in hormone replace- ment therapies (IARC 1979, MedlinePlus 2009b). ... Norethisterone acetate is also administered in several hormone replacement therapies ...
Size: 123KB https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/norethisterone.pdf -
RoC Profile: Progesterone; 15th RoC 2021
... or estrogen-progesterone combinations used as oral contraceptives or menopausal therapies. ... uterine bleeding and in combination hormone-replacement therapies (MedlinePlus 2009). ...
Size: 138KB https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/progesterone.pdf -
ICCVAM Agency Activities
monoclonal antibody therapies and other drugs with more effective, human-relevant methods. ... Identify gaps in translation of these in silico models to therapies and seed discussions ...
https://ntp.niehs.nih.gov/whatwestudy/niceatm/iccvam/agency-activities -
Nomination of BioSentinel Methods for Detection of Botulinum...
Pharmaceutical manufacturing of BoNT-based therapies and cosmetics accounts for an estimated 600,000 animal deaths per year (Adler, 2010). . Development of new BoNT-based therapies ...
Size: 1.7MB https://ntp.niehs.nih.gov/iccvam/methods/biologics/biosentinel/biosentinelcover-508.pdf -
ICCVAM Public Forum: May 2023
Measurement Science in ICCVAM: Elijah Petersen, NIST In Vitro Co-Culture Assays to Assess Safety of CAR-T Cell Therapies: Shari Price, Leidos Biomedical Research (contractor ...
https://ntp.niehs.nih.gov/whatwestudy/niceatm/3rs-meetings/past-meetings/pubforum-2023/iccvamforum-2023 -
RoC Background Document: Cyclosporin A; Nov. 18-19, 1996
3.2.2 CsA, Possibly Other Immunosuppressive Therapies ...... 12 3.2.3 CsA in Combination with Other Immunosuppressive Therapies......
Size: 4.9MB https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/cyclosporin_a1_508.pdf -
Tissue Chips for Drug Screening Program (ICCVAM 2023 Public Forum...
risk assessment to accurately evaluate the efficacy, safety and toxicity of promising therapies https://ncats.nih.gov/tissuechip . Represents 10 Major Organ Systems . Circulatory . ...
Size: 4.9MB https://ntp.niehs.nih.gov/sites/default/files/2023-06/22_tagle_iccvamforum2023_508.pdf -
Measuring U.S. Federal Agency Progress Toward Implementation...
... Scientists also use animals to study basic biological processes (e.g., biochemistry, physiology, behavior), or to develop therapies for diseases. This practice is often referred to ...
Size: 617KB https://ntp.niehs.nih.gov/iccvam/docs/about_docs/iccvam-measuringprogress-feb2021-fd-508.pdf
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